scholarly journals Gastric ulcer: etiological and pathogenetic causes

2021 ◽  
pp. 24-27
Author(s):  
R. O. Sabadishin
Keyword(s):  
Peptic Ulcer ◽  
Gastric Ulcer ◽  
Scientific Theories ◽  
Practical Research

The causes of peptic ulcer of the stomach and duodenum so far not definitively established. The article analyzes two scientific theories of the origin of this disease, which in the process of practical research will be able to improve the treatment of patients with this fairly common pathology

scholarly journals Prevention of peptic ulcer by aqueous extract of Aegle marmelos leaf in rats

2018 ◽  
Vol 12 (1) ◽  
pp. 11-14
Author(s):  
Sharmin Rahman ◽  
Mohammad Rezaul Quader ◽  
Md Ismail Khan
Keyword(s):  
Body Weight ◽  
Peptic Ulcer ◽  
Gastric Ulcer ◽  
Aqueous Extract ◽  
Protective Efficacy ◽  
Albino Rats ◽  
Ulcer Formation ◽  
Aegle Marmelos ◽  
Rat Stomach ◽  
Dose Dependent

Background and objectives: Aegle marmelos (Bael), a medicinal plant, has been widely used indigenously to treat many diseases in Bangladesh and other countries. The present study was carried out to evaluate the efficacy of A. marmelos leaf to prevent ethanol induced gastric ulcer in a rat model.Methods: Thirty two Wister albino rats of either sex, weighing between 100-150g, were fed 200 mg/kg or 400 mg/kg aqueous extract of A. marmelos leaves one hour prior to oral administration of 90% ethanol (1 ml/200 gm body weight) to induce gastric ulcer. The animals were sacrificed after one hour and ulcer scores and index were determined. The protective efficacy of A. marmelos aqueous extract was expressed as percentage protection of ulcer.Results: Aqueous extract exhibited significant (p<0.05) dose dependent protection against gastric ulcer formation by ethanol in rat stomach. Percentage protection of ulcer with 200 mg/kg and 400 mg/kg of aqueous extract of A. marmelos leave were 19.3% and 37.2% respectively compared to standard anti-peptic ulcer drug omeprazole (50.4%).Conclusion: Thus, crude extracts of A. marmelos leave have been shown to have potential ability to prevent experimentally induced peptic ulcer formation in animal model.IMC J Med Sci 2018; 12(1): 11-14

scholarly journals Evaluation of a poly-herbal preparation for the treatment of peptic ulcer

2017 ◽  
Vol 12 (2) ◽  
pp. 11
Author(s):  
Zaman Hayat ◽  
Mueen Ahmad Chaudhry ◽  
. Alamgeer
Keyword(s):  
Peptic Ulcer ◽  
Gastric Ulcer ◽  
Treated Group ◽  
Ulcer Formation ◽  
Ulcer Index ◽  
Herbal Formulation ◽  
High K ◽  
Ulcer Model ◽  
Dose Dependent ◽  
Gross Examination

<p class="Abstract">The aim of this study was to validate the traditional uses of ulcerene, a poly-herbal formulation in ethanol, aspirin and stress-induced gastric ulcer model of rat. The extent of gastric ulcer formation was studied, using ulcer score, ulcer index, percentage cure through gross examination and histopathological evaluation. A significant (p&lt;0.001) dose-dependent anti-ulcerant effect was observed in ulcerene (50 and 100 mg/kg)-treated group with highest effectiveness against ethanol-induced ulcer. The concentration-dependent spasmolytic effect was seen in spontaneously contracting, high K<sup>+</sup> (80 mM) and carbachol (1 µM)-induced jejunum contractions (10, 0.3 and 1 mg/mL), similar to dicyclomine (10, 1 and 3 µM), indicated non-specific spasmolytic mechanism behind the effect. By considering these results, ulcerene can be suggested for the treatment of peptic ulcer.</p>

The medical management of peptic ulcer (II) practical aspect of gastric ulcer at ariga clinic

