scholarly journals Diagnostic parallels in the cytological diagnosis of squamous breast cancer. Clinical case

2021 ◽  
Vol 67 (1) ◽  
pp. 123-126
Author(s):  
Svetlana Smetanina ◽  
Evgeniya Uskova ◽  
Olga Smetanina
Keyword(s):  
Breast Cancer ◽  
Sample Preparation ◽  
Preoperative Diagnosis ◽  
Research Method ◽  
Clinical Case ◽  
Rare Form ◽  
Preoperative Stage ◽  
Radiological Data ◽  
Modern Methods ◽  
Cytological Picture

Introduction. Squamous cell carcinoma is a rare form of breast cancer, makes up no more than 2% of invasive breast cancer, usually found in old age. The effectiveness of the cytological research method in the preoperative diagnosis of breast cancer directly depends on the sample preparation of the obtained material. Description of the clinical case. The possibilities of cytological diagnostics are presented using modern methods of sample preparation such as liquid cytology, cell blocks. Conclusion. Features of the cytological picture in combination with clinical and radiological data should become the basis for reliable diagnosis of squamous breast cancer at the preoperative stage.

scholarly journals Polyarene analysis-based identification of natural and technogenic processes in underground hydrosphere

2021 ◽  
Vol 44 (2) ◽  
pp. 167-173
Author(s):  
A. P. Khaustov ◽  
M. M. Redina
Keyword(s):  
Sample Preparation ◽  
Research Method ◽  
Pollution Sources ◽  
Main Research ◽  
The World ◽  
Modern Methods ◽  
Geochemical Markers

The purpose of the study is to analyze the possibility to identify the pollution genesis of the underground hydrosphere based on the data on polyarenes as geochemical markers. Their marker role is due to their toxicity, persistence and confinement to specific pollution sources and natural and technogenic processes. The main research method is the analysis of indicator ratios of polyarenes. The object of research is groundwater from different regions of the world, which are polluted by natural and anthropogenic polyarenes. The main directions of domestic and foreign researches as well as the problems of their implementation are shown. The use of indicator ratios enabled successful identification of pyro- and petrogenically polluted samples of groundwater also the examples of the study of polyarenes as geochemical markers were demonstrated. The polyarenes are shown to be an effective indicator of the pollution genesis in the underground hydrosphere. However, their analysis requires the use of modern methods of sampling, sample preparation and extraction, which significantly complicates research in practice.

Breast cancer associated with pregnancy: a clinical case

GYNECOLOGY ◽  
2018 ◽  
Vol 20 (1) ◽  
pp. 102-108
Author(s):  
Yu E Dobrokhotova ◽  
S E Arakelov ◽  
S Zh Danelyan ◽  
E I Borovkova ◽  
A E Zykov ◽  
...  
Keyword(s):  
Breast Cancer ◽  
Radiation Therapy ◽  
Clinical Case ◽  
First Trimester ◽  
First Year ◽  
Total Mastectomy ◽  
First Time

Associated with pregnancy is breast cancer, which was first detected during pregnancy, during the first year after childbirth or at any time against lactation. Diagnosis of the disease in the first trimester is an indication for abortion. The detection of the disease after 20 weeks and the desire of the woman to maintain pregnancy is the basis for conducting a total mastectomy followed by polychemotherapy with doxorubicin with cyclophosphamide or with fluorouracil. Radiation therapy during pregnancy is not applied. The timing and method of delivery are determined individually and depend on the stage of the process and the period of pregnancy, when it was identified. A clinical case of a patient with edematous-infiltrative form of breast cancer of the IV stage, diagnosed for the first time in 22 weeks of pregnancy, is presented.

scholarly journals Breast Angiosarcoma with a Preoperative Diagnosis of Late Recurrence of Breast Cancer: A Case Report

2021 ◽  
pp. 604-609
Author(s):  
Rika Kouhashi ◽  
Shinichiro Kashiwagi ◽  
Yuka Asano ◽  
Tamami Morisaki ◽  
Sae Ishihara ◽  
...  
Keyword(s):  
Breast Cancer ◽  
Preoperative Diagnosis ◽  
Vascular Endothelial Cells ◽  
Interstitial Fibrosis ◽  
Late Recurrence ◽  
Breast Conserving Surgery ◽  
Surrounding Tissue ◽  
Axillary Lymph ◽  
Elevated Lesion ◽  
The Right

