scholarly journals The Study of the Wound Healing Activity of the Gel with a Comprehensive Therapeutic Effect

2019 ◽  
Vol 7 (6) ◽  
pp. 908-912
Author(s):  
Liliana Lyubanovna Brkich ◽  
Andrey Anatolievich Nedorubov ◽  
Natalia Valeryevna Pyatigorskaya ◽  
Galina Eduardovna Brkich ◽  
Elena Sergeevna Odintsova
Keyword(s):  
Wound Healing ◽  
Therapeutic Effect ◽  
Specific Activity ◽  
Therapeutic Action ◽  
Infected Wound ◽  
Reference Drug ◽  
Acrylic Polymers ◽  
Infected Wounds ◽  
Derivatives Of ◽  
Wound Healing Activity

AIM: The study was aimed at researching the specific wound healing activity of the drug with a comprehensive therapeutic effect based on derivatives of glucosamine and acrylic polymers to treat the infected wounds of various origins on a model of a planar infected wound. METHODS: The model of septic wounds in rats as per the method of P.I. Tolstykh was used during the study of the specific activity of the drug with a comprehensive therapeutic effect based on derivatives of glucosamine and acrylic polymers for the treatment of infected wounds. The infection was performed with the S. aureus and E. coli strains. The study lasted 18 days, and during this period no full scarring occurred. The wound diameter was chosen as the effectiveness criterion. The planimetric method was used to assess the course of the wound process in experimental animals. RESULTS: The obtained data prove the specific action of the drug with a comprehensive therapeutic action based on derivatives of glucosamine and acrylic polymers to treat the infected wounds of various origins. The study has shown that bacterially infected wounds healed worse than noninfected ones. Both types of wounds — infected and uninfected ones — healed faster when applying the test drug or Levomekol ointment. CONCLUSION: On the model of a planar infected wound, the developed drug with a comprehensive therapeutic action has shown better wound healing effect compared with the Levomekol reference drug.

scholarly journals Study of wound-healing activity of sodium 2-(adamantane-1-yl)-2-hydrazino-5-phenyl-4-oxobutanoate

2021 ◽  
Vol 38 (6) ◽  
pp. 69-73
Author(s):  
Alexander S. Kuznetsov ◽  
Natalya A. Pulina ◽  
Svetlana V. Chashchina
Keyword(s):  
Wound Healing ◽  
Sodium Alginate ◽  
Dosage Form ◽  
Practical Application ◽  
Chemical Methods ◽  
Reference Drug ◽  
Pharmaceutical Substance ◽  
White Rats ◽  
Complex Wound ◽  
Wound Healing Activity

Objective. To study a wound-healing activity of the earlier synthesized compound-leader sodium 2- (adamantan-1-yl)-2-hydrazino-5-phenyl-4-oxobutenoate (1), as well as to establish the possibility of its practical application in the ointment dosage form. Materials and methods. The substance-leader 1 was synthesized by the chemical methods described earlier. The experimental 5 % ointment composition based on an aqueous solution of sodium alginate was developed in compliance with the rules for preparing homogeneous ointments. Its effect on the healing of linear aseptic skin wounds in white rats was studied by the method of wound-tensiometry. Results. The experimental 5 % ointment composition with compound 1 was found to significantly increase the scar tensile strength compared to control without treatment. The developed model ointment showed wound-healing activity comparable to that of the reference drug (Levomekol ointment). Conclusions. The selected substance-leader 1 in the composition of a model 5 % hydrophilic ointment based on sodium alginate exhibits pronounced biological activity and is a candidate for further research as a potential pharmaceutical substance with complex wound-healing and anti-inflammatory property.

scholarly journals Перспективи використання методики лікування інфікованих ран за допомогою личинок падальних мух родини Calliphoridae

2012 ◽  
Vol 3 (1) ◽  
pp. 162-166 ◽  
Author(s):  
L. I. Faly
Keyword(s):  
Wound Healing ◽  
Quality Standards ◽  
Treatment Method ◽  
Therapeutic Action ◽  
Infected Wound ◽  
The Family ◽  
Medicinal Properties

Complex assessment of possibilities of infected wound healing with a help of screwworms of blowfly of the family Calliphoridae in the hospitals of Ukraineis offered. On the basis of available data the mechanism of therapeutic action is shown, and the medicinal properties of substances containing in the secretions and excretions of the blowfly screwworms are described. The gist of the treatment method and traits of the blowfly cultivation in a laboratory are highlighted. The quality standards for specialized biological laboratories are presented. The proposed wound healing method is proved as promising.

scholarly journals Phytochemical Profile, Safety Assessment and Wound Healing Activity of Artemisia absinthium L.

