The present study was aimed to antifungal activity and phytoconstituents of leaves from thePsydrax dicoccosGaertn.The antifungal activity of methanol extract from theP. dicoccosagainstCandida albicans,C. krusei,C. guilliermondii,C. parapsilosis,C. tropicalis, C.glabrata, four dermatophytesviz.,Trichophyton rubrum,T. mentagrophytes,Microsporum gypseumandEpidermophyton flocossum.The methanol extract of the leaves were subjected to Fourier transform infrared spectroscopy (FT-IR) and GasChromatography-Mass Spectroscopic (GC-MS) analysis. The mean zones of inhibition produced by the tested extract in disc diffusion assays against fungal strains were ranged from 7.3 to 15.5 mm. The MIC values were between 125 and 500 µg/ml while, the MFC values were between 250 and 1000 µg/ml. The highest mean zones of inhibition (15.5±0.6 mm) was observed with methanol extract ofP. dicoccosagainstC. albicans. The GC-MS analysis ofP. dicoccosleaves showed the presence of cinnamic acid, 2H-1-Benzopyran-2-one,5,7-dimethoxy,(Z)6,(Z)9-Pentadecadien-1-ol, Benzofuran and n-Hexadecanoic acid as major compounds. Finally it can be concluded that the antifungal activity may be present in cinnamic acid, 2H-1-Benzopyran-2-one, 5, 7-, (Z) 6,(Z)9-Pentadecadien-1-ol, n-Hexadecanoic acid from the methanol extract from theP. dicoccosis highly valuable in medicinal usage and have fewer side effects.