scholarly journals Efficacy of Platelet Rich Plasma (PRP) Gel in Bone Regeneration of Periapical Cystic Lesion

2020 ◽  
Vol 2 (3) ◽  
Author(s):  
Salman Shams
Keyword(s):  
Bone Regeneration ◽  
Cystic Lesion ◽  
Platelet Rich Plasma ◽  
Prp Gel

Effects of Platelet-Rich Plasma and Chitosan Combination on Bone Regeneration in Experimental Rabbit Cranial Defects

2010 ◽  
Vol 36 (3) ◽  
pp. 175-184 ◽  
Author(s):  
ErolÖzgür Oktay ◽  
Bahtiyar Demiralp ◽  
Burak Demiralp ◽  
Sevda Senel ◽  
Abdullah Cevdet Akman ◽  
...  
Keyword(s):  
Bone Formation ◽  
Bone Regeneration ◽  
Platelet Rich Plasma ◽  
The Other ◽  
New Bone Formation ◽  
Control Groups ◽  
Demarcation Line ◽  
Beneficial Effects ◽  
Derivatives Of ◽  
Prp Gel

Abstract This study aimed to investigate and compare the effect of chitosan sponge and platelet-rich plasma (PRP) gel alone as well as their combination on bone regeneration in rabbit cranial defects. Four cranial defects with a 4.5-mm diameter were created in rabbit cranium and grafted with PRP, chitosan sponge alone, and chitosan sponge incorporated with PRP. The rabbits were killed by the fourth and eighth weeks, and the defects were analyzed histologically. Higher bone formation was observed in the PRP group when compared with the other groups at weeks 4 and 8. All parts of the defects were filled with thick trabecular new bone in the PRP group. The amount of new bone formation in the control groups was found to be less when compared with the PRP group and the least in the chitosan group. The defects that were filled with chitosan sponge showed a limited amount of new bone formation and an obvious fibrous demarcation line between chitosan particles and bone. Application of PRP showed a histological tendency toward increased bone formation. Other forms or derivatives of chitosan may have beneficial effects to achieve new bone regeneration.

scholarly journals ANALISA GEL KOMBINASI PLATELET RICH PLASMA DAN CHITOSAN TERHADAP PENINGKATAN JUMLAH OSTEOBLAS SEBAGAI BONE REGENERATION PADA LUKA PASCA EKSTRAKSI GIGI TIKUS WISTAR

2018 ◽  
Vol 5 (2) ◽  
pp. 89
Author(s):  
Intan Maryani ◽  
Yayun Siti Rochmah ◽  
Anang Dwi Parmana
Keyword(s):  
Wound Healing ◽  
Growth Factors ◽  
Bone Regeneration ◽  
Povidone Iodine ◽  
Platelet Rich Plasma ◽  
Control Group ◽  
Osteoprogenitor Cell ◽  
Control Group Design ◽  
Prp Gel ◽  
Chitosan Gel

Background: Extraction has been known as a method for removing the tooth from its socket. Although extraction is frequent, the incidence of post extraction complication are commonly found, about 2,6-30,9%. Complications can inhibit wound healing and bone regeneration of socket. PRP is Platelet Rich Plasma containing growth factors that plays an important role in wound healing, induces bone regeneration and stimulates osteoprogenitor cell into osteoblast cell. Chitosan is a chitin derivate that extracted from the crab shells through deacetylation stage. Chitosan properties are osteoinductive, biocompatible, biodegradable, cell proliferation, antimicrobial, antioxidant, antitumor, and stimulates growth factors capabilities. Purpose: To analyze the combination of PRP and Chitosan gel to increase the number of osteoblast in post extraction wound of wistar rat teeth.Method: True experimental post-test only control group design was done in 28 wistar rats. Sample were divided into 4 groups: PRP gel, combination PRP and Chitosan gel, Chitosan gel and control group Povidone Iodine. Dextra Mandible incisors were extracted and treated accordingly. Number of osteoblast in post extraction socket was observed microscopically after 14 days using IHC staining. Data analyzed by using One Way ANOVA parametric test followed by Post Hoc LSD test.Results: There were statically signifcant di?erence between number of osteoblast in combination PRP and Chitosan gel group compare to PRP gel group (p=0,736), Chitosan gel group (p=0,402) and Povidone Iodine group (p=0,613).Conclusion: Combination PRP and Chitosan gel has a good e?ect in increasingnumber of osteoblast in wound healing post dental extraction

scholarly journals Enhanced regeneration of bone defects using sintered porous Ti6Al4V scaffolds incorporated with mesenchymal stem cells and platelet-rich plasma

RSC Advances ◽  
2021 ◽  
Vol 11 (9) ◽  
pp. 5128-5138
Author(s):  
Ji Li ◽  
Ketao Wang ◽  
Xiaowei Bai ◽  
Qi Wang ◽  
Ningyu Lv ◽  
...  
Keyword(s):  
Stem Cells ◽  
Mesenchymal Stem Cells ◽  
Bone Regeneration ◽  
Platelet Rich Plasma ◽  
Bone Defects ◽  
Regeneration Of Bone

Porous Ti6AI4V scaffolds incorporated with MSC and PRP are more effective in enhancing the bone regeneration.

