Clinical Behaviour and Marginal Sealing of Bulk-Fill Resin Composite Restorations Using Light Amplified High-Intensity LEDs Curing: A Randomized Controlled Clinical Trial

BACKGROUND: Delivering sufficient intensity output of curing lights is mandatory to ensure optimum cure and clinical success of bulk-fill resin composite restorations and to avoid undesirable clinical outcomes. AIM: To evaluate the effectiveness of using light amplified high intensity LED curing on the clinical performance and marginal sealing of posterior bulk-fill resin composite restorations. MATERIAL AND METHODS: This study was designed as a randomised, controlled, double-blind, Unicenter, parallel, two arms, superiority trial with 1:1 allocation ratio. Adult patients who required posterior tooth-coloured restorations were asked to participate in this trial. All participants signed written informed consent after being completely aware of the settings of the study. The participants who fulfilled the eligibility criteria were divided into two groups according to the type of light curing mode used. Adhesive compound proximal cavities were prepared. All restorative materials were applied according to the respective manufacturer’s instructions. Assessments of the restorations were done at baseline (one week after placement of the restoration), after 6 months and after 12 months using the modified US Public Health Service (USPHS) criteria. For quantitative assessment of the marginal sealing, resin replicas were analysed using scanning electron microscopy. Statistical analysis was done using Chi-square, Mann Whitney, independent t-test and dependent t-tests. RESULTS: There were no statistical differences between the two groups for the tested clinical parameters along the study periods. For marginal analysis, there were no statistical differences between the intervention and control group at baseline and six months (p-value = 0.347 and 0.516) respectively. At 12 months the control group showed statistically significant higher percentages (p-value = 0.031). CONCLUSION: Light amplified high-intensity curing units have clinical performance comparable with the conventional LED.

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Does Benzocaine Toothpaste Have More Pain-Relieving Effect Compared To Placebo Toothpaste In Orthodontic Patients? A Double-Blind Randomized Controlled Trial

10.21203/rs.3.rs-866567/v1 ◽

2021 ◽

Author(s):

Ladan Eslamian ◽

Sepideh Soheilifar ◽

Sanaz Soheilifar ◽

Seyed Alireza Mortazavi

Keyword(s):

Orthodontic Treatment ◽

Controlled Trial ◽

Repeated Measure ◽

Control Group ◽

P Value ◽

Eligibility Criteria ◽

Double Blind ◽

Important Challenge ◽

Frequent Consumption ◽

And Control

Abstract Background: Pain management in fixed orthodontic treatment is an important challenge. None of the present methods has been successful in pain relief. The objective of this double-blind cross-over trial was to compare the effect of benzocaine-contained toothpaste and placebo toothpaste on relieving pain caused by fixed orthodontic treatment.Methods and material:Patients undergoing fixed orthodontic treatment at Shahid Beheshti University of Medical Sciences with experience of pain in previous appointment were randomly assigned into 3 groups of 5% benzocaine-contained toothpaste, placebo toothpaste and control group. Eligibility criteria included being in leveling and alignment stage, 6-8 mm space deficiency, no acute or chronic pain or frequent consumption of analgesic drugs. Patients were instructed to use toothpastes 3 times in a day. Main outcome was pain experienced by patients according to Visual Analogue Scale at 8 different time intervals in 7 days. Randomization was done with random numbers in opaque envelopes for sequence of appointments. Blinding was applicable for patients, operator and outcome assessor. Data analysis was done with repeated measure ANOVA for assessing overall effect and Bonferroni for pairwise analysis. P value was assigned to be 0.05.Results: From 33 patients who participated in the study, 27 patients (23 females and 4 males) completed the study. Each patient was randomly allocated to all 3 groups in cross-over design. Mean pain in benzocaine group was less than the placebo and control group (28.63± 25.43, 31.31± 22.09 and 31.20 ± 24.09, respectively). Benzocaine toothpaste group experienced statistically significantly less pain than the other two groups at 2 hours (P˂ 0.015). No adverse event was observed in patients.Conclusion:Benzocaine contained toothpaste can decrease pain perceived at first hours after orthodontic appointment. Registration and protocol: This trial was registered in Iranian Registry of Clinical Trials (IRCT2015010120523N1) at 16/04/2015.

