scholarly journals A Taguchi approach for optimization of mass transfer coefficient in metronidazole drug delivery process and activated carbon as a carrier

2021 ◽  
Vol 9 (4A) ◽  
Author(s):  
Shahad F. Hameed ◽  
◽  
Salih Rushdi ◽  
Zainab T. Al-Sharify ◽  
◽  
...  
Keyword(s):  
Drug Delivery ◽  
Mass Transfer ◽  
Activated Carbon ◽  
Transfer Coefficient ◽  
Mass Transfer Coefficient ◽  
Drug Loading ◽  
Weight Ratio ◽  
Drug Efficacy ◽  
Optimum Point ◽  
Carbon Molecules

New strategies have been developed in the drug delivery system in recent years for applications like pharmacokinetics control, pharmacodynamics, undetermined toxicity, immunity, biophysics, and drug efficacy. The loading process was based on adsorption between activated carbon molecules' surfaces and drug molecules dissolved in ethanol at room temperature, where porous activated carbon has great drug delivery characteristics. The current research is studying the effect of the number of parameters including particle size, the weight of drug to the carrier, weight ratio, drug loading and temperature, time, and pH solution on mass transfer coefficient. The Taguchi program's result shows that the optimum point of maximum loading efficiency is 74% when the activated carbon in nanoparticle was in 11.042 nm size, and 985.6013 m2/g surface area weight drug to AC weight ratio is 1.5. The drug process release obtained an optimum point that gives a better value of mass transfer coefficient of 0.0007777 and 0.0003372 cm/hr in the first hour, 37°C, and pH of 1.5 solutions for both metronidazole/macro AC and metronidazole/Nano AC complexes.

scholarly journals Mass Transfer Coefficient Study for Unloading of Naproxen from Activated Carbon as Drug Delivery

2019 ◽  
Vol 12 (4) ◽  
pp. 232-239
Author(s):  
Shahad Faiz Hameed ◽  
Salih A. Rushdi
Keyword(s):  
Drug Delivery ◽  
Mass Transfer ◽  
Particle Size ◽  
Activated Carbon ◽  
Transfer Coefficient ◽  
Mass Transfer Coefficient ◽  
Surface Area ◽  
Drug Loading ◽  
Weight Ratio ◽  
Drug Carriers

Activated carbon is a porous material that has a great character to be used for drug delivery system as carrier.It is agreed that drug carriers maintain the concentration of drugs within the required range for a long period of time and undetermined toxicity resulting from the use of overdoses , the ability to direct the drug to the affected area, immunity, biophysics, and drug efficacy. activated carbon was used in two different particle sizes (0.6µm size with surface area 544.4704 m2/g and 11.042 nm size with surface area 985.6013m2/g ) and Naproxen was used as a drug model. In this research study the effect of the number of parameters, including particle size, weight of drug to carrier weight ratio, on drug loading and temperature, time ,PH solution on mass transfer coefficient in unloading drug. the result of experiments was find that maximum loading efficiency obtain  when the particle size of activated carbon was in Nano. size and the ratio of weight drug to AC weight was 1.5. The unloading process was studied by studying the mass transfer coefficient and knowing the effect of the variables on its value ,these variables are time and temperature in addition to the PH value of the solution. The highest value of the mass transfer coefficient was obtained at the beginning of the unloading time ,at temperature 37 co and at solution in PH 6.5 .

Study of the Process of Wastewater Treatment with Activated Caron from Dimethylamine and Dimethylformamide in their Joint Presence

2021 ◽  
Vol 25 (2) ◽  
pp. 18-22
Author(s):  
Yu.V. Solovyova ◽  
V.P. Yustratov ◽  
N.S. Golubeva ◽  
I.V. Vasiljeva ◽  
E.V. Nazimova
Keyword(s):  
Mathematical Modeling ◽  
Mass Transfer ◽  
Wastewater Treatment ◽  
Activated Carbon ◽  
Aqueous Solutions ◽  
Transfer Coefficient ◽  
Mass Transfer Coefficient ◽  
Adsorption Column ◽  
Limiting Stage ◽  
Column Process

The regularities and mechanism of adsorption of dimethylformamide and dimethylamine by industrial activated carbon in their joint presence from aqueous solutions are considered. The characteristics of equilibrium adsorption, the limiting stage, and the mass transfer coefficient have been determined. The main parameters of the adsorption column process and the mode of continuous cleaning are calculated by the method of mathematical modeling.

Absorption of oxygen into solutions of polymers

1986 ◽  
Vol 51 (10) ◽  
pp. 2127-2134 ◽  
Author(s):  
František Potůček ◽  
Jiří Stejskal
Keyword(s):  
Mass Transfer ◽  
Aqueous Solutions ◽  
Transfer Coefficient ◽  
Mass Transfer Coefficient ◽  
Flow Rate ◽  
Liquid Flow ◽  
Flow Curve ◽  
Liquid Flow Rate ◽  
Polymer Concentration ◽  
Newtonian Liquids

Absorption of oxygen into water and aqueous solutions of poly(acrylamides) was studied in an absorber with a wetted sphere. The effects of changes in the liquid flow rate and the polymer concentration on the liquid side mass transfer coefficient were examined. The results are expressed by correlations between dimensionless criteria modified for non-Newtonian liquids whose flow curve can be described by the Ostwald-de Waele model.

scholarly journals Development of mass and heat transfer coupled model of hollow fiber membrane for salt recovery from brine via osmotic membrane distillation

2021 ◽  
Vol 33 (1) ◽  
Author(s):  
Sher Ahmad ◽  
Gabriela Vollet Marson ◽  
Waheed Ur Rehman ◽  
Mohammad Younas ◽  
Sarah Farrukh ◽  
...  
Keyword(s):  
Mass Transfer ◽  
Transfer Coefficient ◽  
Mass Transfer Coefficient ◽  
Heat And Mass Transfer ◽  
Hollow Fiber ◽  
Hollow Fiber Membrane ◽  
Membrane Distillation ◽  
Fiber Membrane ◽  
Salt Recovery ◽  
Osmotic Solution

Abstract Background In this research work, a coupled heat and mass transfer model was developed for salt recovery from concentrated brine water through an osmotic membrane distillation (OMD) process in a hollow fiber membrane contactor (HFMC).The model was built based on the resistance-in-series concept for water transport across the hydrophobic membrane. The model was adopted to incorporate the effects of polarization layers such as temperature and concentration polarization, as well as viscosity changes during concentration. Results The modeling equations were numerically simulated in MATLAB® and were successfully validated with experimental data from literature with a deviation within the range of 1–5%. The model was then applied to study the effects of key process parameters like feed concentrations, osmotic solution concentration, feed, and osmotic solution flow rates and feed temperature on the overall heat and mass transfer coefficient as well as on water transport flux to improve the process efficiency. The mass balance modeling was applied to calculate the membrane area based on the simulated mass transfer coefficient. Finally, a scale-up for the MD process for salt recovery on an industrial scale was proposed. Conclusions This study highlights the effect of key parameters for salt recovery from wastewater using the membrane distillation process. Further, the applicability of the OMD process for salt recovery on large scale was investigated. Sensitivity analysis was performed to identify the key parameters. From the results of this study, it is concluded that the OMD process can be promising in salt recovery from wastewater.

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