Evaluation of patients diagnosed with fascioliasis: A six-year experience at a university hospital in Turkey

Introduction: In this study, clinical, laboratory, radiological, and serological examinations of fascioliasis patients were analyzed, and data with a significant impact on differential diagnosis were evaluated. Methodology: Clinical, radiological, and laboratory findings and treatment responses of a total of 22 fascioliasis patients, treated between October 2009 and September 2014, were evaluated. Nineteen patients were diagnosed with fascioliasis at the invasive phase and three patients at the chronic phase. Patients were followed up for clinical, laboratory, and radiology findings for a period of three months to one year after treatment. Results: The most frequent complaints in both groups were abdominal pain, and the most common physical examination finding was epigastric tenderness. In the performed examination, an eosinophil elevation in whole blood count was detected in 19 patients (100%) in the hepatic phase, and in 2 patients (66.6%) in the biliary phase. The results of the Fasciola hepatica indirect hemagglutination assay (IHA) test ordered in the diagnosis were positive in all patients. Treatment with 10 mg/kg/day triclabendazole for two consecutive days was effective. Live parasites were extracted from patients in the biliary phase with endoscopic retrograde cholangiopancreatography. In the follow-ups, remission in IHA titer and clinical and radiological improvement was achieved in all patients. Conclusions: If hypereosinophilia is detected by peripheral smear in patients who are admitted with complaints such as abdominal pain, weakness, nausea, myalgia, and weight loss, radiological evaluation and serological tests should be performed and fascioliasis should be considered in the differential diagnosis.

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Human case of fasciolosis in Serbia treated with triclabendazole

Vojnosanitetski pregled ◽

10.2298/vsp1402202p ◽

2014 ◽

Vol 71 (2) ◽

pp. 202-206 ◽

Cited By ~ 2

Author(s):

Milorad Pavlovic ◽

Zorica Dakic ◽

Branko Milosevic ◽

Milos Korac ◽

Branko Brmbolic ◽

...

Keyword(s):

Alkaline Phosphatase ◽

Differential Diagnosis ◽

Abdominal Pain ◽

Case Report ◽

Fasciola Hepatica ◽

Human Case ◽

Tropical Diseases ◽

Quadrant Abdominal Pain ◽

Biochemical Analyses ◽

Rule Out

Introduction. The number of humans infected by Fasciola hepatica is increasing worldwide. Humans can become accidental hosts by ingesting drinking water or plants contaminated with metacercariae. Case report. We reported a case of a 68-year-old Serbian woman, in which the diagnosis of acute fasciolosis had been established after serious diagnostic concerns. Based on clinical picture (episodic right upper quadrant abdominal pain, febrility and generalized body pain) and biochemical analyses (high eosinophilia and high activity of alkaline phosphatase), she was appointed as suspected to the acute fasciolosis. Stool and duodenal aspirate exams were negative for Fasciola ova. In the absence of adequate serologic diagnostic for fasciolosis in Serbia, the diagnosis was confirmed using enzyme immunoassays and immunoblot at the Institute for Tropical Diseases in Hamburg, Germany. Soon after triclabendazole was administered, the symptoms disappeared and biochemical values returned to normal. Conclusion. The diagnosis of human fasciolosis may be problematic and delayed, especially in non endemic areas, because physicians rarely encounter this disease and a long list of other diseases must be considered in the differential diagnosis. The syndrome of eosinophilia, fever, and right upper quadrant abdominal pain suggest acute fasciolosis. Unclear source does not rule out fasciolosis.

