EYUNOGASTROPLASTICА AS AN EFFECTIVE METHOD FOR PREVENTING FUNCTIONAL DISORDERS AFTER PROXIMAL GASTRIC RESECTION

The objective of this project was to find to what extent loss of weight in the digestive tract might affect tumor size and age in albino rats bearing Walker carcinosarcoma 256. Wet weight, dry weight, and water content were measured upon tongue, esophagus, cardiac stomach, pyloric stomach, jejunum, ileum, cecum, colon, and residual carcass (minus tumor). The animals bore tumors weighing 12 ± 6 (mean ± S.D.) % of host (minus tumor) weight after 18 ± 6 days of tumor growth (group I), 38 ± 12% after 24 ± 6 days (group II), and 93 ± 26% after 29 ± 5 days (group III) and controls were twins of the same sex. There were few significant changes in the animals of group I. In group II, there was loss of dry weight in all organs except pyloric stomach, losses being percentagewise the same as in residual carcass. Loss of dry weight of jejunum and ileum was less in rats of group III than in those of group II. In group III, loss of weight in other organs tended to be less than in residual carcass. Loss of dry weight in residual carcass was not significantly greater in the animals of group III than in those of group II. Water levels were increased in all organs of rats in groups II and III. This evidence indicates that rats of group III may have lived longer after tumor implantation, lost no more carcass weight, and bore larger tumors because they had lost weight in the small bowel at a lesser rate than had the rats of group II.Further studies revealed that lipid shifts were in general less marked in organs which had lost the least weight. In animals bearing large tumors, percentage loss of neutral fat was less in most organs of the digestive tract than in the residual carcass. Increases in the levels of cholesterol and phospholipid were less in pyloric stomach and small bowel than in other organs of the digestive tract. Shifts in the amount of nonlipid dry weight and in levels of lipids and water were in general less in pyloric stomach and small bowel than in other organs of the body. In these respects, pyloric stomach and small bowel resembled brain, heart, and lung. It is suggested that resistance of pyloric stomach and small bowel to the cachectic influence of the tumor may be a factor determining tumor size and length of survival of the host.

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Hepatic and biochemical repercussions of a polyunsaturated fat-rich hypercaloric and hyperlipidic diet in Wistar rats

Arquivos de Gastroenterologia ◽

10.1590/s0004-28032011000200012 ◽

2011 ◽

Vol 48 (2) ◽

pp. 153-158 ◽

Cited By ~ 2

Author(s):

Idália M. B. Burlamaqui ◽

Conceição A. Dornelas ◽

José Telmo Valença Jr ◽

Francisco J. C. Mesquita ◽

Lara B. Veras ◽

...

Keyword(s):

Total Cholesterol ◽

Wistar Rats ◽

Average Weight ◽

Standard Diet ◽

Polyunsaturated Fat ◽

Alcoholic Fatty Liver ◽

The Metabolic Syndrome ◽

Group I ◽

Hyperlipidic Diet ◽

Group Ii

CONTEXT: Non-alcoholic fatty liver disease is characterized by lipid deposits in the hepatocytes and has been associated with obesity, dyslipidemia and type-2 diabetes. It is considered a hepatic manifestation of the metabolic syndrome, of which the main component is insulin resistance leading to hyperinsulinemia and increased production of inflammatory cytokines. Saturated fat promotes hypertriglyceridemia and hyperinsulinemia, reduces levels of high-density cholesterol and increases levels of low-density cholesterol, while polyunsaturated fat is associated with hypolipidemic, antiinflammatory and imunoregulating action. OBJECTIVE: To evaluate the hepatic and biochemical repercussions of a polyunsaturated fat-rich diet in Wistar rats. METHODS: Twenty-two rats were distributed equally in two groups: GI - standard diet (Biobase Bio-tec Ratos e Camundongos®) providing 3.000 kcal/kg and GII - hypercaloric and hyperlipidic diet providing 4.250 kcal/kg (ω-6:ω-3 = 3:1). The animals were euthanized after 23 weeks of experiment. The weight, biochemical parameters and hepatohistological changes were registered. RESULTS: Findings were submitted to variance analysis with the level of statistical significance at 5%. The average weight did not differ significantly between the groups at baseline (P = 0.711), but was greater in Group II by the end of the experiment (P = 0.000). The levels of triglycerides (P = 0.039), total cholesterol (P = 0.015) and HDL (P = 0.005) were higher in Group I than in Group II. Macrovesicular steatosis was significantly more common in Group II than in Group I (P = 0.03). CONCLUSION: Hypercaloric and hyperlipidic diet rich in polyunsaturated fat promotes weight gain and favors the development of hepatic steatosis while reducing serum levels of triglycerides, total cholesterol and HDL.

