scholarly journals Iodometric Quantitative Analysis Method of Ascorbic Acid in Tablets

2019 ◽  
Vol 70 (10) ◽  
pp. 3555-3560
Keyword(s):  
Ascorbic Acid ◽  
Quantitative Analysis ◽  
Standard Deviation ◽  
The Body ◽  
Water Soluble ◽  
Iodometric Titration ◽  
Antioxidant Action ◽  
Titration Method ◽  
Normal Limits ◽  
Relative Standard

Ascorbic acid is a water-soluble vitamin provided with strong antioxidant action, that fulfills an important immune protective role of the body against infections and prevents various cancers appearance. The main goal of this study was to exactly quantify pure ascorbic acid in tablets of two pharmaceuticals. Proposed objective consisted in improvement and application of a iodometric titration method in ascorbic acid quantitative analysis. Ascorbic acid content per tablet in both studied pharmaceuticals was 173.84 mg, very close to official stated amount of active substance (180 mg). Allowed percentage deviation from declared content of pure ascorbic acid was only 3.42 %, below maximum value of ± 5 % imposed by Romanian Pharmacopoeia 10-th Edition, according to European and International standards. Statistical analysis confirmed experimental obtained results and revealed low Standard Error value SE = 0.214476, which has fallen within normal limits. Confidence Level value (95.0 %) = 0.551328 and Standard Deviation SD = 0.525357. were within normal range of values. Relative Standard Deviation (Coefficient of variation or homogeneity) RSD = 26.268% was found below maximum range of accepted values (30-35%). P value = 7.44. 10-6 was located within normal limits, P < 0.001, so the experimental obtained results has shown highest statistical significance. Thus, studied titration method can be successfully used in quantitative analysis of ascorbic acid from different samples. Keywords: ascorbic acid, antioxidant action, quantitative analysis, iodometric titration, statistic study

scholarly journals Iodometric Quantitative Analysis Method of Ascorbic Acid in Tablets

2019 ◽  
Vol 70 (10) ◽  
pp. 3555-3560
Author(s):  
Costinela Valerica Georgescu ◽  
Cristian Catalin Gavat ◽  
Doina Carina Voinescu
Keyword(s):  
Ascorbic Acid ◽  
Quantitative Analysis ◽  
Standard Deviation ◽  
Statistical Significance ◽  
The Body ◽  
Water Soluble ◽  
International Standards ◽  
Titration Method ◽  
Normal Limits ◽  
Relative Standard

Ascorbic acid is a water-soluble vitamin provided with strong antioxidant action, that fulfills an important immune protective role of the body against infections and prevents various cancers appearance. The main goal of this study was to exactly quantify pure ascorbic acid in tablets of two pharmaceuticals. Proposed objective consisted in improvement and application of a iodometric titration method in ascorbic acid quantitative analysis. Ascorbic acid content per tablet in both studied pharmaceuticals was 173.84 mg, very close to official stated amount of active substance (180 mg). Allowed percentage deviation from declared content of pure ascorbic acid was only 3.42 %, below maximum value of � 5 % imposed by Romanian Pharmacopoeia 10-th Edition, according to European and International standards. Statistical analysis confirmed experimental obtained results and revealed low Standard Error value SE = 0.214476, which has fallen within normal limits. Confidence Level value (95.0 %) = 0.551328 and Standard Deviation SD = 0.525357. were within normal range of values. Relative Standard Deviation (Coefficient of variation or homogeneity) RSD = 26.268% was found below maximum range of accepted values (30-35%). P value = 7.44. 10-6 was located within normal limits, P [ 0.001, so the experimental obtained results has shown highest statistical significance. Thus, studied titration method can be successfully used in quantitative analysis of ascorbic acid from different samples.

A Case Of Vitamin C Deficiency Manifesting With Easy Bruising: Suggestion For a Supplementation Protocol

Blood ◽  
2013 ◽  
Vol 122 (21) ◽  
pp. 4743-4743
Author(s):  
Aisha Zaidi ◽  
Padmini Moffett
Keyword(s):  
Ascorbic Acid ◽  
Vitamin C ◽  
Clinical Symptoms ◽  
Conflicts Of Interest ◽  
The Elderly ◽  
The Body ◽  
Water Soluble ◽  
Gingival Hyperplasia ◽  
Vitamin C Deficiency ◽  
Normal Limits

