scholarly journals Clinical and immunologic assessment of a complex of therapeutic-preventive measures concerning chronic catarrhal gingivitis in children with comorbid diabetes mellitus

2020 ◽  
Vol 73 (2) ◽  
pp. 298-301
Author(s):  
Oksana I. Godovanets ◽  
Аnastasiia V. Kotelban ◽  
Petro V. Moroz ◽  
Oleksandr O. Vitkovskyi ◽  
Tetiana S. Kitsak ◽  
...  
Keyword(s):  
Diabetes Mellitus ◽  
Oral Fluid ◽  
Preventive Measures ◽  
Main Group ◽  
Antiseptic Solution ◽  
Similar Tendency ◽  
Group A ◽  
Comparative Group ◽  
The Common

The aim of our study is to increase the efficacy of treatment of chronic catarrhal gingivitis in children suffering from type 1 diabetes mellitus by means of improvement of the methods of pharmacological correction on the basis of investigation of clinical-immunologic peculiarities of the disease. Materials and methods: 2 groups of the study were formed. Children received basic insulin therapy. The treatment of chronic catarrhal gingivitis in children from the main group were suggested the antiseptic solution “Decasan”; pill of a probiotic action “BioGaia ProDentis” and the immune modulator “Imupret”. Children from the comparative group were treated according to the common scheme. Results: The state of the oral hygiene in all the children after treatment improved considerably. According to PMA index inflammatory process was completely eliminated in children from the main group. A similar tendency was observed concerning sextants with gingival bleeding. In children dental calculus was lacking after treatment. Lysozyme activity in the oral fluid of children after treatment increased approximately 37.50% in the main group, and 16,67 % – in the comparison group. A similar tendency was found concerning sIgА level. Conclusions: Therefore, conducted course of the treatment concerning chronic catarrhal gingivitis promoted considerable improvement of the periodontal tissue in children.

scholarly journals CLINICAL STUDY OF OPTIMIZED APPROACHES TO LOCAL PREVENTION OF DENTAL CARIES IN PATIENTS WITH TYPE 1 DIABETES MELLITUS

2019 ◽  
pp. 10-15
Author(s):  
O.A. Udod ◽  
A.S. Kulish
Keyword(s):  
Diabetes Mellitus ◽  
Type 1 Diabetes ◽  
Dental Caries ◽  
Type 1 Diabetes Mellitus ◽  
Preventive Measures ◽  
Comparison Group ◽  
Main Group ◽  
The State ◽  
Degree Of Risk