Plants ◽  
2020 ◽  
Vol 9 (12) ◽  
pp. 1744
Author(s):  
Amel Boudjelal ◽  
Antonella Smeriglio ◽  
Giovanna Ginestra ◽  
Marcella Denaro ◽  
Domenico Trombetta
Keyword(s):  
Wound Healing ◽  
Antibacterial Activity ◽  
Methanol Extract ◽  
In Vivo Studies ◽  
Oral Toxicity ◽  
Artemisia Absinthium ◽  
Traditional Use ◽  
Reference Drug ◽  
Wound Healing Activity

The aim of study was to validate, by in vitro and in vivo studies, the traditional use for wound-healing activity of Artemisia absinthium L. Reversed-phase liquid chromatography coupled with diode array detection and electrospray ion trap mass spectrometry (RP-LC-DAD-ESI-MS) analysis allowed to identify eleven polyphenols with chlorogenic acid as the most abundant compound (3.75 g/100 g of dry extract). After that, antibacterial activity as well as acute dermal and oral toxicity were assessed in animal models. In order to investigate the wound-healing activity of A. absinthium methanol extract, two ointments were formulated (MEO 5% and 10%). The ointment with the highest concentration of plant extract (10%) showed a statistically significant effect on the rats wound contraction, similar to that exerted by the reference drug Cicatryl-Bio. Moreover, A. absinthium methanol extract showed the best antibacterial activity against the Gram-negative Escherichia coli ATCC 10536 (MIC 1.25–2.5 mg/mL) and the Gram-positive Staphylococcus aureus ATCC 6538 (0.31–0.625 mg/mL). The absence of oral and topical toxicity of the treated animals allowed to establish the safety of the ointments. Overall, data collected in the present study support and validate the use of A. absinthium as a wound healing agent in the Algerian traditional medicine.

scholarly journals Assessment of Wound Healing Activity of the Aqueous Extracts ofColutea cilicicaBoiss. & Bal. Fruits and Leaves

2011 ◽  
Vol 2011 ◽  
pp. 1-7 ◽  
Author(s):  
Ipek Peşin Süntar ◽  
Ufuk Koca ◽  
Esra Küpeli Akkol ◽  
Demet Yılmazer ◽  
Murat Alper
Keyword(s):  
Wound Healing ◽  
Histopathological Examination ◽  
Healing Process ◽  
Wound Healing Process ◽  
Aqueous Extracts ◽  
Reference Drug ◽  
Excision Wound ◽  
Wound Model ◽  
Incision Wound ◽  
Wound Healing Activity

The fruiting branches ofColutea cilicicaBoiss. & Bal., along with leaves and fruits, have been used to heal inflammatory wounds at traditional medicine in various parts of Turkey. In order to evaluate the wound healing activity of the plant, aqueous extracts were prepared from the flowering parts and fruits ofColutea cilicicaBoiss. & Bal. by using 40°C distilled water. Incision wound healing models by using tensiometer on rats and excision wound healing models on mice were employed to assess the activity. Significant wound healing activity was observed when ointment formulation of the aqueous extract at 1% concentration was applied on the mentioned models. The fruit extract treated the groups of animals, showing a 78.1% contraction in wounds, which was close to the contraction value of the reference drug Madecassol (100%). On the other hand, the same extract used on the incision wound model demonstrated a significant increase (42%) in wound tensile strength, compared to the flowering aerial parts. Histopathological examination also supported the results shown in both the incision and excision wound models. The wound healing effect was evaluated and compared with the reference ointment Madecassol. Moreover, zinc and vitamin C levels in the fruit (9480 ± 0 mcg g−1; 389 mg g−1) and flowering aerial part (6609 ± 1 mcg g−1; 404 mg g−1) extracts, which might have contributed to the wound healing process, were determined. The experimental data confirmed the traditional usage ofC. cilicicaBoiss.& Bal.

scholarly journals Evaluation of the Wound Healing Potential ofAchillea biebersteiniiAfan. (Asteraceae) byIn VivoExcision and Incision Models

2011 ◽  
Vol 2011 ◽  
pp. 1-7 ◽  
Author(s):  
Esra Küpeli Akkol ◽  
Ufuk Koca ◽  
Ipek Pesin ◽  
Demet Yilmazer
Keyword(s):  
Wound Healing ◽  
Folk Medicine ◽  
Reference Drug ◽  
Excision Wound ◽  
Wound Model ◽  
Achillea Biebersteinii ◽  
Healing Of Wounds ◽  
Wound Healing Effect ◽  
Incision Wound ◽  
Wound Healing Activity

