scholarly journals A New Approach for the Prevention and Treatment of Cardiovascular Disorders: Molecular Hydrogen Significantly Reduces the Effects of Oxidative Stress

2020 ◽  
Author(s):  
Tyler W LeBaron ◽  
Branislav S Kura ◽  
Barbora Kalocayova ◽  
Narcis Tribulova ◽  
Jan Slezak
Keyword(s):  
Oxidative Stress ◽  
Molecular Hydrogen ◽  
Cardiovascular Disorders ◽  
New Approach ◽  
Prevention And Treatment

Potential Protective Effect of Dl-3-n-Butylphthalide on Chronic Cerebral Ischemia Brain Injury

2021 ◽  
Vol 21 ◽  
Author(s):  
Fangfang Zhao ◽  
Yumin Luo
Keyword(s):  
Oxidative Stress ◽  
Cerebral Ischemia ◽  
Brain Dysfunction ◽  
Cerebrovascular Diseases ◽  
Pathophysiological Mechanism ◽  
Chronic Cerebral Ischemia ◽  
Celery Seed ◽  
Prevention And Treatment ◽  
Ischemic Cerebrovascular Diseases ◽  
The Common

: Chronic cerebral ischemia is one of the common ischemic cerebrovascular diseases. Chronic cerebral ischemia can lead to brain dysfunction, and its pathophysiological mechanism involves inflammation, blood-brain barrier destruction, oxidative stress, and other factors. Due to it being difficult to detect, it is easily overlooked, and it is often only observed following onset of cognitive dysfunction. At present, there are few drugs for this treatment. DL-3-N-BUTYLPHTHALIDE (NBP), a compound extracted from celery seed, may play an important role in protecting against brain damage caused by chronic cerebral ischemia. Therefore, we pay more attention to the prevention and treatment of NBP on chronic cerebral ischemia.

Aging, Oxidative Stress, and Cardiovascular Disorders

2010 ◽  
pp. 259-275
Author(s):  
Yi Shi ◽  
Giovanni G. Camici ◽  
Thomas F. Lüscher
Keyword(s):  
Oxidative Stress ◽  
Cardiovascular Disorders

Healthcare

2021 ◽  
pp. 124-152
Author(s):  
Nicholas Freudenberg
Keyword(s):  
Health Care ◽  
Private Equity ◽  
High Tech ◽  
Public Officials ◽  
New Approach ◽  
Medical Progress ◽  
Modern Capitalism ◽  
Prevention And Treatment ◽  
Human Need ◽  
Intensity Radiation

No disease strikes more fear than cancer and none is more resistant to medical progress. This chapter illuminates the weaknesses of a health care system driven by profit rather than human need in addressing cancer. It explains how modern capitalism has undermined progress in cancer prevention and treatment. Reducing tobacco smoking has succeeded in reducing cancer, but pharmaceutical and other industries have not emphasized this approach because it is not profitable. Instead, they develop precision medicines, high intensity radiation, and private equity-financed high-tech oncology centers. While these have helped some patients, they have made cancer care exorbitantly expensive, out of reach of many Americans, and bankrupted those who can afford them. In response, cancer patients and their families, oncologists and other providers, and public officials are demanding a new approach to cancer, one that puts less emphasis on profitable drugs and devices and more on integrated prevention, early intervention, and affordable treatment approaches.

Role of Polyherbal Formulations of Medicinal Plants From Himalayan Regions in the Management of Diabetes

2022 ◽  
pp. 212-229
Author(s):  
Ashfaq Ahmad Shah ◽  
Sumaira Qayoom ◽  
Amit Gupta ◽  
Aqueel Ur Rehman
Keyword(s):  
Quality Of Life ◽  
Oxidative Stress ◽  
Metabolic Diseases ◽  
Polyphenolic Compounds ◽  
Health Concern ◽  
Glucose Measurement ◽  
Diabetes Research ◽  
Cardiovascular Disorders

Current research on phytochemicals is mainly focused on novel phenolic and polyphenolic compounds expressing their potential as therapeutic agents in various diseases like cancer, autoimmune diseases, cardiovascular disorders, diabetes, oxidative stress-related diseases, as well as their properties to inhibit the growth and proliferation of infectious agents. Among the human physiological disorders, one of the most severe endocrine metabolic diseases is Diabetes mellitus which is a clinical disease distinguished by a deficit in the production of insulin or resistance to the action of insulin. Globally, diabetes is an increasing health concern which is now emerging as an epidemic. About 700-800 plants are exhibiting anti-diabetic activity that has been studied. As far as nanotechnology in diabetes research is concerned, it has made possible the buildout of novel glucose measurement as well as insulin delivery modalities that possess the potential to excellently enhance the quality of life of the diabetic patient.

scholarly journals An Immunohistochemical Study of the Increase in Antioxidant Capacity of Corneal Epithelial Cells by Molecular Hydrogen, Leading to the Suppression of Alkali-Induced Oxidative Stress

