scholarly journals Iodometric Quantitative Analysis Method of Ascorbic Acid in Tablets

2019 ◽  
Vol 70 (10) ◽  
pp. 3555-3560
Author(s):  
Costinela Valerica Georgescu ◽  
Cristian Catalin Gavat ◽  
Doina Carina Voinescu
Keyword(s):  
Ascorbic Acid ◽  
Quantitative Analysis ◽  
Standard Deviation ◽  
Statistical Significance ◽  
The Body ◽  
Water Soluble ◽  
International Standards ◽  
Titration Method ◽  
Normal Limits ◽  
Relative Standard

Ascorbic acid is a water-soluble vitamin provided with strong antioxidant action, that fulfills an important immune protective role of the body against infections and prevents various cancers appearance. The main goal of this study was to exactly quantify pure ascorbic acid in tablets of two pharmaceuticals. Proposed objective consisted in improvement and application of a iodometric titration method in ascorbic acid quantitative analysis. Ascorbic acid content per tablet in both studied pharmaceuticals was 173.84 mg, very close to official stated amount of active substance (180 mg). Allowed percentage deviation from declared content of pure ascorbic acid was only 3.42 %, below maximum value of � 5 % imposed by Romanian Pharmacopoeia 10-th Edition, according to European and International standards. Statistical analysis confirmed experimental obtained results and revealed low Standard Error value SE = 0.214476, which has fallen within normal limits. Confidence Level value (95.0 %) = 0.551328 and Standard Deviation SD = 0.525357. were within normal range of values. Relative Standard Deviation (Coefficient of variation or homogeneity) RSD = 26.268% was found below maximum range of accepted values (30-35%). P value = 7.44. 10-6 was located within normal limits, P [ 0.001, so the experimental obtained results has shown highest statistical significance. Thus, studied titration method can be successfully used in quantitative analysis of ascorbic acid from different samples.

scholarly journals Iodometric Quantitative Analysis Method of Ascorbic Acid in Tablets

2019 ◽  
Vol 70 (10) ◽  
pp. 3555-3560
Keyword(s):  
Ascorbic Acid ◽  
Quantitative Analysis ◽  
Standard Deviation ◽  
The Body ◽  
Water Soluble ◽  
Iodometric Titration ◽  
Antioxidant Action ◽  
Titration Method ◽  
Normal Limits ◽  
Relative Standard

Ascorbic acid is a water-soluble vitamin provided with strong antioxidant action, that fulfills an important immune protective role of the body against infections and prevents various cancers appearance. The main goal of this study was to exactly quantify pure ascorbic acid in tablets of two pharmaceuticals. Proposed objective consisted in improvement and application of a iodometric titration method in ascorbic acid quantitative analysis. Ascorbic acid content per tablet in both studied pharmaceuticals was 173.84 mg, very close to official stated amount of active substance (180 mg). Allowed percentage deviation from declared content of pure ascorbic acid was only 3.42 %, below maximum value of ± 5 % imposed by Romanian Pharmacopoeia 10-th Edition, according to European and International standards. Statistical analysis confirmed experimental obtained results and revealed low Standard Error value SE = 0.214476, which has fallen within normal limits. Confidence Level value (95.0 %) = 0.551328 and Standard Deviation SD = 0.525357. were within normal range of values. Relative Standard Deviation (Coefficient of variation or homogeneity) RSD = 26.268% was found below maximum range of accepted values (30-35%). P value = 7.44. 10-6 was located within normal limits, P < 0.001, so the experimental obtained results has shown highest statistical significance. Thus, studied titration method can be successfully used in quantitative analysis of ascorbic acid from different samples. Keywords: ascorbic acid, antioxidant action, quantitative analysis, iodometric titration, statistic study

A Case Of Vitamin C Deficiency Manifesting With Easy Bruising: Suggestion For a Supplementation Protocol

Blood ◽  
2013 ◽  
Vol 122 (21) ◽  
pp. 4743-4743
Author(s):  
Aisha Zaidi ◽  
Padmini Moffett
Keyword(s):  
Ascorbic Acid ◽  
Vitamin C ◽  
Clinical Symptoms ◽  
Conflicts Of Interest ◽  
The Elderly ◽  
The Body ◽  
Water Soluble ◽  
Gingival Hyperplasia ◽  
Vitamin C Deficiency ◽  
Normal Limits