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The effect of magnetic field on hatchability of Japanese quail eggs

Czech Journal of Animal Science ◽

10.17221/3951-cjas ◽

2011 ◽

Vol 51 (No. 8) ◽

pp. 355-360 ◽

Cited By ~ 4

Author(s):

Z. Tarasewicz ◽

D. Szczerbinska ◽

D. Majewska ◽

A. Danczak ◽

M. Ligocki ◽

...

Keyword(s):

Magnetic Field ◽

Body Weight ◽

Variable Magnetic Field ◽

Control Group ◽

Average Weight ◽

Group Iii ◽

Egg Hatchability ◽

Group I ◽

Group Ii ◽

Similar Body

The effect of environmental conditions on hatching indices of poultry eggs is sufficiently important that new methods for their improvement are sought, among others through exposing the eggs during hatching to an artificially generated magnetic field of variable frequency. Hatching eggs in this study came from Pharaoh quail in the 4th month of laying. The flock was kept under optimum microclimate conditions and fed a complete feed mix containing 21% total protein and 11.7 MJ ME. The eggs (n = 150), after weighing, were divided into 3 groups equal in respect of numbers: control (I) and two experimental (II and III). The eggs of group II and III were exposed to the action of variable magnetic field of the same intensity but different times of application. The highest percentage of dead embryos during incubation in relation to fertilised eggs was found in control group (11.36%), while the smallest was from group II (4.17%). The highest value of hatching indices calculated in relation to fertilised eggs was found in group II (91.6%), while the smallest was in group III (83.7%) with 86.3% in control group. The results point to the possibility of increasing egg hatchability indices through the use of additional variable magnetic field. The chicks hatched from eggs exposed to the action of this experimental agent had similar body weight. The average weight of one-day-old chicks ranged from 7.82 g (group II) to 8.05 g (group III). In the last week of rearing, mean body weight in both sexes was similar and ranged from 168 (group I) to 172 g (group III) in males, and from 186 g (group I) to 199 g (group III) in females; these differences were not statistically significant. The females of group III reached sexual maturity at 41 days, this being one and three days (non-significantly) earlier than birds in group I and II.  

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Hypothyroidism and early fetal demise

Journal of obstetrics and women s diseases ◽

10.17816/jowd67349-54 ◽

2018 ◽

Vol 67 (3) ◽

pp. 49-54

Author(s):

Anna A. Olina

Keyword(s):

