Evaluation of Hematological, Serum Biochemical and Tissue Antioxidant Changes in Experimentally Induced Hyperlipidemia in Wistar Albino Rats

2018 ◽  
pp. 1
Author(s):  
Hamsavath Naik ◽  
Ch Srilatha ