scholarly journals Synthesis, Structure, and Radioprotective Activity of the Palladium (II) Complex With Mexidol

2021 ◽  
Vol 18 ◽  
pp. 146-149
Author(s):  
Kh. I. Gasanov ◽  
S. I. Nurullayeva ◽  
Z. H. Babayev ◽  
Sh. H. Gasimov
Keyword(s):  
Complex Anion ◽  
Average Length ◽  
Complex Compounds ◽  
The Body ◽  
Biologically Active ◽  
Palladium Atom ◽  
X Ray ◽  
Square Planar ◽  
Toxicological Studies ◽  
Radioprotective Properties

New complex compounds of palladium (II) with biologically active ligand 2 - ethyl - 6 methyl - 3 - hydroxy-pyridine - mexidol in acidic medium (pH = 5,3) of the following composition have been synthesized – (C8H12O⊕N)2 [PdCl4]. In this case, the ligand is protonated and as a single-charged cation occupies an external coordination sphere. The structure of the complex is proved by X-ray structure analysis. It is shown that the structure is constructed of an isolated complex anion [PdCl4]2- and cation C8H12O⊕N. The square planar coordination of the palladium atom is formed from three chlorine atoms and the formed tetraacidoanion ligand forms a hydrogen bond. The average length of Pd-Cl bond is 2, 3030 Α°, there are no deviations from 900 valence angles of Cl-Pd-Cl. The palladium atom is not shifted from the plane coordination polyhedron (square) and therefore trance angles of Cl-Pd-Cl are 1800. Two different lengths -2,289 Α° and 2,713 Α° of hydrogen bonds are related to the geometric location of the ligand functional group. The obtained 2 – ethyl – 6 – methyl – 3 -hydroxypyridinetrachloro - palladium - mexidazole was tested for radioprotective properties. Toxicity of the preparation is LD50 - 240 mg/kg of animal weight. Toxicological studies of mexidazole in mice, rats and dogs did not reveal cardiotoxic, immunotoxic, embryonic, nephrotoxic, hematoxic and other types of side effects. Mexidazole is removed from the body with urine 5-8 hours after intravenous injection. The carried out biological test showed that the compound, along with radioprotective properties, has some antitumor activity.

scholarly journals Synthesis, Structure, and Radioprotective Activity of the Palladium (II) Complex with Mexidol

2021 ◽  
Vol 8 ◽  
pp. 43-47
Author(s):  
Kh.I. Gasanov ◽  
S.I. Nurullayeva ◽  
Z.H. Babayev
Keyword(s):  
Complex Anion ◽  
Average Length ◽  
Complex Compounds ◽  
The Body ◽  
Biologically Active ◽  
Palladium Atom ◽  
X Ray ◽  
Square Planar ◽  
Toxicological Studies ◽  
Radioprotective Properties

New complex compounds of palladium (II) with biologically active ligand 2 - ethyl - 6 methyl - 3 - hydroxy-pyridine - mexidol in acidic medium (pH = 5,3) of the following composition have been synthesized – . In this case, the ligand is protonated and as a single-charged cation occupies an external coordination sphere. The structure of the complex is proved by X-ray structure analysis. It is shown that the structure is constructed of an isolated complex anion – and cation . The square planar coordination of the palladium atom is formed from three chlorine atoms and the formed tetraacidoanion ligand forms a hydrogen bond. The average length of Pd-Cl bond is 2, 3030 , there are no deviations from 900 valence angles of Cl-Pd-Cl. The palladium atom is not shifted from the plane coordination polyhedron (square) and therefore trance angles of Cl-Pd-Cl are 1800. Two different lengths -2,289 and 2,713 of hydrogen bonds are related to the geometric location of the ligand functional group. The obtained 2 – ethyl – 6 – methyl – 3 -hydroxypyridinetrachloro - palladium - mexidazole was tested for radioprotective properties. Toxicity of the preparation is LD50 - 240 mg/kg of animal weight. Toxicological studies of mexidazole in mice, rats and dogs did not reveal cardiotoxic, immunotoxic, embryonic, nephrotoxic, hematoxic and other types of side effects. Mexidazole is removed from the body with urine 5-8 hours after intravenous injection. The carried out biological test showed that the compound, along with radioprotective properties, has some antitumor activity.