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Etiology of Small Bowel Thickening on Computed Tomography

Canadian Journal of Gastroenterology ◽

10.1155/2012/282603 ◽

2012 ◽

Vol 26 (12) ◽

pp. 897-901 ◽

Cited By ~ 12

Author(s):

Lee Finkelstone ◽

Ellen Wolf ◽

Marjorie W Stein

Keyword(s):

Computed Tomography ◽

Differential Diagnosis ◽

Abdominal Pain ◽

Small Bowel ◽

Small Bowel Obstruction ◽

Medical Records ◽

Final Diagnosis ◽

Ct Scans ◽

Common Cause ◽

One Year

BACKGROUND: Abdominal pain is often evaluated using imaging, most often with computed tomography (CT). While CT is sensitive and specific for certain diagnoses, small bowel thickening is a nonspecific finding on CT with a broad differential diagnosis including infection, inflammation, ischemia and neoplasm.METHOD: A review of medical records of patients who underwent CT scans of the abdomen and pelvis over a one-year period and exhibited small bowel thickening were retrospectively evaluated to determine the final diagnosis.RESULTS: The etiologies of small bowel thickening on CT were as follows: infection (113 of 446 [25.34%]); reactive inflammation (69 of 446 [15.47%]); primary inflammation (62 of 446 [13.90%]); small bowel obstruction (38 of 446 [8.52%]); iatrogenic (33 of 446 [7.40%]); neoplastic (32 of 446 [7.17%]); ascites (30 of 446 [6.73%]); unknown (28 of 446 [6.28%]); ischemic (24 of 446 [5.38%]); and miscellaneous (17 of 446 [3.81%]).CONCLUSION: Infectious and inflammatory (primary or reactive) conditions were the most common cause of small bowel thickening in the present series; these data can be used to formulate a more specific differential diagnosis.

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Fasciola hepatica infection at a University Clinic in Turkey

The Journal of Infection in Developing Countries ◽

10.3855/jidc.5124 ◽

2014 ◽

Vol 8 (11) ◽

pp. 1451-1455 ◽

Cited By ~ 2

Author(s):

Burak Veli Ulger ◽

Murat Kapan ◽

Abdullah Boyuk ◽

Omer Uslukaya ◽

Abdullah Oguz ◽

...

Keyword(s):

Abdominal Pain ◽

Medical Treatment ◽

Effective Treatment ◽

Current Literature ◽

Fasciola Hepatica ◽

Clinical Laboratory ◽

Outcome Data ◽

Medical Faculty ◽

Radiological Findings ◽

Hepatica Infection

Introduction: We aimed to analyze the approaches to the diagnosis and treatment of patients with fascioliasis in light of current literature. Methodology: Thirty-nine patients with fascioliasis admitted to the Surgery Clinic of Dicle Medical Faculty (Turkey) were included in this study. The demographic, clinical, diagnostic, treatment and outcome data were analyzed retrospectively. Results: Abdominal pain (n = 37; 95%) and eosinophilia (n = 31; 79%) were the most common findings. Twenty-seven patients were diagnosed by clinical and radiological findings. Patients were treated with triclabendazole. Thirty-six (92.4%) of the patients improved after medical treatment. Conclusions: The presence of typical clinical, laboratory and radiological findings is sufficient for diagnosis. Triclabendazole administration is often an effective treatment, with improvements occurring over the course of a few months.

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Clinical behavior of Streptococcus pneumoniae meningoencephalitis

Arquivos de Neuro-Psiquiatria ◽

10.1590/s0004-282x2009000600012 ◽

2009 ◽

Vol 67 (4) ◽

pp. 1023-1028 ◽

Cited By ~ 2

Author(s):

Raisa Bu-Coifiu Fanego ◽

Alberto J. Dorta-Contreras ◽

Bárbara Padilla-Docal ◽

Martha O' Farril-Sanchez ◽

Isabel Lopez-Hernandez

Keyword(s):

