scholarly journals EFFECT OF VARIATION OF LUBRICANT CONCENTRATION (MAGNESIUM STEARATE) ON THE PHYSICAL QUALITY OF METOCLOPRAMID HCl TABLETS WITH DIRECT PRINTING METHOD

2021 ◽  
Vol 1 (2) ◽  
pp. 67-75
Author(s):  
Valiandri Puspadina ◽  
Deny Budi Legowo ◽  
Erna Fitriany ◽  
Andri Priyoherianto ◽  
Winda Damayanti
Keyword(s):  
Magnesium Stearate ◽  
Ease Of Use ◽  
Quality Test ◽  
Chewable Tablet ◽  
Physical Quality ◽  
Direct Printing ◽  
Chewable Tablets ◽  
Tablet Hardness ◽  
Printing Method

Metoclopramide HCl is used to relieve nausea and vomiting. Market availability in the form of tablets, syrup and injection. The most preferred drug use by patients is oral medication because of its ease of use. Chewable tablets are a new product as an alternative for treatment in pediatric and adult patients who have difficulty swallowing drugs. This study aims to formulate the chewable tablet preparations of metoclopramide HCl using variations in lubricant concentrations. The variations of magnesium stearate with concentrations of 1%, 2%, and 3% using the direct printing method made to obtain a better physical quality test including organoleptics, weight uniformity, uniformity of size, tablet hardness, tablet brittleness, tablet crush time, uniformity of content. The results of the physical quality test were statistically analyzed using one way ANOVA to determine the effect of variations in the concentration of lubricants on the characteristics of chewable tablets. The results showed that variations in the concentration of magnesium stearate lubricant in the manufacture of metoclopramide HCl chewable tablets had an effect on the physical quality of metoclopramide HCl chewable tablets. The concentration of magnesium stearate which produces metoclopramide HCl chewable tablets with good physical properties is 2%.

scholarly journals Uji Mutu Fisik Metoklopramid HCl Tablet Chewable dengan Variasi Jenis Pengisi sebagai Diluent menggunakan Metode Granulasi Basah

2021 ◽  
Vol 1 (2) ◽  
pp. 76-85
Author(s):  
Umi Latifiana ◽  
Deny Budi Legowo ◽  
Erna Fitriany ◽  
Andri Priyoherianto ◽  
Muhammad Novianto Ainul Huri
Keyword(s):  
New Product ◽  
Wet Granulation ◽  
Test Results ◽  
Quality Test ◽  
Disintegration Time ◽  
Chewable Tablet ◽  
Physical Quality ◽  
Chewable Tablets ◽  
Tablet Hardness

Metoclopramide HCl are used to reduce vomiting and nausea. The availability on the market in the form of tablet, syrup and injection. Patient tend to prefer take drugs by oral use because it was easier. Chewable tablet is the new product as the alternative ways to treatment children and adult patient who had difficulity problem of swallowing drugs. Objectives: This research aims to formulate the chewable metoclopramide HCl tablets using diluent variations to get a better physical quality test. Chewable tablets of metoclopramide HCl are made using diluent variations, they are mannitol, sucrose, lactose. Formula I mannitol, formula II sucrose, and formula III lactose. Chewable tablet preparations are made by the wet granulation method. Data collection was performed on physical characteristics including organoleptic, weight uniformity, uniformity of size, tablet hardness, tablet fragility, disintegration time, metoclopramide HCl levels. Physical quality test results were statistically analyzed to determine the effect of variations in the diluent on the characteristics of chewable tablets. The results of this research have an influence on the physical quality and uniformity of contents of various types of diluent variations between each formulation. In this research, fillers have an important role in the preparation of chewable metoclopramide tablets to determine the physical quality of the tablets and the uniformity of their contents. The variation of diluent that gives better results is mannitol. This is because formulas that use mannitol have uniformity in content that meets the requirements, faster disintegration time, and physical quality of tablets that still meet the requirements, when compared to the first and second formulations. The variation of diluent that gives better results is mannitol.

scholarly journals FORMULATION AND EVALUATION OF CHEWABLE MULTIVITAMIN TABLET

2017 ◽  
Vol 9 (4) ◽  
pp. 61
Author(s):  
Sabina Akhtar ◽  
Pulak Dev
Keyword(s):  
Ascorbic Acid ◽  
Magnesium Stearate ◽  
Direct Compression ◽  
Acceptable Result ◽  
Chewable Tablet ◽  
Drug Content ◽  
Weight Variation ◽  
Dissolution Properties ◽  
Chewable Tablets ◽  
Multivitamin Tablet