2020 ◽  
Vol 2020 ◽  
pp. 1-10
Author(s):  
Cestmir Cejka ◽  
Jan Kossl ◽  
Vladimir Holan ◽  
John H. Zhang ◽  
Jitka Cejkova
Keyword(s):  
Oxidative Stress ◽  
Reactive Oxygen Species ◽  
Antioxidant Capacity ◽  
Molecular Hydrogen ◽  
Reactive Oxygen ◽  
Corneal Neovascularization ◽  
Scar Formation ◽  
Oxygen Species ◽  
Buffer Solution ◽  
Corneal Epithelial

Corneal alkali burns are potentially blinding injuries. Alkali induces oxidative stress in corneas followed by excessive corneal inflammation, neovascularization, and untransparent scar formation. Molecular hydrogen (H2), a potent reactive oxygen species (ROS) scavenger, suppresses oxidative stress and enables corneal healing when applied on the corneal surface. The purpose of this study was to examine whether the H2 pretreatment of healthy corneas evokes a protective effect against corneal alkali-induced oxidative stress. Rabbit eyes were pretreated with a H2 solution or buffer solution, by drops onto the ocular surface, and the corneas were then burned with 0.25 M NaOH. The results obtained with immunohistochemistry and pachymetry showed that in the corneas of H2-pretreated eyes, slight oxidative stress appeared followed by an increased expression of antioxidant enzymes. When these corneas were postburned with alkali, the alkali-induced oxidative stress was suppressed. This was in contrast to postburned buffer-pretreated corneas, where the oxidative stress was strong. These corneas healed with scar formation and neovascularization, whereas corneas of H2-pretreated eyes healed with restoration of transparency in the majority of cases. Corneal neovascularization was strongly suppressed. Our results suggest that the corneal alkali-induced oxidative stress was reduced via the increased antioxidant capacity of corneal cells against reactive oxygen species (ROS). It is further suggested that the ability of H2 to induce the increase in antioxidant cell capacity is important for eye protection against various diseases or external influences associated with ROS production.

scholarly journals Therapeutic effect of molecular hydrogen in corneal UVB-induced oxidative stress and corneal photodamage

2017 ◽  
Vol 7 (1) ◽  
Author(s):  
Cestmir Cejka ◽  
Jan Kossl ◽  
Barbora Hermankova ◽  
Vladimir Holan ◽  
Sarka Kubinova ◽  
...  
Keyword(s):  
Oxidative Stress ◽  
Therapeutic Effect ◽  
Molecular Hydrogen

scholarly journals Molecular hydrogen attenuates gefitinib-induced exacerbation of naphthalene-evoked acute lung injury through a reduction in oxidative stress and inflammation

2019 ◽  
Vol 99 (6) ◽  
pp. 793-806 ◽  
Author(s):  
Yasuhiro Terasaki ◽  
Tetsuya Suzuki ◽  
Kozue Tonaki ◽  
Mika Terasaki ◽  
Naomi Kuwahara ◽  
...  
Keyword(s):  
Oxidative Stress ◽  
Acute Lung Injury ◽  
Lung Injury ◽  
Molecular Hydrogen

Molecular hydrogen: potential in mitigating oxidative-stress-induced radiation injury

2019 ◽  
Vol 97 (4) ◽  
pp. 287-292 ◽  
Author(s):  
Branislav Kura ◽  
Ashim K. Bagchi ◽  
Pawan K. Singal ◽  
Miroslav Barancik ◽  
Tyler W. LeBaron ◽  
...  
Keyword(s):  
Oxidative Stress ◽  
Molecular Hydrogen ◽  
Related Factor ◽  
Nuclear Factor ◽  
Cellular Functions ◽  
Artificial System ◽  
Beneficial Effects ◽  
Rat Hearts ◽  
Pre Treatment

Uncontrolled production of oxygen and nitrogen radicals results in oxidative and nitrosative stresses that impair cellular functions and have been regarded as causative common denominators of many pathological processes. In this review, we report on the beneficial effects of molecular hydrogen in scavenging radicals in an artificial system of•OH formation. As a proof of principle, we also demonstrate that in rat hearts in vivo, administration of molecular hydrogen led to a significant increase in superoxide dismutase as well as pAKT, a cell survival signaling molecule. Irradiation of the rats caused a significant increase in lipid peroxidation, which was mitigated by pre-treatment of the animals with molecular hydrogen. The nuclear factor erythroid 2-related factor 2 is regarded as an important regulator of oxyradical homeostasis, as well as it supports the functional integrity of cells, particularly under conditions of oxidative stress. We suggest that the beneficial effects of molecular hydrogen may be through the activation of nuclear factor erythroid 2-related factor 2 pathway that promotes innate antioxidants and reduction of apoptosis, as well as inflammation.

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