scholarly journals Indicators of Moderate and Severe Preeclampsia in Correlation with Maternal IL10

2016 ◽  
Vol 4 (2) ◽  
pp. 236-242
Author(s):  
Ana Daneva Markova ◽  
Marija Hadži-Lega ◽  
Dragan Mijakoski

AIM: The purpose of the actual study was to evaluate the relationship between the formation of anti-inflammatory cytokine IL10 and several indicators of moderate and severe preeclampsia in the third trimester of pregnancy.MATERIAL AND METHODS: Examination of the indicators of preeclampsia and maternal IL10 levels was conducted in 50 women with pregnancies complicated by varying degrees of preeclampsia in the third trimester of gestation as well as in 50 normotensive patients, hospitalized at the University Clinic of Gynecology and Obstetrics, Skopje, Republic of Macedonia. The levels of IL10 were determined with a commercial test developed by Orgenium Laboratories (Finland), using reagents from AviBion ELISA research kits. Patients with preeclampsia were categorized into moderate and severe preeclampsia group according to the degree of preeclampsia. Logistic regression analysis was used to determine the predictive value of different parameters for the occurrence of severe preeclampsia. Odds ratios and 95% Confidence Intervals were calculated in order to quantify independent associations.RESULTS: The regression analysis detected systolic blood pressure (160 mmHg or higher), diastolic blood pressure (100 mmHg or higher), persistent proteinuria in pregnancy, serum LDH concentration (450 U/L or higher) and reduced serum concentrations of IL10 as significant predictors of severe preeclampsia in pregnant women after adjusting for age. CONCLUSION: The findings of significantly lower serum IL10 concentrations in patients with severe preeclampsia in comparison with respective concentrations in patients with moderate preeclampsia can be considered as major pathognomonic laboratory sign of severe preeclampsia.

Itinerario ◽  
2020 ◽  
Vol 44 (3) ◽  
pp. 471-473
Author(s):  
Paolo Sartori

AbstractThis thematic issue of Itinerario brings together a selection of papers presented at the international conference Beyond the Islamicate Chancery: Archives, Paperwork, and Textual Encounters across Eurasia, which was held at the Austrian Academy of Sciences in Vienna in early October 2018. The conference was the third instalment in a series of collaborations between the Institute of Iranian Studies at the Austrian Academy of Sciences and the University of Pittsburgh examining Islamicate cultures of documentation from different angles. Surviving precolonial and colonial chancery archives across Eurasia provide an unparalleled glimpse into the inner workings of connectivity across writing cultures and, especially, documentary practices. This particular meeting has attempted to situate what has traditionally been a highly technical discipline in a broader historical dialogue on the relationship between state power, the archive, and cultural encounters.


2013 ◽  
Vol 64 (2) ◽  
Author(s):  
Rosman Md. Yusoff ◽  
Faisal Khan ◽  
Asad Mubeen ◽  
Kamran Azam

The purpose of this study is to find out the empirical relationship and influence of Research Environment, Integration of the university with Industry, High-tech Employment and Professional & Managerial Development on the University Performance.A Questionnaire has been used to collect the data. Correlation and Regression analysis were used to determine the relationship and influence of identified dimensions over the University Performance.The findings of the study show that the identified dimensions significantly relate and influence the University Performance. This study would be helpful for the university administration while making policies to upgrade its performance. Less work has been done in Pakistan for the development of universities. This study distinctively identifies and represents the variables and their influence over the university performance. The findings increase the value of the study as it would help the decision makers at the universities to think ‘out of the box’.


1982 ◽  
Vol 101 (2) ◽  
pp. 273-280 ◽  
Author(s):  
E. B. Pedersen ◽  
A. B. Rasmussen ◽  
P. Johannesen ◽  
H. J. Kornerup ◽  
S. Kristensen ◽  
...  

Abstract. Plasma renin concentration (PRC), plasma aldosterone concentration (PAC), and blood pressure were determined in the third trimester in pregnancy, 5 days and 6 months after delivery in pre-eclampsia, essential and transient hypertension in pregnancy and in normotensive pregnant and non-pregnant control subjects. PRC and PAC were elevated several fold above non-pregnant level in all groups during pregnancy. In pre-eclampsia PRC and PAC were 220 and 160%, respectively, above the levels 6 months after delivery, and thus lower than the corresponding values, 360 and 402%, in normotensive pregnancy. In essential and transient hypertension PRC and PAC increased to the same degree as during normotensive pregnancy. Urinary sodium excretion, serum sodium and creatinine clearance were reduced in pre-eclampsia, but not in essential and transient hypertension when compared to normotensive pregnant controls. All the parameters determined were the same as in non-pregnant controls 6 months after delivery in all groups. There were no correlations between blood pressure and PRC or PAC in any of the groups neither in pregnancy nor after delivery. It is concluded that the renin-aldosterone system is stimulated in lesser degree in pre-eclampsia than in both essential hypertension, transient hypertension and normotensive pregnancy, and there was no evidence for a causal relationship between the renin-aldosterone system and blood pressure neither in normotensive nor hypertensive pregnancy.


