scholarly journals AUTOREGULATION OF BRAIN CIRCULATION IN PROGRESSING CARDIAC FAILURE AND ITS RELATION TO THE APPEARANCE OF SEIZURE READINESS

2016 ◽  
Vol 15 (2) ◽  
pp. 86-93
Author(s):  
M.L. Mamalyga ◽  
◽  
L.M. Mamalyga ◽  
Keyword(s):  
Heart Failure ◽  
Blood Flow ◽  
Cardiac Failure ◽  
Early Stage ◽  
Brain Circulation ◽  
Brain Disorders ◽  
Compression Tests ◽  
Cardiac Decompensation ◽  
Severe Stage ◽  
Basilar Arteries

On the early stage of cardiac decompensation, the blood flow in common carotid and basilar arteries does not change, however the seizure readiness (SR) of animals increases. The preserved reaction on hypercapnic and compression tests allows us to stipulate that the increased SR is not related to the circulatory brain disorders. Progressive aggravation of cardiac failure (CF) leads to the severe stage of decompensation accompanied by decreased blood flow in common carotid and basilar arteries, as well as increases SR. At the same time the metabolic cascade of autoregulation is areactive and myogenic is significantly decreased. Ineffective operation of heart in different stages of heart failure shows not the same effect or backup possibilities for cerebral hemodynamic autoregulation affecting the formation and aggravation of SR. The increased SR in cardiac failure is not always caused by brain ischemia.

Acute Poisoning by Intentional Ingestion of Thallous Malonate

1986 ◽  
Vol 5 (6) ◽  
pp. 389-392 ◽  
Author(s):  
H. Aoyama ◽  
M. Yoshida ◽  
Y. Yamamura
Keyword(s):  
Blood Flow ◽  
Cardiac Failure ◽  
Early Stage ◽  
Gastric Lavage ◽  
Acute Poisoning ◽  
Intentional Ingestion ◽  
Main Target

1 A 26-year-old man who ingested 10 g of thallous malonate was treated by gastric lavage and combined haemodialysis and haemoperfusion. 2 At a blood flow of 100 ml/min, the average of thallium clearance values obtained by combined haemoperfusion and haemodialysis at two different times were 50.2 and 60.4 ml/min. 3 Forty hours after ingestion, he died of cardiac failure. A higher concentration of thallium was found in the heart than in other organs, suggesting that the heart is the main target of thallium in the early stage of acute poisoning.

Alterations of endothelium-dependent and -independent regulation of coronary blood flow during heart failure

2002 ◽  
Vol 282 (1) ◽  
pp. H80-H86 ◽  
Author(s):  
Tomiyoshi Saito ◽  
Kazuhira Maehara ◽  
Kazuaki Tamagawa ◽  
Yuji Oikawa ◽  
Takeo Niitsuma ◽  
...  
Keyword(s):  
Heart Failure ◽  
Blood Flow ◽  
Chronic Heart Failure ◽  
Coronary Blood Flow ◽  
Late Stage ◽  
Early Stage ◽  
No Production ◽  
Pressure Flow ◽  
Coronary Pressure ◽  
Rapid Pacing

Conflicting data concerning the changes in basal coronary blood flow and nitric oxide (NO)-releasing capacity in chronic heart failure may be due to different phases or duration of heart failure. To investigate endothelium-dependent and -independent regulation of coronary blood flow in different phases of heart failure, coronary pressure-flow relationships during long diastole were obtained before and after rapid pacing of 3 and 5 wk at 240 beats/min in 12 or 6 dogs. Neither basal coronary blood flow nor the slope of coronary pressure-flow relationships changed; however, zero-flow pressure increased slightly after rapid pacing. Intracoronary injection of N G-nitro-l-arginine methyl ester decreased coronary blood flow at a perfusion pressure of 50 mmHg by ∼20% at baseline, 55% after 3 wk of rapid pacing, and 20% after 5 wk of rapid pacing. Acetylcholine-induced increase in coronary blood flow was maintained for 3 wk but was finally attenuated after 5 wk of rapid pacing. In contrast, the coronary blood flow response to adenosine gradually decreased with time. These results suggest that basal coronary blood flow is maintained until the late stage of heart failure, presumably by an increases in NO production during the early stage and then by other vasodilatory substances during the late stage, and that endothelium-dependent vasodilation via exogenously administered acetylcholine in resistance vessels is not necessarily impaired in the early stage despite the gradual reduction of endothelium-independent vasodilation via adenosine in chronic heart failure.