Contrary to most animals which are capable of obtaining ascorbic acid (vitamin C) by metabolizing glucose, humans require an exogenous source of vitamin C. It is a water-soluble vitamin found in various foods, including citrus fruits (oranges, lemons, grapefruit), green vegetables (peppers, broccoli, cabbage), tomatoes, and potatoes. It is essential for growth and repair of tissues, particularly blood vessels. Deficiency of vitamin C is relatively rare; the third National Health and Nutrition Examination Survey (NHANES III, 1988-1994) found approximately 13% of the US population to be vitamin C deficient. Smoking cigarettes lowers the amount of vitamin C in the body, so smokers are at a higher risk of deficiency. Additionally, alcoholics, the elderly, patients with psychiatric disorders and individuals who experience social isolation are also at risk. Symptoms can manifest after 3 months of deficient intake of vitamin C -containing foods. Since ascorbic acid is required for collagen synthesis, deficiency usually manifests with bleeding gums, ecchymoses, petechiae, coiled hairs and hyperkeratosis. Diagnosis can be established when plasma levels of vitamin C fall below 0.2mg/dl. There are currently no evidence based guidelines for supplementation once low levels are detected. We describe a case of a 33 year old Caucasian female seen in our clinic for easy bruising of 10 years duration. She would wake up in the morning with bruised arms and legs without any inciting trauma. She denied prolonged bleeding after dental extractions, frequent nose bleeds, menorrhagia any genitounrinary or gastrointestinal blood loss. Her exam revealed ecchymoses on her arms and legs with no evidence of perifollicular hemorrhage or gingival hyperplasia. Workup including CBC, Coagulation profile and Von Willibrand factor levels were all within normal limits. She had a vitamin C level of 0.1mg/dl. She was subsequently advised to increase vitamin C intake through fruits and vegetable and was started on vitamin C supplementation with 500mg twice a day for four weeks. Her repeat vitamin C level on her one month follow up was noted to be 1.9mg/dl. She noticed complete resolution of her symptoms. This case illustrates the fact that vitamin C deficiency should be excluded in adults presenting with bruising. It also offers a supplementation regimen that resulted in improvement of clinical symptoms as well as laboratory value normalization. Disclosures: No relevant conflicts of interest to declare.

scholarly journals Role of Vitamin C (Ascorbic Acid) on Human Health- A Review

2005 ◽  
Vol 5 (8) ◽  
pp. 01-12
Author(s):  
Mary K Walingo ◽  
Keyword(s):  
Blood Pressure ◽  
Ascorbic Acid ◽  
Vitamin C ◽  
Human Health ◽  
The Body ◽  
Water Soluble ◽  
Plasma Vitamin ◽  
Risk Of Death ◽  
Increased Risk

Vitamin C, also known as ascorbic acid, abounds in nature and is highly labile. It is a water-soluble vitamin that is lost in large amounts during food processing. It is a vitamin whose prescribed requirement across cultures is not uniform. For example , the prescribed requirement of vitamin C in Great Britain is 30mg/day, while in the U.S.A., it is 60mg/day and 100mg/day in Japan. These variations are unusual and point to the need for further research to establish the acceptable RDAs for diverse populations. The RDA for vitamin C should be more than the amount needed to prevent the occurrence of disease. Vitamin C plays significant functions in the body that enhance its role in the health status of the human body. The biochemical functions of vitamin C include: stimulation of certain enzymes, collagen biosynthesis, hormonal activation, antioxidant, detoxification of histamine, phagocytic functions of leukocytes, formation of nitrosamine, and proline hydroxylation amongst others. These functions are related to the health effects of vitamin C status in an individual. In human health, vitamin C has been associated with reduction of incidence of cancer, blood pressure, immunity, and drug metabolism and urinary hydroxyproline excretion, tissue regeneration. This vitamin is needed for the proper metabolism of drugs in the body through adequate hepatic mixed function oxidase system. Epidemiological data have revealed the preventive and curative role of vitamin C on certain disease conditions in the body though controversies still persist. Vitamin C is effective in protecting against oxidative damage in tissues and also suppresses formation of carcinogens like nitrosamines. There is an inverse relationship with blood pressure and both plasma vitamin C and Vitamin C. Vitamin C has a lowering effect on blood pressure, especially on systolic pressure more than a diastolic pressure. Low levels of plasma vitamin C are associated with stroke and with an increased risk of all cause mortality. Increased consumption of ascorbic acid raises serum ascorbic levels and could decrease the risk of death.

