scholarly journals Sedation-Led chEmotherapy Evades Pain (S.L.E.E.P.)

2021 ◽  
Vol 7 ◽  
Author(s):  
Marco Cirillo
Keyword(s):  
Circadian Rhythm ◽  
Ad Hoc ◽  
Negative Impact ◽  
Daily Life ◽  
Deep Sedation ◽  
Depressive State ◽  
Quality Of Sleep ◽  
Negative Experiences ◽  
Cellular Repair

Chemotherapy and other invasive therapies are often limited by side effects, pain and negative experiences that can limit adherence to the therapy itself. Such negative components add to the patient's depressive state due to the disease. This research project proposes the use of deep sedation during chemotherapy sessions or other disabling therapies in the treatment of tumors or other severe diseases. The proposed protocol provides for an ad hoc hospitalization which could be during the night, during the day or limited to a few hours. Administration during sleep eliminates the memory and the negative impact the treatment has on the rest of the patient's daily life. This approach also agrees with the evidence of the circadian rhythm of cellular repair processes, which is greater at sunrise and sunset and linked to a good quantity and quality of sleep. In conclusion, this project aims to reduce the negative impact and increase the adherence to and efficacy of the therapy itself.

scholarly journals POS0998 SPONDYLOARTHRITIS AND SLEEP DISORDERS

2021 ◽  
Vol 80 (Suppl 1) ◽  
pp. 767.2-768
Author(s):  
S. Lahrichi ◽  
K. Nassar ◽  
S. Janani
Keyword(s):  
Functional Impairment ◽  
Sleep Disturbances ◽  
Negative Impact ◽  
University Hospital ◽  
Quality Of Sleep ◽  
The Mean ◽  
Sleep Deficit ◽  
Impaired Sleep ◽  
The Impact

Background:Spondyloarthropathies (SpA) are a group of chronic and progressive diseases, characterized in particular by a progressive stiffening of the spine, spreading to neighboring joints or to certain tissues, which could lead in the long term to progressive stiffening and functional impairment. This conditioncancauseinsomnia problems and impaired sleep quality.Objectives:To assess the impact of SpA on the quality of sleep.Methods:This is a retrospective study over a period of 4 years from January 2015 to December 2019, including all the medical records of patients with SpA followed in the Department of Rheumatology of the University Hospital of Ibn Rochd, Casablanca. We evaluated for each patient two validated scores: the Epworth somnolence scale rated from 0 to 24, and the Pittsburgh sleep score rated from 0 to 21 with 7 components. Patients with a psychiatric history or who were followed up for neurological pathologies were excluded.Results:178 patients were included. 60.67% were men with an average age of 36.32 years (14-68 years). 45.01% had axial SpA, 29.77% had psoriatic arthritis, and 25.22% were followed for SpA associated with inflammatory bowel disease. 45% had associated comorbidities: there were 18 diabetics and 34 hypertensive, 16.58% were smokers. Clinically, 85.42% presented a back pain initially on examination, 55% presented a polyarthralgia, and 39.88% an oligoarthritis. 63% had radiological sacroiliitis, and 35.14% had bilateral coxitis. 13.48% had a positive HLA B27 and 58.89% had a positive inflammatory assessment with very high activity indices,with a mean of 4.6. 64.66% of the patients received NSAIDs,of which 11% responded well. 57% were treated with csDMARDs, and 17.86% were treated with biologics. At the time of our study, the mean visual analog scale was 5.84 ± 1.7 out of 10 (2-9). The mean Epworth score was 8.38 ± 5.2 (0-21). 56.1% of patients had no sleep debt, 33.3% had a sleep deficit, and only 10.6% had signs of drowsiness. For the overall Pittsburgh score, the mean was 7.02 ± 3.6 (1-18). The mean of “subjective quality of sleep” was 1.12, “sleep latency” was 1.22, “duration of sleep” was 1.06, “usual sleep efficiency” was 0.74, “Sleep disturbance” of 1.28, “use of a sleep medication” of 0.54, and the average of the component concerning “poor shape during the day” was 1.03 out of 3. The LEQUESNE index went from an average of 6 to 8, which corresponds to an average handicap (P = 0.2) over a period of 3 years. 68% of the patients had an alteration in the quality of sleep, starting on average three years after the onset of symptoms. 11% reported having experiencedanxiety and depressive symptoms, and reported having used antidepressants or anxiolytics in the past 5 years.Conclusion:Our study showed the negative impact of SpA on the duration and overall quality of sleep. The degree of pain as well as functional impairment can cause and worsen sleep disturbances in SpA. We have shown that the Pittsburg score increases significantly with the increase of pain.The Lequesne score and that the Epworth score increase with disease activity[1].References:[1]StolwijkC,vanTubergenA,Castillo-OrtizJD,BoonenA.Prevalenceofextra-articularmanifestationsinpatientswithankylosingspondylitis:asystematicreviewandmeta-analysis.AnnRheumDis2015;74:65—73.Disclosure of Interests:None declared.

