Effect of Carum carvi on Experimentally Induced Gastric Mucosal Damage in Wistar Albino Rats

Albizzia procera belongs to family Fabaceae and has several phytoconstituents like flavonoids, terpenes, alkaloids, saponins etc. The plant is commonly used in traditional medicines. The objective of the present study was to assess the ameliorative effect of A. procera leaves extract against an experimentally induced gastric ulcer in albino rats. The antiulcer, antisecretory and cytoprotective properties of an ethanolic extract prepared from the leaves was evaluated. When given in a 200 mg/kg oral (per. os) dose, the extract produced 74% and 85% protection index in ethanol-induced ulcer model and pylorus ligation model, respectively. Additionally, the extract also prohibited the formation of haemorrhage and edema, significantly lessened catalase activity (p<0.0001) and the lipid peroxidation level (p<0.0001) in the glandular tissue of Wistar albino rats. Furthermore, the extract also significantly diminished the total acidity(p<0.0001) of the gastric fluid by increasing its pH (p<0.0001). The occupancy of different phytoconstituents in the extract, such as flavonoids and tannins were identified that may be responsible for its gastro-protective activity. All these results provide a basis explaining the antiulcer ability of A. procera being useful in the management of gastric ulcers.

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Anti-ulcer role of herbomineral siddha drug — Thamira parpam on experimentally induced gastric mucosal damage in rats

Human & Experimental Toxicology ◽

10.1177/0960327109357217 ◽

2010 ◽

Vol 29 (3) ◽

pp. 161-173 ◽

Cited By ~ 2

Author(s):

M. Vasanthkumar ◽

RP Parameswari ◽

V. Vijaya Kumar ◽

MK Sangeetha ◽

V. Gayathri ◽

...

Keyword(s):

Thiobarbituric Acid ◽

Mucosal Damage ◽

Gastric Volume ◽

Gastric Mucosal Damage ◽

Thiobarbituric Acid Reactive Substances ◽

Pylorus Ligation ◽

Ulcerogenic Activity ◽

Per Oral ◽

Experimentally Induced

Anti-ulcerogenic activity of Thamira parpam (TP) was investigated in two ulcer models (aspirin + pylorus ligation and HCl-ethanol). Aspirin—pylorus ligation (Asp 200 mg/kg-7 days + PL-4 hours) and HCl-ethanol (150 mM HCl in 70% ethanol) induction in rat resulted in elevation of thiobarbituric acid reactive substances (TBARS) and depletion of antioxidants (superoxide dismutase [SOD], glutathione [GSH], glutathione peroxidase [GPx]) with high ulcer scores (p < .01). In Asp + PL model, TP treatment showed mild inhibition on ulcer scores, changes in pH, gastric volume, total and free acidity, and elevation of TBARS and depletion of antioxidants. Compared to the ulcer-untreated rats (HCl-ethanol), the herbomineral drug TP treatment (0.5, 1, 2 mg/kg, per oral [p.o.]) attenuated the elevation of TBARS, decrease of antioxidants and nitrite (p < .05). Histopathological examinations were correlated with the antioxidant profile. In conclusion, the prophylactic cytoprotective nature of the herbomineral drug in experimentally induced ulcers could be mediated by its free radical quenching property.

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