The prevalence of dental caries is high in people with type 1 diabetes mellitus and it is about 81.1-100%, however 57.1% are diagnosed with multiple dental caries. The effectiveness of caries prevention is only 48.3%. In the prevention of dental caries has significant role to exogenous methods of prevention with fluorides, but fluoride compounds adversely affect the condition of patients with diabetes mellitus. It’s advisable to use in patients with caries preventive measures containing nanohydroxyapatite and xylitol. The purpose is to conduct a research of optimized approach to local prevention of dental caries in patients with type 1 diabetes mellitus by the fluoride-free agents, taking into account the degree of risk of dental caries in patients and the state of diabetes compensation. Materials and methods. The review of  95 patients with type 1 diabetes mellitus in the state of compensation, subcompensation and decompensation was from 18 to 35 years and disease duration was from 1 to 24 years. The main group included 50 people, the comparison group was 45 people. The index of caries intensity DMF, structure functional indices of enamel acid resistance (TER) were determined in patients. Also the increase in the intensity of dental caries after 6 and 12 months, reducing the increase in caries after 12 months were defined.The patients of the main group, according to individualized approaches, taking into account the degree of risk of dental caries and the state of compensation of diabetes mellitus were subjected to local caries preventive measures, which included the use of fluoride-free products containing nanohydroxyapatite and xylitol, and means of enzymes lactoperoxidase system, patients of the comparison group - traditional local fluoroprophylaxis. Results and discussion. In patients of the main group after 6 months of caries-preventive measures of structure functional indices of enamel acid resistance was 3.52±0.19 points, 12 months – 3.14±0.16 points, the index improved to 1.7 times (p<0,05), compared to baseline (5.26±0,27 points). In the comparison group of patients, after 6 months, enamel acid resistance was 4.09±0.21 points, after 12 months - 3.86±0.18 points, which is only 1.3 times better (p<0.05) than the baseline index (5.02±0.25 points). Before the start of caries preventive measures, the caries intensity index DMF in patients of the main group was 13.7±0.84, after 6 months it increased to 13.8±0.86, the increase in the intensity of caries was 0.1. In the patients of the comparison group, the corresponding indexes of DMF were 12.3±0.85 and 12.6±0.91, increase the intensity of caries was 0.3 and was higher by 3 times. After 12 months, patients in the main group DMF index slightly increased to 14.0±0.87, increase the intensity of caries was 0.3. In the comparison group DMF index value was 13.1±0.93, increase the intensity was significantly higher (2.7 times) and it was 0.8. Reduction of increase the intensity of dental caries was 62.5%. Conclusion. Topical application in patients with type 1 diabetes mellitus of caries prophylactic agents containing nanohydroxyapatite and xylitol, as well as agents with enzymes of the lactoperoxidase system for 12 months on individualized approaches taking into account the degree of risk of dental caries and the state compensation of diabetes mellitus promoted caries resistance of enamel 1.7 times, reducing the intensity of caries by 2.7 times, allowed to reduction the dental caries growth by 62.5%.

scholarly journals Зміни вмісту метаболітів азоту та ендотеліну-1 в ротовій рідині хворих на генералізований пародонтит на тлі цукрового діабету 1 типу з кардіоміопатією

2017 ◽  
Author(s):  
R. Yu. Shkrebnyuk ◽  
Yu. L. Bandrivskyі
Keyword(s):  
Diabetes Mellitus ◽  
Endothelial Dysfunction ◽  
Comparative Evaluation ◽  
Diabetes Mellitus Type 1 ◽  
Main Group ◽  
Diabetes Mellitus Type ◽  
Endothelin 1 ◽  
Comparative Group ◽  
Somatic Diseases

The work adduces the parameters of endothelial dysfunction according to indices (NO2+NO3) and endothelin-1 (ET–1) in оral serum in patients with generalized parodontitis on the backdround of diabetes mellitus type 1 with  cardiomiopathy (main group) and in persons with GP without general somatic diseases (comparative group). When comparative evaluation of frequency of change of ET-1, NO2+NO3 it was established that patients with GP on the background of diabetes mellitus type 1 with cardiomiopathy differs from patients with GP without general somatic diseases more significant changes of metabolites of nitrogen and endothelin-1, where when intensifying of processes in examined patients’ parodontium the meaning of analyzed indices characterized more pronocenced disbalance.

scholarly journals INFLUENCE OF THE TREATMENT AND PREVENTIVE MEASURES ON THE PHYSICAL INDICATORS OF ORAL LIQUID IN CHILDREN WITH CHRONIC CATARRHIC GINGIVITIS AND DIABETES MELLITUS

2021 ◽  
pp. 60-64
Author(s):  
L.F. Kaskova ◽  
V.A. Honcharenko
Keyword(s):  
Diabetes Mellitus ◽  
Oral Cavity ◽  
Oral Fluid ◽  
Preventive Measures ◽  
Treatment And Prevention ◽  
Prophylactic Measures ◽  
Oral Liquid ◽  
Positive Effect ◽  
Over Time ◽  
Complex Drug

The aim of our study was to find out the effect of our proposed treatment and prevention complex, which included oral administration of «Kvertulin» complex drug, «Imupret» drops, «Pikovit» multivitamin drug and «Exodent» local irrigation of the oral cavity with a solution of tooth elixir that influence on the rate of salivation and viscosity of oral fluid in children with chronic catarrhal gingivitis and diabetes mellitus.The treatment and prophylactic measures had positive effect on the homeostasis of the oral cavity, which assisted to reduce the viscosity of the oral fluid, increase the rate of salivation, as evidenced by observation of patients for 6 months. The treatment and prevention complex are recommended to use 2 times a year, as the studied indicators deteriorate over time.