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Effect of Refurbishing Amalgam and Resin Composite Restorations After 12 Years: Controlled Clinical Trial

Operative Dentistry ◽

10.2341/16-267-cr ◽

2017 ◽

Vol 42 (6) ◽

pp. 587-595 ◽

Cited By ~ 4

Author(s):

J Estay ◽

J Martín ◽

P Vildosola ◽

IA Mjor ◽

OB Oliveira ◽

...

Keyword(s):

Resin Composite ◽

Control Group ◽

Controlled Clinical Trial ◽

Initial State ◽

Composite Restorations ◽

Localized Defects ◽

Group A ◽

Usphs Criteria ◽

Group B

SUMMARY Objectives: The aim of this study was to clinically evaluate posterior amalgam and resin composite restorations refurbished over a period of 12 years by investigating the influence of refurbishing on the survival of restorations and comparing their behaviors with respect to controls. Methods and Materials: Thirty-four patients were enrolled, ages 18 to 80 years, with 174 restorations, 48 restorations of resin composite (RC), and 126 restorations of amalgam (AM). Restorations with localized defects in anatomy, roughness, luster, or marginal staining that were clinically judged as suitable for refurbishing according to US Public Health Service (USPHS) Ryge criteria were assigned to group A—refurbishing (n=85; 67 AM, 18 RC)—or group B—control (n=89; 59 AM, 30 RC); the quality of the restorations was evaluated blindly according to the modified USPHS criteria. Two observers conducted evaluations at the initial state (k=0.74) and after one to five, 10, and 12 years (k=0.88). Wilcoxon, Friedman, and Mantel-Cox tests were performed to compare the groups, respectively. Results: After 12 years, both groups experienced a similar decline, except for an evidently better performance in marginal adaptation in RC control (p=0.043) and in anatomy in AM refurbished (p=0.032). Conclusions: After 12 years, no difference was found in the clinical condition and longevity of the refurbished restorations compared to the control group.

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Comparison of the Effect of 0.2% Chlorhexidine Mouthwash and Persica Mouthwash on the Color of Resin Composite

Journal of Isfahan Dental School ◽

10.18502/ijds.v17i1.5917 ◽

2021 ◽

Author(s):

Fatemeh Ebrahimzadeh ◽

Hooman Fakhar ◽

Hosein Akbari ◽

Ramin Mosharraf ◽

Azin Farzad

Keyword(s):

Resin Composite ◽

Control Group ◽

P Value ◽

Patient Dissatisfaction ◽

Composite Restorations ◽

School Of Dentistry ◽

Initial Color ◽

Group B ◽

And Control

Introduction: Discoloration of resin composite restorations can lead to patient dissatisfaction. 0.2% Chlorhexidine and Persica mouthwashes are among the agents that cause discoloration. The aim of this study was to investigate the degree of discoloration caused by the 0.2% Chlorhexidine and Persica mouthwashes on resin composite samples. Materials and Methods: This in-vitro experimental study was conducted in Kashan and Isfahan School of Dentistry in 2020-2021. Number of 30 disc-shaped samples were fabricated from Charisma Diamond resin composite. The initial color of samples was measured by CIE Lab system in spectrophotometer. Then samples were divided into 3 groups (A, B, and C) (n = 10).The control group (A) was placed in distilled water, group B was immersed in the 0.2% Chlorhexidine mouthwash and group C was immersed in the Persica mouthwash. The color of the samples was measured again afterwards. Data were analyzed with One-way ANOVA and t-Test (α = 0.05). Results: The amount of l, a, b and ΔE after using 0.2% Chlorhexidine and Persica mouthwashes increased. The mean of Δl, Δa, Δb and ΔE showed significant differences between groups (p value < 0.05). Conclusion: The discoloration of Persica mouthwash was more than 0.2% Chlorhexidine mouthwash and control group. Therefore, for patients with resin composite restorations, 0.2% Chlorhexidine mouthwash is better.