scholarly journals relationship between circadian rhythm and severity of psoriasis and obesity

2021 ◽  
Vol 27 (1-2) ◽  
pp. 22-29
Author(s):  
Ya.O. Yemchenko ◽  
◽  
K.Ye. Ischeikin ◽  
I.P. Kaidashev ◽  
O.V. Bezeha ◽  
...  
Keyword(s):  
Circadian Rhythm ◽  
Weight Gain ◽  
Negative Correlation ◽  
Negative Impact ◽  
Working Capacity ◽  
High Negative Correlation ◽  
Disease Impact ◽  
Very High

The research aim is to identify the correlation between circadian rhythm in terms of changes in the chronotype of human working capacity and severity of psoriasis progression, obesity, and the disease impact on the quality of patients' life. Materials and Methods. The research focuses on the determination of the PASI, BMI, DIAG indexes and a patient's chronotype of working capacity. Results and Discussion. The results of the correlation analysis showed a very high negative correlation between chronotype of patients' working capacity and BMI. They also demonstrated a high negative correlation between PASI and DIAG indicators and chronotype of patients' working capacity. Conclusions. The circadian rhythm changes to the evening chronotype of human working capacity contribute to psoriasis worsening, weight gain, and negative impact of the disease on the quality of patients' life.

scholarly journals Improvement of Circadian Rhythm of Heart Rate Variability by Eurythmy Therapy Training

2013 ◽  
Vol 2013 ◽  
pp. 1-9 ◽  
Author(s):  
Georg Seifert ◽  
Jenny-Lena Kanitz ◽  
Kim Pretzer ◽  
Günter Henze ◽  
Katharina Witt ◽  
...  
Keyword(s):  
Heart Rate ◽  
Heart Rate Variability ◽  
Circadian Rhythm ◽  
Negative Impact ◽  
Vagal Activity ◽  
Nonlinear Parameters ◽  
Low Frequencies ◽  
Before And After ◽  
Time Domains

Background. Impairment of circadian rhythm is associated with various clinical problems. It not only has a negative impact on quality of life but can also be associated with a significantly poorer prognosis. Eurythmy therapy (EYT) is an anthroposophic movement therapy aimed at reducing fatigue symptoms and stress levels.Objective. This analysis of healthy subjects was conducted to examine whether the improvement in fatigue symptoms was accompanied by improvements in the circadian rhythm of heart rate variability (HRV).Design. Twenty-three women performed 10 hours of EYT over six weeks. Electrocardiograms (ECGs) were recorded before and after the EYT trial. HRV was quantified by parameters of the frequency and time domains and the nonlinear parameters of symbolic dynamics.Results. The day-night contrast with predominance of vagal activity at night becomes more pronounced after the EYT training, and with decreased Ultralow and very low frequencies, the HRV shows evidence of calmer sleep. During the night, the complexity of the HRV is significantly increased indicated by nonlinear parameters.Conclusion. The analysis of the circadian patterns of cardiophysiological parameters before and after EYT shows significant improvements in HRV in terms of greater day-night contrast caused by an increase of vagal activity and calmer and more complex HRV patterns during sleep.

scholarly journals How COVID-19 quarantine might affect the sleep of children and adolescents?