Septic Shock ◽

Differential Diagnosis ◽

Streptococcus Pneumoniae ◽

Brain Edema ◽

Clinical Characteristics ◽

Pediatric Hospital ◽

Laboratory Findings ◽

Clinical Behavior ◽

One Year ◽

Vaccination Campaigns

OBJECTIVE: There was an increased number of cases of meningoencephalitis caused by Streptococcus pneumoniae, after the successful vaccination campaigns against Neisseria meningitidis and Haemophilus influenzae. This paper aims at describing the clinical characteristics, the laboratory findings, the complications, and the therapeutic management of these patients, who have been suffering from this disease since 1993 to 2006. METHOD: Twelve children with Streptococcus pneumoniae meningoencephalitis admitted to the pediatric hospital of San Miguel del Padron, City of Havana in this period were assessed. RESULTS: Children under one year are the most frequently affected. Septic shock and brain edema were the most severe complications. Three patients died, implying that this disease has a serious course. Early treatment of brain edema is very important to reduce mortality. The elective drugs for treatment of these cases of Streptococcus pneumoniae meningoencephalitis were vancomycin combined with cephalosporin, cefotaxime or ceftriaxone type. CONCLUSION: Patients with Streptococcus pneumoniae meningoencephalitis show clinical characteristics, complications, and sequels that are different to other bacterial meningoencephalitis, meaning that they could be helpful for physicians considering the differential diagnosis of meningoencephalitis.

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Part 1: Impact of Capsulectomy Type on Post-Explantation Systemic Symptom Improvement: Findings From the ASERF Systemic Symptoms in Women-Biospecimen Analysis Study

Aesthetic Surgery Journal ◽

10.1093/asj/sjab417 ◽

2021 ◽

Author(s):

Caroline Glicksman ◽

Patricia McGuire ◽

Marshall Kadin ◽

Marisa Lawrence ◽

Melinda Haws ◽

...

Keyword(s):

Clinical Laboratory ◽

Breast Implant ◽

Demographic Data ◽

Breast Implants ◽

Self Report ◽

Symptom Improvement ◽

En Bloc ◽

Laboratory Findings ◽

Systemic Symptoms ◽

One Year

Abstract Background Breast Implant Illness (BII) is a term used to describe a variety of symptoms by patients with breast implants for which there are no abnormal physical or laboratory findings to explain their symptoms. There currently exists a difference of opinion among clinicians and patients concerning the diagnosis and treatment of patients self-reporting BII. Objectives The first aim of this study was to determine if there is a valid indication for "en bloc" capsulectomy in patients self-reporting BII and if the type of capsulectomy performed alters long-term symptom improvement. The second goal was to identify any clinical laboratory differences between the cohorts. This study was funded by the Aesthetic Surgery Education and Research Foundation (ASERF). Methods A prospective blinded study enrolled 150 consecutive subjects divided equally into three cohorts: (A) women with systemic symptoms they attribute to their implants who requested implant removal, (B) women with breast implants requesting removal or exchange who do not have symptoms they attribute to their implants, and (C) women undergoing cosmetic mastopexy who have never had any implanted medical device. The subject's baseline demographic data and a systemic symptoms survey, including PROMIS ® validated questionnaires, was obtained before surgery and at 3-6 weeks, 6 months, and one year. Blood was collected from all three cohorts and implant capsules were collected from Cohorts A and B. Results 150 patients were enrolled between 2019- 2021. Follow-up at 3-6 weeks for all three cohorts was between 98-100%, 78-98% at 6-months, and one year data is currently at 80%. The type of capsulectomy; intact total, total, or partial all showed similar symptom improvement with no statistical difference in the reduction of symptoms based on the type of capsulectomy. Conclusions This study addresses one of the most discussed questions by plastic surgeons, patients, their advocates, and social media. The findings show that patients who self-report BII demonstrate a statistically significant improvement in their symptoms after explantation and that this improvement persists for at least 6 months. This improvement in self-reported systemic was seen regardless of the type of capsulectomy performed.

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Peripheral Lymphadenopathies in Childhood: Experience at a Pediatric Oncology Department in Turkey

10.38092/jpa-2020-362975 ◽

2020 ◽

pp. 66-73

Author(s):

Tuğçe Kalın Güngör ◽

Handan Uğur Dinçaslan ◽

Emel Cabi Ünal ◽

Nurdan Taçyıldız ◽

Leman Gülsan Yavuz

Keyword(s):

