ERECTILE DYSFUNCTION AS A PREDICTOR AND A COMPANION OF CARDIOVASCULAR DISEASE

2021 ◽  
pp. 178-182
Author(s):  
Анна Сергеевна Смольянникова ◽  
Ирина Сергеевна Добрынина ◽  
Анна Александровна Зуйкова ◽  
Елена Анатольевна Ханина ◽  
Марина Николаевна Муравицкая
Keyword(s):  
Blood Pressure ◽  
Erectile Dysfunction ◽  
Cardiovascular Diseases ◽  
High Strength ◽  
Vascular Lesions ◽  
Control Group ◽  
Endocrine Disorders ◽  
Cardiovascular Pathology ◽  
Relationship Of ◽  
The Relationship

Эректильная дисфункция - патология, связанная не только с наличием у больного урологических, психических или эндокринных нарушений. Нарушению эректильной функции способствуют многочисленные факторы, в том числе кардиоваскулярные заболевания, к которым в частности относится атеросклеротическое поражение сосудов на фоне дислипидемии. Эректильная дисфункция часто является первым симптомом системного атеросклероза. Целью исследования является изучение связи эректильной дисфункции и уровня тестостерона крови с дислипидемией и частными проявлениями сердечно-сосудистой патологии для своевременного выявления и начала лечения латентных форм кардиоваскулярных заболеваний. Была проведена оценка соответствующих показателей у выделенных групп исследуемых: основная группа - больные, обратившиеся за помощью по поводу эректильной дисфункции, контрольная группа - относительно здоровые исследуемые, не предъявляющие жалоб на эректильную функцию. В результате оценки полученных данных между количеством баллов, набранных по тесту-опроснику МИЭФ-5, уровнем тестостерона и показателями сАД, дАД, SCORE, общего холестерина и коэффициентом атерогенности выявлены связи умеренной и высокой силы. Пациенты, обратившиеся за амбулаторной помощью по поводу эректильной дисфункции, имели высокие показатели коэффициента атерогенности, что свидетельствует о высокой вероятности атеросклеротического поражения сосудов и в дальнейшем развития сердечно-сосудистой патологии Erectile dysfunction is a pathology associated not only with the presence of urological, mental or endocrine disorders in the patient. Numerous factors contribute to the development of erectile dysfunction, including cardiovascular diseases, which in particular include atherosclerotic vascular damage on the background of dyslipidemia. Erectile dysfunction caused by arteriosclerosis of the penile arteries is often the first symptom of systemic arteriosclerosis. The aim of this research is to study the relationship of erectile dysfunction and blood testosterone levels with dyslipidemia and particular manifestations of cardiovascular pathology for the timely detection and initiation of treatment of latent forms of cardiovascular diseases. To do this, the corresponding indicators were evaluated in the selected groups of subjects: the main group - patients who sought help for erectile dysfunction, the control group-relatively healthy subjects who did not complain about their erectile function. As a result of evaluating the data obtained between the number of points scored according to the MIEF-5 test-questionnaire, the level of testosterone and indicators of systolic blood pressure, diastolic blood pressure, SCORE, total cholesterol and the coefficient of atherogenicity, moderate and high strength relationships were revealed. Patients seeking outpatient care for erectile dysfunction had high rates of atherogenic coefficient, which indicates a high probability of atherosclerotic vascular lesions and further development of cardiovascular pathology

International Cooperative Study on the Relationship between Dietary Factors and Blood Pressure: a Preliminary Report from the Cardiovascular Diseases and Alimentary Comparison (Cardiac) Study

1992 ◽  
Vol 8 (2-3) ◽  
pp. 77-90 ◽  
Author(s):  
Y. Yamori ◽  
Y. Nara ◽  
S. Mizushima ◽  
M. Mano ◽  
M. Sawamura ◽  
...  
Keyword(s):  
Blood Pressure ◽  
Cardiovascular Diseases ◽  
Linear Regression ◽  
Dietary Factors ◽  
Urinary Sodium ◽  
Medical Interview ◽  
Simple Linear Regression ◽  
Sodium Calcium ◽  
Relationship Of ◽  
The Relationship