scholarly journals The structural and functional features of the microcirculatory bed in patients with arterial hypertension and type 2 diabetes mellitus

2005 ◽  
Vol 11 (3) ◽  
pp. 177-180 ◽  
Author(s):  
L. A. Lohankova ◽  
Yu. V. Kotovskaya ◽  
A. S. Milto ◽  
Zh. D. Kobalava
Keyword(s):  
Diabetes Mellitus ◽  
Blood Flow ◽  
Arterial Hypertension ◽  
Control Group ◽  
Microcirculatory Bed ◽  
Type 2 Dm ◽  
Group A ◽  
Functional Features

The structural and functional features of the microcirculatory heel (MCB) were studied in patients with arterial hypertension (AH) in relation to the presence or absence of type 1 diabetes mellitus (DM). Two hundred and twelve patients were examined. These included 110 patients with grades 1 and 2 arterial hypertension (AH) and type 2 DM, 82 patients with AH without type 2 DM, and 20 apparently healthy individuals. Laser Doppler flowmetry (LDF) was used to estimate basal blood flow, the loading test parameters characterizing the structural and functional status of MCB, and the incidence of hemodynamic types of microcirculation. Patients with AH concurrent with type 1 DM were found to have the following microcirculatory features: an increase in perfusion blood flow (microcirculation index, 8,8±1,8 perf. units versus 4,9±0,8 perf, units in patients with AH without DM and 6,7±0,9 perf. units in the control group), a drastic reduction in myogenic activity to 13,2±5,7 % versus 16,7±6,8 and 25,2±6,4 %, respectively, a decrease in vascular resistance, impairment of autoregulation, and low reserve capacities (reserve capillary blood flow was 197,8±31,6 % versus 429,9±82,01 % in the group of AH without DM and 302,8±50,1 % in the control group), a predominance of the hyperemic hemodynamic type (58,8 % in patients with AH and DM, 20,9 % in those with AH without DM, and 20,0 % in the controls). The specific features of the altered microcirculatory bed in patients with AH concurrent with type 2 DM were ascertained. These included the predominance of hyperemic microcirculation, impaired autoregulation. diminished microvascular resistance, and the low reserve capacities of the microcirculatory bed.

Neonatal Diabetes – From Gene Discovery yo Clinical Practice Changes

2013 ◽  
Vol 20 (3) ◽  
pp. 343-352
Author(s):  
Cristian Guja ◽  
Loreta Guja ◽  
Constantin Ionescu-Tîrgovişte
Keyword(s):  
Diabetes Mellitus ◽  
Type 2 Diabetes ◽  
Single Gene ◽  
Neonatal Diabetes ◽  
Monogenic Diabetes ◽  
Special Focus ◽  
Sulphonylurea Treatment ◽  
The Common

Abstract Diabetes mellitus is one of the most common chronic diseases but also one of the most heterogeneous. Apart the common phenotypes of type 1 and type 2 diabetes, around 1-2% of all cases arise from a single gene mutation and are known as monogenic diabetes. Diabetes diagnosed within the first 6 months of life is known as neonatal diabetes and has been extensively studied during the last two decades. Unraveling the genetic cause and molecular mechanism of this rare diabetes phenotype led to a dramatic change in the treatment of these children who often can be switched from insulin to sulphonylurea treatment. The aim of this paper is to review the known genetic causes of neonatal diabetes and to highlight the most recent aspects of the disease caused by mutations in the KATP and insulin genes, with a special focus on the individualized treatment of these cases