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Could Anise decrease the intensity of premenstrual syndrome symptoms in comparison to placebo? A double-blind randomized clinical trial

Journal of Complementary and Integrative Medicine ◽

10.1515/jcim-2019-0077 ◽

2020 ◽

Vol 0 (0) ◽

Author(s):

Maryam Farahmand ◽

Davood Khalili ◽

Fahimeh Ramezani Tehrani ◽

Gholamreza Amin ◽

Reza Negarandeh

Keyword(s):

College Students ◽

Clinical Trial ◽

Premenstrual Syndrome ◽

Intervention Group ◽

Study Groups ◽

Control Group ◽

Controlled Clinical Trial ◽

P Value ◽

Double Blind ◽

High Prevalence

AbstractBackgroundPremenstrual syndrome (PMS) has a high prevalence among women of reproductive ages but despite its high prevalence, it has no determined and absolute treatment, so far. So, the aim of the present study was to compare the effect Pimpinella Anisum (Anise) with placebo on the intensity of the symptoms of PMS.MethodsThe present study was a randomized double-blind controlled clinical trial. College students who were suffering from PMS and had the inclusion criteria were selected and randomly assigned into two groups of intervention (Anise) and control (placebo). Participants in the intervention group, received 110 mg capsules of Anise three times day (a total dose of 330 mg per day); the control group received similar capsules with the same dosing that contained starch. Consumption of the capsules was started 7 days before the start of the menstruation and continued until 3 days after, which was a total of 10 days during two consecutive menstruation cycles. The intensity of the symptoms of premenstrual syndrome was measured using Premenstrual Symptoms Screening Tool (PSST). To compare the intensity of the symptoms between the two study groups, generalized estimating equation statistical method was used.ResultsEventually, sixty-seven 18–35 year old college students who were suffering from premenstrual syndrome were enrolled in the study. Comparing the mean score of the intensity of the syndrome between the two groups after the first and the second menstruation cycles showed a decrease in the intervention group to 13.9 (p-value<0.001; 95% CI: 16.5,−11.4) and 9.8 (p-value<0.001; 95% CI: 12.4,−7.3), respectively.ConclusionResults of the study showed that, in general, Anise was effective in decreasing the symptoms of premenstrual syndrome in comparison to placebo.

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Efficacy and safety of oral hydroxyurea in transfusion-dependent β-thalassaemia: a protocol for randomised double-blind controlled clinical trial

BMJ Open ◽

10.1136/bmjopen-2020-041958 ◽

2020 ◽

Vol 10 (10) ◽

pp. e041958

Author(s):

Nirmani Yasara ◽

Nethmi Wickramarathne ◽

Chamila Mettananda ◽

Aresha Manamperi ◽

Anuja Premawardhena ◽

...

Keyword(s):

Clinical Trial ◽

Sri Lanka ◽

Intervention Group ◽

Primary Outcome Measure ◽

Control Group ◽

Controlled Clinical Trial ◽

Efficacy And Safety ◽

Scientific Publications ◽

Double Blind ◽

Fetal Haemoglobin

IntroductionDespite being one of the first diseases to be genetically characterised, β-thalassaemia remains a disorder without a cure in a majority of patients. Most patients with β-thalassaemia receive only supportive treatment and therefore have a poor quality of life and shorter life spans. Hydroxyurea, which has shown to induce fetal haemoglobin synthesis in human erythroid cells, is currently recommended for the treatment of sickle cell disease. However, its clinical usefulness in transfusion-dependent β-thalassaemia is unclear. Here, we present a protocol for a randomised double-blind controlled clinical trial to evaluate the efficacy and safety of oral hydroxyurea in transfusion-dependent β-thalassaemia.Methods and analysisThis single-centre randomised double-blind placebo-controlled clinical trial is conducted at the Thalassaemia Centre of Colombo North Teaching Hospital, Ragama, Sri Lanka. Adult and adolescent patients with haematologically and genetically confirmed transfusion-dependent β-thalassaemia are enrolled and randomised into the intervention or control group. The intervention group receives oral hydroxyurea 10–20 mg/kg daily for 6 months, while the control group receives a placebo which is identical in size, shape and colour to hydroxyurea without its active ingredient. Transfused blood volume, pretransfusion haemoglobin level, fetal haemoglobin percentage and adverse effects of treatment are monitored during treatment and 6 months post-treatment. Cessation or reduction of blood transfusions during the treatment period will be the primary outcome measure. The statistical analysis will be based on intention to treat.Ethics and disseminationEthical approval has been obtained from the Ethics Committee of Faculty of Medicine, University of Kelaniya (P/116/05/2018) and the trial is approved by the National Medicinal Regulatory Authority of Sri Lanka. Results of the trial will be disseminated in scientific publications in reputed journals.Trial registration numberSLCTR/2018/024; Pre-results.