Contrary to most animals which are capable of obtaining ascorbic acid (vitamin C) by metabolizing glucose, humans require an exogenous source of vitamin C. It is a water-soluble vitamin found in various foods, including citrus fruits (oranges, lemons, grapefruit), green vegetables (peppers, broccoli, cabbage), tomatoes, and potatoes. It is essential for growth and repair of tissues, particularly blood vessels. Deficiency of vitamin C is relatively rare; the third National Health and Nutrition Examination Survey (NHANES III, 1988-1994) found approximately 13% of the US population to be vitamin C deficient. Smoking cigarettes lowers the amount of vitamin C in the body, so smokers are at a higher risk of deficiency. Additionally, alcoholics, the elderly, patients with psychiatric disorders and individuals who experience social isolation are also at risk. Symptoms can manifest after 3 months of deficient intake of vitamin C -containing foods. Since ascorbic acid is required for collagen synthesis, deficiency usually manifests with bleeding gums, ecchymoses, petechiae, coiled hairs and hyperkeratosis. Diagnosis can be established when plasma levels of vitamin C fall below 0.2mg/dl. There are currently no evidence based guidelines for supplementation once low levels are detected. We describe a case of a 33 year old Caucasian female seen in our clinic for easy bruising of 10 years duration. She would wake up in the morning with bruised arms and legs without any inciting trauma. She denied prolonged bleeding after dental extractions, frequent nose bleeds, menorrhagia any genitounrinary or gastrointestinal blood loss. Her exam revealed ecchymoses on her arms and legs with no evidence of perifollicular hemorrhage or gingival hyperplasia. Workup including CBC, Coagulation profile and Von Willibrand factor levels were all within normal limits. She had a vitamin C level of 0.1mg/dl. She was subsequently advised to increase vitamin C intake through fruits and vegetable and was started on vitamin C supplementation with 500mg twice a day for four weeks. Her repeat vitamin C level on her one month follow up was noted to be 1.9mg/dl. She noticed complete resolution of her symptoms. This case illustrates the fact that vitamin C deficiency should be excluded in adults presenting with bruising. It also offers a supplementation regimen that resulted in improvement of clinical symptoms as well as laboratory value normalization. Disclosures: No relevant conflicts of interest to declare.

scholarly journals Role of Vitamin C (Ascorbic Acid) on Human Health- A Review

2005 ◽  
Vol 5 (8) ◽  
pp. 01-12
Author(s):  
Mary K Walingo ◽  
Keyword(s):  
Blood Pressure ◽  
Ascorbic Acid ◽  
Vitamin C ◽  
Human Health ◽  
The Body ◽  
Water Soluble ◽  
Plasma Vitamin ◽  
Risk Of Death ◽  
Increased Risk

Vitamin C, also known as ascorbic acid, abounds in nature and is highly labile. It is a water-soluble vitamin that is lost in large amounts during food processing. It is a vitamin whose prescribed requirement across cultures is not uniform. For example , the prescribed requirement of vitamin C in Great Britain is 30mg/day, while in the U.S.A., it is 60mg/day and 100mg/day in Japan. These variations are unusual and point to the need for further research to establish the acceptable RDAs for diverse populations. The RDA for vitamin C should be more than the amount needed to prevent the occurrence of disease. Vitamin C plays significant functions in the body that enhance its role in the health status of the human body. The biochemical functions of vitamin C include: stimulation of certain enzymes, collagen biosynthesis, hormonal activation, antioxidant, detoxification of histamine, phagocytic functions of leukocytes, formation of nitrosamine, and proline hydroxylation amongst others. These functions are related to the health effects of vitamin C status in an individual. In human health, vitamin C has been associated with reduction of incidence of cancer, blood pressure, immunity, and drug metabolism and urinary hydroxyproline excretion, tissue regeneration. This vitamin is needed for the proper metabolism of drugs in the body through adequate hepatic mixed function oxidase system. Epidemiological data have revealed the preventive and curative role of vitamin C on certain disease conditions in the body though controversies still persist. Vitamin C is effective in protecting against oxidative damage in tissues and also suppresses formation of carcinogens like nitrosamines. There is an inverse relationship with blood pressure and both plasma vitamin C and Vitamin C. Vitamin C has a lowering effect on blood pressure, especially on systolic pressure more than a diastolic pressure. Low levels of plasma vitamin C are associated with stroke and with an increased risk of all cause mortality. Increased consumption of ascorbic acid raises serum ascorbic levels and could decrease the risk of death.