To investigate the epidemiological relationship of dietary factors to blood pressure (BP) and major cardiovascular diseases, we carried out the international cooperative Cardiovascular Diseases and Alimentary Comparison (CARDIAC) Study, which so far involves 48 centers in 20 countries as of August 1991. From each population, 100 men and 100 women aged 50–54 years were randomly selected for BP measurement, 24-h urine collection, blood tests, and medical interview. Various biological markers of diets from urine and blood were analyzed centrally in the Izumo CARDIAC center. Cross center analysis using simple linear regression revealed strong significant correlations of body mass index (BMI) to systolic BP (SBP; p 0.01) and diastolic BP(DBP; p 0.001) in men. 24-h urinary sodium (Na) excretion in men also showed significant correlations with SBP (p 0.05) and DBP p 0.05) even after controling for the effect of BMI (SBP; p 0.05, DBP; p 0.05). Within center analysis using multiple linear regression implied that BMI and Na strongly adversely affect BP, whereas magnesium may have beneficial influence on BP. Multicolinearities among 24h urinary sodium, calcium, and urea nitrogen were noted in men.

scholarly journals Effects of Acupuncture on Lowering Blood Pressure in Postmenopausal Women with Prehypertension or Stage 1 Hypertension: A Propensity Score-Matched Analysis

2021 ◽  
Vol 10 (7) ◽  
pp. 1426
Author(s):  
Bok-Nam Seo ◽  
Ojin Kwon ◽  
Siwoo Lee ◽  
Ho-Seok Kim ◽  
Kyung-Won Kang ◽  
...  
Keyword(s):  
Blood Pressure ◽  
Cardiovascular Diseases ◽  
Propensity Score ◽  
Systolic Blood Pressure ◽  
Diastolic Blood Pressure ◽  
Postmenopausal Women ◽  
Analysis Of Covariance ◽  
Control Group ◽  
Matched Design ◽  
Stage 1

Postmenopausal women have a higher prevalence of hypertension compared to premenopausal women. Hypertension is a risk factor for cardiovascular diseases, the prevalence of which is ever increasing. This study investigated the effects of long-term acupuncture on lowering the blood pressure of postmenopausal women with prehypertension and stage 1 hypertension. Participants were 122 postmenopausal women aged less than 65 years, diagnosed with prehypertension or stage 1 hypertension (systolic blood pressure 120–159 mmHg or diastolic blood pressure 80–99 mmHg). We used a propensity score-matched design. The experimental group (n = 61) received acupuncture for four weeks every six months over a period of two years. The control group (n = 61) received no intervention. An Analysis of covariance (ANCOVA) was performed for the primary efficacy analysis. Relative risk ratios were used to compare group differences in treatment effects. Acupuncture significantly reduced the participants’ diastolic blood pressure (−9.92 mmHg; p < 0.001) and systolic blood pressure (−10.34 mmHg; p < 0.001) from baseline to follow-up. The results indicate that acupuncture alleviates hypertension in postmenopausal women, reducing their risk of developing cardiovascular diseases and improving their health and quality of life.

scholarly journals 600 THE RELATIONSHIP OF CHILDHOOD AND ADULT BLOOD PRESSURE–30 YEARS LATER

1985 ◽  
Vol 19 (4) ◽  
pp. 210A-210A
Author(s):  
Ruth Whittemore ◽  
G J Beck ◽  
Lisa McKay
Keyword(s):  
Blood Pressure ◽  
Relationship Of ◽  
The Relationship

Experimental study of the inhibition effect of CXCL12/CXCR4 in malignant pleural mesothelioma

2018 ◽  
Vol 67 (2) ◽  
pp. 338-345 ◽  
Author(s):  
Jianshuang Li ◽  
Tong Li ◽  
Shuo Li ◽  
Lipeng Xie ◽  
Yi-Lin Yang ◽  
...  
Keyword(s):  
Treatment Group ◽  
Malignant Pleural Mesothelioma ◽  
Synergistic Effects ◽  
Control Group ◽  
Pleural Mesothelioma ◽  
Gene Expressions ◽  
Relationship Of ◽  
The Relationship ◽  
Cxcr4 Axis

Previous studies have demonstrated that CXCL12/CXCR4 axis is closely related to tumors such as malignant pleural mesothelioma (MPM). This research was conducted in order to detect whether CXCL12/CXCR4 inhibitors could restrain MPM and have a synergistic effect with chemotherapy, also to investigate the relationship of CXCL12/CXCR4 with other gene expressions in MPM. Forty mice were injected MPM cells and randomly divided into four groups: the PBS (control group), AMD3100 (CXCR4-CXCL12 antagonist), pemetrexed and AMD3100 plus pemetrexed. The mice were treated respectively for duration of 3 weeks. The size, bioluminescence and weight of tumors were measured. The differences between gene expressions in each group were analyzed. The tumor weights of each treatment group were lower than that of the control group (p<0.05). The bioluminescence of the tumor of the AMD3100 treatment group and the AMD3100 plus pemetrexed treatment group were lower than that of the control group (p<0.05), and AMD3100 was shown to have synergistic effects with pemetrexed (p<0.05). Among the 2.5 billion genes, several hundreds of genes expressed differently between groups. Results show that AMD3100 and pemetrexed can inhibit the growth of MPM in vivo, also that there is a better result if both are used together. Our findings suggest that CXCL12/CXCR4 axis affects a certain amount of gene expression in MPM.