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Effect of high dose statin preloading on TIMI flow in patients presenting with ST-Elevation Myocardial Infarction undergoing Primary Percutaneous Coronary Intervention

QJM ◽

10.1093/qjmed/hcab090.014 ◽

2021 ◽

Vol 114 (Supplement_1) ◽

Author(s):

K Eletriby ◽

A Desoky ◽

N Shawky ◽

A Farag

Keyword(s):

Myocardial Infarction ◽

High Intensity ◽

Coronary Intervention ◽

Control Group ◽

P Value ◽

Primary Pci ◽

Timi Flow ◽

St Segment ◽

Percutaneous Coronary ◽

St Elevation

Abstract Aim and objectives The aim of this study was to assess the impact of high intensity statins used prior to primary PCI in patients presenting with acute STEMI (ST-elevation Myocardial Infarction) on myocardial perfusion and in-hospital MACE (major adverse cardiac events). Patients and Methods The study included 170 patients who presented with acute STEMI to the cardiology department of Ain Shams university hospitals and underwent primary PCI (percutaneous coronary intervention). They were divided into two groups where the first group received high intensity statins (40-80mg of atorvastatin or 20-40mg of rosuvastatin) besides guideline recommended therapy before primary PCI and the 2nd group served as a control group and received guideline recommended therapy, and high intensity statins after going back to the coronary care unit after primary PCI. Post interventional thrombolysis in myocardial infarction (TIMI) flow grade and myocardial blush grade (MBG) were recorded and ST-segment resolution was measured. Results The majority of patients in both groups had the LAD as the culprit vessel for their presentation. In the control group there were 4 patients with TIMI I flow and MBG I, 13 with TIMI II flow and MBG II and 68 with TIMI III flow and MBG III. Meanwhile in the cases group there was 1 patient with TIMI I flow and MBG I, 3 with TIMI II flow and MBG II and 81 with TIMI III flow and MBG III. This difference was statistically significant with a P value of 0.010. There were 34 patients in the cases group who showed complete ST-segment resolution (40%) vs 19 patients (22.4%) in the control group which was statistically significant with a P value of 0.013. In addition, ejection fraction measured by M-mode had values of Mean+-SD of 45.91 ± 5.49 in cases group vs 43.01 ± 8.80 in control group which was statistically significant with a P value of 0.011. There was not a statistically significant difference between the two groups regarding in-hospital death of all causes and stroke after primary PCI. Conclusion High intensity statin loading before primary PCI resulted in improved post-procedural TIMI flow, MBG, complete ST-segment resolution and ejection fraction as measured by M-mode but did not decrease incidence of in-hospital MACE.

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Curcumin nanomicelle versus curcumin improves lipid profile, stress oxidative factors and inflammatory markers in patients undergoing coronary elective angioplasty; A Randomized Clinical Trial

10.21203/rs.2.18679/v1 ◽

2019 ◽

Author(s):

Bijan Helli ◽

Hadis Gerami ◽

Maria Kavianpour ◽

Habib Heybar ◽

Seyed Kianoosh Hosseini ◽

...