2021 ◽  
Vol 11 (1) ◽  
Author(s):  
Samanta Richter ◽  
Luisa Schilling ◽  
Nathália Camargo ◽  
Melissa Taurisano ◽  
Nathália Fernandes ◽  
...  
Keyword(s):  
Circadian Rhythm ◽  
Children And Adolescents ◽  
Current Literature ◽  
Electronic Devices ◽  
International Classification ◽  
Quality Of Sleep ◽  
School Activities ◽  
The Media ◽  
The Subject

OBJECTIVES: To describe the main aspects of altered sleep in children and adolescents in the quarantine of COVID-19. METHODS: A narrative review of the current literature on the topic was carried out, based on the most recent national/international classification. RESULTS: The literature on the subject is still scarce. The sudden changes in routines and transfers of classes to virtual models provided flexibility in school activities, impacting the circadian rhythm of children and adolescents and, consequently, sleep. As a result, the lack of a routine with pre-established schedules by parents, results in longer use of electronic devices, from games to the media. CONCLUSIONS: It is essential that pediatricians advise parents on the importance of establishing a routine of daytime and nighttime activities, which will have an impact on the quality of sleep of children and adolescents during this quarantine period.

Headache and Shunt-Related Impact on Activities of Daily Life in Patients Growing Up with a Ventriculoperitoneal Shunt

2017 ◽  
Vol 79 (03) ◽  
pp. 196-199
Author(s):  
Lina Bellstädt ◽  
Hans-Jakob Steiger ◽  
Sevgi Sarikaya-Seiwert ◽  
Thomas Beez
Keyword(s):  
Quality Of Life ◽  
Chronic Headache ◽  
Negative Impact ◽  
Daily Life ◽  
Future Research ◽  
Psychosocial Outcome ◽  
Growing Up ◽  
Ventriculoperitoneal Shunts ◽  
Per Se

Background/Aims Ventriculoperitoneal shunts (VPS) are a mainstay of treatment for hydrocephalus. Morbidity related to infection and dysfunction is well known, whereas data on psychosocial outcome and quality of life are scarce. Our aim was to assess headache burden and shunt-related impact on daily life in children growing up with a VPS. Methods Patients between 3 and 21 years of age were identified and their families were contacted. A set of standardized questionnaires was used to assess headache and quality of life. Results Fifteen patients with a mean age of 12 years agreed to participate in this study. Satisfaction with the VPS and improvement of the patient's condition was reported by 87%. A total of 67% denied negative impact on everyday life, reported a headache less than once a month, and never or rarely miss school. However, 53% take precautions before special activities. Conclusions The results demonstrate that modern VPS systems are tolerated very well and do not per se reduce quality of life. However, patients adapt to the presence of a VPS by avoiding risks and taking precautions. Chronic headache is not a major problem and not necessarily attributed to the VPS. Nevertheless, most patients asked for technical improvements, which might guide future research and the technical development of VPS.

Do nocturnal headaches matter? A prospective diary study on subjective sleep parameters in snorers and their bed partners

Cephalalgia ◽  
2013 ◽  
Vol 34 (7) ◽  
pp. 533-539
Author(s):  
Stefan Seidel ◽  
Sophie Frantal ◽  
Sabine Salhofer-Polanyi ◽  
Doris Lieba-Samal ◽  
Josef Zeitlhofer ◽  
...  
Keyword(s):  
Negative Impact ◽  
Sleep Time ◽  
Subjective Quality ◽  
Sleep Diary ◽  
Semistructured Interview ◽  
Quality Of Sleep ◽  
Subjective Sleep ◽  
Female Predominance ◽  
Sleep Parameters