V, Cr, Mn, Fe, and Ni in TiO2: Determination by Peak Switching Spark-Source Mass Spectroscopy

1973 ◽  
Vol 27 (4) ◽  
pp. 271-273 ◽  
Author(s):  
Richard L. Beveridge
Keyword(s):  
Mass Spectrometry ◽  
Titanium Dioxide ◽  
Quantitative Analysis ◽  
Standard Deviation ◽  
Mass Spectroscopy ◽  
Linear Calibration ◽  
Source Mass ◽  
Relative Standard ◽  
Switching Mode ◽  
Spark Source Mass Spectroscopy

Spark-source mass spectrometry using the peak switching mode of electrical detection has been used for the quantitative analysis of V, Cr, Mn, Fe, and Ni in titanium dioxide pigments. Standards of differing histories form linear calibration curves down to 0.4 ppm when a source coldfinger was used to condense hydrocarbon species. An over-all relative standard deviation of 12.7% was obtained for V, Cr, Mn, Fe, and Ni in the TiO2 standards.

scholarly journals ROLE OF VITAMIN C IN TYPE 2 DIABETES MELLITUS CASES, A STUDY IN VEDANTA INSTITUTE OF MEDICAL SCIENCES

2019 ◽  
Vol 3 (11) ◽  
Author(s):  
Dr. Umesh Teltumbadr
Keyword(s):  
Placebo Group ◽  
Blood Glucose ◽  
Vitamin C ◽  
Blood Sugar ◽  
Statistical Significance ◽  
Glycated Haemoglobin ◽  
The Body ◽  
Water Soluble ◽  
Study Results

INTRODUCTION:  Diabetes is one of the largest emerging global health problem with 415 million people between the ages of 20 and 70 worldwide estimated as having diabetes in 2015 and Type 2 DM (T2DM) accounts for at least 90% of all cases of diabetes. Vitamin C is naturally present in fruit and vegetables, is often added as a preservative to foods/beverages, and is also used as a dietary supplement. As vitamin C is water-soluble, it has a relatively short half-life in the body due to rapid renal clearance and a regular and adequate intake is required to prevent deficiency. In T2DM patients Vitamin C levels are usually low as blood glucose may compete with vitamin C for uptake into cells due to its structural similarity to the oxidised form, and increased oxidative stress may deplete antioxidant stores. MATERIAL AND METHODS:  A total of 206 T2DM patients were included in the study and were divided randomly in to 2 groups of 103 each. Participant’s demographic and physical activity was noted. Anthropometric data including the body mass index (BMI) and waist and hip circumference were collected. Glycated haemoglobin (HbA1c) was determined in EDTA blood by standard methods. Fasting glucose was measured in blood collected in fluoride oxalate tubes. The vitamin C concentration of the processed samples was determined. Drug (Vitamin C and Placebo) was issued to patients for duration of thirty days at a time all patients were maintained on their usual dietary pattern while limiting their consumption of vitamin C-rich foods throughout the study. RESULTS: Mean age in Vitamin C group was 46.87 ± 6.77while in placebo group it was 42.11 ± 6.46. There were 56 male and 44 female in Vitamin C group. In Placebo group male and female were 60 and 40 respectively. No statistical significance was observed in both the group.At 12 weeks fasting blood sugar levels were decreased by -23.74± 2.74 in patients receiving Vitamin C while in placebo group reduction was -5.44± 3.77. Post meal blood sugar was reduced by -21.72± 2.45in vitamin C group while in placebo it was -8.11± 2.45.CONCLUSION:Supplementation of Vitamin C in T2DM patients can significantly reduce the blood glucose levels and HbA1C levels.

scholarly journals Trace Level Arsenic Quantification through Cloud Point Extraction: Application to Biological and Environmental Samples

2012 ◽  
Vol 2012 ◽  
pp. 1-8
Author(s):  
Kempahanumakkagari Suresh Kumar ◽  
Malingappa Pandurangappa
Keyword(s):  
Ascorbic Acid ◽  
Standard Deviation ◽  
Environmental Samples ◽  
Acidic Medium ◽  
Cloud Point Extraction ◽  
Trace Level ◽  
Biological And Environmental Samples ◽  
Relative Standard ◽  
Surfactant Phase ◽  
Triton X