Subclinical Hypothyroidism ◽

Odds Ratio ◽

Case Control ◽

Thyroid Status ◽

Fetal Demise ◽

Group I ◽

Group Ii ◽

Instrumental Methods ◽

People Group ◽

On Time Delivery

Background. The study is devoted to the evaluation of thyroid status in patients with early fetal demise. The aim of the study was to assess the prevalence of hypothyroidism, including its subclinical forms, in patients with early fetal demise. Materials and methods. It is an observational “case-control” retrospective study. Group I is represented by first-pregnant women with physiological on-time delivery of the healthy child (375 people). Group II consisted of 375 women who had had an episode of early fetal demise for up to 14 weeks. Laboratory and instrumental methods included assessment of TSH and anti-TPO antibodies levels and ultrasound imaging of the thyroid gland. Results. Given TSH levels > 2.5 mU/L, the diagnosis of subclinical hypothyroidism was established in 13.1% of patients in group I and 26.4% in group II. In patients with repeated early fetal demise, the morbidity reached 48.4%. Conclusion. Hypothyroidism can be recognized as a risk factor for early fetal demise (both the first and subsequent episodes) based on the odds ratio calculation. The odds ratio was 2.48 for early fetal demise in the presence of subclinical hypothyroidism and 2.15 for repeat episodes.

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The effect of mineral supplements on resorption in the digestive tract of cattle, with special reference to Bolus alba

Agricultural and Food Science ◽

10.23986/afsci.71652 ◽

1966 ◽

Vol 38 (1) ◽

pp. 59-63

Author(s):

K. Roine ◽

T. Varvikko ◽

L. Lappalainen ◽

K. Östring

Keyword(s):

Digestive Tract ◽

Dry Matter ◽

Inorganic Phosphorus ◽

Mineral Supplements ◽

Group I ◽

Mineral Mixture ◽

The Mean ◽

Group Ii ◽

Sexually Mature

Fourteen sexually mature heads of cattle were divided into two groups; Group I receiving mineral mixture A, containing 15 % of Bolus alba, while Group II were given mixture B, containing no Bolus alba, but 10 % more Ca. Otherwise, both groups received the same feeding. Samples of blood and faeces of the animals were taken monthly for the determination of phosphorus, respectively phosphorus and carotenes. The experiment lasted one stabling period. In Group I, the mean inorganic phosphorus values of the blood were 6.7 mg/100 ml. and in Group 11, 6.1 mg/100 ml. The mean phosphorus values of the faeces were 8.8 gr/kg dry matter in Group I and in Group II, 9.3 gr/kg dry matter. The mean carotene values in Group I were 98.3 mg/kg dry matter and in Group II, 96.3 mg/kg dry matter. However, none of these differencies is statistically significant. On the basis of the present investigation it can be concluded that Bolus alba exerts no detrimental influence on the resorption of phosphorus and carotenes in the digestive tract of cattle.

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The value of melatonin supplementation in postmenopausal women with Helicobacter pylori-associated dyspepsia

10.21203/rs.3.rs-31148/v3 ◽

2020 ◽

Author(s):

Cezary Chojnacki ◽

Marta Mędrek-Socha ◽

Paulina Konrad ◽

Jan Chojnacki ◽

Aleksandra Błońska

Keyword(s):

Postmenopausal Women ◽

Epigastric Pain ◽

Duodenal Mucosa ◽

Endoscopic Examination ◽

Female Hormone ◽

Group Iii ◽

Group I ◽

Group Ii ◽

H Pylori

Abstract Background Dyspeptic syndrome is particularly common in postmenopausal women in the form of epigastric pain. The aim of the study was to assess the role of melatonin in chronic dyspepsia in this group of women, and examine the role of Helicobacter infection.Methods The study comprised 152 subjects including 30 healthy women (Group I), 60 women with asymptomatic H.pylori infection (Group II), and 64 women with H. pylori infection with chronic dyspepsia (Group III). Endoscopic examination was performed, as well as histological assessment of gastric end duodenal mucosa, urease breath test (UBT-13C), and immunoenzymatic assessment of serum 17-β-estradiol, follicle stimulating hormone and melatonin, and urinary 6-sulfatoxymelatonin. In Group III, 14-day antibacterial treatment was introduced with pantoprazole, amoxicillin and levofloxacin followed a six-month treatment with placebo in 32 women (Group IIIa), and melatonin 1 mg/morning and 3 mg/at bedtime in the other 32 women (Group IIIb).Results No significant differences were found between serum level of female hormone. Serum melatonin levels were similar between Group I (12.5 ± 2.72pg/ml) and Group II (10.5±3.73 pg/ml; p>0,05). The level was significantly lower in Group III (5.72±1.42 pg/ml; p<0.001). Eradication of H.pylori was obtained in 75.0% women in Group IIIa, and in 84.3% in Group IIIb (p>0.05). After six months, dyspeptic symptoms resolved in 43.7% patients in Group IIIa and 84.3% in Group IIIb (p<0.001).Conclusion Melatonin supplementation is useful in treating H. pylori-associated dyspepsia, particularly in postmenopausal women with lower levels of this hormone.Trial registration: NCT04352062, date of registration: 15.04.2020.

