scholarly journals ANALISA GEL KOMBINASI PLATELET RICH PLASMA DAN CHITOSAN TERHADAP PENINGKATAN JUMLAH OSTEOBLAS SEBAGAI BONE REGENERATION PADA LUKA PASCA EKSTRAKSI GIGI TIKUS WISTAR

2018 ◽  
Vol 5 (2) ◽  
pp. 89
Author(s):  
Intan Maryani ◽  
Yayun Siti Rochmah ◽  
Anang Dwi Parmana
Keyword(s):  
Wound Healing ◽  
Growth Factors ◽  
Bone Regeneration ◽  
Povidone Iodine ◽  
Platelet Rich Plasma ◽  
Control Group ◽  
Osteoprogenitor Cell ◽  
Control Group Design ◽  
Prp Gel ◽  
Chitosan Gel

Background: Extraction has been known as a method for removing the tooth from its socket. Although extraction is frequent, the incidence of post extraction complication are commonly found, about 2,6-30,9%. Complications can inhibit wound healing and bone regeneration of socket. PRP is Platelet Rich Plasma containing growth factors that plays an important role in wound healing, induces bone regeneration and stimulates osteoprogenitor cell into osteoblast cell. Chitosan is a chitin derivate that extracted from the crab shells through deacetylation stage. Chitosan properties are osteoinductive, biocompatible, biodegradable, cell proliferation, antimicrobial, antioxidant, antitumor, and stimulates growth factors capabilities. Purpose: To analyze the combination of PRP and Chitosan gel to increase the number of osteoblast in post extraction wound of wistar rat teeth.Method: True experimental post-test only control group design was done in 28 wistar rats. Sample were divided into 4 groups: PRP gel, combination PRP and Chitosan gel, Chitosan gel and control group Povidone Iodine. Dextra Mandible incisors were extracted and treated accordingly. Number of osteoblast in post extraction socket was observed microscopically after 14 days using IHC staining. Data analyzed by using One Way ANOVA parametric test followed by Post Hoc LSD test.Results: There were statically signifcant di?erence between number of osteoblast in combination PRP and Chitosan gel group compare to PRP gel group (p=0,736), Chitosan gel group (p=0,402) and Povidone Iodine group (p=0,613).Conclusion: Combination PRP and Chitosan gel has a good e?ect in increasingnumber of osteoblast in wound healing post dental extraction

scholarly journals Collagen quantification in rabbit dermal wounds treated with heterologous platelet-rich plasma gel

2017 ◽  
Vol 38 (1) ◽  
pp. 249 ◽  
Author(s):  
Maria Elisa Marin Marques ◽  
Cecília Braga Laposy ◽  
Mariana Lucas Dos Santos Silva ◽  
Maria Rosa Santos Breda ◽  
Mayara Mascaro Matsumoto ◽  
...  
Keyword(s):  
Wound Healing ◽  
Adverse Reactions ◽  
Platelet Rich Plasma ◽  
Healing Process ◽  
Clinical Signs ◽  
Polarized Light ◽  
Clinical Aspects ◽  
Control Group ◽  
Wound Healing Process ◽  
Prp Gel

Platelet-rich plasma (PRP) has been extensively studied as a biomaterial for wound treatment, and the heterologous PRP is usefulin the event that obtaining the patient’s own blood is impossible. This study aimed to evaluate and compare wound healing in rabbits and quantify the collagen in experimentally induced wounds in a control group and in a group treated with heterologous PRP gel. We hypothesize that this gelis capable of promoting proper healing with no adverse reactions, increased collagen content. The clinical aspects of coloring, edema, hyperemia, exudation, crust, granulation, pain sensitivity, and retraction index of the wounds were measuredon days 7, 14, and 17 after the injury. Collagen quantification by Picrosirius staining and evaluation under polarized light was performed on the 17th day. Crust was present in both groups at all evaluated time points, with the absence of other clinical signs. The wound contraction rate and collagen quantity did not differ between groups. In conclusion, the suggested hypothesis was partially confirmed; the heterologous PRP gel was unable to increase the amount of collagen and accelerate the wound healing process, however, wound healing was efficient and similar in both groups and there was no local adverse reaction. Thus, despite the scarcity of studies in the literature, the heterologous PRP gel is an effective alternative treatment for wounds in the absence of other sources of PRP.