Objective: The overall objective of the present study was to formulate the chewable multivitamin tablet prepared by direct compression method.Methods: The excipient used in this study are mannitol, sucrose, starch, talc, magnesium stearate, vanilla powder for the effective formulation. As it is multivitamin, ascorbic acid, riboflavin, nicotinamide, thiamine HCL are used and evaluated for precompression parameter. The chewable tablets were better presented using sweetener sucrose and vanilla powder as a flavouring agent. The formulated tablet was evaluated for post compression parameter. The chewable tablet are prepared to ensure that they are easily crushed by chewing. The tablet was evaluated for weight variation, hardness, thickness, friability, drug content. Their dissolution properties were assessed using USP (paddle apparatus).Conclusion: From the above study, we conclude that the chewable tablets were prepared by direct compression method and gave the satisfactory and acceptable result. The tablet shows immediate drug release due to direct compressed tabletResults: All the parameter were found within the specification. Drug content of ascorbic acid (103.62%-108.84%), riboflavin (99.88%-112.02%), nicotinamide (93.44%-100.31), thiamine Hcl (105.94%-108.5%) were found.

scholarly journals Development Of Caulis Extract (Tinospora Crispa (L.) Hook. F. & Thomson As Plasmodium In Preparations Tablets

2018 ◽  
Vol 9 (1) ◽  
pp. 6-15
Author(s):  
Patimah Patimah ◽  
Junie Suriawati ◽  
Siti Rahayu Rahmawati
Keyword(s):  
Raw Materials ◽  
Wild Plant ◽  
Wet Granulation ◽  
Materials Testing ◽  
Quality Test ◽  
Physical Quality ◽  
Size Uniformity ◽  
Tablet Dosage

Brotowali (Tinospora crispa (L.) Hook. f. Thomson is a wild plant & in the Woods, fields or planted page near the fence, and the usual planted as medicinal plants. The entire plant (roots, stems, and leaves) has a bitter taste that can be used as a traditional medicine as Plasmodium. This research aims to make the tablet dosage of Caulis extract with gelatin Binder and polivenilpirolidon materials that meet the requirements of the physical quality of a tablet that is acceptable. Prior to the manufacture of tablets do extract raw materials testing which includes the determination of the levels of ash, determination of microbial impurities, testing the determination of aflatoxin levels of impurities, the determination of the levels of pesticide residues, the determination of the level of heavy metal impurities. Caulis extract tablet manufacture is made with two formula with each different binding materials, namely formula I used gelatin formula II 5% and 5% use polivinilpirolidon. The methods used in the manufacture of Caulis extract tablets using a wet granulation method. Granul tested his physical properties obtained covering moist, flow properties, compressibility granule. Tablets obtained physical quality test performed which include uniformity of weight, hardness, size uniformity, compressibility, and the crushed tablets. The data obtained were analyzed statistically using SPSS 15.0 for windows program namely testing T-Test with a 5% confidence. The results showed that the two formula tablets with the uniformity of weight, hardness, size uniformity, compressibility, and the time crushed tablet that meets the requirements of the physical quality of a good tablet. The conclusions of this research are extracted Caulis tablet can be created that meets the requirements of physical quality test tablet.

scholarly journals Preparation and Evaluation of Chewable Tablets of Syzygium cumini Seed Powder

2020 ◽  
Vol 10 (3) ◽  
pp. 58-64
Author(s):  
Sushesh Srivatsa Palakurthi ◽  
Deeksha Jakka ◽  
Harpreeth Singh ◽  
Sahithi Bollavaram ◽  
Sininandini B ◽  
...  
Keyword(s):  
Escherichia Coli ◽  
Bacillus Subtilis ◽  
Guar Gum ◽  
Methyl Cellulose ◽  
Magnesium Stearate ◽  
Bacterial Activity ◽  
Diffusion Method ◽  
Syzygium Cumini ◽  
Chewable Tablet ◽  
Chewable Tablets

Aim of this study is to develop chewable tablets of Syzygium cumini seed powder. It has been chosen to do so as there are no oral solid dosage forms of this seed powder developed so far. There are numerous health benefits and nutrient properties of this seed powder, thus it can be used as a nutraceutical. Phytochemical screening of the Syzygium cumini seed powder has been conducted and the various phyto constituents present were detected. Seven different formulations have been developed by direct compression method out of which five were optimized. All these formulations were developed with Syzygium cumini seed powder as the active ingredient and lactose, acacia, glucose, talc, magnesium stearate, hydroxy propyl methyl cellulose, sodium alginate, guar gum and stevia were used as excipients. Various evaluations tests were performed to check the stability of the chewable tablets. Fourier Transform Infrared Spectroscopy (FTIR) analysis was conducted to check the interactions among the seed powder and the excipients. Anti-bacterial activity of the chewable tablets was tested against three different species of bacteria (Escherichia coli and Bacillus subtilis) by agar diffusion method. It is concluded that the Syzygium cumini seed powder and the developed chewable tablets were active against Escherichia coli and Bacillus subtilis.     Keywords: Syzygium cumini, Chewable tablet, anti-bacterial activity

