Characteristics of Endometrial Cells and the Factors  that Influence the Implantation Process

Infertility is a global health problem faced by 8 - 10% of couples in the world. It means 50 - 80 million couples have infertility problem. Knowledge about comprehensive and profound reproductive system is main asset for managing infertility. When look at various factors those contribute to women infertility, so the role of endometrium is very important. The optimal endometrial environment for receiving blastocyst is a major factor in the process of implantation and pregnancy. This study attempts to review and compare sources from research article, case report, and reviews from reputable international journals. Research by Germeyer et all (2010) shows that optimal growth and development of endometrium are factors those greatly contributes for successful implantation which is continued to pregnancy. The same thing is revealed by Neykova review (2020) which states the success implantation process is determined by the quality of the embryo, the readiness of the endometrium to accept the result of conception and interaction, and communication of molecular cells. Currently, various studies are being developed for evaluating endometrium condition through genetic improvement, the use of new biomarkers, non-invasive method even sophisticated method such as proteomic technique Endometrial Receptivity Assay (ERA) in order to solve women infertility problem.

Download Full-text

Role of shear wave elastography of liver and spleen “as non-invasive method” in prediction of oesophgeal varices in Egyptian patients with liver cirrhosis

Journal of Recent Advances in Medicine ◽

10.21608/jram.2020.112528 ◽

2020 ◽

Vol 1 (2) ◽

pp. 80-89

Author(s):

Madiha Elzeiny ◽

Mohamed Taha ◽

Wafaa El-zefzafy ◽

Eslam Mohamed

Keyword(s):

Liver Cirrhosis ◽

Shear Wave ◽

Shear Wave Elastography ◽

Non Invasive ◽

Egyptian Patients ◽

Invasive Method

Download Full-text

VIRTUAL BRONCHOSCOPY OF MULTISPIRAL COMPUTED TOMOGRAPHY WITH TRAUMATIC INJURIES OF THE MAIN BRONCHUS

Diagnostic radiology and radiotherapy ◽

10.22328/2079-5343-2018-4-63-67 ◽

2019 ◽

pp. 63-67

Author(s):

P. M. Kotlyarov ◽

N. V. Chernichenko ◽

V. P. Kharchenko

Keyword(s):

Computed Tomography ◽

Main Bronchus ◽

Traumatic Rupture ◽

Virtual Bronchoscopy ◽

Traumatic Injuries ◽

Traumatic Lesion ◽

Non Invasive ◽

Invasive Method ◽

Bone Structures

The aim of the study was to evaluate the role of virtual bronchoscopy (VB) in traumatic rupture of the main bronchus Material and methods. Тhe data of virtual bronchoscopy of multispiral computed tomography (MSCT) with multiplanar and 3D reconstructions of 10 patients with traumatic separation of the main bronchus were analyzed. MSCT was carried out by the computer tomograph AquilionONE (320-slice) according to the previously described technique. Results of the study. VB MSCT allowed to determine the presence of a complete or partial rupture of the main bronchus, its distance to the bifurcation of the trachea, the state of the collapsed lung, the presence of fluid in the hemithorax, secondary changes in the bone structures of the chest. The World Bank played an important role in monitoring the adequacy of reconstructive measures on the damaged bronchus, excluding the occurrence of postoperative stenosis. The conclusion. Virtual bronchoscopy of multispiral computed tomography with the capabilities of multiplanar and volumetric reconstructions, postprocessing image processing is an optimal non-invasive method for determining the traumatic lesion of the main bronchi and monitoring the success of the reconstructive surgical manual.

Download Full-text

Changes in Plasma Phospholipid Metabolism Are Associated with Clinical Manifestations of Systemic Sclerosis

Diagnostics ◽

10.3390/diagnostics11112116 ◽

2021 ◽

Vol 11 (11) ◽

pp. 2116

Author(s):

Marija Geroldinger-Simić ◽

Thomas Bögl ◽

Markus Himmelsbach ◽

Norbert Sepp ◽

Wolfgang Buchberger

Keyword(s):

Systemic Sclerosis ◽

High Performance ◽

Clinical Manifestations ◽

Plasma Phospholipid ◽

Phospholipid Metabolism ◽

Internal Organs ◽

New Biomarkers ◽

First Time

Systemic sclerosis (SSc) is an autoimmune disease with fibrosis of the skin and/or internal organs, causing a decrease in quality of life and survival. There is no causative therapy, and the pathophysiology of the SSc remains unclear. Studies showed that lipid metabolism was relevant for autoimmune diseases, but little is known about the role of lipids in SSc. In the present study, we sought to explore the phospholipid profile of SSc by using the lipidomics approach. We also aimed to analyze lipidomics results for different clinical manifestations of SSc. Experiments were performed using high-performance liquid chromatography coupled to mass spectrometry for the lipidomic profiling of plasma samples from patients with SSc. Our study showed, for the first time, significant changes in the level of phospholipids such as plasmalogens and sphingomyelins from the plasma of SSc patients as compared to controls. Phosphatidylcholine plasmalogens species and sphingomyelins were significantly increased in SSc patients as compared to controls. Our results also demonstrated a significant association of changes in the metabolism of phospholipids (phosphatidylcholine and phosphatidylethanolamine plasmalogens species and sphingomyelins) with different clinical manifestations of SSc. Further lipidomic studies might lead to the detection of lipids as new biomarkers or therapeutic targets of SSc.

Download Full-text

Influence of hyperbaric oxygenation and its use in urinary tract diseases

Polish Hyperbaric Research ◽

10.1515/phr-2016-0016 ◽

2016 ◽

Vol 56 (3) ◽

pp. 25-32

Author(s):

Małgorzata Skiba ◽

Agnieszka Pedrycz

Keyword(s):

Urinary Tract ◽

Hyperbaric Oxygen ◽

Hyperbaric Oxygen Therapy ◽

Oxygen Therapy ◽

Hemorrhagic Cystitis ◽

Positive Influence ◽

Non Invasive ◽

Invasive Method ◽

Hyperbaric Therapy

Abstract In this publication, we adduce examples of the use of hyperbaric oxygen therapy in urinary tract diseases. Hyperbaric oxygen therapy has been proved to have a positive influence on the kidneys of animals with diabetes, sepsis or undergoing chemotherapy. In the literature, we can also find many examples of the use of hyperbaric therapy with good clinical outcomes in human patients with prostatic hypertrophy, pyelonephritis, and hemorrhagic cystitis. The first trials of this kind of treatment of urinary tract diseases were started at the end of the twentieth century. In spite of the promising results, and numerous reports on the effectiveness of this non-invasive method of treatment, it is not currently used on a regular basis. Because many factors such as time, multiple applications, the parameters used in the hyperbaric chamber as well as the medications taken by the patient affect the quality of the result, further studies are needed to make hyperbaric therapy more suitable and safer for each patient.

Download Full-text

Testicular responsiveness to hCG during infancy measured by salivary testosterone

Acta Endocrinologica ◽

10.1530/acta.0.1230633 ◽

1990 ◽

Vol 123 (6) ◽

pp. 633-636 ◽

Cited By ~ 2

Author(s):

Leo Dunkel ◽

Ilpo Huhtaniemi

Keyword(s):

Serum Testosterone ◽

Maximal Level ◽

Salivary Testosterone ◽

Non Invasive ◽

Basal Serum ◽

Age Related ◽

Invasive Method ◽

Prepubertal Boys ◽

The Mean

Abstract. To investigate the role of gonadotropins in postnatal testicular activation, testosterone responsiveness to human chorionic gonadotropin was studied in 11 male infants (aged 5-180 days). The boys were given a single im injection of 5000 IU/1.7m2 hCG, and serum and salivary testosterone responses were then measured for 7 days. The results were compared with the serum testosterone responses of 8 older prepubertal boys (aged 1.7-10.4 years) studied with the same protocol. The mean (±sem) basal serum testosterone levels were 2.67±1.27 nmol/l in the infants and 0.09±0.02 nmol/l in the prepubertal boys (p<0.05). Both groups gave a significant response to hCG stimulation (p<0.001, ANOVA, one-way). The stimulated concentrations of serum testosterone were higher in the infants than in the prepubertal boys (p<0.001). The mean basal level of salivary testosterone was 30.5 ±7.0 and the mean maximal level was 97± 10.3 pmol/l in the infants (p<0.001). No age-related changes were observed in either basal or hCG-stimulated levels. In infants the mean (±sem) maximal hCG-stimulated increase was 25 ± 10-fold in serum and 8±4-fold in saliva (p=0.13). A clear stimulatory effect of hCG on testicular testosterone production was found, suggesting that the postnatal increase in serum testosterone concentration in male infants is gonadotropin-mediated. Salivary testosterone concentrations can be increased by hCG, indicating that measurements of salivary testosterone may provide an optional, non-invasive method for assessing gonadal function in children.

Download Full-text

Role of Circulating Biomarkers in Platinum-Resistant Ovarian Cancer

International Journal of Molecular Sciences ◽

10.3390/ijms222413650 ◽

2021 ◽

Vol 22 (24) ◽

pp. 13650

Author(s):

Carolina Maria Sassu ◽

Innocenza Palaia ◽

Serena Maria Boccia ◽

Giuseppe Caruso ◽

Giorgia Perniola ◽

...

Keyword(s):

Ovarian Cancer ◽

Poor Prognosis ◽

Gynecological Cancer ◽

Circulating Biomarkers ◽

Tumor Biopsy ◽

Non Invasive ◽

The Poor ◽

Platinum Resistant ◽

New Biomarkers

Ovarian cancer (OC) is the second most common cause of death in women with gynecological cancer. Considering the poor prognosis, particularly in the case of platinum-resistant (PtR) disease, a huge effort was made to define new biomarkers able to help physicians in approaching and treating these challenging patients. Currently, most data can be obtained from tumor biopsy samples, but this is not always available and implies a surgical procedure. On the other hand, circulating biomarkers are detected with non-invasive methods, although this might require expensive techniques. Given the fervent hope in their value, here we focused on the most studied circulating biomarkers that could play a role in PtR OC.