Anatomical and congenital variations of human dry sternum bone: its embryogenesis and clinical implications

2017 ◽  
Vol 6 (1) ◽  
pp. 300
Author(s):  
Kosuri Kalyan Chakravarthi ◽  
Siddaraju K. S. ◽  
Nelluri Venumadhav ◽  
Sangeeta Atamaram Bali
Keyword(s):  
Average Length ◽  
Anterior Chest Wall ◽  
The Body ◽  
Transverse Diameter ◽  
Xiphoid Process ◽  
Cross Sectional ◽  
X Ray ◽  
Medical College ◽  
Vertical Diameter ◽  
Autopsy Series

Background: The sternum is one of the skeleton parts with frequently detected variation in cross-sectional images or autopsy series. The anatomical or congenital variations of the sternum in the anterior chest wall may involve malignancies, injuries or severe traumas. The aim of the study was undertaken to evaluate the incidence of anatomical and congenital variations of human dry sternum bones.Methods: This study was carried out on 120 dry human sternum bones irrespective of age and sex at Varun Arjun medical college- Banthra, UP, KMCT Medical College, Manassery-Calicut and Melaka Manipal Medical College-Manipal. All the sternum bones were macroscopically inspected for the anatomical and congenital variations of human dry sternum bones. Photographs of the anatomical and congenital variations were taken for proper documentation.Results: Complete sternal foramina in the body of the sternum were noted in 9 bones (7.5%), with an average vertical diameter of 17mm and transverse diameter of 16mm (The highest vertical diameter of 19mm and transverse diameter of 17mm was noted); Incomplete sternal foramina in the body of the sternum were noted in 4 bones (3.3%);Complete sternal foramina in the xiphoid process of the sternum were noted in 7 bones (5.8%) with an average vertical diameter of 6mm and transverse diameter of 8mm; Unusual complete sternal foramina in the body and incomplete sternal foramina in the xiphoid process of the sternum were noted in 8 bones (6.6%); Very rare longer xiphoid process (7.3 cm) with complete sternal foramina was noted in 7 bone (5.8%); Unusual Longer xiphoid process with an average length of 6.7cm with sharp bifid ends was noted in 8 bones (6.6%).Conclusions: The knowledge of existence of anatomical variants and congenital foramina of sternum and xiphoid process found in our study is essential, especially for bone marrow sampling, radiology (X - ray, CT, MRI, and USG) reporting, pathology autopsy and forensic medicine post-mortem reporting and patoacupuncture practice to avoid complications during various surgical procedures.

scholarly journals S4N4 und seine Derivate: Isolierung und Struktur von Pd2(S3N)2(S3N2) / S4N4 and its Derivatives: Isolation and Structure of Pd2(S3N)2(S3N2)

1982 ◽  
Vol 37 (3) ◽  
pp. 276-280 ◽  
Author(s):  
Ulf Thewalt
Keyword(s):  
Dinuclear Complex ◽  
Palladium Atom ◽  
Space Group ◽  
X Ray ◽  
Square Planar

Abstract The reaction of S4N4 with PdCl2 in methanol yields among other products the dinuclear complex Pd2 (S3N)2(S3N2) (D): dark red needles, space group R"3̄ with a = 32.759(15), c = 6.516(4) Å and Z = 18. The structure of D was determined by an X-ray analysis. Each palladium atom is part of an almost planar PdS3N metallocycle. The SNSNS group acts as a bridge whereby each of its terminal S atoms is bonded to both Pd atoms. The Pd atoms possess a square planar coordination by four S atoms. The coordination planes form an angle of 114.9°. The Pd-Pd distance of 2.921(2) Å is rather short.