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The effectiveness of starter feeds for young Yakutian horse feeding in winter

Кормопроизводство ◽

10.25685/krm.2021.2021.3.006 ◽

2021 ◽

pp. 6-6

Author(s):

Р.В. Иванов ◽

У.В. Хомподоева ◽

И.В. Алфёров ◽

М.Н. Пак ◽

Д.Н. Шахурдин

Keyword(s):

Agricultural Research ◽

Exchange Energy ◽

Control Group ◽

Winter Period ◽

Average Weight ◽

Group I ◽

Nutrient Consumption ◽

Group Ii ◽

Almost All ◽

Young Horses

Научно-исследовательская работа по испытанию рецептуры комбикорма-стартера для молодняка лошадей проведена в научно-производственном стационаре лаборатории селекции и разведения лошадей ЯНИИСХ «Олбуордаах» в Амгинском улусе. Комбикорм-стартер для молодняка I опытной группы состоял из 30% местного овса, 31,5% сухой пивной дробины, 7% ячменя, 14% отрубей пшеничных, 8% жмыха подсолнечного, 0,3% соли кемпендяйской, 1,5% фелуцена с биотином, Se, Mg и 0,69% премикса для лошадей «Классик» в количестве 10 г на 100 кг живой массы. Для опытной группы II рецептура отличалась включением пробиотика «Сахабактисубтил» (0,01%). При потреблении 7,58–7,64 кг сухого вещества сено-овсяного рациона молодняк лошадей до 1 года испытывает дефицит практически всех основных питательных веществ, макро-, микроэлементов и витаминов, за исключением сырой клетчатки, магния и марганца. Установлено, что животные опытных групп лучше использовали питательные вещества корма. Достоверно высокие коэффициенты переваримости отмечены у опытной группы II. Молодняк опытных групп I и II превосходил аналогов контрольной группы по переваримой энергии на 5,52 и 7,85 абс.% (136,3 ± 0,17 и 136,3± 2,14 МДж), обменной энергии — на 6,81 и 9,03 абс.% (77,8 ± 1,25 и 79,7 ± 1,19 МДж) соответственно (Р ≥ 0,95). Обменность валовой энергии у молодняка опытных групп была выше на 6,14 и 8,39 абс.%, чем у аналогов контрольной группы. Полученные данные свидетельствуют о том, что дополнительное кормление молодняка комбикормом с добавлением пробиотической культуры «Сахабактисубтил» в весенне-зимний период способствовало значительному повышению уровня продуктивного использования энергии. Применение комбикормов-стартеров в зимнем кормлении молодняка до 1 года способствовало повышению среднесуточного прироста молодняка лошадей на 7 и 9% по сравнению с контролем. Восполнение недостатка железа, кобальта и йода в рационе молодняка до 1 года при зимнем стационарном кормлении способствовало сохранению упитанности животных. The experiment took place at the laboratory of Horse Breeding of the Yakut Agricultural Research Institute “Olbuordaakh”. The aim was to test the composition of starter feeds for young horses. The forage for group I contained 30% of local oats, 31.5% of dry brewer’s grains, 7% of barley, 14% of wheat bran, 8% of sunflower cake, 0.3% of Kempendyay salt, 1.5% of “Felutsen” with biotin, Se, Mg and 0.69% of horse premixture “Klassik” (10 g per 100 kg of body weight). Group II additionally consumed probiotic “Sakhabaktisubtil” (0.01%). Feeding animals of up to 1 year-old with 7.58–7.64 kg of dry matter (DM) of hay and oats led to the deficiency in almost all essential nutrients, macro-, micronutrients and vitamins except for crude fiber, magnesium and manganese. Experimental groups showed better results of nutrient consumption. Group II had significantly better digestibility indices. Groups I and II exceeded the control group in digestible energy by 5.52 and 7.85 absolute % (136.3 ± 0.17 and 136.3 ± 2.14 MJ), exchange energy — by 6.81 and 9.03 absolute % (77.8 ± 1.25 and 79.7 ± 1.19 MJ), respectively (Р ≥ 0.95). Groups I and II had higher proportion of exchange energy — by 6.14 and 8.39 absolute %. “Sakhabaktisubtil” used in the spring-winter period improved the effectiveness of energy metabolism. Starter feeds used in winter increased daily average weight gain by 7 and 9%. Providing sufficient concentrations of Fe, Co and I effectively maintained animal weight in winter.