scholarly journals Reduced loss aversion in subclinical negative symptoms and hypomania

2020 ◽  
Author(s):  
Federica Klaus ◽  
Justin Chumbley ◽  
Erich Seifritz ◽  
Stefan Kaiser ◽  
Matthias Hartmann-Riemer
Keyword(s):  
Loss Aversion ◽  
Negative Symptoms ◽  
Control Group ◽  
Inverse Relation ◽  
Symptom Dimensions ◽  
Binary Choices ◽  
Relationship Of ◽  
The Relationship ◽  
Behavioral Phenomenon ◽  
Higher Sensitivity

AbstractLoss aversion is a behavioral phenomenon that describes a higher sensitivity to losses than to gains and influences decisions. Decision-making is altered in several psychopathologic states, such as in the two symptom dimensions of hypomania and negative symptoms. It has been argued that progress in our understanding of psychopathology requires a reorientation from the traditional, syndrome-based perspective to a more detailed study of individual constituent symptoms. In the present study, we made careful efforts to dissociate the relationship of loss aversion to negative symptoms, from its relationship with hypomanic symptoms. We selected a sample of 45 subjects from a healthy student population (n = 835) according to psychopathologic scales for hypomania and negative symptoms and stratified them into a control group (n = 15), a subclinical hypomania group (n = 15) and a negative symptoms group (n = 15). Participants completed a loss aversion task consisting of forced binary choices between a monetary gamble and a riskless choice with no gain or loss. We found, that these two symptom dimensions of hypomania and negative symptoms have a similar inverse relation to loss aversion as demonstrated by analysis of variance. Further research is warranted to describe the underlying psychological and neurobiological mechanisms at play. Given the partially opposing nature of hypomania and negative symptoms it further needs to be elucidated whether they are linked to loss aversion via dissociable mechanisms.

scholarly journals HUBUNGAN INDEKSMASSA TUBUH DAN LINGKAR PINGGANG DENGAN TEKANAN DARAH LAKI-LAKI DEWASA

2018 ◽  
Vol 9 (2) ◽  
pp. 193-199
Author(s):  
Tamariani Manullang
Keyword(s):  
Blood Pressure ◽  
Waist Circumference ◽  
Systolic Blood Pressure ◽  
Study Design ◽  
Computer Software ◽  
Adult Males ◽  
Cross Sectional ◽  
Relationship Of ◽  
The Relationship

Prevalence of hypertension in adult males was highest in PuskesmasBasuki Rahmat (16.2%) as many as 648 cases of hypertension patients which hasincreased compared to 2012 by 12% in cases of hypertension totaled 482 patients((Dinkes Kota, 2013). This study aims to determine the relationship of body massindex (BMI) and waist circumference (WC) with systolic blood pressure (BP) in adultmales in Puskesmas Basuki Rahmat Bengkulu City in 2015. The study design wasdescriptive analytic with cross sectional approach. Study location was in PuskesmasBasuki Rahmat City of Bengkulu. Samples were selected using purposive samplingtotalling 68 people. Criterias sample were being adult males who occupied inPuskesmas Basuki Rahmat City of Bengkulu, aged ≥ 18 years, agreed to beinterviewed,and able to communicate actively. Data were obtained include BMI, WCand systolic BP adult males and processed using computer software with pearsoncorrelation analysis.The results showed that there was relationship between BMI andsystolic BP (p = 0.0005; r = 0.395); between WC and systolic BP (p = 0.004 and r =0.347) in adult males. This study concluded that there was relationship between BMIand WC with systolic BP in adult males in Puskesmas Basuki Rahmat Bengkulu Cityin 2015.

scholarly journals RELATIONSHIP OF LIPID PEROXIDATION PROCESSES AND CHRONIC INFLAMMATION WITH ATHEROSCLEROTIC VASCULAR CHANGES AND INDICATORS ENDOTHELIAL DYSFUNCTION IN PATIENTS WITH CKD STAGES II-IV