1966 ◽  
Vol 1 (4) ◽  
pp. 48-48
Author(s):  
I. Yokoyama ◽  
M. Abe ◽  
H. Koizumi ◽  
M. Iwasaki ◽  
Y. Kawashima ◽  
...  
Keyword(s):  
Peptic Ulcer ◽  
Gastric Ulcer ◽  
Medical Management ◽  
Practical Aspect

GASTRIC ULCER OF THE PYLORUS SIMULATING. HYPERTROPHIC PYLORIC STENOSIS

PEDIATRICS ◽  
1950 ◽  
Vol 6 (6) ◽  
pp. 897-907
Author(s):  
ARTHUR R. C. COLE
Keyword(s):  
Differential Diagnosis ◽  
Peptic Ulcer ◽  
Gastric Ulcer ◽  
Pyloric Stenosis ◽  
Recent Literature ◽  
Hypertrophic Pyloric Stenosis ◽  
Diagnostic Procedures ◽  
Peptic Ulcers ◽  
Infancy And Childhood ◽  
History Of

A brief review of the natural history of peptic ulcer in infancy and childhood is given. The symptomatology, differential diagnosis and diagnostic procedures are presented. The diagnosis of peptic ulcer should be considered more often in infancy and childhood and the proper diagnostic procedures instituted. A case of gastric ulcer simulating hypertrophic pyloric stenosis is presented. A summary of 31 cases with peptic ulcers found at autopsy at the Babies Hospital from January 1, 1924 to January 1, 1950 is given. From a summary of coexistent disease found in the autopsy cases at the Babies Hospital and reports from the recent literature, it would appear that diseases of the central nervous, gastrointestinal and respiratory systems are commonly present in cases which have shown peptic ulcer at autopsy.

Features of the course of peptic ulcer disease in children and adolescents

1985 ◽  
Vol 66 (5) ◽  
pp. 377-377
Author(s):  
N. A. Cherkasova ◽  
H. S. Bikbulatova ◽  
V. N. Leonova
Keyword(s):  
Duodenal Ulcer ◽  
Peptic Ulcer ◽  
Gastric Ulcer ◽  
Peptic Ulcer Disease ◽  
Children And Adolescents ◽  
Ulcer Disease

There were 26 patients with gastric ulcer and duodenal ulcer (17 boys, 9 girls) aged from 9 to 18 years under observation.

Acute pancreatitis

2010 ◽  
pp. 2557-2567
Author(s):  
R. Carter ◽  
C.J. McKay
Keyword(s):  
Acute Pancreatitis ◽  
Peptic Ulcer ◽  
Gastric Ulcer ◽  
Abdominal Pain ◽  
Serum Amylase ◽  
Perforated Peptic Ulcer ◽  
Upper Limit ◽  
Abdominal Emergencies ◽  
Idiopathic Acute Pancreatitis ◽  
Upper Abdominal

Acute pancreatitis affects 300 to 600 new patients per million population per year and is most commonly caused by gallstones or alcohol, but there are many other causes and associations. Careful imaging reveals that most so-called idiopathic acute pancreatitis is due to small (1–3 mm diameter) gallstones. Diagnosis is made by a combination of a typical presentation (upper abdominal pain and vomiting) in conjunction with raised serum amylase (> × 3 upper limit of normal) and/or lipase (> × 2 upper limit of normal). Several acute abdominal emergencies can mimic acute pancreatitis and may be associated with a raised serum amylase. These include perforated peptic ulcer (particularly perforated posterior gastric ulcer) and acute mesenteric ischaemia. In equivocal cases, a CT scan is indicated in order to exclude other causes and confirm the diagnosis....

scholarly journals Helicobacter Pylori Associated Antral Gastritis in Peptic Ulcer Disease Patients and Normal Healthy Population of Kashmir, India

1998 ◽  
Vol 4 (3) ◽  
pp. 135-139 ◽  
Author(s):  
Gh. Jeelani Romshoo ◽  
G. M. Malik ◽  
M. Youssuf Bhat ◽  
Ab. Rashid rather ◽  
Javaid Ahmad Basu ◽  
...  
Keyword(s):  
Helicobacter Pylori ◽  
Peptic Ulcer ◽  
Gastric Ulcer ◽  
Peptic Ulcer Disease ◽  
Healthy Volunteers ◽  
Chronic Gastritis ◽  
Healthy Population ◽  
Ulcer Disease ◽  
Antral Gastritis ◽  
H Pylori