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The value of melatonin supplementation in postmenopausal women with Helicobacter pylori-associated dyspepsia

BMC Women s Health ◽

10.1186/s12905-020-01117-z ◽

2020 ◽

Vol 20 (1) ◽

Author(s):

Cezary Chojnacki ◽

Marta Mędrek-Socha ◽

Paulina Konrad ◽

Jan Chojnacki ◽

Aleksandra Błońska

Keyword(s):

Postmenopausal Women ◽

Epigastric Pain ◽

Duodenal Mucosa ◽

Endoscopic Examination ◽

Female Hormone ◽

Group Iii ◽

Group I ◽

Group Ii ◽

H Pylori

Abstract Background Dyspeptic syndrome is particularly common in postmenopausal women in the form of epigastric pain. The aim of the study was to assess the role of melatonin in chronic dyspepsia in this group of women, and examine the role of Helicobacter infection. Methods The study comprised 152 subjects including 30 healthy women (Group I), 60 women with asymptomatic H.pylori infection (Group II), and 64 women with H. pylori infection with chronic dyspepsia (Group III). Endoscopic examination was performed, as well as histological assessment of gastric end duodenal mucosa, urease breath test (UBT-13C), and immunoenzymatic assessment of serum 17-β-estradiol, follicle stimulating hormone and melatonin, and urinary 6-sulfatoxymelatonin. In Group III, 14-day antibacterial treatment was introduced with pantoprazole, amoxicillin and levofloxacin followed a six-month treatment with placebo in 32 women (Group IIIa), and melatonin 1 mg/morning and 3 mg/at bedtime in the other 32 women (Group IIIb). Results No significant differences were found between serum level of female hormone. Serum melatonin levels were similar between Group I (12.5 ± 2.72 pg/ml) and Group II (10.5 ± 3.73 pg/ml; p > 0,05). The level was significantly lower in Group III (5.72 ± 1.42 pg/ml; p < 0.001). Eradication of H.pylori was obtained in 75.0% women in Group IIIa, and in 84.3% in Group IIIb (p > 0.05). After six months, dyspeptic symptoms resolved in 43.7% patients in Group IIIa and 84.3% in Group IIIb (p < 0.001). Conclusion Melatonin supplementation is useful in treating H. pylori-associated dyspepsia, particularly in postmenopausal women with lower levels of this hormone. Trial registration NCT04352062, date of registration: 15.04.2020.