Prospects of antigen-specific therapy in type 1 diabetes mellitus

2012 ◽  
Vol 15 (4) ◽  
pp. 28-32
Author(s):  
Tatiana Vasil'evna Nikonova ◽  
Yulia Viktorovna Alekseeva
Keyword(s):  
Diabetes Mellitus ◽  
Type 1 Diabetes ◽  
Type 1 Diabetes Mellitus ◽  
Pancreatic Beta Cells ◽  
Large Scale ◽  
Specific Immunotherapy ◽  
Preventive Measures ◽  
Therapeutic Agents ◽  
Specific Therapy

Type 1 diabetes mellitus is commonly recognized as an autoimmune disease characterized by progressive destruction of pancreatic ?-beta-cells. Progress in diagnostics at preclinical stage is accompanied with active development of preventive measures. So far, there are no specific therapeutic agents approved for clinical practice. However, ongoing large-scale studies have outlined some promising solutions, antigen-specific immunotherapy being one of them.

scholarly journals The Stricter the Better? The Relationship between Targeted HbA1cValues and Metabolic Control of Pediatric Type 1 Diabetes Mellitus

2016 ◽  
Vol 2016 ◽  
pp. 1-7 ◽  
Author(s):  
Marcin Braun ◽  
Bartlomiej Tomasik ◽  
Ewa Wrona ◽  
Wojciech Fendler ◽  
Przemyslawa Jarosz-Chobot ◽  
...  
Keyword(s):  
Diabetes Mellitus ◽  
Type 1 Diabetes ◽  
Type 1 Diabetes Mellitus ◽  
Metabolic Control ◽  
Meta Analysis ◽  
Group A ◽  
Study Population ◽  
A Prospective Study ◽  
Pediatric Type 1 Diabetes

Introduction. It remains unclear howHbA1crecommendations influence metabolic control of paediatric patients with type 1 diabetes mellitus. To evaluate this we compared reportedHbA1cwith guideline thresholds.Materials and Methods. We searched systematically MEDLINE and EMBASE for studies reporting onHbA1cin children with T1DM and grouped them according to targetedHbA1cobtained from regional guidelines. We assessed the discrepancies in the metabolic control between these groups by comparing meanHbA1cextracted from each study and the differences between actual and targetedHbA1c.Results. We included 105 from 1365 searched studies. The median (IQR)HbA1cfor the study population was 8.30% (8.00%–8.70%) and was lower in “6.5%” than in “7.5%” as targetedHbA1clevel (8.20% (7.85%–8.57%) versus 8.40% (8.20%–8.80%);p=0.028). Median difference between actual and targetedHbA1cwas 1.20% (0.80%–1.70%) and was higher in “6.5%” than in “7.5%” (1.70% (1.30%–2.07%) versus 0.90% (0.70%–1.30%), resp.;p<0.001).Conclusions. Our study indicates that the 7.5% threshold results inHbA1clevels being closer to the therapeutic goal, but the actual values are still higher than those observed in the “6.5%” group. A meta-analysis of raw data from national registries or a prospective study comparing both approaches is warranted as the next step to examine this subject further.

scholarly journals SPEAKING OF PREVENTION OF ACUTE PANCREATITIS AFTER ENDOSCOPIC CHOLANGIOPANCREATO-GRAPHY

2020 ◽  
pp. 45-48
Author(s):  
V. I. Lupaltsov ◽  
N. N. Skalii ◽  
A. I. Yagnyuk ◽  
V. S. Kotovshchіkov
Keyword(s):  
Acute Pancreatitis ◽  
Clinical Practice ◽  
Pancreatic Necrosis ◽  
Preventive Measures ◽  
Comparison Group ◽  
Main Group ◽  
Pancreatic Ducts ◽  
Terminal Part ◽  
Highly Effective ◽  
The Common