Aim: To study the association of Helicobacter pylori infection with chronic antral gastritis in peptic ulcer disease patients and healthy population of Kashmir.Methods: 50 peptic ulcer patients (duodenal ulcer = 46, gastric ulcer = 2 and combined duodenal and gastric ulcer = 2) and 30 asymptomatic healthy volunteers were included in this study. Peptic ulcer was diagnosed on endoscopic examination. 4–6 punch biopsies were taken from gastric antrum in all the individuals and in case of gastric ulcer an additional biopsy was taken from the edge of the ulcer to exclude its malignant nature. Helicobacter pylori (H. pylori) organism was diagnosed using three different test methods, viz. Histology (using Giemsa Stain), Microbiology (Gram Stain) and Biochemistry (using one minute Endoscopy Room Test). Histological diagnosis of H. pylori was taken as the “gold standard” for the presence of H. pylori organism. Histological diagnosis of gastritis was made using Hematoxylin and Eosin Stain and the gastritis was classified as active chronic gastritis and superficial chronic gastritis.Results: Out of 30 peptic ulcer disease patients with associated antral gastritis, 27 (90%) were positive for H. pylori on histological examination (13 superficial chronic gastritis and 14 active chronic gastritis) whereas out of 8 healthy volunteers with histological evidence of chronic antral gastritis, H. pylori was observed in 7 individuals (87.50%) (4 active chronic gastritis and 3 superficial chronic gastritis).Conclusion: A highly significant association between H. pylori infection with chronic antral gastritis both in peptic ulcer disease patients and healthy volunteers of Kashmir was found in this study. Association between H. pylori infection and chronic gastritis was 90% in peptic ulcer group and 87.50% in healthy population (P<0.005).

scholarly journals GASTROPROTECTIVE EFFECT OF SESBANIA GRANDIFLORA LINN. SEEDS EXTRACT.

2020 ◽  
Vol 9 (2) ◽  
Author(s):  
Pallavi. B ◽  
Sunil. N ◽  
Syed Mansoor Ahamed ◽  
Nandheesh R.
Keyword(s):  
Peptic Ulcer ◽  
Gastric Ulcer ◽  
Small Intestine ◽  
World Population ◽  
Total Acidity ◽  
Peptic Ulcers ◽  
Ulcer Index ◽  
Standard Drug ◽  
Sesbania Grandiflora ◽  
Gastroprotective Effect

Background: A peptic ulcer is a sore in the lining of the stomach or the first part of the small intestine. Ulcer can be developed inside the inner lining of the stomach (gastric ulcer) or the small intestine (duodenal ulcer). Peptic ulcers are usually aggravated by an imbalance between destructive and defensive factors in the stomach, it affects nearly 10% of world population. The objective of the study was to investigate the protective effect of ethanolic extract of Sesbania grandiflora Linn. Seeds (SGEE) on peptic ulcer induced by ethanol in experimental rats. Objectives: Gastroprotective effect of Sesbania grandiflora Linn. Seeds extract on experimental Materials and Methods: The gastroprotective effect of SGEE was studied using ethanol (70% ) induced acute gastric ulcer models. The animals were divided into five groups, each group contains six animals. SGEE was administered in two doses, (200 mg/kg and 400 mg/kg, p.o). The parameters investigated include acid volume, pH, total acidity, ulcer index, total protein, glutathione, lipid peroxidase, catalase & histopathological studies. Results: 1. In gastroprotective effect study, SGEE significantly inhibited the development of ulcers induced by ethanol. The SGEE significantly reduced the acid volume, total acidity, total acidity, ulcer index, lipid peroxidation & increases in pH, glutathione & catalase level. Histopathogical studies also revealed that SGEE is gastro-protective. Ranitidine (100 mg/kg) is used as standard drug. Conclusion: All the observation implies that SGEE possess significant protective activity against ethanol induced gastric ulcer in experimental rats. 400 mg/kg doses has shown more protection compared to 200 mg/kg (dose dependent activity was obtained). Keywords: Antiulcer; Sesbania grandiflora; Ethanol; Ranitidine.

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