scholarly journals Mildly Infected and Presumed Asymptomatic Carriers of SARS-CoV-2; Implications in Spread and Control of COVID-19

2020 ◽  
Vol 1 (supplement) ◽  
Author(s):  
Raees Khan ◽  
Shumaila Naz ◽  
Fawad Muhammad ◽  
Syed Babar Jamal ◽  
Sumra Wajid Abbasi ◽  
...  
Keyword(s):  
Clinical Trials ◽  
Middle East ◽  
Severe Acute Respiratory Syndrome ◽  
Middle East Respiratory Syndrome ◽  
Asymptomatic Carriers ◽  
Death Toll ◽  
The World ◽  
Asymptomatic Individuals ◽  
And Control ◽  
Active Investigation

The death toll and the total number of infected individuals due to the ongoing pandemic of SARS-CoV-2 infection have exceeded that of Severe Acute Respiratory Syndrome (SARS) and Middle East Respiratory Syndrome (MERS) as the disease has raged around the world. So far the global efforts to tackle COVID-19 include the launch of Sputnik V vaccine by Russia, 42 vaccines presently undergoing clinical trials on humans and around 92 vaccines under preclinical active investigation in animals. Majority of the SARS-CoV-2 infected individuals have been reported to show mild symptoms whereas a considerable number show no symptoms at all. SARS-CoV-2 is believed to spread from infected individuals who are asymptomatic in addition to the symptomatic individuals. In this review we discussed how the mildly infected and asymptomatic individuals raise serious concerns and complicate the processes of screening, detection, quarantine, tracking and treatmentthatareinpracticetopreventthetransmissionofthe COVID-19.

scholarly journals Does the novel coronavirus 2019 like heart more than the other family members of coronaviruses?

2020 ◽  
Vol 12 (2) ◽  
pp. 156-157
Author(s):  
Mohammad Mostafa Ansari Ramandi ◽  
Mohammadreza Baay ◽  
Nasim Naderi
Keyword(s):  
Middle East ◽  
Severe Acute Respiratory Syndrome ◽  
Family Members ◽  
Middle East Respiratory Syndrome ◽  
The Other ◽  
The Novel ◽  
The World ◽  
Future Challenges ◽  
Novel Coronavirus ◽  
Coronavirus Infections

The disaster due to the novel coronavirus disease 2019 (COVID-19) around the world has made investigators enthusiastic about working on different aspects of COVID-19. However, although the pandemic of COVID-19 has not yet ended, it seems that COVID-19 compared to the other coronavirus infections (the Middle East Respiratory Syndrome [MERS] and Severe Acute Respiratory Syndrome [SARS]) is more likely to target the heart. Comparing the previous presentations of the coronavirus family and the recent cardiovascular manifestations of COVID-19 can also help in predicting possible future challenges and taking measures to tackle these issues.

scholarly journals Covid-19: The Wuhan Pandemic

2020 ◽  
Vol 10 (3) ◽  
pp. 251-253
Author(s):  
Tooba Masood
Keyword(s):  
Middle East ◽  
Severe Acute Respiratory Syndrome ◽  
Large Family ◽  
Respiratory Illness ◽  
Middle East Respiratory Syndrome ◽  
Human Beings ◽  
The World ◽  
Novel Virus ◽  
Prevention Guidelines

Coronavirus belongs to a large family of viruses that usually cause respiratory illness in human beings that can be mild and severe depending upon the strain. In 2002, the outbreak of SARS (severe acute respiratory syndrome) reported more than 8000 infected cases with 774 mortalities. In 2012, the outbreak of MERS (middle east respiratory syndrome) infected around 2494 people and 858 deaths were reported according to the WHO. In January 2020, a new strain of coronavirus named 2019-nCoV has been identified in China. The number of confirmed cases has been increasing reaching 5,593,631 cases worldwide with 353,334 deaths up till 28th May 2020 according to WHO situation report-129. Concerned authorities are working on minimizing its spread. Prevention guidelines have been released by WHO, hoping to control the transmission and save the world from the effects of this novel virus.

scholarly journals A comprehensive review about SARS-CoV-2

2020 ◽  
Vol 15 (9) ◽  
pp. 625-648
Author(s):  
SK Manirul Haque ◽  
Omar Ashwaq ◽  
Abdulla Sarief ◽  
Abdul Kalam Azad John Mohamed
Keyword(s):  
Middle East ◽  
Severe Acute Respiratory Syndrome ◽  
Respiratory Tract ◽  
Middle East Respiratory Syndrome ◽  
Gastrointestinal Infections ◽  
Comprehensive Review ◽  
Host Interaction ◽  
The World ◽  
Severe Fever

