scholarly journals Aggressive Posterior Retinopathy of Prematurity (AP-ROP)

2018 ◽  
pp. 63-68
Keyword(s):  
High Risk ◽  
Early Diagnosis ◽  
Laser Treatment ◽  
Premature Infants ◽  
Retinopathy Of Prematurity ◽  
Clinical Course ◽  
Clinical Findings ◽  
Posterior Pole ◽  
Diagnosis And Treatment ◽  
Preterm Babies

Aggressive retinopathy of prematurity (AP-ROP) has subtle clinical findings that may preclude early diagnosis and treatment. Premature infants with AP-ROP have a progressive clinical course and may benefit from early laser treatment. Although subjective in nature, plus disease, and any posterior pole changes especially at the border of the vascular and avascular retina should be carefully evaluated, keeping AP-ROP in mind in especially high-risk preterm babies.

THYMOSIN IN THE EARLY DIAGNOSIS AND TREATMENT OF HIGH RISK HOMOSEXUALS AND HEMOPHILIACS WITH AIDS-LIKE IMMUNE DYSFUNCTION

1984 ◽  
Vol 437 (1 Acquired Immu) ◽  
pp. 88-97 ◽  
Author(s):  
Paul H. Naylor ◽  
Richard S. Schulof ◽  
Marcelo B. Sztein ◽  
Thomas J. Spira ◽  
Paul R. McCurdy ◽  
...  
Keyword(s):  
High Risk ◽  
Early Diagnosis ◽  
Immune Dysfunction ◽  
Diagnosis And Treatment

Galactosaemia

1987 ◽  
Vol 5 (3-4) ◽  
pp. 175-188 ◽  
Author(s):  
L B. Sardharwalla ◽  
J. E. Wraith
Keyword(s):  
High Risk ◽  
Early Diagnosis ◽  
Mental Development ◽  
Diagnosis And Treatment ◽  
Early Age ◽  
Biochemical Genetics ◽  
Classical Galactosaemia ◽  
Eventual Outcome ◽  
Very High

This paper reviews galactosaemia and describes the experience of the Willink Biochemical Genetics Unit in the management of classical galactosaemia. Galactokinase and UDPgalactose-4-epimerase deficiency are dealt with briefly. The former disorder is readily treated with a galactose free diet and if this is started early in life, the only complication, cataracts, is avoided. Epimerase deficiency is a relatively ‘new’ disorder and little is known about the eventual outcome of affected patients. Early observations suggest that the prognosis is likely to be poor even in those patients diagnosed and treated soon after birth. Classical galactosaemia leads to a number of long term complications. The prognosis for normal mental development in affected patients is poor. Unfortunately this does not appear to be reversible by early diagnosis and treatment and whilst every effort should be made to establish an early diagnosis our experience suggests that there is no difference in the ultimate mental development between those who are detected within the first two weeks of life and those before the age of six weeks. In addition female homozygotes are at a very high risk of developing ovarian failure at an early age.

scholarly journals Management of Critically Ill Patients with COVID-19: What We Learned and What We Do

2020 ◽  
Vol 10 (3) ◽  
Author(s):  
Ata Mahmoodpoor ◽  
Kamran Shadvar ◽  
Ali Akbar Ghamari ◽  
Mojtaba Mohammadzadeh Lameh ◽  
Roghayeh Asghari Ardebili ◽  
...  
Keyword(s):  
Intensive Care Unit ◽  
Intensive Care ◽  
Early Diagnosis ◽  
Critically Ill ◽  
Critically Ill Patients ◽  
Standard Care ◽  
Clinical Course ◽  
Diagnosis And Treatment ◽  
To Receive

: There are many unknown questions and puzzle pieces that should describe the clinical course of COVID-19 and its complications, especially ARDS. We provide the initial immediate surge response to allow every patient in need of an ICU bed to receive one. Till our knowledge is improved, the most important intervention in the treatment of critically ill patients with COVID-19 seems to be the level of standard care and appropriate and early diagnosis and treatment. It seems that each center should have its protocol on the management of critically ill COVID-19 patients regarding prevention, diagnosis, and treatment. This treatment should now be performed regardless of the reason which lies behind the pathophysiology of this disease, which is yet unknown. In this report, we share our experience in the management of critically ill COVID-19 patients during the 2 months in our intensive care unit.

2017 GPOH Guidelines for Diagnosis and Treatment of Patients with Neuroblastic Tumors

2017 ◽  
Vol 229 (03) ◽  
pp. 147-167 ◽  
Author(s):  
Thorsten Simon ◽  
Barbara Hero ◽  
Johannes Schulte ◽  
Hedwig Deubzer ◽  
Patrick Hundsdoerfer ◽  
...  
Keyword(s):  
Clinical Trials ◽  
High Risk ◽  
Multimodal Treatment ◽  
Malignant Disease ◽  
Clinical Course ◽  
Low Risk ◽  
Diagnosis And Treatment ◽  
Risk Patients ◽  
Neuroblastic Tumors ◽  
Patients Experience

AbstractThe clinical course of neuroblastoma is more heterogeneous than any other malignant disease. Most low-risk patients experience regression after limited or even no chemotherapy. However, more than half of high-risk patients die from disease despite intensive multimodal treatment. Precise patient characterization at diagnosis is key for risk-adapted treatment. The guidelines presented here incorporate results from national and international clinical trials to produce recommendations for diagnosing and treating neuroblastoma patients in German hospitals outside of clinical trials.

