scholarly journals Applying a System Dynamics Approach for the Pharmaceutical Industry: Simulation and Optimization of the Quality Control Process

2021 ◽  
Vol 17 ◽  
pp. 983-996
Author(s):  
Evripidis P. Kechagias ◽  
Dimitrios M. Miloulis ◽  
Georgios Chatzistelios ◽  
Sotiris P. Gayialis ◽  
Georgios A. Papadopoulos

As countries interact more and more, technology gains a decisive role in facilitating today’s increased need for interconnection. At the same time, systems, becoming more advanced as technology progresses, feed each other and can produce highly complex and unpredictable results. However, with this ever-increasing need for interconnected operations, complex problems arise that need to be effectively tackled. This need extends far beyond the scientific and mechanical fields, covering every aspect of life. Systemic Thinking Philosophy and the System Dynamics methodology now seem to be more relevant than ever and their practical implementation in real-life industrial cases has started to become a trend. Companies that decide to implement such approaches can achieve significant improvements to the effectiveness of their operations and gain a competitive advantage. This research, influenced by the Systemic Thinking Philosophy, applies a System Dynamics approach in practice by improving the quality control process of a pharmaceutical company. The process is modeled, simulated, analyzed, and improvements are performed to achieve more effective and efficient operations. The results show that all these steps led to a successful identification and optimization of the critical factors, and a significant process improvement was achieved.

2021 ◽  
pp. 1-11
Author(s):  
Song Gang ◽  
Wang Xiaoming ◽  
Wu Junfeng ◽  
Li Shufang ◽  
Liu Zhuowen ◽  
...  

In view of the production quality management of filter rods in the manufacturing and execution process of cigarette enterprises, this paper analyzes the necessity of implementing the manufacturing execution system (MES) in the production process of filter rods. In this paper, the filter rod quality system of cigarette enterprise based on MES is fully studied, and the constructive information management system demand analysis, cigarette quality control process, system function module design, implementation and test effect are given. This paper utilizes the Fuzzy analytic hierarchy process to find the optimal system for processing the manufacturing of cigarette. The implementation of MSE based filter rod quality information management system for a cigarette enterprise ensures the quality control in the cigarette production process. Through visualization, real-time and dynamic way, the information management of cigarette production is completed, which greatly improves the quality of cigarette enterprise manufacturing process.


Cell ◽  
2021 ◽  
Vol 184 (11) ◽  
pp. 2896-2910.e13
Author(s):  
Haifeng Jiao ◽  
Dong Jiang ◽  
Xiaoyu Hu ◽  
Wanqing Du ◽  
Liangliang Ji ◽  
...  

2013 ◽  
Vol 141 (2) ◽  
pp. 798-808 ◽  
Author(s):  
Zhifang Xu ◽  
Yi Wang ◽  
Guangzhou Fan

Abstract The relatively smooth terrain embedded in the numerical model creates an elevation difference against the actual terrain, which in turn makes the quality control of 2-m temperature difficult when forecast or analysis fields are utilized in the process. In this paper, a two-stage quality control method is proposed to address the quality control of 2-m temperature, using biweight means and a progressive EOF analysis. The study is made to improve the quality control of the observed 2-m temperature collected by China and its neighboring areas, based on the 6-h T639 analysis from December 2009 to February 2010. Results show that the proposed two-stage quality control method can secure the needed quality control better, compared with a regular EOF quality control process. The new method is, in particular, able to remove the data that are dotted with consecutive errors but showing small fluctuations. Meanwhile, compared with the lapse rate of temperature method, the biweight mean method is able to remove the systematic bias generated by the model. It turns out that such methods make the distributions of observation increments (the difference between observation and background) more Gaussian-like, which ensures the data quality after the quality control.


PLoS ONE ◽  
2021 ◽  
Vol 16 (3) ◽  
pp. e0247925
Author(s):  
Pooi-Mun Wong ◽  
Shreya R. K. Sinha ◽  
Chee-Kong Chui

Blockchain has been applied to quality control in manufacturing, but the problems of false defect detections and lack of data transparency remain. This paper proposes a framework, Blockchain Quality Controller (BCQC), to overcome these limitations while fortifying data security. BCQC utilizes blockchain and Internet-of-Things to form a peer-to-peer supervision network. This paper also proposes a consensus algorithm, Quality Defect Tolerance (QDT), to adopt blockchain for during-production quality control. Simulation results show that BCQC enhances data security and improves defect detections. Although the time taken for the quality control process increases with the number of nodes in blockchain, the application of QDT allows multiple inspections on a workpiece to be consolidated at a faster pace, effectively speeding up the entire quality control process. The BCQC and QDT can improve the quality of parts produced for mass personalization manufacturing.