Background The objective of this study was to assess the influence of nocturnal headaches (NH) on subjective sleep parameters prospectively in habitual snorers and their bed partners. Methods We recruited habitual snorers and their bed partners via newspaper articles. The participants completed a semistructured interview, filled in questionnaires about quality of sleep (PSQI), daytime sleepiness (ESS), depression (SDS) and anxiety (SAS) and they kept a 90-day headache and sleep diary. Results Seventy-six snorers (25 female) and 41 bed partners (31 female) completed the study recording a total of 6690 and 3497 diary days, respectively. NH were recorded on 222 (3.3%) and 79 (2.2%) days in 32 (42%) snorers and 17 (41%) bed partners, respectively. Snorers with NH showed significantly higher PSQI (5 ± 3 vs. 4 ± 2, p = 0.004), SAS (38 ± 11 vs. 31 ± 10, p = 0.011) and SDS scores (39 ± 12 vs. 34 ± 10, p = 0.048) than snorers without NH. For bed partners with NH we found a significant female predominance (sex ratio f:m = 16:1 vs. 12:12, p = 0.005) and significantly higher SAS scores (38 ± 6 vs. 33 ± 8, p = 0.030) compared with bed partners without NH. The subjective quality of sleep in habitual snorers ( p < 0.001) as well as their bed partners ( p = 0.017) was negatively influenced by NH, but not total sleep time. Discussion NH occurred in around 40% of snorers and their bed partners at least once during the 90-day observation period. Our results confirmed a negative impact on the subjective quality of sleep in both groups.

scholarly journals Circadian rhythm of COPD symptoms in clinically based phenotypes. Results from the STORICO Italian observational study

2019 ◽  
Vol 19 (1) ◽  
Author(s):  
Nicola Scichilone ◽  
◽  
Raffaele Antonelli Incalzi ◽  
Francesco Blasi ◽  
Pietro Schino ◽  
...  
Keyword(s):  
Physical Activity ◽  
Circadian Rhythm ◽  
Depression Scale ◽  
Early Morning ◽  
Trial Registration ◽  
Anxiety And Depression ◽  
Chronic Obstructive ◽  
Quality Of Sleep ◽  
Night Time

Abstract Background Chronic Obstructive Pulmonary Disease (COPD) encompasses various phenotypes that severely limit the applicability of precision respiratory medicine. The present investigation is aimed to assess the circadian rhythm of symptoms in pre-defined clinical COPD phenotypes and its association with health-related quality of life (HR-QoL), the quality of sleep and the level of depression/anxiety in each clinical phenotype. Methods The STORICO (NCT03105999) Italian observational prospective cohort study enrolled COPD subjects. A clinical diagnosis of either chronic bronchitis (CB), emphysema (EM) or mixed COPD-asthma (MCA) phenotype was made by clinicians at enrollment. Baseline early-morning, day-time and nocturnal symptoms (gathered via the Night-time, Morning and Day-time Symptoms of COPD questionnaire), HR-QoL (via the St. George’s Respiratory Questionnaire), anxiety and depression levels (via the Hospital Anxiety and Depression Scale), quality of sleep (via COPD and Asthma Sleep Impact Scale), physical activity (via the International Physical Activity Questionnaire) as well as lung function were recorded. Results 606 COPD subjects (age 71.4 ± 8.2 years, male 75.1%) were studied. 57.9, 35.5 5.3 and 1.3% of the sample belonged to the CB, EM, MCA and EM + CB phenotypes respectively. The vast majority of subjects reported early-morning and day-time symptoms (79.5 and 79.2% in the CB and 75.8 and 77.7% in the EM groups); the proportion suffering from night-time symptoms was higher in the CB than in the EM group (53.6% vs. 39.5%, p = 0.0016). In both CB and EM, indiscriminately, the presence of symptoms during the 24-h day was associated with poorer HR-QoL, worse quality of sleep and higher levels of anxiety/depression. Conclusions The findings highlight the primary classificatory role of nocturnal symptoms in COPD. Trial registration Trial registration number: NCT03105999, date of registration: 10th April 2017.

scholarly journals Being a Cancer Patient during the Time of COVID-19: Impact of the Pandemic on the Anxiety and the Sleeping Quality of Oncology Patients

Chemotherapy ◽  
2021 ◽  
pp. 1-8
Author(s):  
Zeynep Gülsüm Güç ◽  
Ahmet Alacacıoğlu ◽  
Merve Güleç Yazır ◽  
Mehmet Eren Kalender ◽  
Sinan Ünal ◽  
...  
Keyword(s):  
Sleep Quality ◽  
Cancer Patients ◽  
Active Treatment ◽  
Low Income ◽  
Pittsburgh Sleep Quality Index ◽  
Negative Impact ◽  
Quality Of Sleep ◽  
Independent Variable ◽  
Univariate Analyses