Download Full-text

ROLE OF DERMATOSCOPY IN CHRONIC DERMATOSES DIAGNOSIS

International Medical Journal ◽

10.37436/2308-5274-2020-2-11 ◽

2020 ◽

pp. 53-56

Author(s):

G. S. Chekhovska

Keyword(s):

Differential Diagnosis ◽

Lupus Erythematosus ◽

Skin Diseases ◽

Seborrheic Dermatitis ◽

Hair Follicles ◽

Discoid Lupus Erythematosus ◽

Non Invasive ◽

Invasive Method ◽

Vascular Structures

Dermatoscopy is a valuable auxiliary non−invasive method used in the diagnosis of inflammatory, parasitic and viral skin diseases. Treatment of dermatoses is based on the results of analysis of melanin, follicular−horny and vascular components. Diagnosis begins with polarized dermatoscopy and then progresses to non−polarized using immersion fluid. At dermatoscopic inspection of a psoriatic plaque the point vessels evenly distributed along all the surface (a symptom of "scattered red pepper") are noted. Eczema is characterized by focal accumulation of blood vessels in the form of dots, peeling, yellowish crusts. Examination of discoid lupus erythematosus foci often reveals individual linear or branched vessels, their location is random. Red herpes zoster is dermatoscopically characterized by vascular structures in the form of large granular horny plugs of whitish color with a pearly sheen. The most informative is dermatoscopy in the differential diagnosis of erythematous form of rosacea and seborrheic dermatitis. On the erythematous background, dilated vessels around the sebaceous hair follicles, large vascular polygons formed from vessels thicker than in healthy skin and seborrheic dermatitis are found. At inspection of the fresh centers of a sclero−atrophic lichen diffuse unstructured zones of white color with a peripheral erythematous corolla and with numerous light comedic structures on a surface are visualized. At dermatoscopy of the Little − Lassueur syndrome in follicular papules on skin gray, violet points located in the form of a circle are noted. Dermatoscopy is increasingly used in dermatology, especially in the differential diagnosis of dermatoses of inflammatory and parasitic nature.

Download Full-text

Investigating a Non-Invasive Method of Measuring the Quality of Latent Hazard Schemas of Novice Teen and Experienced Adult Drivers

Proceedings of the Human Factors and Ergonomics Society Annual Meeting ◽

10.1177/1541931213601163 ◽

2016 ◽

Vol 60 (1) ◽

pp. 712-716 ◽

Cited By ~ 1

Author(s):

Atefeh Katrahmani ◽

Matthew Romoser ◽

Siby Samuel

Keyword(s):

Eye Tracking ◽

Situation Awareness ◽

Verbal Protocol ◽

Verbal Protocols ◽

Non Invasive ◽

Schema Development ◽

Invasive Method ◽

Hazardous Element ◽

Experienced Adult

The main objective of this study was to investigate the development of a non-invasive tool for assessing the quality of a driver’s latent hazard schema. Verbal and eye tracking protocols were mapped to Endsley’s model of situation awareness (SA) as a means of measuring schema development. Participants were asked to drive a simulator with various hazard scenarios. Verbal protocol results showed that teenswere less likely to verbally associate subtle cues and accurately state what ‘could happen’. The verbal protocols of teens consisted primarily of simple statements of what was happening and what they were currently doing. Whereas, experienced drivers’ verbal protocols indicated higher levels of processing of the driving environment and contained projections of what could happen. In mapping driver commentary and eye glances for potential hazards in which the hazardous element is hidden from view, experienced adult drivers achieved overall higher level of situation awareness than teen drivers.

Download Full-text

Using a Microwave Sensor as an Online Indicator of Neurological Impairment during Surgical Procedures

Key Engineering Materials ◽

10.4028/www.scientific.net/kem.543.368 ◽

2013 ◽

Vol 543 ◽

pp. 368-372 ◽

Cited By ~ 10

Author(s):

Jung H. Goh ◽

Alex Mason ◽

Mark Field ◽

Paul Browning ◽

Ahmed Al-Shamma'a

Keyword(s):

Cost Effective ◽

Neurological Impairment ◽

Treatment Regimes ◽

Non Invasive ◽

Microwave Sensor ◽

Wide Range ◽

Invasive Method ◽

Aortic Aneurysm Surgery ◽

Online Methods

Lactate is known to be an indicator of neurological impairment during aortic aneurysm surgery. It is suggested that analysis of cerebrospinal fluid (CSF) removed during such surgery could provide useful information in this regard. Medical professionals find the prospect of online detection of such analytes exciting, as current practice is time consuming and leads to multiple invasive procedures. Advancing from the current laboratory based analysis techniques to online methods could provide the basis for improved treatment regimes, better quality of care, and enhanced resource efficiency within hospitals. Accordingly, this article considers the use of a low power microwave sensor to detect varying lactate concentrations. Microwave sensors provide a rapid non-invasive method of material analysis, which is robust, cost-effective, and has huge potential for a wide range of biomedical applications.

Download Full-text