scholarly journals The effect of ethanol extract of Sarang Semut plant (Hypnophytum formicarum) towards Angiogenesis for wound healing after tooth extraction: Experimental research on Marmot (Cavia cobaya)

2016 ◽  
Vol 28 (3) ◽  
Author(s):  
Sartika Amelia Putri ◽  
Efa Ismardianita
Keyword(s):  
Wound Healing ◽  
Tooth Extraction ◽  
Povidone Iodine ◽  
Ethanol Extract ◽  
Extraction Methods ◽  
Control Group ◽  
Test Results ◽  
Control Group Design ◽  
Accelerate Wound Healing ◽  
Group I

Introduction: Tooth extraction causing injuries, to accelerate wound healing was given medication. Drugs commonly used for wound healing after tooth extraction is povidone iodine act as bacteriostatic for all germs. Excessive use of povidone iodine can cause side effects such as itching, pain in the area around the wound, swelling and dermatitis, so it sought a safe substitute drugs derived from herbs. One of the herbs are often used by people in the Mentawai Islands is a Sarang Semut's root species of Hypnophytum formicarum. This study was aimed to determine the effect of sarang semut’s extract orally for angiogenesis in wound healing after tooth extraction. Methods: This research was experimental with posttest only control group design. Subjects were 48-animal marmots were divided into 4 groups, will be deprived of his left mandibular insisivus. Group I (control 0,5% CMC, treatment group II, III, IV with 4,65mg, and 9.3 mg 6,2 mg dose tuber ethanol extract dissolved anthill in CMC 0.5%), were given 3 ml orally, 3 times a day until the day of decapitation. Futher histological preprations made by HE staining and the observed area is apex, medial, servical,and lateral used 400x magnification. The data was analyzed with parametric test One-Way ANOVA, and to see the significance between dose used LSD test. Results: The results showed that the extract of sarang semut effect (p<0,05) on the angiogenesis in wound healing after tooth extraction. Conclusion: The most effective concentration was 4,65 mg.

scholarly journals A Comparison Study of Growth Factor Expression following Treatment with Transcutaneous Electrical Nerve Stimulation, Saline Solution, Povidone-Iodine, and Lavender Oil in Wounds Healing

2013 ◽  
Vol 2013 ◽  
pp. 1-9 ◽  
Author(s):  
Adalet Koca Kutlu ◽  
Dilek Çeçen ◽  
Seren Gülşen Gürgen ◽  
Oya Sayın ◽  
Ferihan Çetin
Keyword(s):  
Wound Healing ◽  
Growth Factors ◽  
Growth Factor ◽  
Nerve Stimulation ◽  
Transcutaneous Electrical Nerve Stimulation ◽  
Saline Solution ◽  
Povidone Iodine ◽  
Control Group ◽  
Electrical Nerve Stimulation ◽  
Lavender Oil

This study compared the effects of transcutaneous electrical nerve stimulation (TENS), saline solution (SS), povidone-iodine (PI), and lavender oil (Lavandula angustifolia) through expression of growth factors in a rat model of wound healing. Six experimental groups were established, each containing 8 rats: a healthy group with no incision wounds, an incision-control group, an incision and TENS group, an incision and SS group, an incision and PI group, and an incision and lavender oil group. Experiments continued for 5 days, after which the skin in the excision area was removed. Tissue concentrations of epidermal growth factor (EGF) and platelet-derived growth factor (PDGF)-A were measured using enzyme-linked immunosorbent assay (ELISA). Tissue expressions of EGF, PDGF-A, and fibroblast growth factor (FGF)-2 were determined using immunohistochemistry. Wound closure progressed more rapidly in the TENS and lavender oil groups than in the control and other study groups. In particular, PDGF-A expressions in the dermis and EGF expression in the epidermis were significantly intense in the TENS group (P<0.05). In addition, ELISA levels of growth factors such as PDGF-A and EGF were significantly higher in TENS group compared to the control group (P<0.05). These immunohistochemical and ELISA results suggest that TENS may improve wound healing through increasing growth factors in the dermis and epidermis more than other topical applications.

scholarly journals Pharmacological Evaluation of Chrozophora tinctoria as Wound Healing Potential in Diabetic Rat’s Model

2016 ◽  
Vol 2016 ◽  
pp. 1-7 ◽  
Author(s):  
Harikesh Maurya ◽  
Monika Semwal ◽  
Susheel Kumar Dubey
Keyword(s):  
Wound Healing ◽  
Disease Control ◽  
Povidone Iodine ◽  
Diabetic Rats ◽  
Control Group ◽  
Standard Drug ◽  
Group Iii ◽  
Group I ◽  
Elevated Blood Glucose Level ◽  
Pharmacological Potential