Analysis of Chinese herbal formulae recommended for COVID-19 in different schemes in China: A data mining Approach

2020 ◽  
Vol 23 ◽  
Author(s):  
LiWei Yin ◽  
YaCen Gao ◽  
ZiPing Li ◽  
MengYu Wang ◽  
KaiXin Chen
Keyword(s):  
Data Mining ◽  
Early Stage ◽  
Herbal Medicines ◽  
Chinese Herbs ◽  
Recovery Stage ◽  
Prescription Pattern ◽  
Middle Stage ◽  
Chinese Herbal ◽  
Severe Stage ◽  
Herbal Formulae

Background: Novel coronavirus pneumonia (NCP), or coronavirus disease 2019 (COVID-19), is a worldwide health threat that has affected millions of people globally. Traditional Chinese medicine (TCM) has been introduced for the treatment of COVID-19. However, efficacy differs among herbal medicines, and the ideal prescription pattern for TCM herbal formulae for COVID-19 treatment needs to be explored. Therefore, the data mining method has been used in this study to analyze the TCM prescription pattern for COVID-19. Objective: The aim of this study was to analyze the TCM prescription pattern in Regional Schemes in China for COVID-19 in order to provide a new reference for the use of TCM in COVID-19 treatment. Method: By searching the TCM treatment protocols of COVID-19 in 23 Regional Schemes, TCM syndromes and herbal medicines were analyzed by data mining. The Ancient and Modern Medical Case Cloud Platform (V2.1 personal Edition) was used to perform frequency statistics, correlation analysis, and cluster analysis. A total of 82 TCM syndromes and 171 Chinese herbal medicines were found. The course of the disease can be divided into the early stage, middle stage, severe stage, and recovery stage. Results: In the early stage, the focus is primarily on resolving dampness, dispelling cold, and diffusing the lungs. In the middle stage, the treatment priority is clearing heat and resolving toxins, promoting lung function, and relieving asthma. In the severe stage, the focus is on tonifying Qi, restoring Yang, and relieving depletion of Yin and Yang. In the recovery stage, the main treatment is to invigorate the spleen and regulate Qi, tonify Qi, nourish Yin, and clear residual disease evil. There are certain differences between the Regional Schemes and the Nation Schemes, but the core prescription pattern of the former is consistent with the latter. The effectiveness of these 171 Chinese herbs include but are not limited to inhibiting COVID-19, strengthening immune system function, preventing heart failure, acting as antioxidants, oxidative stress inhibitory effects, maintaining organ function, and improving leukocyte survival. Conclusion: This study may help to improve understanding of TCM herbal prescription pattern, practices, reveal the efficacy of combinations of Chinese herbs, and provide new ideas for TCM treatment for COVID-19.

Myocardial Blood Flow Response to Pacing Tachycardia and to Dipyridamole Infusion in Patients With Dilated Cardiomyopathy Without Overt Heart Failure

Circulation ◽  
1995 ◽  
Vol 92 (4) ◽  
pp. 796-804 ◽  
Author(s):  
Danilo Neglia ◽  
Oberdan Parodi ◽  
Michela Gallopin ◽  
Gianmario Sambuceti ◽  
Assuero Giorgetti ◽  
...  
Keyword(s):  
Heart Failure ◽  
Blood Flow ◽  
Myocardial Blood Flow ◽  
Dilated Cardiomyopathy ◽  
Blood Flow Response ◽  
Flow Response

scholarly journals Laser Doppler blood flowmeter as a useful instrument for the early detection of lower extremity peripheral arterial disease in hemodialysis patients: an observational study

2019 ◽  
Vol 20 (1) ◽  
Author(s):  
Takeo Ishii ◽  
Shizuka Takabe ◽  
Yuki Yanagawa ◽  
Yuko Ohshima ◽  
Yasuhiro Kagawa ◽  
...  
Keyword(s):  
Blood Flow ◽  
Peripheral Arterial Disease ◽  
Early Stage ◽  
Arterial Disease ◽  
Hemodialysis Patients ◽  
Laser Doppler ◽  
Doppler Flowmetry ◽  
Skin Perfusion ◽  
Dorsal Area ◽  
Peripheral Arterial