Differential Diagnosis ◽

Clinical Laboratory ◽

Laboratory Findings ◽

Abnormal Chest ◽

Malignant Group ◽

Chest X Ray ◽

Systemic Symptoms ◽

Reactive Hyperplasia ◽

Physical Findings ◽

Benign Group

Introduction: Palpable lymph nodes are very common physical examination findings in childhood, and sometimes it can be challenging to say if it is benign or malignant. Objectives: This retrospective study evaluated 157 children admitted to an oncology department because of lymphadenopathy and aimed to determine the clinical, laboratory, and epidemiologic data valuable for differential diagnosis. Materials and Methods: One hundred fifty-two cases were analyzed, which were defined as either malignant or benign by the etiology. The benign cases were also defined to three groups as ‘viral lymphadenopathy’, ‘bacterial lymphadenopathy’, and ‘other reactive lymphadenopathy’. Results: A specific cause for lymphadenopathy was documented in 61 (40,1%) cases. Of 152 cases, benign causes were detected in 133 (87,5%), and malignant causes were detected in 19 (12,5%) cases. The most frequent cause in the benign group was reactive hyperplasia (59,8%) and in the malignant group was lymphoma (7,3%). A biopsy was performed from 19 of the cases for diagnosis. Malign causes were detected in 12 (58%), and benign causes were detected in the remaining 7 (42%). In terms of differential diagnosis, some symptoms, physical findings, and laboratory tests showed meaningful differences between the case groups Conclusions: The following findings were determined as being important to alert physicians about the probability of a malignant disorder: location of lymphadenopathy, number of associated systemic symptoms, size of lymph node, abnormal laboratory findings, abnormal chest X-ray.

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A Case Report of Acute Acalculous Cholecystitis and Acute Hemorrhagic Cystitis due to Salmonella Typhi

Case Reports in Medicine ◽

10.1155/2014/758583 ◽

2014 ◽

Vol 2014 ◽

pp. 1-3 ◽

Cited By ~ 3

Author(s):

Hatice Beyazal Polat ◽

Mehmet Beyazal ◽

Fatma Beyazal Çeliker

Keyword(s):

Abdominal Pain ◽

Clinical Laboratory ◽

Hemorrhagic Cystitis ◽

Rare Condition ◽

Acalculous Cholecystitis ◽

Salmonella Typhi ◽

Acute Acalculous Cholecystitis ◽

Infectious Agents ◽

Laboratory Findings ◽

Underlying Diseases

Acute acalculous cholecystitis and acute hemorrhagic cystitis due to Salmonella Typhi are a rare condition. A 24-year-old female patient was admitted to our clinic with abdominal pain, nausea, fever, headache, urinary burning, and bloody urine. Based on clinical, laboratory, and radiological evaluations, the patient was diagnosed with acute acalculous cholecystitis and acute hemorrhagic cystitis due to Salmonella Typhi. The patient was treated with intravenous ceftriaxone for two weeks. After the treatment, the patient's clinical and laboratory findings improved. Acute acalculous cholecystitis due to Salmonella Typhi concomitant with acute hemorrhagic cystitis is very rare and might be difficult to diagnose. Infectious agents such as Salmonella Typhi should be considered when acute acalculous cholecystitis and acute hemorrhagic cystitis are detected in adult patients with no underlying diseases.

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Importance of complex diagnostic approach in differential diagnosis of alveolar echinococcosis

Helminthologia ◽

10.1515/helmin-2015-0047 ◽

2015 ◽

Vol 52 (4) ◽

pp. 298-302 ◽

Cited By ~ 5

Author(s):

M. Szilágyiová ◽

Ľ. Laca ◽

D. Antolová ◽

E. Nováková ◽

R. Rosoľanka ◽

...

