Analysis of Chinese herbal formulae recommended for COVID-19 in different schemes in China: A data mining Approach

2020 ◽  
Vol 23 ◽  
Author(s):  
LiWei Yin ◽  
YaCen Gao ◽  
ZiPing Li ◽  
MengYu Wang ◽  
KaiXin Chen
Keyword(s):  
Data Mining ◽  
Early Stage ◽  
Herbal Medicines ◽  
Chinese Herbs ◽  
Recovery Stage ◽  
Prescription Pattern ◽  
Middle Stage ◽  
Chinese Herbal ◽  
Severe Stage ◽  
Herbal Formulae

Background: Novel coronavirus pneumonia (NCP), or coronavirus disease 2019 (COVID-19), is a worldwide health threat that has affected millions of people globally. Traditional Chinese medicine (TCM) has been introduced for the treatment of COVID-19. However, efficacy differs among herbal medicines, and the ideal prescription pattern for TCM herbal formulae for COVID-19 treatment needs to be explored. Therefore, the data mining method has been used in this study to analyze the TCM prescription pattern for COVID-19. Objective: The aim of this study was to analyze the TCM prescription pattern in Regional Schemes in China for COVID-19 in order to provide a new reference for the use of TCM in COVID-19 treatment. Method: By searching the TCM treatment protocols of COVID-19 in 23 Regional Schemes, TCM syndromes and herbal medicines were analyzed by data mining. The Ancient and Modern Medical Case Cloud Platform (V2.1 personal Edition) was used to perform frequency statistics, correlation analysis, and cluster analysis. A total of 82 TCM syndromes and 171 Chinese herbal medicines were found. The course of the disease can be divided into the early stage, middle stage, severe stage, and recovery stage. Results: In the early stage, the focus is primarily on resolving dampness, dispelling cold, and diffusing the lungs. In the middle stage, the treatment priority is clearing heat and resolving toxins, promoting lung function, and relieving asthma. In the severe stage, the focus is on tonifying Qi, restoring Yang, and relieving depletion of Yin and Yang. In the recovery stage, the main treatment is to invigorate the spleen and regulate Qi, tonify Qi, nourish Yin, and clear residual disease evil. There are certain differences between the Regional Schemes and the Nation Schemes, but the core prescription pattern of the former is consistent with the latter. The effectiveness of these 171 Chinese herbs include but are not limited to inhibiting COVID-19, strengthening immune system function, preventing heart failure, acting as antioxidants, oxidative stress inhibitory effects, maintaining organ function, and improving leukocyte survival. Conclusion: This study may help to improve understanding of TCM herbal prescription pattern, practices, reveal the efficacy of combinations of Chinese herbs, and provide new ideas for TCM treatment for COVID-19.

scholarly journals Discussion on the Characteristics and Symptom Classification of COVID-19 in Chinese Medicine

2021 ◽  
Vol 5 (4) ◽  
pp. 128-132
Author(s):  
Na Yang ◽  
Yun Li ◽  
Wangbo Cao ◽  
Danan Yang
Keyword(s):  
Chinese Medicine ◽  
Early Stage ◽  
Blood Stasis ◽  
Recovery Stage ◽  
Main Method ◽  
Middle Stage ◽  
Severe Stage ◽  
Number Of Patients ◽  
Novel Coronavirus

Covid-19 (Novel coronavirus pneumonia, NCP) was characterized by fever, dry cough, fatigue, greasy tongue coating and pulsating pulse. According to the literature, with those four symptoms, examination and identification, it is believed that NCP belongs to the category of “pandemic” in Chinese medicine. The main infection is dampness, infection location in triple energizer, the basic pathogenesis is characterized by “dampness, phlegm, blood stasis heat, toxin and deficiency.” According to the law of blood transfer of symptom differentiation of triple energizer and weiqi-yingxue the treatment is divided into stages, such as early stage, middle stage, severe stage and recovery stage. Most of the patients were early stage and middle stage, which were the direct transmission of the disease. A small number of patients had the reverse transmission of pericardium and the internal and external detachment. The main method of treatment is to remove infection, remove dampness and detoxify. In addition, to grasp the treatment of early stage and middle stage patients, helps to stop the disease from developing, and it is the key to reduce the criticality of the disease, as well as reduce the mortality.

scholarly journals Application of Spontaneous Photon Emission in the Growth Ages and Varieties Screening of Fresh Chinese Herbal Medicines