The coronavirus disease (COVID-19) was first identified in China, December 2019. Since then, it has spread the length and breadth of the world at an unprecedented, alarming rate. Severe acute respiratory syndrome coronavirus (SARS-CoV)-2, which causes COVID-19, has much in common with its closest homologs, SARS-CoV and Middle East respiratory syndrome-CoV. The virus–host interaction of SARS-CoV-2 uses the same receptor, ACE2, which is similar to that of SARS-CoV, which spreads through the respiratory tract. Patients with COVID-19 report symptoms including mild-to-severe fever, cough and fatigue; very few patients report gastrointestinal infections. There are no specific antiviral strategies. A few strong medications are under investigation, so we have to focus on proposals which ought to be taken to forestall this infection in a living host.

scholarly journals COVID-19: The Immune Responses and Clinical Therapy Candidates

2020 ◽  
Vol 21 (15) ◽  
pp. 5559 ◽  
Author(s):  
Sareh Zhand ◽  
Marie Saghaeian Jazi ◽  
Saeed Mohammadi ◽  
Roozbeh Tarighati Rasekhi ◽  
Ghassem Rostamian ◽  
...  
Keyword(s):  
Clinical Trials ◽  
Middle East ◽  
Severe Acute Respiratory Syndrome ◽  
Immune Responses ◽  
Drug Administration ◽  
Food And Drug Administration ◽  
Middle East Respiratory Syndrome ◽  
Adults And Children ◽  
Repurposed Drugs ◽  
Present Understanding

The pandemic of coronavirus disease 2019 (COVID-19), with rising numbers of patients worldwide, presents an urgent need for effective treatments. To date, there are no therapies or vaccines that are proven to be effective against severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2). Several potential candidates or repurposed drugs are under investigation, including drugs that inhibit SARS-CoV-2 replication and block infection. The most promising therapy to date is remdesivir, which is US Food and Drug Administration (FDA) approved for emergency use in adults and children hospitalized with severe suspected or laboratory-confirmed COVID-19. Herein we summarize the general features of SARS-CoV-2’s molecular and immune pathogenesis and discuss available pharmacological strategies, based on our present understanding of SARS-CoV and Middle East respiratory syndrome coronavirus (MERS-CoV) infections. Finally, we outline clinical trials currently in progress to investigate the efficacy of potential therapies for COVID-19.

scholarly journals Nations’ Responses and Control Measures in Confrontation with the Novel Coronavirus Disease (COVID-19) Outbreak: A Rapid Review

2020 ◽  
Author(s):  
Parinaz Tabari ◽  
Mitra Amini ◽  
Mohsen Moghadami ◽  
Mahsa Moosavi
Keyword(s):  
Middle East ◽  
Severe Acute Respiratory Syndrome ◽  
Management Strategies ◽  
Control Measures ◽  
Rapid Review ◽  
The Novel ◽  
Rapid Rate ◽  
The World ◽  
Novel Coronavirus ◽  
And Control

The outbreak of Coronavirus disease 2019 (COVID-19) has posed a significant concern in many countries due to the rapid rate of transmission between humans. Taking advantage of the experience of the last epidemics in 2002 Severe Acute Respiratory Syndrome Coronavirus (SARS-CoV) and 2012 Middle East Respiratory Syndrome Coronavirus (MERS-CoV), some regions of the world were well- prepared for the new outbreak. However, other countries needed to be adapted to the situation promptly. Many management strategies were established, and some restrictions were introduced in some regions. In this review, we aimed to determine countries’ public responses to the epidemic of COVID-19 and how they developed administrative approaches towards the outbreak.

scholarly journals Middle East Respiratory Syndrome Coronavirus and Severe Acute Respiratory Syndrome Coronavirus

2020 ◽  
Vol 41 (04) ◽  
pp. 568-578 ◽  
Author(s):  
Jaffar A. Al-Tawfiq ◽  
Ziad A. Memish
Keyword(s):  
Middle East ◽  
Severe Acute Respiratory Syndrome ◽  
Emerging Infectious Diseases ◽  
Case Fatality ◽  
Severe Pneumonia ◽  
Middle East Respiratory Syndrome ◽  
Zoonotic Pathogen ◽  
Clinical Presentations ◽  
The World ◽  
Novel Coronavirus

AbstractEmerging infectious diseases continue to be of a significant importance worldwide with the potential to cause major outbreaks and global pandemics. In 2002, the world had witnessed the appearance of the severe acute respiratory syndrome coronavirus in China which disappeared abruptly within 6 months. About a decade later, a new and emerging novel coronavirus named the Middle East respiratory syndrome coronavirus (MERS-CoV) was described in a patient from Saudi Arabia. These two coronaviruses shared multiple similarities in the epidemiology, clinical presentations, and posed challenges in its prevention and management. Seven years since its discovery, MERS-CoV continues to be a lethal zoonotic pathogen capable of causing severe pneumonia with high case fatality rates and the ability to cause large health care-associated outbreaks.

