scholarly journals Mass Transfer Coefficient Study for Unloading of Naproxen from Activated Carbon as Drug Delivery

2019 ◽  
Vol 12 (4) ◽  
pp. 232-239
Author(s):  
Shahad Faiz Hameed ◽  
Salih A. Rushdi
Keyword(s):  
Drug Delivery ◽  
Mass Transfer ◽  
Particle Size ◽  
Activated Carbon ◽  
Transfer Coefficient ◽  
Mass Transfer Coefficient ◽  
Surface Area ◽  
Drug Loading ◽  
Weight Ratio ◽  
Drug Carriers

Activated carbon is a porous material that has a great character to be used for drug delivery system as carrier.It is agreed that drug carriers maintain the concentration of drugs within the required range for a long period of time and undetermined toxicity resulting from the use of overdoses , the ability to direct the drug to the affected area, immunity, biophysics, and drug efficacy. activated carbon was used in two different particle sizes (0.6µm size with surface area 544.4704 m2/g and 11.042 nm size with surface area 985.6013m2/g ) and Naproxen was used as a drug model. In this research study the effect of the number of parameters, including particle size, weight of drug to carrier weight ratio, on drug loading and temperature, time ,PH solution on mass transfer coefficient in unloading drug. the result of experiments was find that maximum loading efficiency obtain  when the particle size of activated carbon was in Nano. size and the ratio of weight drug to AC weight was 1.5. The unloading process was studied by studying the mass transfer coefficient and knowing the effect of the variables on its value ,these variables are time and temperature in addition to the PH value of the solution. The highest value of the mass transfer coefficient was obtained at the beginning of the unloading time ,at temperature 37 co and at solution in PH 6.5 .

scholarly journals A Taguchi approach for optimization of mass transfer coefficient in metronidazole drug delivery process and activated carbon as a carrier

2021 ◽  
Vol 9 (4A) ◽  
Author(s):  
Shahad F. Hameed ◽  
◽  
Salih Rushdi ◽  
Zainab T. Al-Sharify ◽  
◽  
...  
Keyword(s):  
Drug Delivery ◽  
Mass Transfer ◽  
Activated Carbon ◽  
Transfer Coefficient ◽  
Mass Transfer Coefficient ◽  
Drug Loading ◽  
Weight Ratio ◽  
Drug Efficacy ◽  
Optimum Point ◽  
Carbon Molecules

New strategies have been developed in the drug delivery system in recent years for applications like pharmacokinetics control, pharmacodynamics, undetermined toxicity, immunity, biophysics, and drug efficacy. The loading process was based on adsorption between activated carbon molecules' surfaces and drug molecules dissolved in ethanol at room temperature, where porous activated carbon has great drug delivery characteristics. The current research is studying the effect of the number of parameters including particle size, the weight of drug to the carrier, weight ratio, drug loading and temperature, time, and pH solution on mass transfer coefficient. The Taguchi program's result shows that the optimum point of maximum loading efficiency is 74% when the activated carbon in nanoparticle was in 11.042 nm size, and 985.6013 m2/g surface area weight drug to AC weight ratio is 1.5. The drug process release obtained an optimum point that gives a better value of mass transfer coefficient of 0.0007777 and 0.0003372 cm/hr in the first hour, 37°C, and pH of 1.5 solutions for both metronidazole/macro AC and metronidazole/Nano AC complexes.

Study of the Process of Wastewater Treatment with Activated Caron from Dimethylamine and Dimethylformamide in their Joint Presence

2021 ◽  
Vol 25 (2) ◽  
pp. 18-22
Author(s):  
Yu.V. Solovyova ◽  
V.P. Yustratov ◽  
N.S. Golubeva ◽  
I.V. Vasiljeva ◽  
E.V. Nazimova
Keyword(s):  
Mathematical Modeling ◽  
Mass Transfer ◽  
Wastewater Treatment ◽  
Activated Carbon ◽  
Aqueous Solutions ◽  
Transfer Coefficient ◽  
Mass Transfer Coefficient ◽  
Adsorption Column ◽  
Limiting Stage ◽  
Column Process

The regularities and mechanism of adsorption of dimethylformamide and dimethylamine by industrial activated carbon in their joint presence from aqueous solutions are considered. The characteristics of equilibrium adsorption, the limiting stage, and the mass transfer coefficient have been determined. The main parameters of the adsorption column process and the mode of continuous cleaning are calculated by the method of mathematical modeling.

scholarly journals On the three-phase mass transfer with solid particles adhered to the gas-liquid interface