2017 ◽  
Vol 2017 ◽  
pp. 1-10 ◽  
Author(s):  
Xiaolei Zhao ◽  
Jingxiang Pang ◽  
Jialei Fu ◽  
Meina Yang ◽  
Eduard Van Wijk ◽  
...  
Keyword(s):  
Photon Emission ◽  
Herbal Medicines ◽  
Chinese Herbs ◽  
Bioactive Constituents ◽  
Curative Effect ◽  
Active Compounds ◽  
Chinese Herbal Medicines ◽  
Chinese Herbal ◽  
Living Organisms ◽  
Natural Medicines

Ultraweak photon emission emitted by all living organisms has been confirmed to be a noninvasive indicator for their physiological and pathological characteristics. In this study, we investigated the characteristics of spontaneous photon emission (SPE) and the contents of specific active compounds of roots and flowers buds of several fresh Chinese herbal medicines (natural medicines) with different growth ages and varieties. The results revealed that the contents of specific active compounds from same species herbs with different growth ages and varieties were significantly different, and this difference could be reflected by their SPE. Because the contents of specific bioactive constituents in Chinese herbs are closely related to their quality and curative effect, the SPE measurement technique may contribute to the quality control of Chinese herbal medicine in the future.

scholarly journals Chinese herbal medicines with beneficial effects

2021 ◽  
Vol 1 (2) ◽  
pp. 79-83
Author(s):  
De-an Guo ◽  
Wenlong Wei ◽  
Changliang Yao ◽  
Jianqing Zhang ◽  
Qirui Bi
Keyword(s):  
Herbal Medicines ◽  
Extreme Environment ◽  
Chinese Herbs ◽  
Exploration And Exploitation ◽  
Chinese Herbal Medicines ◽  
Beneficial Effects ◽  
Medical Needs ◽  
Chinese Herbal ◽  
Potential Applications ◽  
Herbal Species

Abstract Among the vast resources of traditional Chinese medicine (TCM) herbal species, only a handful of Chinese herbs are growing in frigid regions or extreme environment but they have a unique property. The most recognizable TCM herb falling in this category is Panax ginseng, which is widely considered the representative tonic herb with oceans of beneficial effects on human health. In this article, we will introduce several typical Chinese herbal medicines with beneficial effects aiming to arouse broader attention from the scientific community to expand the exploration and exploitation on this for their potential applications to meet the increasingly demanding medical needs.

scholarly journals Promoting Effects on Proliferation and Chondrogenic Differentiation of Bone Marrow-Derived Mesenchymal Stem Cells by Four “Kidney-Tonifying” Traditional Chinese Herbs

2015 ◽  
Vol 2015 ◽  
pp. 1-8 ◽  
Author(s):  
Bin Cai ◽  
Ai-guo Zhang ◽  
Xian Zhang ◽  
Wen-jie Ge ◽  
Guo-da Dai ◽  
...  
Keyword(s):  
Stem Cells ◽  
Bone Marrow ◽  
Chondrogenic Differentiation ◽  
Herbal Medicines ◽  
Chinese Herbs ◽  
Radix Astragali ◽  
Saussurea Involucrata ◽  
Positive Effects ◽  
Chinese Herbal ◽  
Herba Epimedii

Traditional Chinese medicine can promote the proliferation of bone marrow-derived mesenchymal stem cells (BMSCs). We chose four “Kidney-tonifying” Chinese herbal medicines, Radix Astragali, Salvia, Herba Epimedii, and Saussurea Involucrata, to evaluate whether they had positive effects on the proliferation of BMSCs and TGF-β1-induced chondrogenic differentiation of BMSCs. The four Chinese herbal medicines were intragastrically administered to Sprague-Dawley rats, respectively, to prepare drug-containing serums of corresponding Chinese herbs. BMSCs were isolated, cultured, and exposed to culture solution containing 1%, 5%, 10%, and 15% (v/v) Radix Astragali-, Salvia-, Herba Epimedii-, and Saussurea Involucrata-containing serum, respectively. TGF-β1-induced BMSCs were addressed in the same manner. Collagen type II protein was assessed by immunofluorescence methods. To assess whether the drug-containing serums had positive effects on the proliferation of BMSCs and TGF-β1-induced BMSCs, MTT method was assessed. The proliferation of BMSCs was significantly enhanced when exposed to culture solutions containing 1% and 5% Radix Astragali-, 1% and 5% Salvia-, 5% Herba Epimedii-, and 1%, 5%, and 10% Saussurea Involucrata-containing serum. The proliferation of TGF-β1-induced BMSCs was significantly enhanced when exposed to 1%, 5%, and 15% Radix Astragali-, 10% and 15% Salvia-, 5%, and 15% Herba Epimedii-, and 1%, 5%, and 10% Saussurea Involucrata-containing serum.