Binding sites between palladium(II) and nucleosides or nucleotides and crystal structure of [Pd(diethylenetriamine)(guanosine)](ClO4)2

1980 ◽  
Vol 58 (4) ◽  
pp. 381-386 ◽  
Author(s):  
F. D. Rochon ◽  
P. C. Kong ◽  
B. Coulombe ◽  
R. Melanson
Keyword(s):  
Crystal Structure ◽  
Binding Sites ◽  
Palladium Atom ◽  
X Ray Diffraction ◽  
Orthorhombic Space Group ◽  
X Ray ◽  
R Factor ◽  
Square Planar ◽  
Purine Ring ◽  
Coordination Plane

The interactions between [Pd(dien)Cl]Cl and some nucleosides and nucleotides were studied by nmr. The binding site of guanosine, guanosinemonophosphoric acid, xanthosine, and inosine is N(7). Cytidine is coordinated to palladium through N(3). Adenosinemonophosphate acts as a bidentate, binding two different palladium atoms at N(1) and N(7).The crystal structure of [Pd(dien)(guanosine)](ClO4)2 has been determined by X-ray diffraction. The crystals are orthorhombic, space group P212121, with a = 13.422, b = 14.587, c = 12.432, and Z = 4. The structure was refined by block-diagonal least-squares analysis to a conventional R factor of 0.047 and a weighted Rw = 0.043. The coordination around the palladium atom is square planar. Guanosine is bonded to palladium through N(7). The planar purine ring makes an angle of 63.4° with the palladium coordination plane. The structure is stabilized by hydrogen bonding.

scholarly journals SYNTHESIS AND RESEARCH OF NEW HETEROMETAL COMPLEXES Cо(II), Ni(II), Cu(II) AND Mn(II) BASED ON V(V) AND 5-(4-PYRIDYL)-1,3,4-OXADIAZOLE-2(3H)-THIONE LUBRICANTS

2020 ◽  
pp. 43-47
Keyword(s):  
Complex Compounds ◽  
Biologically Active ◽  
Ligand Molecule ◽  
X Ray ◽  
Ammonium Vanadate ◽  
Composition And Structure ◽  
Competitive Coordination ◽  
Oxadiazole Derivatives ◽  
Mixed Metal Complexes ◽  
Active Substances

The oxadiazole derivatives complex compounds with metals are biologically active substances. The aim of the study was to study the interaction of the chlorides of Co (II), Ni (II), Cu (II) and Mn (II) with 5-(4-pyridyl)-1,3,4-oxadiazole-2(3H)–thione, ammonium vanadate. Competitive coordination of donor centers, electronic and geometric structures of the ligand molecule were studied on the basis of the quantum-chemical software package Gaussian09 LanL2DZ. It was shown that 5-(4-pyridyl)-1,3,4-oxadiazole-2(3H)-thione ligand is partially coordinated through a localized nitrogen or sulfur atoms at formation of the complex. А procedure was developed for the synthesis of new mixed-metal complexes. The composition and structure of the synthesized compounds were studied using elemental analysis, termogravimetric and X-ray phase analysis and IR spectroscopy.

scholarly journals Potassium tetracyanidoaurate(III) monohydrate: a redetermination

IUCrData ◽  
2017 ◽  
Vol 2 (3) ◽  
Author(s):  
Nobuyuki Matsushita ◽  
Wataru Noguchi ◽  
Rikako Tanaka
Keyword(s):  
Diffraction Data ◽  
Complex Anion ◽  
Three Dimensional ◽  
Complex Salt ◽  
Potassium Cation ◽  
X Ray Diffraction ◽  
Acta Cryst ◽  
X Ray ◽  
Square Planar ◽  
Cyanide Ligands

The structure of the title metal complex salt, K[Au(CN)4]·H2O, has been redetermined using X-ray diffraction data at 173 K in order to improve the precision. The previous determination was based on neutron diffraction data [Bertinotti & Bertinotti (1970). Acta Cryst. B26, 422–428]. The title compound crystallizes in the space group P212121 with one potassium cation, one [Au(CN)4]− anion and one water molecule in the asymmetric unit. The AuIII atom lies on a general position and has an almost square-planar coordination sphere defined by four cyanide ligands. Interactions between the potassium cation and N atoms of the complex anion, as well as O—H...N hydrogen bonds, lead to the formation of a three-dimensional framework structure.