Angiosarcoma is a malignant mesenchymal tumor characterized by the presence of vascular endothelial cells. Although rare, angiosarcoma developing in the mammary glands has a poor prognosis. We report a case of breast angiosarcoma with a preoperative diagnosis of late recurrence of breast cancer. A 78-year-old woman noticed a tumor in her right breast and visited our hospital. The patient had undergone breast-conserving surgery and axillary lymph node dissection from the right breast 12 years before the visit. The tumor was diagnosed as T4bN0M0, stage IIIB. Anastrozole was administered as postoperative adjuvant therapy for 5 years; the patient also received 50-Gy whole-breast radiation therapy after surgery. Physical examination during her visit revealed an elevated lesion with blue purpura around the nipple in the right breast. We performed breast ultrasound and detected a well-defined 19.6 × 16.4 × 10.7 mm hypoechoic tumor in the left subareolar area. The patient underwent core needle biopsy (CNB). Based on the CNB specimen findings, she was suspected to experience late local recurrence after surgery. Therefore, she underwent total mastectomy after breast-conserving surgery. A dark-red tumor sized 18 × 12 mm was found in a specimen from the nipple. The pathological diagnosis of the specimen revealed short spindle-shaped tumor cells with strong nuclear pleomorphism and a significant interstitial fibrosis. Immunohistochemistry using D2-40 and CD31 antibodies showed irregular luminal proliferation at the anastomosis, infiltration into the surrounding tissue, and massive necrosis, thereby leading to the diagnosis of breast angiosarcoma. We have reported a case of breast angiosarcoma with a preoperative diagnosis of late recurrence of breast cancer.

scholarly journals EFEKTIFITAS PENDIDIKAN KESEHATAN TENTANG KANKER PAYUDARA TERHADAP MOTIVASI MELAKUKAN SADARI PADA WANITA USIA SUBUR

2017 ◽  
Vol 5 (1) ◽  
Author(s):  
Ditya Yankusuma ◽  
Augustin Pramulya
Keyword(s):  
Breast Cancer ◽  
Health Education ◽  
Research Method ◽  
Women Of Childbearing Age ◽  
Childbearing Age ◽  
Cancer Disease ◽  
Central Java ◽  
Post Test ◽  
Initial Survey ◽  
Paired T Test

The prevalence of breast cancer is quite high in Indonesia, amounting to 40 per 100.000women (DepKes RI, 2014). While estimation of the largest number of breast cancerpatients in 2013 found in Central Java is 11.511 (KemenKes RI, 2015). The results of theinitial survey on Keloran villagers, obtained 1 citizen died of breast cancer. Residentsencountered during the initial survey of 10 women of childbearing age said that until nowhad never received socialization about SADARI and had never done SADARI. Purpose ofthe study: to know the influence of health education about breast cancer disease tomotivate to do SADARI on Women Age Fertile in Keloran Wonogiri regency.Subjects: the population in this study were women aged between 20-45 years old,amounting to 32 people. This research method researchers used a pre-experimentaldesign research design with the approach of one group pre test post test method.Results: the result of paired t-test is 0.000 (p <0.05) which statistically there is differenceof mean and moderate mean of motivation. Conclusion there is an influence of healtheducation on the motivation of women of childbearing age in Keloran Wonogiri Village.Keywords: health education, SADARI, motivation

scholarly journals Pigmented Bowen’s disease mimicking melanoma clinically and dermoscopically

2014 ◽  
Vol 72 (1) ◽  
Author(s):  
Daniel Holanda Daniel
Keyword(s):  
Carcinoma In Situ ◽  
Clinical Case ◽  
Left Thigh ◽  
Bowen’S Disease ◽  
Seborrheic Keratosis ◽  
Cutaneous Lesions ◽  
Rare Form ◽  
Bowen's Disease ◽  
Basal Cell Carcinomas

A variety of cutaneous lesions can mimic melanoma, such as melanocytic nevi, lentigines, seborrheic keratosis, blue nevi, pigmented basal cell carcinomas and dermatofibromas. This report describes a rare clinical case of a female patient who presented a lesion on the left thigh, which was clinically and dermoscopically compatible with melanoma. The patient underwent excision of the lesion, and histopathology confirmed a diagnosis of pigmented Bowen’s disease. The purpose of this report is to draw attention to the fact that pigmented Bowen’s disease, a rare form of squamous cell carcinoma in situ, should also be considered as a differential diagnosis of malignant melanoma.  

scholarly journals Primary multiple BRCA associated breast cancer and ovarian cancer (clinical case)