Abstract Background A simpler method for detecting atherosclerosis obliterans is required in the clinical setting. Laser Doppler flowmetry (LDF) is easy to perform and can accurately detect deterioration in skin perfusion. We performed LDF for hemodialysis patients to determine the correlations between blood flow in the lower limbs and peripheral arterial disease (PAD). Methods This retrospective study included 128 hemodialysis patients. Patients were categorized into the non-PAD group (n = 106) and PAD group (n = 22), 14 early stage PAD patients were included in the PAD group. We conducted LDF for the plantar area and dorsal area of the foot and examined skin perfusion pressure (SPP) during dialysis. Results SPP-Dorsal Area values were 82.1 ± 22.0 mmHg in the non-PAD, and 59.1 ± 20.3 mmHg in PAD group, respectively (p < 0.05). The LDF-Plantar blood flow (Qb) values were 32.7 ± 15.5 mL/min in non-PAD group and 21.5 ± 11.3 mL/min in PAD group (p < 0.001). A total of 21 non-PAD patients underwent LDF before and during dialysis. The LDF-Plantar-Qb values were 36.5 ± 17.6 mL/min before dialysis and 29.6 ± 17.7 mL/min after dialysis (p < 0.05). We adjusted SPP and LDF for PAD using logistic regression, SPP-Dorsal-Area and LDF-P were significantly correlated with PAD (p < 0.05). The receiver-operating characteristic curve analysis indicated cut-off values of 20.0 mL/min for LDF-Plantar-Qb during dialysis. Conclusion LDF is a simple technique for sensitive detection of early-stage PAD. This assessment will help physicians identify early-stage PAD, including Fontaine stage II in clinical practice, thereby allowing prompt treatment.

Successful Surgical and Anesthetic Management of Vein of Galen Aneurysm in a Neonate in Congestive Heart Failure

Neurosurgery ◽  
1988 ◽  
Vol 22 (5) ◽  
pp. 908-910 ◽  
Author(s):  
Jane Matjasko ◽  
Walker Robinson ◽  
Daniel Eudaily
Keyword(s):  
Heart Failure ◽  
Congestive Heart Failure ◽  
Cardiac Failure ◽  
Growth And Development ◽  
Anesthetic Management ◽  
Vascular Supply ◽  
Vein Of Galen ◽  
Vein Of Galen Malformation ◽  
Vein Of Galen Aneurysm

Abstract A 12-day-old infant in intractable cardiac failure due to a vein of Galen malformation was treated successfully with serial ligation of the majority of the vessels feeding the malformation. Despite some residual vascular supply to the malformation, the congestive heart failure has disappeared and growth and development have been normal over a 3-year follow-up period.

scholarly journals Cerebral blood flow autoregulation in ischemic heart failure

2017 ◽  
Vol 312 (1) ◽  
pp. R108-R113 ◽  
Author(s):  
J. R. Caldas ◽  
R. B. Panerai ◽  
V. J. Haunton ◽  
J. P. Almeida ◽  
G. S. R. Ferreira ◽  
...  
Keyword(s):  
Heart Failure ◽  
Blood Flow ◽  
Cerebral Blood Flow ◽  
Healthy Volunteers ◽  
Neurological Complications ◽  
Ischemic Heart ◽  
Step Response ◽  
Ischemic Heart Failure ◽  
Arterial Blood ◽  
End Tidal

Patients with ischemic heart failure (iHF) have a high risk of neurological complications such as cognitive impairment and stroke. We hypothesized that iHF patients have a higher incidence of impaired dynamic cerebral autoregulation (dCA). Adult patients with iHF and healthy volunteers were included. Cerebral blood flow velocity (CBFV, transcranial Doppler, middle cerebral artery), end-tidal CO2 (capnography), and arterial blood pressure (Finometer) were continuously recorded supine for 5 min at rest. Autoregulation index (ARI) was estimated from the CBFV step response derived by transfer function analysis using standard template curves. Fifty-two iHF patients and 54 age-, gender-, and BP-matched healthy volunteers were studied. Echocardiogram ejection fraction was 40 (20–45) % in iHF group. iHF patients compared with control subjects had reduced end-tidal CO2 (34.1 ± 3.7 vs. 38.3 ± 4.0 mmHg, P < 0.001) and lower ARI values (5.1 ± 1.6 vs. 5.9 ± 1.0, P = 0.012). ARI <4, suggestive of impaired CA, was more common in iHF patients (28.8 vs. 7.4%, P = 0.004). These results confirm that iHF patients are more likely to have impaired dCA compared with age-matched controls. The relationship between impaired dCA and neurological complications in iHF patients deserves further investigation.

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