Summary. Purpose. To study the manometric control of pressure in the pancreatic ducts when performing ERCP and to determine its capabilities in the early diagnosis of postmanipulative pancreatitis. Materials and methods. The study was conducted to identify postmanipulative pancreatitis in 122 patients with impaired patency of the terminal part of the common bile duct who underwent ERCP. Patients were divided into two groups: the main – 58 patients and the comparison group – 64 patients. In 58 patients of the main group, the pressure in the pancreatic duct was studied by the device we developed. One makes it possible to register early signs of acute postmanipulative pancreatitis with conducting timely preventive measures for its development. Results. Using the proposed device that records the pressure in the pancreatic ducts, acute postmanipulative pancreatitis was diagnosed in 6.9 % of patients in the main group, while in the comparison group it developed in 21.9 % of cases. Mild forms of APMP in the comparison group were noted in 11 patients and in 4 patients in the main group. Severe APMP caused by focal pancreatic necrosis occurred in three cases of the comparison group. Conclusions. 1. ERCP is a highly effective method for diagnosing diseases of the pancreatobiliary zone, at the same time, sometimes fraught with the danger of developing serious complications, one of which is acute postmanipulative pancreatitis. 2. Monometric control during ERCP is a highly effective method for the diagnosis of early forms of acute postmanipulative pancreatitis, which can be recommended in the clinical practice of endoscopic surgeries.

scholarly journals Вплив лікувально-профілактичних заходів на показники ротової рідини та клінічний стан тканин пародонта у дітей 6–7 років, хворих на гінгівіт

2017 ◽  
Author(s):  
O. V. Avdeev ◽  
Y. K. Zmarko ◽  
A. B. Boykiv ◽  
R. O. Drevnitska
Keyword(s):  
Clinical Supervision ◽  
Oral Fluid ◽  
Urease Activity ◽  
Comparison Group ◽  
Local Therapy ◽  
Main Group ◽  
Control Group ◽  
Results Of Treatment ◽  
Comparative Group ◽  
Anti Inflammatory

The high prevalence of inflammatory processes in the periodontitis of children, the ineffective effectiveness of preventive and curative measures can contribute to the development of generalized periodontitis, therefore it remains urgent to develop pathogenetic effects in the treatment of chronic catarrhal gingivitis.The aim of the study – a comparative assessment of the traditional treatment of chronic catarrhal gingivitis in children aged 6–7 years with therapy using an anti-inflammatory gel with neovitin.Materials and Methods. 61 children aged 6–7 years, suffering from chronic catarrhal gingivitis, were taken under clinical supervision and divided into groups: the main (30 children) and the comparative (31 children). All children underwent conventional therapy in accordance with the protocols for the provision of medical care – basic therapy. In the main group, for a month, pathogenetic agents were used: an anti-inflammatory gel with neovitin, hygiene products were recommended. In the comparative group, 3 % hydrogen peroxide solution was used for local therapy, for rinsing of the mouth (during the first week of treatment) – Rotokan, a therapeutic and prophylactic toothpaste.Examination and control examinations were carried out with the hygienic state of the mouth determined by the hygienic index of Yu. A. Fedorov and V. V. Volodkina, prevalence and intensity of the inflammatory process in the gums with the help of the Schiller-Pisarev test and the PMA index, oral fluid index (lysozyme content, formation of oxydradicals, urease activity, degree of dysbiosis, pH and viscosity).Results and Discussion. After the treatment, elimination of gum inflammation in patients of the main group was accompanied by a decrease in the PMA index by 3.8 times; formation of oxyradicals decreased in children of the main group by 6.35 %; in the comparative group – by 6.15 %. Urease activity decreased in children of the main group by 16.37 % (p<0.05), the viscosity of the oral fluid of children decreased in 2.65 times in the main group and in 2.13 times in the comparative group (p<0.05). The lysozyme content increased in children of the main group by 15.61 % (p<0.05) in the comparison group – by 9.63% (p<0.05). The treatment after 0.5 years caused an increase in the lysozyme content in the oral fluid of the children of the main group to the level of the control group. The degree of dysbiosis decreased in the main group, in the comparison group tended to increase.Conclusions. The use of the proposed therapy with gel with neovitin contributed to the best results of treatment: reducing the degree of inflammation of the gums, the number of visits to the doctor, improving the indices of nonspecific protection in the oral fluid of 6-7 years-old children and, to a greater extent, six months after the treatment.

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