Objective. The study was designed to evaluate pharmacological potential of hydroalcoholic leaves extract of Chrozophora tinctoria intended for wound healing in diabetic rats’ model. Methods. The method used to evaluate the pharmacological potential of hydroalcoholic leave extract was physical incision rat model. In this model, cutting of the skin and/or other tissues with a sharp blade has been made and the rapid disruption of tissue integrity with minimal collateral damage was observed shortly. Animals used in the study were divided into four groups that consist of six animals in each group. Group I serves as normal control, Group II serves as disease control, Group III was used as standard treatment (Povidone iodine 50 mg/kg b.w.), and Group IV was used for test drug (C. tinctoria 50 mg/kg b.w.). Result. The hydroalcoholic leave extract of Chrozophora tinctoria has been significantly observed to heal the wound (98%) in diabetic rats within 21 days, while standard drug (Povidone iodine) healed the wound about 95% in the same condition. The oral dose (50 mg/kg b.w.) of Chrozophora tinctoria was also found to improve the elevated blood glucose level in comparison to disease control group, which increased after the oral administration of Streptozotocin. Conclusion. The Chrozophora tinctoria has significant wound healing potential in the animal having physically damaged tissue in diabetic condition.

scholarly journals PENGARUH PEMBERIAN GEL KOMBINASI EKSTRAK GETAH PEPAYA (Carica papaya L) DAN EKSTRAK DAGING LIDAH BUAYA (Aloe vera) TERHADAP PROSES PENYEMBUHAN ULKUS TRAUMATIKUS PADA MALE WISTAR RATS YANG MENDERITA DIABETES MELITUS

2015 ◽  
Vol 2 (1) ◽  
pp. 41
Author(s):  
Umi Kulsum ◽  
Ratnawati Hendari ◽  
Siti Chumaeroh
Keyword(s):  
Wound Healing ◽  
Ulcer Healing ◽  
Wistar Rats ◽  
Povidone Iodine ◽  
Healing Process ◽  
Aloe Vera ◽  
Control Group ◽  
Significant Difference ◽  
Male Wistar Rats ◽  
Papaya Latex

Introduction: Research on the use of papaya and aloevera sap on wound healing each been done, but effects the combination of the two extracts on wound healing in diabetes mellitus condition has not been done.Purpose: This study aims to determine the effect of a gel combination of papaya latex and aloevera flesh extracts on the traumatics ulcer healing process in diabetic rats.Methods: True experimental laboratory research with the post-test-only control group design that performed on 28 male wistar rats which were divided intofour groups: DM and non-DM rat that treatment with povidone iodine and gel combination of papaya latex and aloevera flesh extract. The treatment was done for 7 days with smearing that was given 2x/day. Traumatics ulcer healing seen from the number of fibroblasts that then were analyzed by One WayAnova and post hoc LSD test.Results: The results showed the number of fibroblasts in DM and non-DM rat with povidone iodine were 44.6 and 42.73; in the DM and non-DM rat with a gel combination of papaya latex and aloe vera flesh extracts were 61.10 and 77.03. One Way Anova test resulted p-value = 0.000, it was mean that there were at least a significant difference on the number of fibroblasts in the two groups. Differences of the number fibroblasts was shown in all groups, except in the group DM and non-DM rats with povidone iodine (p = 0.764).Conclusion: Conclusion of the study was the provision of a gel combination of papaya latex and aloevera flesh extracts effect on the traumatics ulcer healing process in diabetic rats.

scholarly journals Uji Daya Hambat Air Perasan Buah Jeruk Nipis (Citrus aurantifolia s.) Terhadap Pertumbuhan Bakteri Staphylococcus Aureus Secara In Vitro

2013 ◽  
Vol 2 (1) ◽  
pp. 05 ◽  
Author(s):  
Abdul Razak ◽  
Aziz Djamal ◽  
Gusti Revilla
Keyword(s):  
Staphylococcus Aureus ◽  
Wound Healing ◽  
Contact Time ◽  
Experimental Methods ◽  
Control Group ◽  
Control Group Design ◽  
Citrus Aurantifolia ◽  
Group Design ◽  
Growth Of Bacteria