V, Cr, Mn, Fe, and Ni in TiO2: Determination by Peak Switching Spark-Source Mass Spectroscopy

1973 ◽  
Vol 27 (4) ◽  
pp. 271-273 ◽  
Author(s):  
Richard L. Beveridge
Keyword(s):  
Mass Spectrometry ◽  
Titanium Dioxide ◽  
Quantitative Analysis ◽  
Standard Deviation ◽  
Mass Spectroscopy ◽  
Linear Calibration ◽  
Source Mass ◽  
Relative Standard ◽  
Switching Mode ◽  
Spark Source Mass Spectroscopy

Spark-source mass spectrometry using the peak switching mode of electrical detection has been used for the quantitative analysis of V, Cr, Mn, Fe, and Ni in titanium dioxide pigments. Standards of differing histories form linear calibration curves down to 0.4 ppm when a source coldfinger was used to condense hydrocarbon species. An over-all relative standard deviation of 12.7% was obtained for V, Cr, Mn, Fe, and Ni in the TiO2 standards.

scholarly journals Trace Level Arsenic Quantification through Cloud Point Extraction: Application to Biological and Environmental Samples

2012 ◽  
Vol 2012 ◽  
pp. 1-8
Author(s):  
Kempahanumakkagari Suresh Kumar ◽  
Malingappa Pandurangappa
Keyword(s):  
Ascorbic Acid ◽  
Standard Deviation ◽  
Environmental Samples ◽  
Acidic Medium ◽  
Cloud Point Extraction ◽  
Trace Level ◽  
Biological And Environmental Samples ◽  
Relative Standard ◽  
Surfactant Phase ◽  
Triton X

A sensitive solvent-free extraction protocol for the quantification of arsenic at trace level has been described. It is based on the reaction of arsenic (V) with molybdate in acidic medium in presence of antimony (III) and ascorbic acid as a reducing agent to form a blue-colored arsenomolybdenum blue complex. The complex has been extracted into surfactant phase using Triton X-114, and its absorbance was measured at 690 nm. The detection limit, working range, and the relative standard deviation were found to be 1 ng mL−1, 10–200 ng mL−1, and 1.2%, respectively. The effect of common ions was studied, and the method has been applied to determine trace levels of As(III) and As(V) from a variety of samples like environmental, biological, and commercially procured chemicals.

Quantitative Analysis of Phenaglycodol

1968 ◽  
Vol 51 (3) ◽  
pp. 631-633
Author(s):  
Robert P Snell
Keyword(s):  
Quantitative Analysis ◽  
Standard Deviation ◽  
Qualitative Analysis ◽  
Relative Standard Deviation ◽  
Carbon Disulfide ◽  
Quantitative Measurement ◽  
Spectrophotometric Analysis ◽  
Relative Standard ◽  
Tablet Preparation

Abstract A procedure has been developed for the quantitative and qualitative infrared spectrophotometric analysis of phenaglycodol in tablets and capsules. The procedure consists of a liquid-liquid partition of the drug between chloroform and an aqueous alkaline phase. The quantitative measurement is made at about 9.85 μ relative to a carbon disulfide reference, using the baseline technique. Qualitative analysis employs the KBr disk technique. Five collaborators obtained a relative standard deviation of ± 1.88% for a tablet preparation and ± 1.61% for a capsule preparation. It is recommended that the method be adopted as official, first action.

scholarly journals QUANTITATIVE ANALYSIS OF ACETAMINOPHEN AND IBUPROFEN MIXTURE IN TABLET UTILIZING CENTERED AVERAGE ON SPECTRUM RATIO BY SPECTROPHOTOMETRIC TECHNIQUE

2018 ◽  
Vol 11 (12) ◽  
pp. 344 ◽  
Author(s):  
Muchlisyam Bachri ◽  
Tuty R P ◽  
Edward R
Keyword(s):  
Absorption Spectrum ◽  
Quantitative Analysis ◽  
Standard Deviation ◽  
Phosphate Buffer ◽  
Regression Equations ◽  
Relative Standard ◽  
Coefficient Corrélation ◽  
Standard Solution ◽  
Spectrum Ratio

Objectives: Centered average on spectrum ratio by spectrophotometric technique has been done validated for acetaminophen (ACT) and ibuprofen (IBU) in mixture. The goal of this research is to analyze concurrent determination of ACT and IBU mixture in tablet, using pH 7.2 phosphate buffer and ethanol (91:9) as solvent mixture.Methods: The spectrophotometric technique was made by addition of standard solution from IBU, and the absorption spectrum of each drug has been recorded, which is divided by corresponding concentration as a dividing factor; after that, the centered flat of ratio spectra of ACT and IBU concentrations was determined by calibration graphs with measuring at obtained maximum wavelengths 244 nm for ACT and 221 nm for IBU.Results: The research results showed that linearly correlation acetominophen and IBU are 3.0–9.0 μg/mL and 5.0–13.0 μg/mL, respectively, and linearly regression equations are 1.5800X+0.4809 and 0.0991X+0.0205 with coefficient correlation are 0.9962 and 0.9990. Result of ACT and IBU in local tablet is 100.72±0.12% and 98.82±0.06% with the average of percentage recovery for ACT and IBU is 100.01% and 100.31%, and relative standard deviation value is 0.03% and 0.06% respectively.Conclusion: It can be concluded that centered average on spectrum ratio spectrophotometric technique is a smooth, accelerated, correct, and rigid for the analysis of ACT and IBU in mixture.