Keyword(s):

Differential Diagnosis ◽

Cystic Echinococcosis ◽

Alveolar Echinococcosis ◽

Clinical Laboratory ◽

Molecular Techniques ◽

Positive Serology ◽

Surgical Biopsy ◽

Serological Tests ◽

Larval Stages ◽

Long Time

Summary Alveolar and cystic echinococcosis, serious parasitic diseases caused by larval stages of Echinococcus multilocularis and E. granulosus has been diagnosed in Slovakia for a long time. Study presents case of 49-years old patient with accidentally diagnosed one big (60 mm) and multiple small (2 - 24 mm) hypoechogenic structures localised in right liver lobe. According to positive serology to E. granulosus antigen and results of imaging examinations the patient was classifi ed as possible case of cystic echinococcosis and treated with mebendazole. Later, due to the worsening of clinical, laboratory and CT fi ndings surgical biopsy was performed and surgical biopsy and subsequent PCR examination of liver tissue confi rmed the diagnosis of alveolar echinococosis. Clinical picture of disease imitating cystic echinococcosis in presented case report, together with results of serological tests confi rmed importance of accurate differential diagnosis of echinococcosis. Each aspect of clinical and laboratory results should be considered responsibly, however, sometimes only molecular techniques can solve the problem of differential diagnosis.

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Spontaneous Renal Artery Dissection in a Normotensive Young Male

The Scientific World JOURNAL ◽

10.1100/tsw.2004.87 ◽

2004 ◽

Vol 4 ◽

pp. 346-349

Author(s):

John A. Taylor ◽

Eric C. Martin ◽

Ihor S. Sawczuk

Keyword(s):

Differential Diagnosis ◽

Abdominal Pain ◽

Renal Artery ◽

Fibromuscular Dysplasia ◽

Rare Event ◽

Young Male ◽

Artery Dissection ◽

Renovascular Disease ◽

One Year ◽

Superior Pole

We report a case of spontaneous superior pole renal artery dissection in a healthy forty-one year old man. Spontaneous renal artery dissection is a rare event occurring in patients with hypertension or renovascular disease such as fibromuscular dysplasia. This case demonstrates the importance of maintaining renovascular accidents as part of the differential diagnosis of abdominal pain.

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Evaluation of Subacute Thyroiditis: Frequency, Clinical Manifestation and Laboratory Findings

10.21203/rs.3.rs-460073/v1 ◽

2021 ◽

Author(s):

Marziyeh Bagheri ◽

farhad Abbasi ◽

Kamran Mirzaei ◽

Manizhe mohamadi ◽

mohammadreza kalantarhormozi

Keyword(s):

Sore Throat ◽

Clinical Laboratory ◽

Clinical Symptoms ◽

Clinical Manifestations ◽

Cross Sectional Study ◽

Subacute Thyroiditis ◽

Laboratory Findings ◽

Cross Sectional ◽

Inappropriate Treatment ◽

One Year

Abstract Introduction: Subacute thyroiditis (SAT) is a type of viral thyroiditis, which is often a self-limiting illness, but it causes diagnostic mistakes due to a number of clinical symptoms and leads to inappropriate treatment. In this study, clinical, laboratory and demographic findings of patients have been investigatedMethods: This descriptive cross-sectional study was performed on 40 patients (27 female-13 male) with subacute thyroiditis during one year. Data included age, sex, clinical symptoms (fever, sore throat, otalgia, fatigue, sweating ...) and laboratory findings. (ESR, CRP, TSH, T4 and WBC). Their files were extracted and analyzed with SPSS.Results: In this study, 67% of the patients were women with the mean age of 38.48 ± 8.7. Female to male ratio was 2.7 to 1. The most common clinical symptoms were fever (57.5%) and sore throat (55%). Laboratory findings: ESR, TSH,T4 and WBC with average of 67.32, 0.283, 15.368 and 12.456, respectively. CRP positive in 80% of patients who underwent this test. 80 percent of the patients responded to the treatment. The recurrence rate was estimated 42% and 11% for those who received NSAIDs and Prednisolone, respectivelyConclusion: In this study, SAT was most prevalent in women in their fourth decade of life. Clinical symptoms were consistent with most studies in terms of prevalence and incidence. There was no significant association between the age and sex of the patients and their clinical manifestations and laboratory results from laboratory considerations, low concentrations of TSH, high levels of ESR and positive CRP were found to be helpful in diagnosis. Prednisolone proved to be more effective in treating SAT.

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