scholarly journals Stature Estimation for Bosnian Male Population

2006 ◽  
Vol 6 (1) ◽  
pp. 62-67 ◽  
Author(s):  
Nermin Sarajlić ◽  
Zdenko Cihlarž ◽  
Eva Elvira Klonowski ◽  
Ivan Selak
Keyword(s):  
Bosnia And Herzegovina ◽  
Standard Error ◽  
Average Length ◽  
The Body ◽  
Long Bones ◽  
Male Population ◽  
Stature Estimation ◽  
X Ray ◽  
Missing Persons ◽  
Left And Right

Since 1996, the Trotter and Gleser formulae to determine the stature of recovered missing persons in Bosnia and Herzegovina have been used. The purpose of this study is to develop appropriate stature estimation formulae from the length of the femur, tibia and fibula for use in the Bosnia and Herzegovina to help in identifications of the victims. Research was undertaken on 50 male cadavers, of individuals who died between the ages of 23 to 54 years. The cadaver length was measured and the length of the long bones was obtained from X-ray photographs. The length of the cadavers of the individuals who died after age of 45 years was corrected according to Giles' table. This study established that using Trotter and Gleser's formulae underestimate stature of tall people in the current population of Bosnia and Herzegovina. Smallest standard error of estimate is observed in the formula that uses the sum of the length of femur and fibula. There are no statistically significant differences between the length of the bones from the left and right sides of the body. Therefore, formulae developed from the average length of bone pairs are recommended for use.

X-ray micro tomography in the scanning electron microscope

1978 ◽  
Vol 36 (1) ◽  
pp. 106-107 ◽  
Author(s):  
W. Brünger
Keyword(s):  
Electron Beam ◽  
Electron Microscope ◽  
Scanning Electron Microscope ◽  
Target Surface ◽  
The Body ◽  
X Rays ◽  
Cross Sectional ◽  
X Ray ◽  
Micro Tomography ◽  
Scanning Electron

Reconstructive tomography is a new technique in diagnostic radiology for imaging cross-sectional planes of the human body /1/. A collimated beam of X-rays is scanned through a thin slice of the body and the transmitted intensity is recorded by a detector giving a linear shadow graph or projection (see fig. 1). Many of these projections at different angles are used to reconstruct the body-layer, usually with the aid of a computer. The picture element size of present tomographic scanners is approximately 1.1 mm2.Micro tomography can be realized using the very fine X-ray source generated by the focused electron beam of a scanning electron microscope (see fig. 2). The translation of the X-ray source is done by a line scan of the electron beam on a polished target surface /2/. Projections at different angles are produced by rotating the object.During the registration of a single scan the electron beam is deflected in one direction only, while both deflections are operating in the display tube.

Great Increase of Numbers of Virus Particles by Irradiating C3H Mouse Mammary Tumors Transplanted into Male Mice

1972 ◽  
Vol 30 ◽  
pp. 272-273
Author(s):  
P. J. Melnick ◽  
J. W. Cha ◽  
E. Samouhos
Keyword(s):  
Subcutaneous Tissue ◽  
Mammary Tumors ◽  
The Body ◽  
X Ray ◽  
Virus Particles ◽  
Mouse Mammary Tumors ◽  
Transplantable Tumors ◽  
C3h Mice ◽  
Cobalt Radiation ◽  
Enzyme Changes

Spontaneous mammary tumors in females of a high tumor strain of C3H mice were cut into small fragments that were Implanted into the subcutaneous tissue of the back of males of the same strain, where they grew as transplantable tumors. When about Cm. In diameter daily fractional radiation was begun, applied to the tumors, the rest of the body being shielded by a lead shield. Two groups were treated with 150 and 200 r X-ray dally, of half value layer 0.6mm. copper; a third group was treated with 500 r cobalt radiation dally. The primary purpose was to examine the enzyme changes during radiation, with histochemlcal technics.

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