scholarly journals Prediction Methods of Herbal Compounds in Chinese Medicinal Herbs

Molecules ◽  
2018 ◽  
Vol 23 (9) ◽  
pp. 2303 ◽  
Author(s):  
Ke Han ◽  
Lei Zhang ◽  
Miao Wang ◽  
Rui Zhang ◽  
Chunyu Wang ◽  
...  
Keyword(s):  
Herbal Medicine ◽  
Virtual Screening ◽  
Chinese Herbal Medicine ◽  
Screening Method ◽  
Herbal Medicines ◽  
Chinese Herbs ◽  
Prediction Methods ◽  
Chinese Herbal Medicines ◽  
Advantages And Disadvantages ◽  
Chinese Herbal

Chinese herbal medicine has recently gained worldwide attention. The curative mechanism of Chinese herbal medicine is compared with that of western medicine at the molecular level. The treatment mechanism of most Chinese herbal medicines is still not clear. How do we integrate Chinese herbal medicine compounds with modern medicine? Chinese herbal medicine drug-like prediction method is particularly important. A growing number of Chinese herbal source compounds are now widely used as drug-like compound candidates. An important way for pharmaceutical companies to develop drugs is to discover potentially active compounds from related herbs in Chinese herbs. The methods for predicting the drug-like properties of Chinese herbal compounds include the virtual screening method, pharmacophore model method and machine learning method. In this paper, we focus on the prediction methods for the medicinal properties of Chinese herbal medicines. We analyze the advantages and disadvantages of the above three methods, and then introduce the specific steps of the virtual screening method. Finally, we present the prospect of the joint application of various methods.

Effects of Herbal Medicines on Pain Management

2020 ◽  
Vol 48 (01) ◽  
pp. 1-16 ◽  
Author(s):  
Yun Luo ◽  
Chong-Zhi Wang ◽  
Richard Sawadogo ◽  
Ting Tan ◽  
Chun-Su Yuan
Keyword(s):  
Pain Management ◽  
Emotional Experience ◽  
Herbal Medicines ◽  
Chinese Herbs ◽  
Integrative Approach ◽  
Chinese Herbal ◽  
Relieve Pain ◽  
Alternative Measures ◽  
Chinese Medicine Theory ◽  
Aconitum Carmichaeli

Pain is an unpleasant sensory and emotional experience in many diseases and is often caused by intense or damaging stimuli. Pain negatively affects the quality of life and increases high health expenditures. Drugs with analgesic properties are commonly used to relieve pain, but these Western medications could be overwhelmed by side effects including tolerance and addiction. Herbal medicines may provide alternative measures for pain management. In this review paper, after introduction of Chinese medicine theory and treatment modality, emphasis is placed on the application of Chinese herbs and herbal formulations in pain management. Three of the most commonly used herbs, i.e., Corydalis yanhusuo, Ligusticum chuanxiong, and Aconitum carmichaeli, are reviewed. Subsequently, using this ancient medical remedy, Chinese herbal formulation in treating common medical conditions associated with pain, such as headache/migraine, chest pain, abdominal pain, low back pain, neuropathic pain, osteoarthritis, and cancer pain, is presented. Chinese herbal medicines could be considered as a complementary and integrative approach in the modern armamentarium in combating pain.

scholarly journals Study of Antifungal Activity Using Three Chinese Medicine Herbs

2021 ◽  
Vol 71 (4) ◽  
pp. 322-329
Author(s):  
Anming Zhu ◽  
Shiming Ren ◽  
Xueqi Li ◽  
Xiaoqi Zhao ◽  
Lei Wang ◽  
...  
Keyword(s):  
Chinese Medicine ◽  
Antifungal Activity ◽  
Herbal Medicines ◽  
Wood Preservative ◽  
Growth Cycle ◽  
Inhibitory Effect ◽  
Chinese Herbs ◽  
Primary Data ◽  
Chinese Herbal ◽  
Direct Killing