<b><i>Objective:</i></b> In this study, we aimed to assess anxiety and sleep quality in cancer patients treated or followed up at our clinic at the time of the outbreak of the COVID-19 pandemic. <b><i>Methods:</i></b> Seven hundred and sixty-one patients who were either treated or followed up at our oncology clinic between April 2020 and May 2020 were included. Patients were assessed with the State-Trait Anxiety Inventory (STAI) and the Pittsburgh Sleep Quality Index (PSQI). <b><i>Results:</i></b> Mean scores of the 761 participants were STAI, 43.45 ± 9.34 (range, 23–75), and PSQI, 5.67 ± 4.24 (range, 0–19). Quality of sleep was found bad in 447 (58.7%) (global score ≥5). Univariate analyses demonstrated statistical differences by stage of cancer, status of treatment, subgroup of treatment, monthly income, and levels of education in anxiety and sleep quality levels. Multivariate analyses showed active treatment (OR: 21.4; 95% CI: 9.08–50.4; <i>p</i> &#x3c; 0.001) as the major independent variable that affected sleep quality; the major independent variable associated with anxiety was low income (OR: 4.43; 95% CI: 1.69–11.5; <i>p</i> = 0.002). <b><i>Conclusion:</i></b> Anxiety and sleep quality levels were found comparable to pre-pandemic reports, and the pandemic was not observed to have additional negative impact on cancer patients. Also, universal basal anxiety and sleep disorder that accompany cancer or active treatment were observed in our study. The accurate effects of the pandemic can be analyzed in further studies using repeated data obtained from the same patient group.

FEATURES OF THE DAILY LIFE OF YOUNG PEOPLE FROM POST-SOVIET STATES IN MOSCOW IN THE CONTEXT OF THE COVID-19 PANDEMIC

2021 ◽  
pp. 31-39
Author(s):  
Galina I. Оsadchaya ◽  
Keyword(s):  
Young People ◽  
Union Member ◽  
Negative Impact ◽  
Daily Life ◽  
Member States ◽  
The Social ◽  
The Everyday ◽  
Coronavirus Infection ◽  
New Situation

The article reveals the change in the behavior of young people from post-Soviet states in Moscow under the influence of the social and economic impact on the everyday life of the coronavirus, it is substantiated that the improvement in the quality of their daily life is due to how successfully the Governments of their countries and the EAEU as a whole will interact in the context of the COVID 19 pandemic. We conducted a questionnaire survey of young citizens belonging to the representatives of the "millennials" and "post-millennials" generation (18-38 years old), the EAEU member states and candidates for joining the EAEU (Armenia, Belarus, Kazakhstan, Kyrgyzstan, Russia, Moldova, Tajikistan), living, studying or working in Moscow. In April-June 2020, 3,065 people were interviewed (Armenia-417 people, Belarus-463 people, Kazakhstan-406 people, Kyrgyzstan — 399 people, Moldova — 405 people, Russia — 588 people, Tajikistan — 387 people). Only from 21 to 32% of respondents from different countries noted that nothing has changed in their lives. The survey showed that the new situation causes a feeling of fear. The understanding that a person himself cannot eliminate the negative impact of the pandemic leads to the fact that about a fifth of the respondents feel anxiety and irritation, 6.5% — fear, despair and hopelessness. It should be noted that after all, 4 out of 10 respondents maintain a good, optimistic (23.7%) and normal, even (44.0%) mood. The EAEU countries intend to continue working towards a joint response to the threat of coronavirus infection. It should be borne in mind that the nature of such interaction will have certain limits associated with the current level of integration. However, the States of the region are aware that the coronavirus crisis and the "Great Quarantine" may turn out to be a historical fork in the opportunities for the real sector of the economy of the Union member states and requires strengthening unity.

Sign in / Sign up

Export Citation Format

Share Document