2019 ◽  
Vol 6 (1) ◽  
pp. 22-27
Author(s):  
Semiha Aydın Özkan ◽  
Gülay Rathfisch ◽  
Özlem Karabulut ◽  
Türkan Karaca

2020 ◽  
Vol 2020 ◽  
pp. 1-5
Author(s):  
Shiho Nagayama ◽  
Hironori Takahashi ◽  
Shohei Tozawa ◽  
Risa Narumi ◽  
Rie Usui ◽  
...  

An interstitial pregnancy that continues beyond the second trimester is a rare phenomenon. We report a patient with an interstitial pregnancy undiagnosed until the third trimester. A multiparous woman was referred to us because of preeclampsia at 26 weeks of gestation. The placental position was the right fundus, and color Doppler ultrasound revealed myometrial thinning and subplacental hypervascularity, leading to a suspicion of placenta accreta spectrum (PAS). Emergency cesarean section was performed at 281/7 weeks of gestation due to severe preeclampsia. The right tubal horn to the isthmus of the fallopian tube bulged with placental adhesion and a part of the tube had ruptured, with the omentum adhering to the ruptured part. Interstitial and tubal isthmic pregnancy with uterine rupture was diagnosed.


2019 ◽  
Vol 28 (5) ◽  
pp. 345-355 ◽  
Author(s):  
Kimie Okada ◽  
Izumi Saito ◽  
Chihiro Katada ◽  
Takeshi Tsujino

Author(s):  
Rachel J. Skow ◽  
Andrew R. Steele ◽  
Graham M. Fraser ◽  
Margie H. Davenport ◽  
Craig D. Steinback

Isometric handgrip (IHG) is used to assess sympathetic nervous system responses to exercise and may be useful at predicting hypertension in both pregnant and non-pregnant populations. We have previously observed altered sympathetic nervous system control of blood pressure in late pregnancy. Therefore, we measured muscle sympathetic nerve activity (MSNA) and blood pressure during muscle metaboreflex activation (IHG) in normotensive pregnant women in the third trimester compared to healthy non-pregnant women. Nineteen pregnant (32±3wks gestation) and fourteen non-pregnant women were matched for age, non/pre-pregnant BMI, and parity. MSNA (microneurography), heart rate (ECG), and arterial blood pressure (Finometer) were continuously recorded during ten minutes of rest, and then during two-minutes of IHG at 30% of maximal voluntary contraction, and two-minutes of post-exercise circulatory occlusion (PECO). Baseline SNA was elevated in pregnant (41±11 bursts/min) compared to non-pregnant women (27 ± 9 bursts/minute; p=0.005); however, the sympathetic baroreflex gain and neurovascular transduction were not different between groups (p=0.62 and p=0.32, respectively). During IHG and PECO there was no significant differences in the pressor response (∆MAP) during IHG and PECO was not different between groups (p=0.25, main effect of group) nor the sympathetic response (interaction effect: p=0.16, 0.25, and 0.27 for burst frequency, burst incidence, and total SNA respectively). These data suggest that pregnant women who have maintained sympathetic baroreflex and neurovascular transduction also have similar sympathetic and pressor responses during exercise.


2019 ◽  
Vol 9 (1) ◽  
Author(s):  
Diane Farrar ◽  
Gillian Santorelli ◽  
Debbie A. Lawlor ◽  
Derek Tuffnell ◽  
Trevor A. Sheldon ◽  
...  

Abstract The incidence of gestational hypertension (GH) and pre-eclampsia (PE) is increasing. Use of blood pressure (BP) change patterns may improve early detection of BP abnormalities. We used Linear spline random-effects models to estimate BP patterns across pregnancy for white British and Pakistani women. Pakistani women compared to white British women had lower BP during the first two trimesters of pregnancy, irrespective of the development of GH or PE or presence of a risk factor. Pakistani compared to white British women with GH and PE showed steeper BP increases towards the end of pregnancy. Pakistani women were half as likely to develop GH, but as likely to develop PE than white British women. To conclude; BP trajectories differ by ethnicity. Because GH developed evenly from 20 weeks gestation, and PE occurred more commonly after 36 weeks in both ethnic groups, the lower BP up to the third trimester in Pakistani women resulted in a lower GH rate, whereas PE rates, influenced by the steep third trimester BP increase were similar. Criteria for diagnosing GH and PE may benefit from considering ethnic differences in BP change across pregnancy.


2011 ◽  
Vol 32 (2) ◽  
Author(s):  
Wolfgang Huber

Violent religious extremism is seen as one of the mega-problems of the 21st century. This article � based on a key lecture at the conference on �Violence in a democratic South Africa� at the University of Pretoria and the David de Villiers memorial lecture at the University of Stellenbosch, both held during August 2010 � critically discussed the interaction between religion and violence in our present-day, globalised world. Three different propositions on the relationship between religion and violence were scrutinised. In countering the proposition that religion, or more specifically monotheism, necessarily leads to violence, it was argued that violence is not an inherent, but rather an acquired or even an ascribed quality of religion. The second proposition that religion leads to non-violence was affirmed to the extent that religions do provide a strong impulse to overcome violence. However, they also tend to accept violence as an inevitable part of reality and even justify the use of violence on religious grounds. The third proposition was regarded as the most convincing, for it argues that the link between religion and violence is contingent. Some situations do seem to make the use of violence inevitable; however, religions should refrain from justifying the use of violence and maintain a preferential option for nonviolence.


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