AbstrakJeruk Nipis (Citrus aurantifolia S.) merupakan salah satu tanaman obat keluarga yang banyak terdapat ditengah masyarkat dan banyak digunakan sebagai ramuan tradisional. Bagian yang sering digunakan adalah air perasannya, dengan salah satu manfaat dapat digunakan untuk menghilangkan jerawat serta penyembuhan luka agar tidak terjadi abses. Jerawat dan abses pada luka merupakan salah satu infeksi yang disebabkan oleh bakteri Staphylococcus aureus.Tujuan Penelitian ini adalah untuk mengetahui daya hambat air perasan buah jeruk nipis (Citrus aurantifolia S.) terhadap pertumbuhan bakteri Staphylococcus aureus secara invitro. Penelitian dilakukan dengan metoda eksperimental laboratorium dengan desain postest only control group design yang dilakukan di Laboratorium Mikrobiologi Fakultas Kedokteran Universitas Andalas.Hasil penelitian menunjukan bahwa air perasan buah jeruk nipis memiliki daya hambat terhadap pertumbuhan bakteri Staphylococcus aureus dengan berbagai konsentrasi yaitu 25%, 50%, 75%, dan 100% dan terdapat pengaruh lama kontak terhadap pertumbuhan bakteri dimana bakteri tidak tumbuh seteleh kontak 5 menit pertama dan diikuti menit-menit berikutnya dengan air perasan buah jeruk nipis konsentrasi 100%. Jadi, semakin tinggi konsentrasi air perasan buah jeruk nipis dan semakin lama kontak dengan bakteri Staphylococcus aureus maka daya hambatnya semakin baik.Kata kunci: Uji Daya Hambat, Air Perasan Buah Jeruk Nipis, Staphylococcus aureus.Abstract Lime (Citrus aurantifolia S.) is kind of family’s herbal medicine, most using in the community is widely used as a traditional herb. The most common used part is the lime fruit squeeze with one of the function is used for removing acne and wound healing to prevent the form of abscess. Pimples and abscesses of the wound is one of the infections caused by the bacterium Staphylococcus aureus.The purpose of this study was to determine the inhibition of lime fruit (Citrus aurantifolia S.) squeeze towards the growth of the bacteria Staphylococcus aureus in vitro condition. The study was conducted with laboratory experimental methods to the design of control group design postest only performed at the Laboratory of Microbiology Faculty of Medicine, University of Andalas.The results showed that the lime fruit (Citrus aurantifolia S.) squeeze has the ability to inhibite the bacterial growth of Staphylococcus aureus with various concentrations of 25%, 50%, 75%, and 100% and there is the effect of contact time on the growth of bacteria which the bacteria do not grow after contact the first 5 minutes and the next minute followed by lime fruit squeeze with 100% concentration lime fruit squeeze. Thus, the higher the concentration of lime fruit squeeze and the longer the contact with the bacteria Staphylococcus aureus is the better towards.Keywords:Inhibition test, The Lime Fruit Squeeze, Staphylococcus Aureus.

scholarly journals PENGARUH AIR REBUSAN DAUN BINAHONG DALAM MEMPERCEPAT PENYEMBUHAN LUKA PERINEUM MASA NIFAS

2021 ◽  
Vol 8 (1) ◽  
pp. 15-23
Author(s):  
Rinni Gusnimar ◽  
Nora Veri ◽  
Cut Mutiah
Keyword(s):  
Wound Healing ◽  
Wound Care ◽  
Complementary Therapy ◽  
Control Group ◽  
P Value ◽  
Control Group Design ◽  
Group Design ◽  
Quasi Experimental ◽  
Perineal Wounds ◽  
Postpartum Mothers

