scholarly journals Erythema nodosum

2016 ◽  
Vol 19 (1) ◽  
pp. 5-9
Author(s):  
Vasile Valeriu Lupu ◽  
◽  
Ancuţa Ignat ◽  
Gabriela Stoleriu ◽  
Angelica Cristina Marin ◽  
...  
Keyword(s):  
Inflammatory Bowel Disease ◽  
Erythema Nodosum ◽  
Bed Rest ◽  
Nonsteroidal Antiinflammatory Drugs ◽  
Sudden Onset ◽  
Lower Limbs ◽  
Antiinflammatory Drugs ◽  
Rheumatologic Diseases ◽  
Systemic Corticosteroids ◽  
Inflammatory Bowel

Erythema nodosum is the most frequent clinicopathologic variant of panniculitis. Triggers are represented by infections, sarcoidosis, rheumatologic diseases, inflammatory bowel disease, medications, autoimmune disorders, pregnancy and malignancy. Erythema nodosum typically manifests by the sudden onset of symmetrical, erythematous, warm nodules, usually located on the lower limbs. Often the lesions are bilaterally distributed. Treatment of erythema nodosum should be directed to the underlying associated condition, if identified. Usually, nodules of erythema nodosum regress spontaneously within a few weeks, and bed rest is often sufficient treatment. Nonsteroidal antiinflammatory drugs and potassium iodide may be helpful drugs to enhance analgesia and resolution. Systemic corticosteroids are rarely indicated in erythema nodosum and before these drugs are administered, an underlying infection should be ruled out.

Effects of nonsteroidal antiinflammatory drugs on inflammatory bowel disease: a case-control study

2000 ◽  
Vol 95 (8) ◽  
pp. 1949-1954 ◽  
Author(s):  
Joseph B. Felder ◽  
Burton I. Korelitz ◽  
Ramona Rajapakse ◽  
Samuel Schwarz ◽  
Angelo P. Horatagis ◽  
...  
Keyword(s):  
Inflammatory Bowel Disease ◽  
Bowel Disease ◽  
Case Control Study ◽  
Case Control ◽  
Nonsteroidal Antiinflammatory Drugs ◽  
Antiinflammatory Drugs ◽  
Inflammatory Bowel ◽  
Control Study

scholarly journals P114 A screening tool for the early diagnosis of extraintestinal manifestations in inflammatory bowel disease: the EMAIL questionnaire

2020 ◽  
Vol 14 (Supplement_1) ◽  
pp. S192-S193
Author(s):  
A Busacca ◽  
G Ingrassia Strano ◽  
E Giuffrida ◽  
L Guida ◽  
B Scrivo ◽  
...  
Keyword(s):  
Inflammatory Bowel Disease ◽  
Early Diagnosis ◽  
Bowel Disease ◽  
Multidisciplinary Approach ◽  
Screening Tool ◽  
Erythema Nodosum ◽  
Demographic Data ◽  
Extraintestinal Manifestations ◽  
History Of ◽  
Inflammatory Bowel

Abstract Background Data on prevalence of extraintestinal manifestations (EIMs) in inflammatory bowel disease (IBD) range from 6% up to 47%. Recently, several red flags and questionnaires have been proposed for early diagnosis of articular manifestations. Our aim was to analyse the prevalence of EIMs in a single-centre prospective cohort, using a comprehensive questionnaire developed by our group to detect all EIMs (EMAIL questionnaire). Methods Patients with IBD attending our Clinic from November 2017 to January 2019 were interviewed using a two-part questionnaire, the first part for clinical-demographic data and the second part for EIMs. Patients positive to screening were referred for multidisciplinary approach. Results Two hundred and six IBD patients were interviewed, 114 (55.3%) Crohn’s disease (CD) and 92 (44.7%) ulcerative colitis (UC), 52.4% male, mean age 46.7 years (SD ± 15,2). Sixty (53%) CD patients and 48 (52%) UC patients, in total 108, had history of at least one EIM. Articular EIMs were found in 49 patients (24%); peripheral arthritis was found in 14% (29/206), axial arthritis in 9.7% (20 patients): seven patients (3.4%) had ankylosing spondylitis, 13 (6.3%) sacroiliitis. Cutaneous EIMs were detected in 39 patients (19%), erythema nodosum in 15 patients (7.3%), pyoderma gangrenosum in 9 (4.4%), psoriasis in 15 (7.3%) and folliculitis in 7 (3.4%). Ocular EIMs were observed in 35 patients (17%): uveitis in 7 patients (3.4%), conjunctivitis in 8 (3.9%), optic neuritis in 2, glaucoma in 2 patients, cataract in 13 (6,3%), dry eye in 4 (1.9%), central serous chorioretinopathy in 1. Hepatobiliary EIMs were observed in 31 patients (15%): 26 steatosis (12.6%), 5 (2.4%) primary sclerosing cholangitis. Four (2%) patients had DVT. Articular EIMs were more frequent in CD patients (p = 0.001). Skin manifestations were more frequent in female (p = 0.002) in CD (p = 0,032) and related with IBD activity (<0.001). Hepatobiliary manifestations were more frequent in male (p = 0,017) and in UC (p = 0,044). There was a significant correlation between DVT and IBD activity (p = 0,016). Conclusion The questionnaire developed by our group proved to be a sensitive screening tool. Articular and cutaneous EIMs are more frequent in CD, hepatobiliary EIMs are more frequent in UC. A gender difference has been found since cutaneous EIMs are more frequent in females, hepatobiliary more in males. Cutaneous EIMs and DVT are related with IBD activity.