Keyword(s):

Clinical Trial ◽

Lipid Profile ◽

Inflammatory Markers ◽

Interleukin 1 ◽

Stress Index ◽

Inflammatory Factors ◽

Control Group ◽

Controlled Clinical Trial ◽

Double Blind ◽

Stress Oxidative

Abstract Background: Curcumin exhibited antioxidant and anti-inflammatory effects. The aim of this study, assess and compare curcumin and nano- curcumin effects on lipid profile, oxidative stress index and inflammatory factors of heart patients.Methods: This Randomized, Double-Blind, Placebo-Controlled Clinical Trial conducted on 90 patients undergoing coronary elective angioplasty. Patients were randomly divided into 3 groups. The first group received a 500 mg capsule of curcumin daily. The second group received an 80 mg capsule of nano- curcumin daily. The placebo group also received capsules similar to curcumin for 8 weeks. Lipid profile, stress oxidative factors and inflammatory markers measured in baseline and end of the investigation.Results: At the end of study, statistically significant changes was seen in the total cholesterol (TC), triglyceride (TG) and low density lipoprotein (LDL) in the intervention groups to the control group (p<0.05). These changes in the nano-curcumin group were greater than the curcumin group. Curcumin and nano-curcumin supplementation also caused a statistically significant improvement in plasma levels of total antioxidant capacity (TAC), malondialdehyde (MDA), Superoxide dismutase (SOD), glutathione peroxidase (GSH-Px), high-sensitivity C-reactive protein (hs-CRP), Interleukin 1 beta (IL-1β) and tumor necrosis factor alpha (TNF-α) in comparison to the placebo (p<0.05).Conclusion: Complementary therapy of cardiovascular patients with curcumin and nano-curcumin supplements, could improve lipid profile, stress oxidative index and, inflammatory factors. The effects of curcumin on nano formula may be better for cardiac patients due to high bioavailability. However, further investigation is suggested in this regard.

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Efficacy and Safety of Ejiao (Asini Corii Colla) in Women With Blood Deficient Symptoms: A Randomized, Double-Blind, and Placebo-Controlled Clinical Trial

Frontiers in Pharmacology ◽

10.3389/fphar.2021.718154 ◽

2021 ◽

Vol 12 ◽

Author(s):

Li Zhang ◽

Zhongju Xu ◽

Tao Jiang ◽

Jialu Zhang ◽

Pinxian Huang ◽

...

Keyword(s):

Chinese Medicine ◽

Traditional Chinese Medicine ◽

Blood Cell ◽

Control Group ◽

Placebo Control ◽

Controlled Clinical Trial ◽

Efficacy And Safety ◽

Double Blind ◽

Placebo Control Group ◽

Sf 36

Equus asinus L [Equidae; Asini Corii Colla] (donkey-hide gelatin, Ejiao), a well-known traditional Chinese medicine, has been widely used to nourish the blood, especially for women. The aim of this study was to assess the efficacy and safety of Ejiao in blood-deficient patients. A total of 210 participants were recruited and randomly allocated into the placebo control group and Ejiao-treated group (6 g/day). The primary outcomes on the efficacy of Ejiao included traditional Chinese medicine symptom scores, blood indicators, and SF-36. The secondary outcomes were changes in fireness and safety evaluation. Results showed that Ejiao treatment for 8 weeks had significantly improved dizziness symptoms. Among the tested 24 blood biochemical parameters, the hematocrit and red blood cell numbers decreased in the placebo control group, but decreased significantly less in the Ejiao treatment group. The white blood cell and neutrophil counts increased in the Ejiao group but were within the normal range. In addition, the quality of life improved as the scores in SF-36 domains were significantly higher in the Ejiao group. At the same time, there was no significant change in the fire–heat symptoms score or other safety parameters. Considering all these, our study showed that Ejiao has a promising effect in women suffering from blood deficiency without obvious adverse effects.