AGROINTEK ◽  
2019 ◽  
Vol 13 (1) ◽  
pp. 72
Author(s):  
Andan Linggar Rucitra ◽  
S Fadiah

<p><em>Telon oil is</em><em> one of </em><em> </em><em>the </em><em>traditional medicine in the form of </em><em> </em><em>liquid preparations that serves to provide a sense of warmth to the wearer. PT</em><em>.X</em><em> is one of the companies that produce</em><em> </em><em>telon</em><em> oil</em><em>.</em><em> To maintain</em><em> the quality of telon oil from PT.X</em><em> product</em><em>, required overall quality control that is starting from the quality control of raw materials, quality control process to the quality control of the final product. The purpose of this research is to know the application of Statistical Quality Control (SQC) in controlling the quality of telon oil in PT X. </em><em>F</em><em>inal product</em><em> quality</em><em> become one of the measurement of success of a process, so it needs a good quality control. SQC method used in this research is Pareto Diagram and Cause and Effect Diagram. Pareto diagram is a bar graph </em><em>that </em><em>show the problem based on the order of the number of occurrences of the most number of problems until the least happened. A causal diagram is often called a fishbone diagram, a tool for identifying potential causes of an effect or problem. The result of applying the method indicates that 80% defect is caused by unsuitable volume and on the incompatibility of Expired Date (ED) code. The damage is caused by several factors namely the method, labor, and machine while the most potential factor is the volume conformity to reduce the number of defect products.</em></p>


Author(s):  
A. V. Samonov ◽  
S. A. Sharov

The work looks at directions of developing regulatory and procedural and technological basis of weapons system software control and quality assurance processes. We present an improved software life cycle model and describe an automated technique of implementing a systemic end-to-end software quality control process.


2017 ◽  
Vol 5 (1) ◽  
pp. 35-42
Author(s):  
LIa Alfa Rosida ◽  
Sudiro Sudiro

The indicator achievement of minimum service standard (MSS) for the accuracy of distributingdrugs in Pharmacy Unit of Keluarga Sehat Hospital has not been achieved, even the incidence ofthe distributionerror from 2013 to 2016 continues to increase. The purpose of this researchwas to analyze the quality control process in the implementation of MSS in Pharmacy Unit of Keluarga Sehat Hospital. This was a qualitative research, with research subject 3pharmacy officers and 3 people of pharmacy management services.Data collectedby in-depth interview and observation of pharmaceutical performance report data and analysed by content analysis. The result of the research showed that the evaluation of pharmacy staff performance has not been implemented, because there is no performance appraisal indicator yet. Comparison was done only by comparing reports with general target, medical support manager double job resulted in no feedback to Pharmacy Unit, and so it has not supported the implementation of MSS. The Improvement of performancehas not been implementedand has notfound the concept of improvement. The new management will attempt to conduct a comparative study, including pharmacy installation into the Quality Control Group (GKM) or Problem Solving for Better Health (PSBH), find the cause of the problem and develop the policy. It can be concluded that the quality control of the MSS in the Pharmacy Unit still not going well and need to be improved especially related to quality performance appraisal and performance improvement based on the SOP.


2021 ◽  
Vol 11 (01) ◽  
pp. 123-136
Author(s):  
Ronald Waliaula Wanyonyi ◽  
Olivia Wanjeri Mwangi ◽  
Charles Wambugu Mwangi

2012 ◽  
Vol 263-266 ◽  
pp. 839-842 ◽  
Author(s):  
Zhong Qiu Jiang

SPC (statistical process control) and EPC (engineering process control) is the scientific methods of quality quality control and quality improvement. It is the difficult problems of quality control process for network manufacturing enterprise how to effectively solve the dynamic quality fluctuation monitoring and the fluctuation abnormal diagnostic analysis and timely process adjustments, this paper designs the intelligent quality control mode and function system architecture, the modes expatiates quality management network based on quality control network of the workshop level and enterprise class network, and researches the integration applications of statistical process control and enterprise ERP quality system, and applies J2EE technology to achieve the system organic combination of design and development.


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