Assessment of Cymoxanil in Soil, Water and Vegetable Samples

2021 ◽  
Vol 34 (1) ◽  
pp. 80-86
Author(s):  
Ajay Kumar Sahu ◽  
Manish Kumar Rai ◽  
Joyce Rai ◽  
Yaman Kumar Sahu ◽  
Deepak Kumar Sahu ◽  
...  
Keyword(s):  
Standard Deviation ◽  
Soil Water ◽  
Chemical Substance ◽  
Molar Absorptivity ◽  
Water Soluble ◽  
Starch Solution ◽  
Vegetable Samples ◽  
Relative Standard ◽  
Coloured Complex

The present work describes a newly developed method for the spectrophotometric determination of cymoxanil in soil, water and vegetable samples. The detection of the target chemical substance is based on the reaction of cyanide released from the hydrolysed product of cymoxanil with potassium iodide-potassium iodate to form a blue-coloured complex in the presence of starch solution. This complex is water-soluble and shows maximum absorbance at 580 nm. For this complex, Beer's law is obeyed over the concentration range of 2-50 μg mL−1 with molar absorptivity 1.2×105 L mol-1cm-1 and Sandell’s sensitivity 1.0×10-3 µg cm-2. The reproducibility was assessed by carrying out seven days replicate analysis of a solution containing 10 µgmL-1 of cymoxanil in a final solution of a volume of 10 mL. The standard deviation and relative standard deviation for the absorbance value were found to be ± 2.9×10-3 and 1.6% respectively. The proposed method is free from the interference of other toxicants. The analytical parameters were optimized and the method was applied to the determination of cymoxanil in water, soil, and vegetable samples.

scholarly journals Green Chemistry: A Simple Manual Apparatus for Potentiometric and Conductometric Micro-Titration of Small Samples for the Educational Laboratory

2021 ◽  
Vol 16 (1) ◽  
pp. 13-20
Keyword(s):  
Standard Deviation ◽  
Conductometric Titration ◽  
Test Tube ◽  
Small Samples ◽  
Titration Method ◽  
Liquid Samples ◽  
Relative Standard ◽  
Macro Scale ◽  
Reagent Consumption ◽  
Acids And Bases

A simple manual micro-titration method is proposed for the potentiometric and conductometric titration of 200 to 800 µL of liquid samples. The sample to be titrated is dispensed into the titration chamber; the bottom section of a plastic test tube that is glued to the center of a small stirring magnet. After inserting the sensing probe and the tip of the titrant delivery tip into the titration chamber, the chamber-stirring magnet assembly is spun at low speed using a conventional magnetic stirrer. Titrant is delivered (with 0.2 µL resolution) from the submerged tip of a 100-µL capacity micro-pipette by rotating the plunger with the locking ring unlocked. The apparatus has been used for potentiometric titration and conductometric titration of acids and bases usually encountered in educational laboratories. Compared with macro-scale titrations, the obtained accuracy was between +2.2% and -3.9% relative error and the precision ranged between 1.6% and 2.9% relative standard deviation. The proposed procedure cuts the reagent consumption to 1% or less compared with conventional macro-scale titrations.

scholarly journals The Total Amount and Composition Determination of Crocetin and Its Derivatives from Gardenia Yellow by HPLC-MS-MS

2021 ◽  
Vol 4 (3) ◽  
pp. 01-08
Author(s):  
Bodi Hui
Keyword(s):  
Standard Deviation ◽  
Molecular Mass ◽  
Reference Sample ◽  
Water Soluble ◽  
Gardenia Jasminoides ◽  
External Reference ◽  
Composition Determination ◽  
Relative Standard ◽  
Z Value

Consisting of crocetin derivatives as major color materials, gardenia yellow is a water-soluble food colorant extracted from the fruits of Gardenia jasminoides Ellis. However, as color materials, the total crocetin and its derivative amount and composition cannot be determined because the structures of some crocetin derivatives are currently unknown and the commercially-available reference sample is still short. This study aims to develop a method for the total amount and composition determinations of crocetin and its derivatives from gardenia yellow. In practice, the absorption coefficient of each crocetin derivative is calculated from that of crocetin and the negative correlation of absorbance with molecular mass of each derivative, while the molecular mass of each crocetin derivative is substituted by the m/z value of its parent ion on MS. The relative standard deviation (RSD) of reproducibility was 3.17%. The recovery of added external reference sample was ≥97±1.61%. The minimum detection limit was 7.44μg/mL.

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