Clinical Case of Visceral Toxocariasis in a Patient with Breast Cancer in Anamnesis

We report a case of visceral toxocariasis of the liver in a patient after complex treatment of breast cancer. It was decided to demonstrate this clinical case in a view of the complexity of the differential diagnosis of visceral toxocariasis and metastatic liver disease.

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Pathohistological and Immunohistochemical Analysis, Differential Diagnosis, Prognosis and Complex Treatment in a Rare Lymphoepithelioma-Like Breast Cancer

Advances in Bioengineering and Biomedical Science Research ◽

10.33140/abbsr.04.01.03 ◽

2021 ◽

Vol 4 (1) ◽

Keyword(s):

Breast Cancer ◽

Differential Diagnosis ◽

Clinical Case ◽

Medical Literature ◽

Immunohistochemical Analysis ◽

Breast Tumors ◽

Oncological Treatment ◽

Malignant Breast ◽

The Right ◽

Epithelial Neoplasm

We present a 78-year-old woman with a rare neoplasm of the right mammary gland – Lymphoepithelioma-like carcinoma (LELC). Lymphoepithelioma-like carcinoma is an undifferentiated neoplasm, consisting of malignant epithelial cells on the background of lymphocytes. Pathomorphological features and immunohistochemical (IHC) analysis determines the rare pathohistological variant of breast cancer. This clinical case of lymphoepithelioma-like breast cancer is the 34th published in medical literature in English. In the discussion, we emphasize the importance of immunohistochemical analysis to assess the differential diagnosis with other benign and malignant breast tumors . Lymphoepithelioma-like breast cancer is an extremely malignant epithelial neoplasm with an unfavorable prognosis, requiring complex oncological treatment.

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Pictorial Review: Sonographic Patterns of Diffuse and Focal Fatty Infiltration of the Liver: Differential Diagnosis to Metastatic Liver Disease

Oncology Research and Treatment ◽

10.1159/000089395 ◽

2005 ◽

Vol 28 (12) ◽

pp. 659-664 ◽

Cited By ~ 1

Author(s):

Christian Görg ◽

Tillmann Bert

Keyword(s):

Differential Diagnosis ◽

Liver Disease ◽

Fatty Infiltration ◽

Pictorial Review ◽

Sonographic Patterns ◽

Metastatic Liver

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Selective internal radiation therapy (SIRT) for treatment of patients with breast cancer with metastatic liver disease.

Journal of Clinical Oncology ◽

10.1200/jco.2010.28.15_suppl.1135 ◽

2010 ◽

Vol 28 (15_suppl) ◽

pp. 1135-1135

Author(s):

M. Michl ◽

R. T. Hoffmann ◽

R. Laubender ◽

A. Haug ◽

P. Bartenstein ◽

...

Keyword(s):

Breast Cancer ◽

Radiation Therapy ◽

Liver Disease ◽

Selective Internal Radiation Therapy ◽

Internal Radiation ◽

Selective Internal Radiation ◽

Internal Radiation Therapy ◽

Metastatic Liver

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Clinical case: Complicated differential diagnosis between postsurgical and functional hypoparathyroidism.

Endocrine Abstracts ◽

10.1530/endoabs.70.ep74 ◽

2020 ◽

Author(s):

Elena Kovaleva ◽

Anna Eremkina ◽

Julia Krupinova ◽

Natalia Mokrysheva

Keyword(s):

Differential Diagnosis ◽

Clinical Case

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Breast cancer associated with pregnancy: a clinical case

GYNECOLOGY ◽

10.26442/2079-5696_20.1.102-108 ◽

2018 ◽

Vol 20 (1) ◽

pp. 102-108

Author(s):

Yu E Dobrokhotova ◽

S E Arakelov ◽

S Zh Danelyan ◽

E I Borovkova ◽

A E Zykov ◽

...

Keyword(s):

Breast Cancer ◽

Radiation Therapy ◽

Clinical Case ◽

First Trimester ◽

First Year ◽

Total Mastectomy ◽

First Time

Associated with pregnancy is breast cancer, which was first detected during pregnancy, during the first year after childbirth or at any time against lactation. Diagnosis of the disease in the first trimester is an indication for abortion. The detection of the disease after 20 weeks and the desire of the woman to maintain pregnancy is the basis for conducting a total mastectomy followed by polychemotherapy with doxorubicin with cyclophosphamide or with fluorouracil. Radiation therapy during pregnancy is not applied. The timing and method of delivery are determined individually and depend on the stage of the process and the period of pregnancy, when it was identified. A clinical case of a patient with edematous-infiltrative form of breast cancer of the IV stage, diagnosed for the first time in 22 weeks of pregnancy, is presented.

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Use of Roncoleukin in the complex treatment of pancreatic necrosis on the example of a clinical case

Terapevt (General Physician) ◽

10.33920/med-12-2005-07 ◽

2020 ◽

pp. 51-56

Author(s):

Svetlana Styazhkina ◽

Tatyana Chernyshova ◽

Olga Neganova ◽

Yuliya Russkikh ◽

Raniya Gazimzyanova

Keyword(s):

Clinical Practice ◽

Clinical Case ◽

Pancreatic Necrosis ◽

Complex Treatment ◽

Urgent Surgery

Today, the problem of pancreonecrosis remains in the leading positions in urgent surgery. The incidence of this pathology increases every year. This article presents the results of the analysis of the use of the drug "Roncoleukin" in clinical practice for pancreonecrosis. The study was conducted to evaluate the effectiveness of this drug.