Infeksi nifas menjadi salah satu penyebab kematian ibu di negara berkembang termasuk Indonesia. Beberapa penyebab pemicu terjadinya infeksi nifas seperti pelayanan kebidanan, daya tahan tubuh, perawatan nifas, gizi, anemia dan kebersihan genetalia. Pada masa nifas penting untuk merawat luka perineum karena kuman bisa masuk melalui luka bekas jahitan pada perineum agar tidak menyebabkan infeksi. Salah satu alternatif terapi nonfarmakologis yang dapat digunakan untuk penyembuhan luka perineum masa nifas adalah daun binahong. Tujuan penelitian ini menguji pengaruh daun binahong dalam mempercepat penyembuhan luka perineum pada masa nifas. Penelitian ini menggunakan rancangan quasi experimental dengan pendekatan posttest only control group design. Posttest only control group design merupakan pengumpulan data dilakukan sesudah perlakuan. Total sampel yang digunakan dalam penelitian ini adalah 32 orang ibu nifas sesuai dengan kriteria inklusi. Data diobservasi berupa derajat kesembuhan luka perineum dengan menggunakan instrumen lembar observasi penyembuhan luka perineum pada skala REEDA (Redness, Edema, Ecchymosis, Discharge dan Approximation). Hasil penelitian menunjukan terdapat pengaruh pemberian rebusan Daun binahong terhadap penyembuhan luka perineum pada ibu nifas. Rerata hasil uji Uji statistik Mann Whitney, pada kelompok perlakuan adalah 11,83 lebih rendah dibandingkan pada kelompok kontrol, yaitu 21,8 (p-value = 0,001). Penelitian ini menunjukan bahwa ada pengaruh pemberian rebusan daun binahong mampu mempercepat penyembuhan luka perineum dibandingkan iodine povidone 10%. Daun binahong dapat menjadi alternatif terapi komplementer pada ibu nifas yang mengalami luka robekan perineum.   One of the main causes of maternal death in developing countries is puerperal infection. Midwifery care, body immunity, postnatal care, nutrition, anemia and genetalia hygiene are factors that trigger puerperal infections. The perineal rupture if not treated properly will cause an infection in the suture wound in the perineum. Wound care is important because germs can enter through the suture marks on the perineum and cause infection. Non-pharmacological therapies that can be used to accelerate wound healing are Anredera cordifolia. The research design was quasi experimental with posttest approach Only Control Group Design, namely data collection was done after treatment. The total sample was 32 postpartum mothers according to inclusion criteria. The data observed in this study were the degree of healing of perineal wounds using the REEDA scale perineal wound healing observation sheet instrument (Redness, Edema, Ecchymosis, Discharge and Approximation). Based on the results of the Mann Whitney test, the mean rank of the results in the treatment group was 11.83 lower than the control group, namely 21.8 (p-value = 0.001). Effect of giving Anredera cordifolia leaves on the healing of perineal wounds in postpartum mothers significantly. Care with giving Anredera cordifolia leaves can accelerate the healing of perineal wounds compared to 10% iodine povidone. Anredera cordifolia leaves can be used as a complementary therapy for postpartum mothers who experience perineal torn wounds.

scholarly journals Platelet-Rich Plasma with Endothelial Progenitor Cells Accelerates Diabetic Wound Healing in Rats by Upregulating the Notch1 Signaling Pathway

2019 ◽  
Vol 2019 ◽  
pp. 1-12 ◽  
Author(s):  
Cheng Zhang ◽  
Yu Zhu ◽  
Shengdi Lu ◽  
Wanrun Zhong ◽  
Yanmao Wang ◽  
...  
Keyword(s):  
Wound Healing ◽  
Growth Factors ◽  
Signaling Pathway ◽  
Platelet Rich Plasma ◽  
Diabetic Wound ◽  
Endothelial Progenitor ◽  
Notch1 Signaling ◽  
Diabetic Wound Healing ◽  
Notch1 Signaling Pathway ◽  
Diabetic Wounds

Diabetic wounds, as a kind of refractory wound, are very difficult to heal. Both endothelial progenitor cell (EPC) transplantation and platelet-rich plasma (PRP) can improve diabetic wound healing to some extent. However, PRP application cannot provide reparative cells, while EPC transplantation cannot replenish the required growth factors for wound healing. Thus, when applied alone, neither of these factors is sufficient for effective wound healing. Furthermore, the proliferation, differentiation, and fate of the transplanted EPCs are not well known. Therefore, in this study, we examined the efficacy of combined PRP application with EPC transplantation in diabetic wound healing. Our results indicated that PRP application improved EPC proliferation and migration. The Notch signaling pathway plays a key role in the regulation of the proliferation and differentiation of stem cells and angiogenesis in wound healing. The application of PRP upregulated the Notch pathway-related gene and protein expression in EPCs. Furthermore, experiments with shNotch1-transfected EPCs indicated that PRP enhanced the function of EPCs by upregulating the Notch1 signaling pathway. In vivo studies further indicated that the combination of PRP and EPC transplantation increased neovascularization, reduced wound size, and improved healing in rat wound models. Thus, PRP application can provide the necessary growth factors for wound healing, while EPC transplantation offers the required cells, indicating that the combination of both is a potent novel approach for treating diabetic wounds.