2015 ◽  
pp. 13-20
Author(s):  
O.M. Loboda ◽  
І.V. Krasyuk ◽  
V.V. Alexeeva ◽  
L.V. Korol ◽  
V.Y. Druanska ◽  
...  
Keyword(s):  
Lipid Peroxidation ◽  
Endothelial Dysfunction ◽  
Chronic Inflammation ◽  
Inflammatory Cytokines ◽  
Vascular Lesions ◽  
Control Group ◽  
Bilateral Carotid ◽  
Ckd Stage ◽  
Anti Inflammatory ◽  
Relationship Of

The aim of our study was to determine the relationship of processes of atherogenesis and indicators of endothelial dysfunction with the processes of activation of lipid peroxidation (LPO) and chronic inflammation in patients with CKD stages II-IV. Material and methods. Levels of proinflammatory and anti-inflammatory cytokines, indicators of lipid peroxidation, the thickness of the intima-media (IMT) of the carotid artery, ankle-brachial index (ABI) were measured in 90 patients with CKD stage II-IV (30 - CKD st. II, 31 patients with CKD st. III and 29 st. IV CKD patients) and 30 healthy subjects (control group). The correlation analysis was performed to identify the possible association between the obtained parameters of atherosclerotic vascular lesions and endothelial dysfunction and indices of lipid peroxidation and pro- and anti-inflammatory cytokines. Results. The average levels of interferon-y, interleukin (IL) -1p and IL-10 in patients with CKD II-IV Art. were significantly increased compared with the corresponding values in the control group. The average levels of malondialde- hyde (MDA) of serum and MDA of erythrocyte in CKD patients was significantly increased compared with the corresponding values in the control group, and the antioxidant system indices - total peroxidase activity of erythrocytes and serum levels of the sulfhydrylgroups was significantly reduced relative to the corresponding values in the group control. 39 (43%) patients with CKD st. II-IV were recorded carotid atherosclerotic changes. The IMT (from 0.91 to 1.29 mm) defined in 22 (56%) patients and atherosclerotic plaques (IMT > 1,3 mm) defined in 17 (44%) patients. Bilateral carotid atherosclerotic lesions was observed in 14 (36%) patients with CKD st. II-IV. Endothelial dysfunction was observed in 71 (79%) patients with CKD st. II-IV. There was a statistically significant association between indicators of chronic inflammation, lipid peroxidation and indicators of atherosclerotic vascular lesions and endothelial dysfunction. Conclusion. Pathological processes ofLPO activation, chronic inflammation are closely linked between themselves and progression of atherosclerotic vascular lesions in CKD.

scholarly journals Relationship of Type 2 Diabetes Mellitus Duration with The Occurrence of Erectile Dysfunction at Puskesmas Denpasar Barat I

2021 ◽  
Vol 2 (1) ◽  
pp. 23-28
Author(s):  
Alexander Petra Sihite ◽  
I Gusti Ngurah Pramesemara ◽  
I Wayan Surudarma
Keyword(s):  
Diabetes Mellitus ◽  
Type 2 Diabetes ◽  
Type 2 Diabetes Mellitus ◽  
Erectile Dysfunction ◽  
Cross Sectional ◽  
Type 2 Dm ◽  
Number Of Patients ◽  
Relationship Of ◽  
The Relationship

Background: Type 2 diabetes mellitus is a metabolic disease that characterized by high blood sugar levels. This condition is often not noticed immediately and usually patient starting to realize it when complications have been occurred. A long-term complication of type 2 DM that occurred in men is erectile dysfunction (ED). ED is a condition when a person is unable to achieve or maintain an erection for sexual intercourse. One factor that influence the occurrence of ED and its severity in type 2 DM patients is the duration of the disease. Objective: The aim of this study was to determine the relationship of type 2 DM duration and the occurrence of ED. Methods: This study is an observational analytic cross-sectional study conducted at the Puskesmas (Public Health Center) Denpasar Barat I. The research data was obtained through medical record data and fill the International Index of Erectile Function (IIEF-5) questionnaire on 36 type 2 DM patients aged around 40-60 years. The statistical analysis used was Fisher's exact test. Results: The results showed that of the 36 samples, 19 (52.8%) samples had type 2 DM <24 months and 17 (47.2%) samples had type 2 DM >24 months. It was found that 5 (13.9%) samples did not experience ED while the rest experienced ED with different severity. There was a significant relationship between the type 2 DM duration and the occurrence of erectile dysfunction at Puskesmas Denpasar Barat I (p = 0.022). Conclusion: Study has found that type 2 DM patients with the longer duration (>24 months)  have a higher occurrence of ED and tended to be more severe compared to those with shorter duration (<24 months). Further studies should be performed with higher number of patients and more controlled risk factor so it will be more accurate in determining the relationship between the duration of type 2 DM and ED.

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