Risk Factors for Developing Osteonecrosis After Prophylaxis in Steroid-treated Rabbits

2008 ◽  
Vol 35 (12) ◽  
pp. 2391-2394 ◽  
Author(s):  
GORO MOTOMURA ◽  
TAKUAKI YAMAMOTO ◽  
KEITA MIYANISHI ◽  
KYOKO KONDO ◽  
YOSHIO HIROTA ◽  
...  
Keyword(s):  
Risk Factors ◽  
Triglyceride Level ◽  
Steroid Injection ◽  
Plasma Concentrations ◽  
Density Lipoprotein ◽  
Positive Association ◽  
Plasma Triglyceride ◽  
Lipid Lowering ◽  
Plasma Triglyceride Level ◽  
Lipid Lowering Agent

ObjectiveBoth abnormal lipid metabolisms and coagulopathy have been suggested to be associated with the development of steroid-induced osteonecrosis (ON). We examined plasma risk factors for development of steroid-induced ON in rabbits after prophylaxis with a lipid-lowering agent and/or an anticoagulant.MethodsSeventy adult male rabbits were injected intramuscularly once with 20 mg/kg methylprednisolone acetate. Fifty-five rabbits received prophylaxis with probucol (a lipid-lowering agent; n = 20) or warfarin (an anticoagulant; n = 14) or both (n = 21). Probucol and warfarin were administered beginning 1 to 2 weeks prior to steroid injection. Two weeks after steroid injection, the bilateral femora and humeri were examined histopathologically for the presence of ON. Based on a logistic regression model, laboratory variables before steroid injection were assessed to determine whether they demonstrated any association with the risk of ON.ResultsTwenty-one rabbits developed ON. In the univariate analyses, significant positive associations were observed between plasma concentrations of triglyceride and low-density lipoprotein and the risk of development of ON. In the multivariate model, only the plasma triglyceride level suggested a positive association. Even after adjusting for probucol and warfarin use, the plasma triglyceride level was still suggested to be a predictor for development of ON. Rabbits with higher baseline triglyceride levels had a more pronounced triglyceride increase in their response to steroids.ConclusionOur study suggests that, after prophylaxis with probucol and/or warfarin, plasma triglyceride level is associated with the development of steroid-induced ON in rabbits.

Abstract P127: Racial Disparities in Risk Factor Control in Older Adults with Diabetes: The Atherosclerosis Risk in Communities (ARIC) Study

Circulation ◽  
2015 ◽  
Vol 131 (suppl_1) ◽  
Author(s):  
Christina Parrinello ◽  
Ina Rastegar ◽  
Job G Godino ◽  
Michael D Miedema ◽  
Kunihiro Matsushita ◽  
...  
Keyword(s):  
Risk Factors ◽  
Older Adults ◽  
Risk Factor ◽  
Racial Disparities ◽  
Low Density Lipoprotein ◽  
Density Lipoprotein ◽  
Lipid Lowering ◽  
Tight Control ◽  
Risk Factor Control ◽  
Atherosclerosis Risk In Communities

Background: Racial disparities in risk factor control have been documented in middle-aged adults, but much less is known about older adults with diabetes. Our findings will inform clinical guidelines on appropriate risk factor control in older adults with diabetes. Methods: In 2011-13, 6,538 ARIC participants attended visit 5, and 4,988 provided data on all key covariates used in these analyses. Of these, 31% had diagnosed diabetes (N=1,561, 72% white, mean age=75 years) and were included in this study. Tight control of risk factors was defined according to American Diabetes Association guidelines: hemoglobin A1c <7%; low-density lipoprotein cholesterol <100 mg/dL; systolic blood pressure (BP) <140 mmHg and diastolic BP <80 mmHg. We evaluated risk factor control overall and by race. We used logistic regression and predictive margins to assess independent associations of race with tight risk factor control. Results: Among older adults with diabetes, 64% used glucose-lowering medication, 70% lipid-lowering medication and 82% BP-lowering medication. Only 5% of participants did not take medication for any of these risk factors. Tight control was observed in 72% for glucose, 64% for lipids and 70% for BP. Only 34% had tight control of all three. A higher proportion of whites than blacks consistently achieved tight control ( Figure ). In multivariable analyses of persons with diabetes who were treated for risk factors, racial disparities in tight control of lipids and BP remained significant: adjusted prevalence ratios and 95% CIs (white vs black) were 1.04 (0.91, 1.17) for glucose, 1.21 (1.08-1.34) for lipids, 1.15 (1.03-1.26) for BP, and 1.33 (0.95, 1.70) for tight control of all three risk factors. Conclusions: Our results highlight racial disparities in risk factor control in older adults with diabetes that were not explained by demographic or clinical characteristics. Further studies are needed to elucidate the determinants of disparities in risk factor control and strategies to address these.