Effectiveness of autologous platelet-rich plasma gel in the treatment of hard-to-heal leg ulcers: a randomised control trial

2019 ◽  
Vol 28 (10) ◽  
pp. 658-667 ◽  
Author(s):  
Domantas Rainys ◽  
Adas Cepas ◽  
Karolina Dambrauskaite ◽  
Irena Nedzelskiene ◽  
Rytis Rimdeika
Keyword(s):  
Platelet Rich Plasma ◽  
Size Reduction ◽  
Control Group ◽  
Leg Ulcers ◽  
Tissue Formation ◽  
Granulation Tissue Formation ◽  
Wound Contamination ◽  
Wound Size ◽  
Autologous Platelet Rich Plasma ◽  
Prp Gel

Objective: Regenerative medicine products such as autologous platelet-rich plasma (autologous PRP) gel may speed up the process of healing. Clinical studies show promising results in the treatment of diabetic foot ulcers (DFUs), however there is lack of scientific evidence of autologous PRP effectiveness in treating leg ulcers of other aetiology. This study evaluates the effectiveness of autologous PRP gel in the treatment of hard-to-heal leg ulcers compared with existing conventional treatment. Method: A prospective, randomised controlled, open-labelled clinical trial was carried out between 2014 and 2018. An eight-week study protocol was chosen or until 100% wound re-epithelialisation was observed. Wound size reduction, granulation tissue formation, microbiological wound bed changes and safety were evaluated. Results: A total of 69 patients (35 in the autologous PRP group and 34 in the control group) were included in the study; 25.71% of the autologous PRP group and 17.64% of control group had ulcers completely re-epithelialised (p>0.05). Wound size reduction in the autologous PRP group was 52.35% and 33.36% in the control group (p=0.003). The autologous PRP group showed superiority over conventional treatment in wound bed coverage with granulation (p=0.001). However, more frequent wound contamination was observed at the end of treatment in the autologous PRP group (p=0.024). No severe adverse events were noted during the study. Both treatment methods were considered equally safe. Conclusion: Topical application of autologous PRP gel in leg ulcers of various aetiology show beneficial results in wound size reduction and induces the granulation tissue formation. However, it is associated with more frequent microbiological wound contamination.

The Role of Autologous PRP on Deep Partial-Thickness Burn Wound Healing in Bama Pigs

2020 ◽  
Vol 41 (3) ◽  
pp. 657-662 ◽  
Author(s):  
Yanwei Sun ◽  
Yongqian Cao ◽  
Ran Zhao ◽  
Famei Xu ◽  
Dan Wu ◽  
...  
Keyword(s):  
Wound Healing ◽  
Growth Factors ◽  
Growth Factor ◽  
Healing Process ◽  
Control Group ◽  
Therapeutic Effects ◽  
Partial Thickness ◽  
Partial Thickness Burn ◽  
The Mean ◽  
Partial Thickness Burns

Abstract In this study, we aimed to evaluate the therapeutic effects of autologous platelet-rich plasma (PRP) on deep partial-thickness burns in Bama pigs. Deep partial-thickness burn wounds were created on the back of Bama pigs. The reepithelialization time was compared between the PRP and control groups. The mean score of Ki67 (+) cells and α-SMA (+) vessels, the mean thickness of epidermis and dermis of the healing wounds were determined via H&E staining and immunohistochemical assay. The levels of the growth factors epidermal growth factor (EGF), basic fibroblast growth factor (bFGF), and vascular endothelial growth factor (VEGF) were examined by ELISA. Our data showed that the time to wound reepithelialization was shorter in the PRP group compared with the control group. The thickness of the epidermis was larger in the PRP group compared with the control group. On the 7th and 14th days after the treatment, the mean score of Ki67 (+) cells and α-SMA (+) vessels were higher in the PRP group compared with the control group. The PRP group showed higher levels of growth factors (EGF, bFGF, and VEGF) compared with the control group by ELISA. The results indicated that PRP could improve wound healing process of deep partial-thickness burns in Bama pigs. The PRP increased the thickness of epidermis of the healed wounds, cell proliferation, and angiogenesis. We demonstrated that applying PRP had a greater potential for the treatment of deep partial-thickness burns.

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