2003 ◽  
Vol 1 (2) ◽  
pp. 160-177
Author(s):  
Endre Nagy
Keyword(s):  
Mass Transfer ◽  
Particle Size ◽  
Transfer Coefficient ◽  
Mass Transfer Coefficient ◽  
Mass Transfer Rate ◽  
Liquid Interface ◽  
Solid Particles ◽  
Transfer Model ◽  
Transfer Rates ◽  
Layer Packing

AbstractA heterogeneous, multi-layer mass transfer model is proposed for prediction of the effect of multi-layer packing of catalyst particles adhered to the gas-liquid interface. The behavior of the mass transfer rate with respect to the multi-layer packing, to the particle size and mass transfer coefficient without particles is discussed. It is shown that enhancement can be considerably increased by multi-layer packing compared to that of mono-layer packing, depending on the values of particle size and mass transfer coefficient. The predicted mass transfer rates using the proposed model was verified with experimental data taken from the literature. The model presented should be superior to that of published in the literature.

scholarly journals Effect of particles on hydrodynamics and mass transfer in a slurry bubble column: Correlation of experimental data

2021 ◽  
Author(s):  
Huahai Zhang ◽  
Zhongshan Guo ◽  
Yuelin Wang ◽  
Xiankun Shen ◽  
Tiefeng Wang
Keyword(s):  
Experimental Data ◽  
Mass Transfer ◽  
Particle Size ◽  
Transfer Coefficient ◽  
Mass Transfer Coefficient ◽  
Particle Concentration ◽  
Bubble Column ◽  
Gas Holdup ◽  
Operating Conditions ◽  
Slurry Bubble Column

The effects of particle concentration and size on hydrodynamics and mass transport in a slurry bubble column were experimentally studied. With increasing particle concentration, the averaged gas holdup, gas holdup of small bubbles and gas-liquid volumetric mass transfer coefficient decreased, while the gas holdup of large bubbles increased slightly. With increasing particle size, the averaged gas holdup and kla remained unchanged when the particle size increased from 55 to 92 m, but decreased significantly when the particle size was further increased to 206 m. A liquid turbulence attenuation model which could quantitatively describe the effects of particle concentration and size was first proposed. Semi-empirical correlations were obtained based on extensive experimental data in a wide range of operating conditions and corrected liquid properties. The gas holdup and mass transfer coefficient calculated by the correlations agreed with the experimental data from both two-phase and three-phase bubble columns

Formulating SLN and NLC as Innovative Drug Delivery Systems for Non-Invasive Routes of Drug Administration

2020 ◽  
Vol 27 (22) ◽  
pp. 3623-3656 ◽  
Author(s):  
Bruno Fonseca-Santos ◽  
Patrícia Bento Silva ◽  
Roberta Balansin Rigon ◽  
Mariana Rillo Sato ◽  
Marlus Chorilli
Keyword(s):  
Drug Delivery ◽  
Particle Size ◽  
Drug Release ◽  
Drug Loading ◽  
Average Particle Size ◽  
Delivery Systems ◽  
Average Particle ◽  
Minor Importance ◽  
Routes Of Administration ◽  
Non Invasive

Colloidal carriers diverge depending on their composition, ability to incorporate drugs and applicability, but the common feature is the small average particle size. Among the carriers with the potential nanostructured drug delivery application there are SLN and NLC. These nanostructured systems consist of complex lipids and highly purified mixtures of glycerides having varying particle size. Also, these systems have shown physical stability, protection capacity of unstable drugs, release control ability, excellent tolerability, possibility of vectorization, and no reported production problems related to large-scale. Several production procedures can be applied to achieve high association efficiency between the bioactive and the carrier, depending on the physicochemical properties of both, as well as on the production procedure applied. The whole set of unique advantages such as enhanced drug loading capacity, prevention of drug expulsion, leads to more flexibility for modulation of drug release and makes Lipid-based nanocarriers (LNCs) versatile delivery system for various routes of administration. The route of administration has a significant impact on the therapeutic outcome of a drug. Thus, the non-invasive routes, which were of minor importance as parts of drug delivery in the past, have assumed added importance drugs, proteins, peptides and biopharmaceuticals drug delivery and these include nasal, buccal, vaginal and transdermal routes. The objective of this paper is to present the state of the art concerning the application of the lipid nanocarriers designated for non-invasive routes of administration. In this manner, this review presents an innovative technological platform to develop nanostructured delivery systems with great versatility of application in non-invasive routes of administration and targeting drug release.

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