A sensitive solvent-free extraction protocol for the quantification of arsenic at trace level has been described. It is based on the reaction of arsenic (V) with molybdate in acidic medium in presence of antimony (III) and ascorbic acid as a reducing agent to form a blue-colored arsenomolybdenum blue complex. The complex has been extracted into surfactant phase using Triton X-114, and its absorbance was measured at 690 nm. The detection limit, working range, and the relative standard deviation were found to be 1 ng mL−1, 10–200 ng mL−1, and 1.2%, respectively. The effect of common ions was studied, and the method has been applied to determine trace levels of As(III) and As(V) from a variety of samples like environmental, biological, and commercially procured chemicals.

Quantitative Analysis of Phenaglycodol

1968 ◽  
Vol 51 (3) ◽  
pp. 631-633
Author(s):  
Robert P Snell
Keyword(s):  
Quantitative Analysis ◽  
Standard Deviation ◽  
Qualitative Analysis ◽  
Relative Standard Deviation ◽  
Carbon Disulfide ◽  
Quantitative Measurement ◽  
Spectrophotometric Analysis ◽  
Relative Standard ◽  
Tablet Preparation

Abstract A procedure has been developed for the quantitative and qualitative infrared spectrophotometric analysis of phenaglycodol in tablets and capsules. The procedure consists of a liquid-liquid partition of the drug between chloroform and an aqueous alkaline phase. The quantitative measurement is made at about 9.85 μ relative to a carbon disulfide reference, using the baseline technique. Qualitative analysis employs the KBr disk technique. Five collaborators obtained a relative standard deviation of ± 1.88% for a tablet preparation and ± 1.61% for a capsule preparation. It is recommended that the method be adopted as official, first action.

scholarly journals Estudio del perfil antropométrico del jugador juvenil de balonmano en la Región de Murcia (Study Profile Anthropometric Youth Handball Player in Murcia)

Retos ◽  
2015 ◽  
pp. 80-85
Author(s):  
Helena Vila Suárez ◽  
J. Arturo Abraldes Valeiras ◽  
Nuria Rodríguez Suárez
Keyword(s):  
Body Composition ◽  
Statistical Analysis ◽  
Standard Deviation ◽  
Statistical Significance ◽  
The Body ◽  
Juvenile Male ◽  
Anova Analysis ◽  
Anthropometric Data ◽  
Made In ◽  
Descriptive Statistical Analysis

Determinar la composición corporal y las diferentes características físicas y condicionales fue el primer objetivo planteado en este estudio, donde se valoraron a 45 jugadores de balonmano masculino de la Región de Murcia, correspondiente a la categoría juvenil. Los clubes analizados han sido el Murcia, Alhama, Jumilla y Águilas. El segundo objetivo de este trabajo consiste en establecer diferencias entre los equipos valorados y las líneas de juego de carácter ofensivo. El proceso de recogida de datos antropométricos se llevó a cabo siguiendo el protocolo estipulado por el ISAK. El análisis estadístico realizado fue en primer lugar descriptivo y, posteriormente, un análisis inferencial para establecer las diferencias estadísticas entre los distintos equipos y sus líneas de juego, en todas las variables de estudio. La valoración condicional se centró básicamente en la determinación del somatotipo, en la evaluación de la velocidad de lanzamiento y en la fuerza isométrica de tren superior. Los equipos de la parte superior de la tabla presentan valores superiores en las variables antropométricas pero sin ser estadísticamente significativas estas diferencias. Se constata la importancia de la mesomorfia como característica predominante en el somatotipo del jugador de balonmano. Las mayores velocidades se alcanzaron en los lanzamientos en los que hay desplazamiento previo.Abstract: The aim of this study was two fold, first to determine the body composition, physical and conditional characteristics of male handball players, who were playing in juvenile level in Murcia. A Second objective was to establish differences among the teams evaluated and offensive playing lines. The teams analyzed were playing in Murcia, Alhama, Jumilla and Águilas. 45 juvenile male handball players participated in this study. Anthropometric data were collected following ISAK protocols. A descriptive statistical analysis was made in order to obtains means and standard deviation of the simple. An ANOVA analysis was performed in order to establish differences among teams and its playing lines. The somatotype, throwing velocity and grip were analyzed in all teams The best teams show higher values in anthropometric variables than the worts, but these differences does not reach statistical significance. Mesomorphy is a very important characteristic in handball player. Higher throwing velocities were reach in throwings with previous displacements.

