scholarly journals Effect of Laurusnobilis extract and Atorvastatin on Liver and Kidney function of Hyperlipidemia Male Rats

2022 ◽  
Vol 10 (1) ◽  
Keyword(s):  
Kidney Function ◽  
Male Rats ◽  
Liver And Kidney

Combined Effects of Fluoride and Cadmium on Liver and Kidney Function in Male Rats

2013 ◽  
Vol 155 (3) ◽  
pp. 396-402 ◽  
Author(s):  
Junmin Zhang ◽  
Jingjuan Song ◽  
Jun Zhang ◽  
Xiao Chen ◽  
Meixia Zhou ◽  
...  
Keyword(s):  
Kidney Function ◽  
Male Rats ◽  
Combined Effects ◽  
Liver And Kidney

Effect of Vitamin D3 on Liver and Kidney Function of Diabetes Mellitus Male Rats

2020 ◽  
pp. 80-83
Keyword(s):  
Kidney Function ◽  
Vitamin D3 ◽  
Total Protein ◽  
Diabetic Rats ◽  
Male Rats ◽  
Control Group ◽  
Group 4 ◽  
Liver And Kidney ◽  
Group 2 ◽  
Animal House

The present study was carried out in the animal house and laboratories of the College of Veterinary Medicine/ University of Basrah to investigate the role of the administration of vitamin D3 on liver and kidney function of alloxan induced toxic in mature male rats. For this purpose, 48 male rats were divided into 4 groups with 12 animals in each as the following; group (1), animals of were administered with D.W(0.2ml)/day by oral gavages for 6 weeks as control group, group(2) were injected intraperitoneally with 150 mg/kg b.w of alloxan as diabetic group, group (3) were injected with alloxan then administered with 500 UI/kg/day of alpha 25-hydroxy vitamin D3 by gavages for 6 weeks orally, group (4) were injected with alloxan then administer 1000 UI/kg/day of alpha 25-hydroxy vitamin D3 by gavages for 6 weeks orally. At the end of the experiment, animals were euthanized and blood samples were obtained for some biochemical assessment of liver and kidneys.In compares with control, alloxan treated rats recorded a significant increase (p≤0.05)in serum concentration of ALT, AST,ALP ,urea and creatinine, while there was a significant decrease (p≤0.05) in serum total protein. On other hand, administration of vitamin D3 for diabetic rats induced a significant improvement (P≤0.05) of serum ALT, AST, ALP, total protein urea and creatinine.

scholarly journals Effects of 1:1 Mixture of Anogeissus leiocarpus and Terminalia avicennioides Root Bark Extracts on Haematological Parameters, Liver and Kidney Function Indices of Male Rats

2018 ◽  
Vol 12 (5) ◽  
pp. 41-45
Author(s):  
Amadu Kayode Salau ◽  
◽  
Musa Toyin Yakubu ◽  
Adenike Temidayo Oladiji ◽  
◽  
...  
Keyword(s):  
Alkaline Phosphatase ◽  
Body Weight ◽  
Kidney Function ◽  
Blood Cells ◽  
Male Rats ◽  
Haematological Parameters ◽  
Root Bark ◽  
Liver And Kidney ◽  
Glutamyl Transferase ◽  
Anogeissus Leiocarpus

Background: This study evaluated the effects of 1:1 mixture of aqueous root bark extracts of Anogeissus leiocarpus (DC) Guill & Perr (Combretaceae) and Terminalia avicennioides Guill & Perr (Combretaceae) in male rats. Methods: Male rats were orally administered a 1:1 mixture of both extracts (250, 500 and 1000 mg/kg body weight) for seven days. Liver and kidney function indices, haematological parameters and the levels of malondialdehyde were evaluated in the animals at 7 days post-administration of the mixture of the extracts. Results: Administration of mixture of the extract significantly (p<0.05) increased the activities of liver and kidney alkaline phosphatase and reduced the serum alkaline phosphatase, liver and serum aspartate aminotransferase, alanine aminotransferase and gamma glutamyl transferase activities. The mixture also decreased the levels of serum chloride ions, liver and kidney malondialdehyde. Furthermore mixture significantly (p<0.05) increased the serum total protein concentrations whereas the levels of serum albumin, creatinine, urea, potassium, sodium and bicarbonate ions, red blood cells, white blood cells and their related indices were not significantly (p>0.05) altered. Conclusions: The present study revealed that the mixture caused functional toxicity of the liver and kidney of male rats without any evidence of haematotoxicity. The consumption of the 1:1 mixture of the plant extracts at 250, 500 and 1000 mg/kg body weight has some toxic implications in male rats.

The protective role of luteolin against the methotrexate-induced hepato-renal toxicity via its antioxidative, anti-inflammatory, and anti-apoptotic effects in rats

2021 ◽  
pp. 096032712199190
Author(s):  
AA Dar ◽  
A Fehaid ◽  
S Alkhatani ◽  
S Alarifi ◽  
WS Alqahtani ◽  
...  
Keyword(s):  
Renal Toxicity ◽  
Histopathological Examination ◽  
Protective Role ◽  
Male Rats ◽  
Antioxidant Enzyme Activities ◽  
Serum Samples ◽  
Liver And Kidney ◽  
Anti Inflammatory ◽  
Induced Changes ◽  
Apoptotic Effects