Recent Patents and Advances on Nanotechnologies against Coronavirus

2020 ◽  
Vol 14 ◽  
Author(s):  
Roozbeh Abedini-Nassab ◽  
Naeemeh Mahdaviyan
Keyword(s):  
Middle East ◽  
Severe Acute Respiratory Syndrome ◽  
Genome Sequencing ◽  
Middle East Respiratory Syndrome ◽  
Detection Methods ◽  
Prevention Strategies ◽  
Infected People ◽  
The Third ◽  
The World ◽  
Novel Coronavirus

: Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) is one of the seven known coronaviruses infecting humans; HKU1, 229E, NL63, OC43, acute respiratory syndrome coronavirus (SARS-CoV), Middle East respiratory syndrome coronavirus (MERS-CoV), and SARS-CoV-2, the last three of which can cause severe symptoms in patients. COVID-19, previously known as 2019 novel coronavirus, caused by SARS-CoV-2, was first reported in Wuhan, China, in late 2019, and quickly resulted in a major epidemic across the world. Although the origin of SARS-CoV-2 is not clear yet, genome sequencing results suggest that this is the third reported spillover of an animal coronavirus to humans, from 2002. The development of detection, therapeutic, and prevention strategies for COVID-19 is a fundamental task towards curing infected people and competing with the pandemic. Because of their similarities, scientists believe that treatment/detection methods similar to what were used against the illnesses caused by SARS-CoV or MERS-CoV may be effective for curing/detecting COVID-19. Here, we review the recent nanotechnology techniques used for treating and testing SARS-CoV, MERS-CoV, and SARS-CoV-2, and potential therapeutic options for curing COVID-19.

scholarly journals COVID-19 Pandemic Between Severity Facts and Prophylaxis

2021 ◽  
Vol 16 (11) ◽  
pp. 1934578X2110412
Author(s):  
Hui Liu ◽  
Wenxia Zhu ◽  
Yilin Wu ◽  
Caini Jiang ◽  
Lili Huo ◽  
...  
Keyword(s):  
Middle East ◽  
Severe Acute Respiratory Syndrome ◽  
Infectious Virus ◽  
Middle East Respiratory Syndrome ◽  
The Novel ◽  
Healthy Nutrition ◽  
The World ◽  
Seasonal Flu ◽  
Novel Coronavirus ◽  
Nutrition Habits

Before COVID-19, many viruses have infected humans, so what caused COVID-19 to be considered as a pandemic? COVID-19 belongs to the coronavirus family that includes severe acute respiratory syndrome (SARS) and Middle East Respiratory Syndrome (MERS). This family has caused a large number of deaths all over the world. How risky is the novel coronavirus? People and their careers were disrupted, and many businesses all over the world are now closed. From here, it seems to us that this virus is something that can make people feel afraid. In this article, we will try to understand the severity of this virus, and then disclose the available ways to confront it and ways that might improve the ability to face it, either now or in the future. Upon comparing COVID-19 with seasonal flu, we have found that COVID-19 is about 10 times more deadly, although it is not the most infectious virus. In this review, we will discuss how healthy nutrition and lifestyle may help to prevent and treat diseases, and especially COVID-19. We will focus on how to follow healthy nutrition habits and lifestyles to stop the dangers of COVID-19.

scholarly journals COVID-19 An update on oral symptoms, newer variants, second wave and vaccination drive in India — A Review

2021 ◽  
Vol 7 (3) ◽  
pp. 155-160
Author(s):  
Srilekha Jayakumar ◽  
Chakravarthy Srinivas Vineetha ◽  
Bindu Meera John ◽  
Karthikeyan Arumugam ◽  
Dinesh Sridhar
Keyword(s):  
Middle East ◽  
Severe Acute Respiratory Syndrome ◽  
World Health Organisation ◽  
Middle East Respiratory Syndrome ◽  
World Health ◽  
Virus Diseases ◽  
Corona Virus ◽  
The World ◽  
Oral Symptoms ◽  
Second Wave

A serious threat to world now is the emergence of COVID-19 (Corona Virus Diseases-2019). When compared to its precursor virus, SARS (Severe acute respiratory syndrome – now called as SARS-CoV-1) and MERS (Middle East respiratory syndrome), this virus spreads more rapidly. The emergence of this virus happened in december 2019 in Wuhan. World Health Organisation announced this virus outbreak as a pandemic on March 202020. The current threat to the world is the emergence of second wave of COVID -19 that has shaken many countries in world and its peak in India was in the month of may 2021 which had drastically affected the country. Hence this review gives a comprehensive update on corona virus and its newer oral symptoms and about treatment approaches and vaccines currently available in India.

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