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Interventional Oncology Approach to Hepatic Metastases

Seminars in Interventional Radiology ◽

10.1055/s-0040-1719189 ◽

2020 ◽

Vol 37 (05) ◽

pp. 484-491

Author(s):

Cathal O'Leary ◽

Michael C. Soulen ◽

Susan Shamimi-Noori

Keyword(s):

Liver Disease ◽

Liver Function ◽

Interventional Oncology ◽

Hepatic Metastases ◽

Locoregional Therapy ◽

Treatment Modalities ◽

Patient Specific ◽

Curative Intent ◽

Locoregional Therapies ◽

Metastatic Liver

AbstractMetastatic liver disease is one of the major causes of cancer-related morbidity and mortality. Locoregional therapies offered by interventional oncologists alleviate cancer-related morbidity and in some cases improve survival. Locoregional therapies are often palliative in nature but occasionally can be used with curative intent. This review will discuss important factors to consider prior to palliative and curative intent treatment of metastatic liver disease with locoregional therapy. These factors include those specific to the tumor, liver function, liver reserve, differences between treatment modalities, and patient-specific considerations.

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Impact of Pharmaceutical Prophylaxis on Radiation-Induced Liver Disease Following Radioembolization

Cancers ◽

10.3390/cancers13091992 ◽

2021 ◽

Vol 13 (9) ◽

pp. 1992

Author(s):

Max Seidensticker ◽

Matthias Philipp Fabritius ◽

Jannik Beller ◽

Ricarda Seidensticker ◽

Andrei Todica ◽

...

Keyword(s):

Breast Cancer ◽

Metastatic Breast Cancer ◽

Liver Disease ◽

Positive Impact ◽

Metastatic Breast ◽

Normal Liver ◽

Liver Parenchyma ◽

Breast Cancer Patients ◽

Radiation Induced ◽

The Impact

Background: Radioembolization (RE) with yttrium-90 (90Y) resin microspheres yields heterogeneous response rates in with primary or secondary liver cancer. Radiation-induced liver disease (RILD) is a potentially life-threatening complication with higher prevalence in cirrhotics or patients exposed to previous chemotherapies. Advances in RILD prevention may help increasing tolerable radiation doses to improve patient outcomes. This study aimed to evaluate the impact of post-therapeutic RILD-prophylaxis in a cohort of intensely pretreated liver metastatic breast cancer patients; Methods: Ninety-three patients with liver metastases of breast cancer received RE between 2007 and 2016. All Patients received RILD prophylaxis for 8 weeks post-RE. From January 2014, RILD prophylaxis was changed from ursodeoxycholic acid (UDCA) and prednisolone (standard prophylaxis [SP]; n = 59) to pentoxifylline (PTX), UDCA and low-dose low molecular weight heparin (LMWH) (modified prophylaxis (MP); n = 34). The primary endpoint was toxicity including symptoms of RILD; Results: Dose exposure of normal liver parenchyma was higher in the modified vs. standard prophylaxis group (47.2 Gy (17.8–86.8) vs. 40.2 Gy (12.5–83.5), p = 0.017). All grade RILD events (mild: bilirubin ≥ 21 µmol/L (but <30 μmol/L); severe: (bilirubin ≥ 30 µmol/L and ascites)) were observed more frequently in the SP group than in the MP group, albeit without significance (7/59 vs. 1/34; p = 0.140). Severe RILD occurred in the SP group only (n = 2; p > 0.1). ALBI grade increased in 16.7% patients in the MP and in 27.1% patients in the SP group, respectively (group difference not significant); Conclusions: At established dose levels, mild or severe RILD events proved rare in our cohort. RILD prophylaxis with PTX, UDCA and LMWH appears to have an independent positive impact on OS in patients with metastatic breast cancer and may reduce the frequency and severity of RILD. Results of this study as well as pathophysiological considerations warrant further investigations of RILD prophylaxis presumably targeting combinations of anticoagulation (MP) and antiinflammation (SP) to increase dose prescriptions in radioembolization.

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Acute Disseminated Encephalomyelitis (ADEM): A Demyelinating Disease with Specific Morphological Features

International Journal of Surgical Pathology ◽

10.1177/1066896921993562 ◽

2021 ◽

pp. 106689692199356

Author(s):

Fleur Cordier ◽

Lars Velthof ◽

David Creytens ◽

Jo Van Dorpe

Keyword(s):

Central Nervous System ◽

Nervous System ◽

Differential Diagnosis ◽

Clinical Case ◽

Demyelinating Disease ◽

Acute Disseminated Encephalomyelitis ◽

Demyelinating Diseases ◽

Demyelinating Disorder ◽

Immune Mediated ◽

The Central Nervous System

Acute disseminated encephalomyelitis (ADEM) is a rare immune-mediated inflammatory and demyelinating disorder of the central nervous system. Its characteristic perivenular demyelination and inflammation aid in the differential diagnosis with other inflammatory demyelinating diseases. Here, we present a clinical case of ADEM, summarize its histological hallmarks, and discuss pitfalls concerning the most important neuropathological differential diagnoses.

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