PENGARUH KUALITAS INFORMASI DAN KUALITAS LAYANAN TERHADAP SIKAP DALAM PENGGUNAAN SISTEM APLIKASI DENGAN KEMUDAHAN PENGGUNAAN SEBAGAI VARIABEL INTERVENING PADA JASA TRANSPORTASI ONLINE (GOJEK) DI YOGYAKARTA

2019 ◽  
Vol 27 (2) ◽  
pp. 119-133
Author(s):  
Putri Aprilia Isnaini ◽  
Ida Bagus Nyoman Udayana
Keyword(s):  
Social Media ◽  
Quality Of Service ◽  
Information Quality ◽  
Sampling Technique ◽  
Ease Of Use ◽  
Quality Of Services ◽  
Quality Of Information ◽  
Transportation Services ◽  
Application Systems

This writing is done to determine the effect of information quality and service quality on attitudes in the use of application systems with the ease of use of the system as an intervining variable in online transportation services (gojek) in Yogyakarta. The sample in this study is customers who use online motorcycle transportation services in Yogyakarta. The sampling technique uses accidental sampling technique. Data collection is done by distributing online questionnaires through the Goegle form and distributed with social media such as WhatsApp and Instagram on a 1-4 scale to measure 4 indicators. The results of this study show 1) the quality of information affects the ease of use, 2) the quality of service affects the ease of use, 3) the quality of information influences attitudes in use, 4) the quality of services does not affect attitudes in use, and 5) ease of use attitude in use.

The Utilization of Red Dragon Fruit Peel Extract (Hylocereus costaricencis) As A Natural Colorant of Dried Noodle

2020 ◽  
Vol 2 (1) ◽  
Author(s):  
Silaturahmi Silaturahmi ◽  
Zaidiyah Zaidiyah ◽  
Tengku Mia Rahmiati
Keyword(s):  
Product Diversification ◽  
Fruit Peel ◽  
Physical Quality ◽  
Natural Colorant ◽  
Randomized Design ◽  
Solid Loss ◽  
Dragon Fruit ◽  
Completely Randomized Design ◽  
Peel Extract

The use of colorants in the dried noodle manufactures is an effort of product diversification. Besides of being used as a natural coloring agent, this peel extract is also used to improve nutritional value of the expected product. The purpose of this study was to determine the effect of red dragon fruit peel extract on the physical quality of dried noodle.  The study was conducted by using Completely Randomized Design (CRD) method with one factor, namely concentration of red dragon fruit peel extract (N1 = 10 ml, N2 = 15 ml, N3 = 20 ml, N4 = 25 ml, N5 = 30 ml).  The observations of its physical quality consisted of water absorption, solid loss during cooking, and organoleptic tests (aroma and color).  The best quality of dried noodle was obtained by using 30 ml red dragon fruit peel extract (N5) with physical properties, namely DSA levels of 351.92%, solid loss during cooking 4.78%, aroma 3.79 (like) and color 3.89 (like).

Formulation and In-vitro Evaluation of Chewable Tablets of Montelukast Sodium

2015 ◽  
Vol 5 (3) ◽  
Author(s):  
Laxman Devkota ◽  
Bhupendra Poudel ◽  
Junu Silwal
Keyword(s):  
In Vitro Release ◽  
Magnesium Stearate ◽  
Physical Parameters ◽  
Artificial Sweetener ◽  
Leukotriene Receptor Antagonist ◽  
Montelukast Sodium ◽  
Chewable Tablets ◽  
Leukotriene Receptor ◽  
Vitro Release

The objective of the present study is to develop chewable tablets containing different pharmaceutical compositions with simple manufacturing procedures using different excipients. Mannitols, L-HPC 11, Aspartame, Crospovidone, Crospovidone, Aerosil, and Magnesium Stearate are used as excipients for effective formulation of anti-asthmatic drug Montelukast. Montelukast is a selective, orally acting leukotriene receptor antagonist that is used for the treatment of asthma and seasonal allergic rhinitis. Montelukast chewable tablets were prepared by Direct Compression methods using suitable excipients. The chewable tablets were better presented using artificial sweetener Aspartame as flavouring agent. A total of forteen formulations were prepared and the granules were evaluated for pre-compression parameters. The formulated tablets were evaluated for post-compression parameters .The results showed that all the physical parameters were within the acceptable limits. The in vitro release study of all the formulations showed good release. The study concludes that aforementioned excipients can be used to design chewable montelukast sodium tablets.

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