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LOSS OF WEIGHT AND LIPID SHIFTS IN ORGANS OF THE DIGESTIVE TRACT OF TUMOR-BEARING RATS IN RELATION TO TUMOR SIZE

Canadian Journal of Biochemistry and Physiology ◽

10.1139/y60-084 ◽

1960 ◽

Vol 38 (1) ◽

pp. 673-681

Author(s):

Carl E. Boyd ◽

Eldon M. Boyd ◽

Audrey A. Deyette

Keyword(s):

Small Bowel ◽

Digestive Tract ◽

Tumor Size ◽

Dry Weight ◽

Water Levels ◽

Group Iii ◽

Group I ◽

Loss Of Weight ◽

Group Ii ◽

Pyloric Stomach

The objective of this project was to find to what extent loss of weight in the digestive tract might affect tumor size and age in albino rats bearing Walker carcinosarcoma 256. Wet weight, dry weight, and water content were measured upon tongue, esophagus, cardiac stomach, pyloric stomach, jejunum, ileum, cecum, colon, and residual carcass (minus tumor). The animals bore tumors weighing 12 ± 6 (mean ± S.D.) % of host (minus tumor) weight after 18 ± 6 days of tumor growth (group I), 38 ± 12% after 24 ± 6 days (group II), and 93 ± 26% after 29 ± 5 days (group III) and controls were twins of the same sex. There were few significant changes in the animals of group I. In group II, there was loss of dry weight in all organs except pyloric stomach, losses being percentagewise the same as in residual carcass. Loss of dry weight of jejunum and ileum was less in rats of group III than in those of group II. In group III, loss of weight in other organs tended to be less than in residual carcass. Loss of dry weight in residual carcass was not significantly greater in the animals of group III than in those of group II. Water levels were increased in all organs of rats in groups II and III. This evidence indicates that rats of group III may have lived longer after tumor implantation, lost no more carcass weight, and bore larger tumors because they had lost weight in the small bowel at a lesser rate than had the rats of group II.Further studies revealed that lipid shifts were in general less marked in organs which had lost the least weight. In animals bearing large tumors, percentage loss of neutral fat was less in most organs of the digestive tract than in the residual carcass. Increases in the levels of cholesterol and phospholipid were less in pyloric stomach and small bowel than in other organs of the digestive tract. Shifts in the amount of nonlipid dry weight and in levels of lipids and water were in general less in pyloric stomach and small bowel than in other organs of the body. In these respects, pyloric stomach and small bowel resembled brain, heart, and lung. It is suggested that resistance of pyloric stomach and small bowel to the cachectic influence of the tumor may be a factor determining tumor size and length of survival of the host.

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The ways to improve the results of the pylorus-preserving gastric resection

Klinicheskaia khirurgiia ◽

10.26779/2522-1396.2021.5-6.03 ◽

2021 ◽

Vol 88 (5-6) ◽

pp. 3-7

Author(s):

V. V. Grubnik ◽

R. P. Nikitenko ◽

A. N. Kvasha ◽

V. V. Mishchenko ◽

N. D. Parfentieva

Keyword(s):

Gastric Resection ◽

Operative Procedures ◽

Pyloric Sphincter ◽

Postgastrectomy Syndrome ◽

Conventional Procedure ◽

Group I ◽

Vascular Structures ◽

Group Ii ◽

Arteries And Veins

Objective. To enhance the results efficacy of the pylorus-preserving gastric resection. Materials and methods. Retrospective estimation of results of the pylorus-preserving gastric resection was conducted while various operative procedures application in 64 patients, ageing 34-75 yrs old. The average age of the patients was (52.5 ± 6.2) yrs old. Results. The patients were divided into two Groups. In Group I (n = 36) the pylorus-preserving gastric resection was performed in accordance to conventional procedure - without identification of infrapyloric arteries and veins as well as vagal branches, innervating pyloric sphincter. In Group II (n = 28) accurate dissection was performed, using special optic technique for preservation of all vascular structures, going to pylorus. Conclusion. The pylorus-preserving gastric resection owes several advantages, because it prevents the postgastrectomy syndrome development.

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