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Effect of Probiotics on Allergic Rhinitis: A Randomized, Controlled, Clinical Trial

Galen Medical Journal ◽

10.31661/gmj.v9i0.1918 ◽

2020 ◽

Vol 9 ◽

pp. 1918 ◽

Cited By ~ 1

Author(s):

Mahnaz Sadeghi-Shabestari ◽

Yalda Jabbari Moghaddam ◽

Hasan Rezapoor ◽

Mojataba Sohrabpour

Keyword(s):

Clinical Trial ◽

Allergic Rhinitis ◽

Standard Therapy ◽

Control Group ◽

Controlled Clinical Trial ◽

P Value ◽

Nasal Discharge ◽

Oral Corticosteroids ◽

And Control

Background: Allergic rhinitis (AR) is one of the most common diseases in the world and affects about 10-50% of the general population. Probiotics are live microorganisms that help the normal state of the intestine, and if prescribed correctly, they can stimulate the mucosal immune system to prevent inflammatory symptoms of allergy and atopy. The present study aims to investigate the role of probiotics in the treatment of AR when added to standard therapy as adjuvant agents. Materials and Methods: In this clinical trial study, 28 patients older than 15 years with AR randomly divided into probiotics and control groups. The probiotics group received standard therapy for AR accompanied by probiotic capsules every 12 hours for eight weeks, whereas the control group received standard therapy for AR with placebo capsules as the same protocol. Data were analyzed using SPSS Version 23 (IBM Corporation, Armonk, NY, USA) and, the P-value less than 0.05 was considered statistically significant. Results: In the probiotics group, 14.3% of patients had sneezing at the baseline, which significantly decreased to 4.6% (P<0.01). Also, the necessity for nasal and oral corticosteroids after treatment with probiotics in the probiotics group was less than the control group (P<0.01). Although cough, nasal discharge, conchae hypertrophy, and night sleep disorders reduced after treatment with probiotics, this reduction was not statistically significant between the two groups. Conclusion: Based on the results of this clinical trial, the use of probiotics had no significant effect on the outcome of patients with AR. [GMJ.2020;9:e1918]

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Effect of Diode Laser (810 nm) Irradiation on Marginal Microleakage of Multi-mode Adhesive Resins in Class V Composite Restorations

Journal of lasers in medical sciences ◽

10.15171/jlms.2019.45 ◽

2019 ◽

Vol 10 (4) ◽

pp. 275-282

Author(s):

Niusha Golbar ◽

Shahin Kasraei ◽

Anahit Afrasiabi ◽

Elahe Mostajir ◽

Seyed Masoud Mojahedi

Keyword(s):

Diode Laser ◽

Resin Composite ◽

Control Group ◽

Blue Dye ◽

Adhesive Systems ◽

Universal Adhesive ◽

Class V ◽

Composite Restorations ◽

Self Etch ◽

Multi Mode

Introduction: Some studies have shown that laser irradiation on unpolymerized adhesives can improve composite-dentin adhesion. The aim of the present study was to evaluate the effect of the diode laser (810 nm) on the microleakage of multi-mode adhesive systems at enamel and dentin margins of composite restorations. Methods: Classic class V boxes were prepared on 48 sound premolar teeth and randomly divided into 6 groups (n=16). In the control groups, Scotchbond Universal (SBC), G-Premio (GBC), and Ambar U (AMC) were used by a self-etch mode. In the test groups (SBL, GBL, ABL), the 810 nm diode laser was irradiated (1 W) for 10 seconds before the polymerization of the adhesive. The boxes were restored by the resin composite. After finishing and polishing, the samples were thermocycled (5°C to 55°C) for 1000 cycles and then immersed in 0.1% methylene blue dye (48 hours). Dye penetration through the gingival and occlusal margins was measured by Stereomicroscope. The data were analyzed at the 5% significance level using Kruskal-Wallis and Mann-Whitney U tests. Results: Significant differences were found between the control and test groups (P<0.05). The occlusal margins of the SBL and GBL groups and the cervical margin of the SBL group exhibited the lowest microleakage (P<0.05). The AM control group showed maximum microleakage at cervical and occlusal margins. Conclusion: The irradiation of the 810 nm diode laser on the unpolymerized universal adhesive systems in a self-etch mode caused a significant reduction in enamel and dentin marginal microleakage of composite restorations.

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