2020 ◽  
pp. 248-257
Author(s):  
I. B. Kononenko ◽  
A. V. Snegovoy ◽  
Y. A. Bozhchenko ◽  
D. N. Kravchenko ◽  
Vladimir Yu. Selchuk ◽  
...  
Keyword(s):  
Breast Cancer ◽  
Ovarian Cancer ◽  
Clinical Case ◽  
Brca2 Mutation ◽  
Cumulative Risk ◽  
Brca2 Gene ◽  
Left Breast ◽  
Luminal A ◽  
Uterine Tube ◽  
Luminal B

Introduction. The study of mutation in BRCA1/2 genes was first initiated in the USA and Europe, and later in Russia. Statistics indicate that women with the BRCA1/BRCA2 mutation have a higher risk of breast and/or ovarian cancer than the general population. According to different authors, the average cumulative risk among BRCA1 carriers is 65% (range 44–78%) for breast cancer and 39% (range 18–54%) for ovarian cancer. For mutation carriers in the BRCA2 gene, the risk for breast cancer is 45–49%, while the risk for RNA is 11–18%. However, in patients already diagnosed with breast cancer or ovarian cancer, the risk of a second tumor persists throughout life and may remain high even in old age. Treatment of BRCA-associated breast cancer and/or ovarian cancer is almost the same as treatment for sporadic cancer, and includes surgical, radiation, and drug anticancer therapy. However, there are some features that need to be considered in clinical practice. Clinical case. In this article we present the clinical experience of the treatment of a 32-year-old patient with BRCA1-associated primary multiple synchronous breast cancer and metachronous uterine tube cancer. In July 2015, the patient was diagnosed with synchronous cancer of both breast (Luminal A right breast cancer and Luminal B left breast cancer). As part of a treatment and with the patient’s consent, a bilateral adnexectomy was performed. In the histological examination of the operating material, the uterine tube cancer was diagnosed in situ. From 16.03.2016 to the present time the patient receives adjuvant endocrinotherapy without signs of disease progression. Conclusion. This clinical case study presents the importance of a combined approach to the treatment and prevention of BRCAassociated cancer.

scholarly journals Clinical case of the treatment of metastatic luminal breast cancer

2021 ◽  
pp. 160-166
Author(s):  
A. F. Nasretdinov ◽  
A. V. Sultanbaev ◽  
K. V. Menshikov ◽  
Sh. I. Musin ◽  
N. I. Sultanbaeva ◽  
...  
Keyword(s):  
Breast Cancer ◽  
Clinical Trials ◽  
Hormone Therapy ◽  
Hormone Receptor ◽  
Clinical Case ◽  
Luminal Breast Cancer ◽  
Hormone Receptor Positive ◽  
Long Time ◽  
Visceral Metastases

Hormone therapy currently open up the prospect of long-term, comfortable and relatively low-toxic treatment for patients with hormone receptor – positive advanced breast cancer. For a long time, the presence of visceral metastases prompted oncologists to abandon hormone therapy in favor of cytostatic agents. Now days, even in the presence of visceral metastases, clinical guidelines allow use of modern hormonal therapy in the absence of a visceral crisis. In particular, the so-called CDK 4/6 inhibitors, presented on the Russian market by drugs: palbociclib, ribociclib and abemacyclib, became the drugs that significantly improved the  results of  hormone therapy. Each of  them has demonstrated its effectiveness in  clinical trials; moreover, there are lots of clinical cases demonstrating the benefits of this therapy in real clinical practice. The article presents a clinical case of treatment of advanced hormone receptor-positive breast cancer. The effectiveness of treatment with CDK 4/6 inhibitors has been demonstrated, a comparatively analysed with the data obtained in the course of clinical trials. The analysis of the tactics of treatment of cytomegalovirus infection of the cornea during therapy with ribociclib was carried out. 

scholarly journals CLINICAL CASE OF SUCCESFUL APPLICATION OF KADSYLA APPLICATION IN METASTATIC HER2 POSITIVE BREAST CANCER

2017 ◽  
pp. 56-58
Author(s):  
D. D. Sakaeva
Keyword(s):  
Breast Cancer ◽  
Targeted Therapy ◽  
Clinical Case ◽  
Complete Response ◽  
Trastuzumab Emtansine ◽  
Her2 Positive ◽  
Her2 Positive Breast Cancer ◽  
Pet Ct ◽  
Positive Breast Cancer

A clinical case of trastuzumab emtansine in therapy line 4 in patient with metastatic HER2positive breast cancer is provided. After 10  courses of targeted therapy by the drug a complete  response to the therapy was obtained. By results of PET CT conducted in the period from December 2015  to September 2017 the complete response is preserved.

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