Aerobic Capacity, Obesity, and Atherosclerotic Risk Factors in Male Adolescents

PEDIATRICS ◽  
1985 ◽  
Vol 75 (5) ◽  
pp. 813-818
Author(s):  
Raymond R. Fripp ◽  
James L. Hodgson ◽  
Peter O. Kwiterovich ◽  
John C. Werner ◽  
H. Gregg Schuler ◽  
...  
Keyword(s):  
Risk Factors ◽  
Blood Pressure ◽  
Body Mass Index ◽  
Regression Analysis ◽  
Body Mass ◽  
Linear Regression Analysis ◽  
Density Lipoprotein ◽  
Plasma Triglyceride ◽  
Lipoprotein Cholesterol ◽  
Atherosclerotic Risk Factors

Correlations between aerobic capacity, obesity, and atherosclerotic risk factors were evaluated in adolescents with low-to-moderate levels of physical fitness. Subjects with higher levels of fitness had a more favorable risk profile with decreased body mass index, lower systolic and diastolic blood pressure and plasma triglyceride levels, and higher plasma high-density lipoprotein-cholesterol levels. Simple linear regression analysis revealed an association between body mass index and blood pressure, plasma triglyceride and plasma highdensity lipoprotein-cholesterol. The level of aerobic fitness as determined by exercise duration was also associated with the same atherosclerotic risk factors. However, multiple linear regression analysis demonstrated that body mass index provided the largest explanation, by those variables examined, of the interindividual variance in blood pressure, plasma triglyceride, and high-density lipoprotein-cholesterol. Aerobic fitness contributed only minimally to the variation in these risk factors. These findings suggest that if aerobic conditioning is used to modify atherosclerotic risk factors, it should be accompanied by a reduction in weight in adolescents with low-to-moderate levels of physical fitness.

Reduction by Phytate-reduced Soybean β-Conglycinin of Plasma Triglyceride Level of Young and Adult Rats

2001 ◽  
Vol 65 (5) ◽  
pp. 1071-1075 ◽  
Author(s):  
Toshiaki AOYAMA ◽  
Mitsutaka KOHNO ◽  
Tsutomu SAITO ◽  
Kensuke FUKUI ◽  
Kiyoharu TAKAMATSU ◽  
...  
Keyword(s):  
Triglyceride Level ◽  
Plasma Triglyceride ◽  
Plasma Triglyceride Level ◽  
Adult Rats

scholarly journals Genetic variation in Tanis was associated with elevating plasma triglyceride level in Chinese nondiabetic subjects

2013 ◽  
Vol 12 (1) ◽  
pp. 97 ◽  
Author(s):  
Ying Gao ◽  
Xiang Xie ◽  
Yi-Tong Ma ◽  
Yi-Ning Yang ◽  
Xiao-Mei Li ◽  
...  
Keyword(s):  
Genetic Variation ◽  
Triglyceride Level ◽  
Plasma Triglyceride ◽  
Plasma Triglyceride Level

scholarly journals The Positive Association between Plasma Myristic Acid and ApoCIII Concentrations in Cardiovascular Disease Patients Is Supported by the Effects of Myristic Acid in HepG2 Cells

2020 ◽  
Vol 150 (10) ◽  
pp. 2707-2715 ◽  
Author(s):  
Oliviero Olivieri ◽  
Giulia Speziali ◽  
Annalisa Castagna ◽  
Patrizia Pattini ◽  
Silvia Udali ◽  
...  
Keyword(s):  
Myristic Acid ◽  
Hepg2 Cells ◽  
Plasma Lipids ◽  
Plasma Concentrations ◽  
Plasma Lipid ◽  
Positive Association ◽  
Fold Increase ◽  
Lipid Lowering ◽  
In Vitro Experiments