Overview of Non-infectious Uveitis, Mechanisms, Immunopathology, Classification, and General Clinical Findings

2020 ◽  
pp. 221-226
Keyword(s):  
Differential Diagnosis ◽  
Early Diagnosis ◽  
Clinical Findings ◽  
Common Type ◽  
Diagnosis And Treatment ◽  
Systemic Diseases ◽  
Immune Mediated ◽  
Infectious Uveitis ◽  
Eye Damage

Uveitis is the inflammation of the anterior, intermediate, or posterior uvea, the pigmented part of the eye.  Uveitis can be infectious or non-infectious presented as autoimmune and immune-mediated. Non-infectious uveitis is the most common type of uveitis. It can be idiopathic or secondary to systemic diseases. Differential diagnosis is important, if early diagnosis and treatment are not applied, permanent eye damage can occur. In this review, an overview of non-infectious uveitis is examined with the mechanism, immunopathology, and classification.

scholarly journals Macular Development in Aggressive Posterior Retinopathy of Prematurity

2015 ◽  
Vol 2015 ◽  
pp. 1-5 ◽  
Author(s):  
Hemang K. Pandya ◽  
Lisa J. Faia ◽  
Joshua Robinson ◽  
Kimberly A. Drenser
Keyword(s):  
Birth Weight ◽  
Laser Treatment ◽  
Gestational Age ◽  
Retinopathy Of Prematurity ◽  
Laser Photocoagulation ◽  
Posterior Pole ◽  
Close Proximity ◽  
Postmenstrual Age ◽  
The Mean ◽  
Anterior Posterior

Purpose. To report anatomic outcomes after early and confluent laser photocoagulation of the entire avascular retina, including areas in close proximity to the fovea, in patients with APROP. We aspire to demonstrate fundoscopic evidence of transverse growth and macular development following laser treatment in APROP.Methods. Retrospective review of 6 eyes with APROP that underwent confluent laser photocoagulation of the entire avascular retina. Photographic fundoscopic imaging was performed using the RetCam to compare outcomes after treatment.Results. Mean birth weight and gestational age were 704.8 g and 24.33 weeks, respectively. There were 2 females and 1 male. The average time to laser was 9.3 weeks after birth, with the mean postmenstrual age of 34 weeks. Two eyes had zone 1 and 4 eyes had posterior zone 2 disease. Three eyes developed 4A detachments, which were successfully treated. All 6 eyes experienced transverse growth, with expansion of the posterior pole and anterior displacement of the laser treatment.Conclusion. Confluent photocoagulation of the entire avascular retina, regardless of foveal proximity, should be the mainstay for treating APROP. Examination should be conducted within 5–10 days to examine areas previously hidden by neovascularization to ensure prudent therapy. Macular development involves both transverse and anterior-posterior growth.

scholarly journals Association of Maternal Age to Development and Progression of Retinopathy of Prematurity in Infants of Gestational Age under 33 Weeks

2014 ◽  
Vol 2014 ◽  
pp. 1-5 ◽  
Author(s):  
Atsuro Uchida ◽  
Masayuki Miwa ◽  
Hajime Shinoda ◽  
Takashi Koto ◽  
Norihiro Nagai ◽  
...  
Keyword(s):  
Risk Factors ◽  
Laser Treatment ◽  
Premature Infants ◽  
Gestational Age ◽  
Retinopathy Of Prematurity ◽  
Maternal Age ◽  
University Hospital ◽  
Eye Screening ◽  
Stepwise Method ◽  
Median Birth Weight

Aim. To find predictive and indicative markers of risk for development of retinopathy of prematurity (ROP) and its progression to the stage requiring laser treatment, in premature infants whose gestational age (GA) was under 33 weeks.Methods. We retrospectively reviewed medical records of 197 premature infants born in 2005–2010 whoseGA<33weeks and underwent eye screening at Keio University Hospital. The association between candidate risk factors and development or progression of ROP was assessed.Results. Among the 182 eligible infants (median GA, 29.1 weeks; median birth weight (BW), 1028 g), 84 (46%) developed any stage of ROP, of which 45 (25%) required laser treatment. Multivariate analysis using a stepwise method showed that GA (P=0.002; 95% confidence interval (CI), 0.508–0.858), BW (P<0.001; 95% CI, 0.994–0.998), and lower maternal age (P=0.032; 95% CI, 0.819–0.991) were the risk factors for ROP development and GA (P<0.001; 95% CI, 0.387–0.609) and lower maternal age (P=0.012; 95% CI, 0.795–0.973) were for laser treatment. The odds ratio of requiring laser treatment was 3.3 when the maternal age was <33 years.Conclusion. ROP was more likely to be developed and progressed in infants born from younger mother and low GA.

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