scholarly journals [Corrigendum] Overexpression of septin‑7 inhibits melatonin‑induced cell apoptosis in human fetal osteoblastic cells via suppression of endoplasmic reticulum stress

2021 ◽  
Vol 25 (1) ◽  
Author(s):  
Xiaotong Meng ◽  
Yue Zhu ◽  
Lin Tao ◽  
Sichao Zhao ◽  
Shui Qiu
Keyword(s):  
Endoplasmic Reticulum ◽  
Endoplasmic Reticulum Stress ◽  
Cell Apoptosis ◽  
Osteoblastic Cells

Involvement of endoplasmic reticulum stress in homocysteine-induced apoptosis of osteoblastic cells

2012 ◽  
Vol 30 (4) ◽  
pp. 474-484 ◽  
Author(s):  
Su-Jung Park ◽  
Ki-Jo Kim ◽  
Wan-Uk Kim ◽  
Il-Hoan Oh ◽  
Chul-Soo Cho
Keyword(s):  
Endoplasmic Reticulum ◽  
Endoplasmic Reticulum Stress ◽  
Osteoblastic Cells ◽  
Induced Apoptosis

Effect of Metformin Intervention on Pancreatic β-Cell Apoptosis

2022 ◽  
Vol 12 (4) ◽  
pp. 873-877
Author(s):  
Dongqian Xie ◽  
Zhicheng Gao ◽  
Mei Liu ◽  
Defeng Wang
Keyword(s):  
Cell Cycle ◽  
Cell Proliferation ◽  
Endoplasmic Reticulum ◽  
Endoplasmic Reticulum Stress ◽  
Cell Apoptosis ◽  
Dependent Manner ◽  
Cycle Arrest ◽  
High Glucose Condition ◽  
M Phase ◽  
Signaling Activation

Metformin is shown to have hypoglycemic effects. However, the relationship between metformin’s intervention in FFA-induced endoplasmic reticulum stress-mediated insulin resistance (IR) and insulin β-cell apoptosis under high-glucose condition remains unclear. Our study intends to assess their relationship. Human pancreatic β-cells were treated with metformin and cell proliferation and IR were detected by MTT assay along with detection of Wnt/β-catenin signaling by RT-PCR, cell cycle and apoptosis by flow cytometry. Metformin inhibited β cell proliferation which was mediated by FFA-induced endoplasmic reticulum stress in a time-dependent and dose-dependent manner as well as induced cell cycle arrest at G2/M phase. In addition, metformin inhibited β-catenin signaling activation and decreased the expression of c-myc, Dvl-2, survivin, Dvl-3, GSK-3β (p-ser9) and promoted GSK-3 (p-tyr216) and Axin-2 expression. In conclusion, metformin inhibits Wnt/β-catenin signaling and promotes FFA to induce endoplasmic reticulum stress, thereby mediating pancreatic β-cells behaviors.

20(S)-Protopanaxadiol, a metabolite of ginsenosides, induced cell apoptosis through endoplasmic reticulum stress in human hepatocarcinoma HepG2 cells

2011 ◽  
Vol 668 (1-2) ◽  
pp. 88-98 ◽  
Author(s):  
Guo-Yuan Zhu ◽  
Ying-Wei Li ◽  
Anfernee Kai-Wing Tse ◽  
Desmond Kwok-Po Hau ◽  
Chung-Hang Leung ◽  
...  
Keyword(s):  
Endoplasmic Reticulum ◽  
Endoplasmic Reticulum Stress ◽  
Cell Apoptosis ◽  
Hepg2 Cells
Sign in / Sign up

Export Citation Format

Share Document