Abstract Chinese medicine herbal extracts are ideal candidates to replace toxic industrial wood preservatives thanks to their antifungal and nontoxic properties. To investigate the antifungal activity of Chinese herbal medicines, in this study, Trametes versicolor fungi were selected as test strains to evaluate the antifungal properties of Fructus Cnidii, Fructus Forsythiae, and Radix Stemonae. The results show that Fructus Cnidii has a strong inhibitory effect against T. versicolor, whereas Fructus Forsythiae and Radix Stemonae have a weak inhibitory effect. The hyphae growth cycle shows that the three studied Chinese herbs disrupt the growth of T. versicolor. Moreover, instead of direct killing, the Chinese herbal medicine demonstrated inhibition ability. Furthermore, the morphological and toxicological evidence shows that Fructus Cnidii affected the expression of proteins or enzymes to achieve the inhibition goal. In sum, this study could provide both primary data and a theoretical foundation for further developing and applying for traditional Chinese medicine as a green type of wood preservative.

Neuraminidase 1 and its Inhibitors from Chinese Herbal Medicines: An Emerging Role for Cardiovascular Diseases

2021 ◽  
pp. 1-20
Author(s):  
Jun-Yuan Zhang ◽  
Qian-Qian Chen ◽  
Jia Li ◽  
Lei Zhang ◽  
Lian-Wen Qi
Keyword(s):  
Sialic Acid ◽  
Cardiovascular Diseases ◽  
Chinese Herb ◽  
Herbal Medicines ◽  
Chinese Herbs ◽  
Chinese Herbal Medicines ◽  
Chinese Herbal ◽  
Scutellariae Radix ◽  
Cytoplasmic Vesicles

Neuraminidase, also known as sialidase, is ubiquitous in animals and microorganisms. It is predominantly distributed in the cell membrane, cytoplasmic vesicles, and lysosomes. Neuraminidase generally recognizes the sialic acid glycosidic bonds at the ends of glycoproteins or glycolipids and enzymatically removes sialic acid. There are four types of neuraminidases, named as Neu1, Neu2, Neu3, and Neu4. Among them, Neu1 is the most abundant in mammals. Recent studies have revealed the involvement of Neu1 in several diseases, including cardiovascular diseases, diabetes, cancers, and neurological disorders. In this review, we center the attention to the role of Neu1 in cardiovascular diseases, including atherosclerosis, ischemic myocardial injury, cerebrovascular disease, congenital heart disease, and pulmonary embolism. We also summarize inhibitors from Chinese herbal medicines (CHMs) in inhibiting virus neuraminidase or human Neu1. Many Chinese herbs and Chinese herb preparations, such as Lonicerae Japonicae Flos, Scutellariae Radix, Yupingfeng San, and Huanglian Jiedu Decoction, have neuraminidase inhibitory activity. We hope to highlight the emerging role of Neu1 in humans and potentially titillate interest for further studies in this area.

scholarly journals New Insights into the Mechanisms of Chinese Herbal Products on Diabetes: A Focus on the “Bacteria-Mucosal Immunity-Inflammation-Diabetes” Axis

2017 ◽  
Vol 2017 ◽  
pp. 1-13 ◽  
Author(s):  
Zezheng Gao ◽  
Qingwei Li ◽  
Xuemin Wu ◽  
Xuemin Zhao ◽  
Linhua Zhao ◽  
...  
Keyword(s):  
Mucosal Immunity ◽  
Chinese Herbs ◽  
Diabetes Research ◽  
Natural Health Product ◽  
Natural Health ◽  
Herbal Products ◽  
Chinese Herbal ◽  
Herbal Formulae

Diabetes, especially type 2, has been rapidly increasing all over the world. Although many drugs have been developed and used to treat diabetes, side effects and long-term efficacy are of great challenge. Therefore, natural health product and dietary supplements have been of increasing interest alternatively. In this regard, Chinese herbs and herbal products have been considered a rich resource of product development. Although increasing evidence has been produced from various scientific studies, the mechanisms of action are lacking. Here, we have proposed that many herbal monomers and formulae improve glucose homeostasis and diabetes through the BMID axis; B represents gut microbiota, M means mucosal immunity, I represents inflammation, and D represents diabetes. Chinese herbs have been traditionally used to treat diabetes, with minimal side and toxic effects. Here, we reviewed monomers such as berberine, ginsenoside,M. charantiaextract, and curcumin and herbal formulae such as Gegen Qinlian Decoction, Danggui Liuhuang Decoction, and Huanglian Wendan Decoction. This review was intended to provide new perspectives and strategies for future diabetes research and product.

Sign in / Sign up

Export Citation Format

Share Document