Achilleaspecies are widely used for diarrhea, abdominal pain, stomachache and healing of wounds in folk medicine. To evaluate the wound healing activity of the plant, extracts were prepared with different solvents; hexane, chloroform, ethyl acetate and methanol, respectively from the roots ofAchillea biebersteinii. Linear incision by using tensiometer and circular excision wound models were employed on mice and rats. The wound healing effect was comparatively evaluated with the standard skin ointment Madecassol. Then-hexane extract treated groups of animals showed 84.2% contraction, which was close to contraction value of the reference drug Madecassol (100%). On the other hand the same extract on incision wound model demonstrated a significant increase (40.1%) in wound tensile strength as compared to other groups. The results of histoptological examination supported the outcome of linear incision and circular excision wound models as well. The experimental data demonstrated thatA. biebersteiniidisplayed remarkable wound healing activity.

Wound Healing Activity of Ten Indigenous Plants in Incision and Excision Wound Models in Albino Rats

2012 ◽  
Vol 2 (9) ◽  
pp. 56-58
Author(s):  
Vasanthalaxmi K Vasanthalaxmi K ◽  
◽  
Saraswathi Udupa ◽  
Laximinarayana Udupa
Keyword(s):  
Wound Healing ◽  
Albino Rats ◽  
Indigenous Plants ◽  
Excision Wound ◽  
Wound Healing Activity

Comparison of the ficus for the wound healing activity in various species

2020 ◽  
Vol 10 (4) ◽  
pp. 67-70
Author(s):  
Mothilal K ◽  
Akila CR ◽  
Mahender K ◽  
Chaitanya Kumar K ◽  
Ravi D
Keyword(s):  
Wound Healing ◽  
Wound Closure ◽  
Subcutaneous Tissue ◽  
Significant Activity ◽  
Herbal Extracts ◽  
Standard Drug ◽  
Excision Wound ◽  
Injuries And Wounds ◽  
Skin Conditions ◽  
Wound Healing Activity

Injuries and wounds are any sorts of damage to the skin or subcutaneous tissue. Usually, any wounds of such sorts are self-healed. Sometimes, there may be a delay in healing, and that delay is caused due to the functional delays in various processes of wound healing. All the Ficus plants show similar activities like the antioxidant, anti-inflammatory and wound healing properties 7including skin conditions like ulcers and rheumatism. The anthelmintic property and immunomodulatory are also seen. The herbal extracts of the same family of Ficus in different plants were investigated for the wound healing activity in the excision wound method, and the extracts showed significant activity compared to the drug. All the extracts showed a better healing ability, but the extract of FBO-100 showed the highest activity followed by FMO followed by FHO and finally the FRO. Overall, the activity of the extract ointment was comparable and was significant compared to the standard drug ointment. The wound closure of the extract ointment treated groups were better and were completed in 12 days, and the activity was more than 96%. The herbal extracts of the same family of Ficus in different plants were investigated for the wound healing activity in the excision wound method, and the extracts showed significant activity compared to the drug. The plants of microcarpa, benghalensis, religiosa and hispida are compared for the activity, and the order showed for the activity was FBO>FMO>FHO>FRO.

In Vivo Wound Healing Activity of Spirulina platensis

2019 ◽  
Vol 18 (1) ◽  
pp. 06-16
Author(s):  
R. Seghiri ◽  
A. Essamri
Keyword(s):  
Wound Healing ◽  
Spirulina Platensis ◽  
Therapeutic Agent ◽  
Conventional Medicine ◽  
Folk Medicine ◽  
Chemical Burns ◽  
Amount Of Substance ◽  
Test Population ◽  
Wound Healing Activity

Spirulina is a microalga used in traditional folk medicine in Morocco for the treatment of various health disorders. The wound healing activity of Moroccan Spirulina is unknown. In the current study, aqueous extracts of Spirulina platensis were investigated for acute toxicity and wound healing activity in Swiss Albino mice and White New Zealand rabbits, respectively. The LD50 (amount of substance required to kill 50% of the test population) of the microalga was greater than 5,000 mg/kg. Healing after application of the same amount of ointment on differently induced (mechanical, chemical, and thermal) wounds was about the same, over five weeks. Aqueous extract had remarkable healing activity on rabbits’ skin, possessing significantly greater healing effect for mechanical and chemical burns than controls. Moreover, the hair growing time was faster in treated groups; Spirulina-treated groups did not show any contamination with microbes compared to others. This study affirms that Spirulina platensis can be considered as a potential therapeutic agent for wound healing not only as a complementary medicine but also in conventional medicine.

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