scholarly journals Burden and Disease Characteristics of Patients with Psoriatic Arthritis: A Population-based Cross-sectional Study

2019 ◽  
Vol 46 (7) ◽  
pp. 716-720 ◽  
Author(s):  
Hasan G. Tekin ◽  
Jashin J. Wu ◽  
Russel Burge ◽  
Julie Birt ◽  
Alexander Egeberg
Keyword(s):  
Psoriatic Arthritis ◽  
Population Based ◽  
Cross Sectional Study ◽  
Nonsteroidal Antiinflammatory Drugs ◽  
Considerable Proportion ◽  
Antiinflammatory Drugs ◽  
Cross Sectional ◽  
Disease Characteristics ◽  
Systemic Corticosteroids ◽  
Comorbid Diseases

Objective.To describe the prevalence and treatment regimes, disease characteristics, and comorbid diseases among patients with psoriatic arthritis (PsA) in Denmark.Methods.All Danish individuals aged ≥ 18 years with rheumatologist-diagnosed PsA were linked in nationwide administrative registers.Results.Among 4.7 million individuals in Denmark, 10,577 patients with PsA had been diagnosed by a rheumatologist. A female predominance (54.5–59.8%) was seen among patients with PsA, and about half of the patients (53.0%) had received no treatment or treatment only with nonsteroidal antiinflammatory drugs/systemic corticosteroids, while 32.9% had received nonbiological disease-modifying antirheumatic drugs (DMARD) and 14.1% had been treated with biologicals. Cutaneous psoriasis was recorded in 66.2–72.3% of patients with PsA, and patients with severe PsA had the highest prevalences of distal interphalangeal arthropathy, spondylitis, and arthritis mutilans. Smoking and comorbid diseases such as hypertension, diabetes, depression, and anxiety were seen frequently in patients with PsA, but did not significantly differ across severities of PsA.Conclusion.Disease burden appeared to be significant in patients with PsA across all severities. A considerable proportion of patients with PsA did not receive active antipsoriatic treatment, and about 1 out of 3 patients was not diagnosed with psoriasis. Cutaneous symptoms of psoriasis in patients with PsA might be either underreported or undertreated.

scholarly journals Drug-associated Cutaneous Vasculitis: Study of 239 Patients from a Single Referral Center

2014 ◽  
Vol 41 (11) ◽  
pp. 2201-2207 ◽  
Author(s):  
Francisco Ortiz-Sanjuán ◽  
Ricardo Blanco ◽  
José L. Hernández ◽  
Trinitario Pina ◽  
María C. González-Vela ◽  
...  
Keyword(s):  
Laboratory Data ◽  
Bed Rest ◽  
Skin Lesions ◽  
Immunosuppressive Drugs ◽  
Nonsteroidal Antiinflammatory Drugs ◽  
Consensus Conference ◽  
Cutaneous Vasculitis ◽  
Drug Discontinuation ◽  
Antiinflammatory Drugs ◽  
Tertiary Referral Hospital

Objective.The 2012 International Chapel Hill Consensus Conference on the Nomenclature of Vasculitides defined drug-associated immune complex vasculitis as a distinct entity included within the category of vasculitis associated with probable etiology. In the present study we assessed the clinical spectrum of patients with drug-associated cutaneous vasculitis (DACV).Methods.Case records were reviewed of patients with DACV treated at a tertiary referral hospital over a 36-year period. A diagnosis of DACV was considered if the drug was taken within a week before the onset of the disease.Results.From a series of 773 unselected cutaneous vasculitis cases, 239 patients (30.9%; 133 men and 106 women; mean age 36 yrs) were diagnosed with DACV. Antibiotics (n = 149; 62.3%), mainly β-lactams and nonsteroidal antiinflammatory drugs (NSAID; n = 24; 10%) were the most common drugs. Besides skin lesions (100%), the most common clinical features were joint (51%) and gastrointestinal (38.1%) manifestations, nephropathy (34.7%), and fever (23.8%). The most remarkable laboratory data were increased erythrocyte sedimentation rate (40.2%), presence of serum cryoglobulins (26%), leukocytosis (24.7%), positive antinuclear antibodies (21.1%), anemia (18.8%), and positive rheumatoid factor (17.5%). Despite drug discontinuation and bed rest, 108 patients (45.2%) required medical treatment, mainly corticosteroids (n = 71) or immunosuppressive drugs (n = 7). After a median followup of 5 months, relapses occurred in 18.4% of patients, and persistent microhematuria or renal insufficiency in 3.3% and 5%, respectively.Conclusion.DACV is generally associated with antibiotics and NSAID. In most cases it has a favorable prognosis, although a small percentage of patients may develop residual renal damage.