Methotrexate (MTX) is frequently used drug in treatment of cancer and autoimmune diseases. Unfortunately, MTX has many side effects including the hepato-renal toxicity. In this study, we hypothesized that Luteolin (Lut) exhibits protective effect against the MTX-induced hepato-renal toxicity. In order to investigate our hypothesis, the experiment was designed to examine the effect of exposure of male rats to MTX (20 mg/kg, i.p., at day 9) alone or together with Lut (50 mg/kg, oral for 14 days) compared to the control rats (received saline). The findings demonstrated that MTX treatment induced significant increases in the liver and kidney functions markers in serum samples including Aspartate transaminase (AST), Alanine transaminase (ALT), creatinine, urea and uric acid. MTX also mediated an oxidative stress expressed by elevated malondialdehyde (MDA) level and decreased level of reduced glutathione (GSH), antioxidant enzyme activities, and downregulation of the Nrf2 gene expression as an antioxidant trigger. Moreover, the inflammatory markers (NF-κB, TNF-α, and IL-1β) were significantly elevated upon MTX treatment. In addition, MTX showed an apoptotic response mediated by elevating the pro-apoptotic (Bax) and lowering the anti-apoptotic (Bcl-2) proteins. All of these changes were confirmed by the observed alterations in the histopathological examination of the hepatic and renal tissues. Lut exposure significantly reversed all the MTX-induced changes in the measured parameters suggesting its potential protective role against the MTX-induced toxicity. Finally, our findings concluded the antioxidative, anti-inflammatory and anti-apoptotic effects of Lut as a mechanism of its protective role against the MTX-induced hepato-renal toxicity in rats.

The Obesogenic Potency of Various High-Caloric Diet Compositions in Male Rats, and Their Effects on Expression of Liver and Kidney Proteins Involved in Drug Elimination

2017 ◽  
Vol 106 (6) ◽  
pp. 1650-1658 ◽  
Author(s):  
Ali Abdussalam ◽  
Osama H. Elshenawy ◽  
Yousef A. bin Jardan ◽  
Ayman O.S. El-Kadi ◽  
Dion R. Brocks
Keyword(s):  
Male Rats ◽  
Drug Elimination ◽  
Liver And Kidney ◽  
High Caloric Diet

scholarly journals Evaluation of the Coating with TiO2 Nanoparticles as an Option for the Improvement of the Characteristics of NiTi Archwires: Histopathological, Cytotoxic, and Genotoxic Evidence

2018 ◽  
Vol 2018 ◽  
pp. 1-11 ◽  
Author(s):  
Javier Morán-Martínez ◽  
Roberto Beltrán del Río-Parra ◽  
Nadia Denys Betancourt-Martínez ◽  
Rubén García-Garza ◽  
Joel Jiménez-Villarreal ◽  
...  
Keyword(s):  
Cell Viability ◽  
Blood Sample ◽  
Tio2 Nanoparticles ◽  
Niti Alloy ◽  
Renal Tissue ◽  
Male Rats ◽  
Histopathological Analysis ◽  
Liver And Kidney ◽  
The Times ◽  
Nuclear Alterations

For the EPD, different voltages and different times were used. Male rats were used in four groups (n=3) with different treatments. The blood sample was obtained for genotoxic analysis and liver and kidney organs were removed for histopathological analysis. The amount of NPs TiO2 deposited on the samples of the arches increases gradually in the times of 15 and 30 s. At all voltages, however, at 45, 60, 75, and 90 s, there is an increase up to 25 V. Cell viability in lymphocytes treated with TiO2 NPs did not cause genotoxicity. In the histopathological findings of hepatic and renal tissue, nuclear alterations and necrosis were observed. The objective of the study was to improve the physical and biocompatibility characteristics of the NiTi arches for which the EPD is used. The technique for the deposition of TiO2 NPs was used, where this technique could be used as an economical and versatile way to perform homogeneous depositions even on surfaces with the complexity of the NiTi alloy. As for genotoxicity and cytotoxicity, we continue to have controversial results.

scholarly journals Glutathione Conjugates of Ochratoxin a as Biomarkers of Exposure / Glutationski Konjugati Okratoksina A Kao Biomarkeri Izloženosti

2012 ◽  
Vol 63 (4) ◽  
pp. 417-427 ◽  
Author(s):  
Mariana Tozlovanu ◽  
Delphine Canadas ◽  
Annie Pfohl-Leszkowicz ◽  
Christine Frenette ◽  
Robert J. Paugh ◽  
...  
Keyword(s):  
Ochratoxin A ◽  
Rat Kidney ◽  
Female Rats ◽  
Amide Bond ◽  
Male Rats ◽  
Dark Agouti ◽  
Female Rat ◽  
Male And Female ◽  
Male And Female Rats ◽  
Liver And Kidney

AbstractIn the present study the photoreactivity of the fungal carcinogen ochratoxin A (OTA) has been utilised to generate authentic samples of reduced glutathione (GSH) and N-acetylcysteine (NAC) conjugates of the parent toxin. These conjugates, along with the nontoxic OTα, which is generated through hydrolysis of the amide bond of OTA by carboxypeptidase A, were utilised as biomarkers to study the metabolism of OTA in the liver and kidney of male and female Dark Agouti rats. Male rats are more susceptible than female rats to OTA carcinogenesis with the kidney being the target organ. Our studies show that the distribution of OTA in male and female rat kidney is not significantly different. However, the extent of OTA metabolism was greater in male than female rats. Much higher levels of OTα were detected in the liver compared to the kidney, and formation of OTα is a detoxification pathway for OTA. These findings suggest that differences in metabolism between male and female rats could provide an explanation for the higher sensitivity of male rats to OTA toxicity

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