scholarly journals QUANTITATIVE ANALYSIS OF ACETAMINOPHEN AND IBUPROFEN MIXTURE IN TABLET UTILIZING CENTERED AVERAGE ON SPECTRUM RATIO BY SPECTROPHOTOMETRIC TECHNIQUE

2018 ◽  
Vol 11 (12) ◽  
pp. 344 ◽  
Author(s):  
Muchlisyam Bachri ◽  
Tuty R P ◽  
Edward R
Keyword(s):  
Absorption Spectrum ◽  
Quantitative Analysis ◽  
Standard Deviation ◽  
Phosphate Buffer ◽  
Regression Equations ◽  
Relative Standard ◽  
Coefficient Corrélation ◽  
Standard Solution ◽  
Spectrum Ratio

Objectives: Centered average on spectrum ratio by spectrophotometric technique has been done validated for acetaminophen (ACT) and ibuprofen (IBU) in mixture. The goal of this research is to analyze concurrent determination of ACT and IBU mixture in tablet, using pH 7.2 phosphate buffer and ethanol (91:9) as solvent mixture.Methods: The spectrophotometric technique was made by addition of standard solution from IBU, and the absorption spectrum of each drug has been recorded, which is divided by corresponding concentration as a dividing factor; after that, the centered flat of ratio spectra of ACT and IBU concentrations was determined by calibration graphs with measuring at obtained maximum wavelengths 244 nm for ACT and 221 nm for IBU.Results: The research results showed that linearly correlation acetominophen and IBU are 3.0–9.0 μg/mL and 5.0–13.0 μg/mL, respectively, and linearly regression equations are 1.5800X+0.4809 and 0.0991X+0.0205 with coefficient correlation are 0.9962 and 0.9990. Result of ACT and IBU in local tablet is 100.72±0.12% and 98.82±0.06% with the average of percentage recovery for ACT and IBU is 100.01% and 100.31%, and relative standard deviation value is 0.03% and 0.06% respectively.Conclusion: It can be concluded that centered average on spectrum ratio spectrophotometric technique is a smooth, accelerated, correct, and rigid for the analysis of ACT and IBU in mixture.

scholarly journals Quantitative Analysis of Volatile Impurities in Diallyldimethylammonium Chloride Monomer Solution by Gas Chromatography Coupled with Liquid-Liquid Extraction

2017 ◽  
Vol 2017 ◽  
pp. 1-9 ◽  
Author(s):  
Cheng Liu ◽  
Yuejun Zhang ◽  
Haiying Wang ◽  
Weixin Wang
Keyword(s):  
Gas Chromatography ◽  
Quantitative Analysis ◽  
Quantitative Methods ◽  
Allyl Chloride ◽  
Internal Standard ◽  
International Standards ◽  
Diallyldimethylammonium Chloride ◽  
Relative Standard ◽  
Monomer Solution ◽  
Volatile Impurities

The quantitative analysis method for volatile impurities in diallyldimethylammonium chloride (DADMAC) monomer solution was established in this paper. The volatile impurities were quantitatively analyzed with trichloromethane as extraction solvent and n-hexane as internal standard by using gas chromatography (GC) coupled with solvent extraction, and the chromatographic conditions, quantitative methods, and extraction conditions were systematically investigated in detail. The results showed that excellent linear relationships of 5 volatile impurities (dimethylamine, allyldimethylamine, allyl chloride, allyl alcohol, and allyl aldehyde) were obtained in the range of 1–100 mg·L−1. The method also showed good specificity, recovery (95.0%–107.5%), and relative standard deviation (RSD, 1.40%–7.67%). This method could accurately detect the whole volatile impurities in DADMAC monomer solution quantitatively in one time with a low detection limit. Furthermore, this method is conducive to the preparation of highly pure DADMAC monomer and the development of national and international standards of the DADMAC monomer product quality, and the results could provide a strong foundation for the regulation and mechanism research of impurities on monomer reactivity in polymerization.

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