Predictive factors for erythema nodosum and pyoderma gangrenosum in inflammatory bowel disease

2014 ◽  
Vol 29 (2) ◽  
pp. 291-295 ◽  
Author(s):  
Javier Ampuero ◽  
María Rojas-Feria ◽  
Manuel Castro-Fernández ◽  
Cristina Cano ◽  
Manuel Romero-Gómez
Keyword(s):  
Inflammatory Bowel Disease ◽  
Pyoderma Gangrenosum ◽  
Predictive Factors ◽  
Bowel Disease ◽  
Erythema Nodosum ◽  
Inflammatory Bowel

Adult acute calcific discitis confined to the nucleus pulposus in the cervical spine

2013 ◽  
Vol 19 (2) ◽  
pp. 170-173 ◽  
Author(s):  
Shahrzad Azizaddini ◽  
Saeed Arefanian ◽  
Navid Redjal ◽  
Brian P. Walcott ◽  
Reza Mollahoseini
Keyword(s):  
Cervical Spine ◽  
Nucleus Pulposus ◽  
Pediatric Population ◽  
Adult Population ◽  
Symptom Relief ◽  
Rare Condition ◽  
Nonsteroidal Antiinflammatory Drugs ◽  
Sudden Onset ◽  
Antiinflammatory Drugs ◽  
Nonsurgical Management

Acute calcific discitis is a rare condition in the pediatric population and has been reported in only 2 instances in the adult population. This report describes a case of acute calcific discitis that uniquely presented in the adult cervical spine. A 22-year-old woman presented with the chief complaint of sudden-onset neck pain. Nonsurgical management, including nonsteroidal antiinflammatory drugs, provided moderate symptom relief. Radiography revealed nucleus pulposus calcification at the C2–3 level. Contrast-enhanced MRI did not reveal any additional abnormalities. Further nonsurgical management, including physical therapy and nonsteroidal antiinflammatory drugs, led to complete symptom relief within 6 months. Follow-up imaging demonstrated that the calcification had nearly resolved. Acute calcific discitis should be managed conservatively; the prognosis for a complete recovery is excellent. The pathophysiology of the disorder is yet to be elucidated, and the disorder is not exclusive to the pediatric population.

scholarly journals Doença inflamatória intestinal com eritema nodoso como manifestação inicial – dois casos clínicos

2018 ◽  
Vol 28 (3) ◽  
pp. 31062
Author(s):  
Ana Catarina G. De Carvalho ◽  
Ana Margarida da S. Fonseca ◽  
Eunice Maria R. Moreira da Costa ◽  
Susana Alexandra J. C. Lira ◽  
Ana Clara C. G. G. Dos Reis
Keyword(s):  
Inflammatory Bowel Disease ◽  
Crohn’S Disease ◽  
Crohn's Disease ◽  
Bowel Disease ◽  
Erythema Nodosum ◽  
Abdominal Ultrasound ◽  
Chronic Inflammatory Disease ◽  
Therapeutic Opportunity ◽  
Inflammatory Bowel ◽  
Prognostic Implications

AIMS: To describe two cases of inflammatory bowel disease whose diagnosis was preceded by the appearance of erythema nodosum and to alert to this extra-intestinal manifestation as the initial presentation of the disease.CASES DESCRIPTION: Two adolescents of 12 and 15 years of age were referred to the pediatrics emergency department because of erythema nodosum accompanied by anorexia and weight loss. The available diagnostic tests were suggestive of chronic inflammatory disease and the abdominal ultrasound was suggestive of inflammatory bowel disease. The diagnosis of Crohn's disease was confirmed after completion of upper digestive endoscopy and total colonoscopy with biopsies.CONCLUSIONS: Erythema nodosum may be the form of presentation of potentially serious diseases with well established therapies and prognostic implications. In children or adolescents with erythema nodosum, the index of suspicion of inflammatory bowel disease should be high, although other differential diagnoses should be considered. The importance of early diagnosis of inflammatory bowel disease in pediatric age refers to the therapeutic opportunity and specific complications in this age group, as growth disturbance, which occurs more frequently in Crohn's disease.

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