Platelet-Rich Plasma: A Study of the Variables that May Influence Its Effect on Bone Regeneration

2015 ◽  
Vol 18 (5) ◽  
pp. 1051-1064 ◽  
Author(s):  
Mª del Mar Jovani-Sancho ◽  
Chirag C Sheth ◽  
Mariano Marqués-Mateo ◽  
Miguel Puche-Torres
Keyword(s):  
Bone Regeneration ◽  
Platelet Rich Plasma

Direct and Indirect Effects of a Combination of Adipose-Derived Stem Cells and Platelet-Rich Plasma on Bone Regeneration

2015 ◽  
Vol 21 (5-6) ◽  
pp. 895-905 ◽  
Author(s):  
Satoshi Tajima ◽  
Morikuni Tobita ◽  
Hakan Orbay ◽  
Hiko Hyakusoku ◽  
Hiroshi Mizuno
Keyword(s):  
Stem Cells ◽  
Bone Regeneration ◽  
Indirect Effects ◽  
Platelet Rich Plasma ◽  
Adipose Derived Stem Cells ◽  
Direct And Indirect Effects

Histologic Evaluation of Osseous Regeneration Following Combination Therapy With Platelet-Rich Plasma and Bio-Oss in a Rat Calvarial Critical-Size Defect Model

2015 ◽  
Vol 41 (5) ◽  
pp. 543-549 ◽  
Author(s):  
Philip J. DeNicolo ◽  
M. Kelly Guyton ◽  
Michael F. Cuenin ◽  
Steven D. Hokett ◽  
Mohamed Sharawy ◽  
...  
Keyword(s):  
Bone Regeneration ◽  
Bone Growth ◽  
Critical Size ◽  
Close Contact ◽  
Platelet Rich Plasma ◽  
Critical Size Defect ◽  
Histologic Evaluation ◽  
Hematoxylin And Eosin ◽  
Hematoxylin And Eosin Stain ◽  
Osseous Regeneration

Platelet-rich plasma (PRP) is an autogenous source of growth factors shown to facilitate human bone growth. Bio-Oss, an osteoconductive xenograft, is used clinically to regenerate periodontal defects, restore dental alveolar ridges, and facilitate sinus-lift procedures. The purpose of this study was to analyze whether a combination of PRP and Bio-Oss would enhance bone regeneration better than either material alone. PRP and/or Bio-Oss were administered in an 8-mm critical-size defect (CSD) rat calvarial model of bone defect between 2 polytetrafluoroethylene membranes to prevent soft tissue incursion. Eight weeks after the induction of the CSD, histologic sections were stained with hematoxylin and eosin stain and analyzed via light microscopy. Qualitative analyses revealed new bone regeneration in all 4 groups. The Bio-Oss and PRP plus Bio-Oss groups demonstrated greater areas of closure in the defects than the control or PRP-only groups because of the space-maintaining ability of Bio-Oss. The groups grafted with Bio-Oss showed close contact with new bone growth throughout the defects, suggesting a stronger graft. The use of PRP alone or in combination with Bio-Oss, however, did not appear to enhance osseous regeneration at 8 weeks. Areas grafted with Bio-Oss demonstrated greater space-maintaining capacity than controls, and PRP was an effective vehicle for placement of the Bio-Oss. However, at 8 weeks this study was unable to demonstrate a significant advantage of using PRP plus Bio-Oss over using Bio-Oss alone.

scholarly journals A Preliminary Evaluation of Lyophilized Gelatin Sponges, Enhanced with Platelet-Rich Plasma, Hydroxyapatite and Chitin Whiskers for Bone Regeneration

Cells ◽  
2013 ◽  
Vol 2 (2) ◽  
pp. 244-265 ◽  
Author(s):  
Isaac Rodriguez ◽  
Scott Sell ◽  
Jennifer McCool ◽  
Gunjan Saxena ◽  
Andrew Spence ◽  
...  
Keyword(s):  
Bone Regeneration ◽  
Platelet Rich Plasma ◽  
Preliminary Evaluation ◽  
Chitin Whiskers

scholarly journals Evaluation of platelet-rich plasma gel as an angiogenesis-inducing agent in canineadvancement skin flaps

2020 ◽  
Vol 40 (6) ◽  
pp. 474-478
Author(s):  
Grazielle A.S. Aleixo ◽  
Maria C.O.C. Coelho ◽  
Telga L.A. Almeida ◽  
Márcia F. Pereira ◽  
Miriam N. Teixeira ◽  
...  
Keyword(s):  
Blood Vessel ◽  
Skin Color ◽  
Platelet Rich Plasma ◽  
Skin Flap ◽  
Skin Flaps ◽  
Experimental Conditions ◽  
Significant Difference ◽  
Experimental Group ◽  
Prp Gel ◽  
Made In

ABSTRACT: This work aimed to evaluate the effect of platelet-rich plasma (PRP) on advancement skin flaps in dogs regarding improvement of vascularization, with focus on increasing its viable area, since there are reports that it is a potential angiogenesis stimulator. The experimental group was composed of eight adult bitches, in which two advancement skin flaps were made in the ventral abdominal region. No product was applied in the control flap (CF), while PRP was used in the contralateral flap, called treated flap (TF). The areas were clinically evaluated every two days until the 7th postoperative day regarding skin color and presence of necrosis. At 10 days, both flaps were removed and submitted to histological examination and blood vessel morphometry. The vessels counted in each group were statistically analyzed by the F-test at 1% probability. Results showed no significant difference in macroscopic changes in the wound, or CF and TF vascularization, thus suggesting that PRP gel did not improve advancement skin flap angiogenesis in bitches under the experimental conditions in which this research was developed.

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