ABSTRACT Background In the settings of primary and secondary prevention for coronary artery disease (CAD), a crucial role is played by some key molecules involved in triglyceride (TG) metabolism, such as ApoCIII. Fatty acid (FA) intake is well recognized as a main determinant of plasma lipids, including plasma TG concentration. Objectives The aim was to investigate the possible relations between the intakes of different FAs, estimated by their plasma concentrations, and circulating amounts of ApoCIII. Methods Plasma samples were obtained from 1370 subjects with or without angiographically demonstrated CAD (mean ± SD age: 60.6 ± 11.0 y; males: 75.8%; BMI: 25.9 ± 4.6 kg/m2; CAD: 73.3%). Plasma lipid, ApoCIII, and FA concentrations were measured. Data were analyzed by regression models adjusted for FAs and other potential confounders, such as sex, age, BMI, diabetes, smoking, and lipid-lowering therapies. The in vitro effects of FAs were tested by incubating HepG2 hepatoma cells with increasing concentrations of selected FAs, and the mRNA and protein contents in the cells were quantified by real-time RT-PCR and LC-MS/MS analyses. Results Among all the analyzed FAs, myristic acid (14:0) showed the most robust correlations with both TGs (R = 0.441, P = 2.6 × 10−66) and ApoCIII (R = 0.327, P = 1.1 × 10−31). By multiple regression analysis, myristic acid was the best predictor of both plasma TG and ApoCIII variability. Plasma TG and ApoCIII concentrations increased progressively at increasing concentrations of myristic acid, independently of CAD diagnosis and gender. Consistent with these data, in the in vitro experiments, an ∼2-fold increase in the expression levels of the ApoCIII mRNA and protein was observed after incubation with 250 μM myristic acid. A weaker effect (∼30% increase) was observed for palmitic acid, whereas incubation with oleic acid did not affect ApoCIII protein or gene expression. Conclusions Plasma myristic acid is associated with increased ApoCIII concentrations in cardiovascular patients. In vitro experiments indicated that myristic acid stimulates ApoCIII expression in HepG2 cells.

scholarly journals EDEM3 Modulates Plasma Triglyceride Level through Its Regulation of LRP1 Expression

iScience ◽  
2020 ◽  
Vol 23 (4) ◽  
pp. 100973
Author(s):  
Yu-Xin Xu ◽  
Gina M. Peloso ◽  
Taylor H. Nagai ◽  
Taiji Mizoguchi ◽  
Amy Deik ◽  
...  
Keyword(s):  
Triglyceride Level ◽  
Plasma Triglyceride ◽  
Plasma Triglyceride Level

Plasma Exchange for the Management of Cyclosporin A-Induced Hypertriglyceridemia

1988 ◽  
Vol 11 (3) ◽  
pp. 209-211 ◽  
Author(s):  
M. Valbonesi ◽  
D. Occhini ◽  
C. Capra ◽  
R. Frisoni ◽  
M. Fella ◽  
...  
Keyword(s):  
Bone Marrow ◽  
Bone Marrow Transplantation ◽  
Cyclosporin A ◽  
Disease Progression ◽  
Plasma Exchange ◽  
Triglyceride Level ◽  
Clinical Picture ◽  
Marrow Transplantation ◽  
Plasma Triglyceride ◽  
Plasma Triglyceride Level

The Authors report a case of hypertriglyceridemia complicating the course of a patient receiving cyclosporin A after bone marrow transplantation. When the patient was seen at the hemapheresis unit the clinical picture was characterized by headache, increasing visual and neurological disturbances. Plasma triglyceride level was 3215 mg/dl. Two plasma exchange sessions reduced triglycerides to 486 mg/dl and halted the disease progression. This may represent the first plasma exchange treatment of cyclosporin A-induced hypertriglyceridemia.

Relationship between Hyperlipidemia, Cardiovascular Disease and Stroke: a Systematic Review

2020 ◽  
Vol 16 ◽  
Author(s):  
Aladeen Alloubani ◽  
Refat Nimer ◽  
Rama Samara
Keyword(s):  
Risk Factors ◽  
Cardiovascular Disease ◽  
Risk Factor ◽  
Prognostic Significance ◽  
Vascular Diseases ◽  
Positive Association ◽  
Cholesterol Concentration ◽  
Lipid Lowering ◽  
Mortality And Morbidity ◽  
The Impact

Background:: Globally, dyslipidemia has been shown to be an independent predictor of many cardiovascular and cerebrovascular events, which lead to recent advocacy towards dyslipidemia prevention and control as a key risk factor and its prognostic significance to reduce the burden of stroke and myocardial infarction. Aim:: This study aimed to evaluate hyperlipidemia as a risk factor connected with stroke and CVD. Moreover, having identified this risk factor, the study evaluates how hyperlipidemia has been examined earlier and what can be done in the future. Methods:: All prospective studies concerning hyperlipidemia as risk factors for stroke and CVD were identified by a search of PubMed/MEDLINE and EMBASE databases with keywords hyperlipidemia, risk factors, stroke, and cardiovascular disease. Results:: The constant positive association between the incidence of coronary heart disease and cholesterol concentration of LDL is apparent in observational studies in different populations. Thus, the reduction of LDL cholesterol in those populations, particularly with regard to initial cholesterol concentrations, can reduce the risk of vascular diseases. However, the impact of using lipid-lowering drugs, such as statins, has been demonstrated in several studies as an important factor in decreasing the mortality and morbidity in rates of patients with stroke and CVD. Conclusion:: After reviewing all the research mentioned in this review, it can be confirmed that hyperlipidemia is a risk factor for stroke and correlated in patients with CVD.

Sign in / Sign up

Export Citation Format

Share Document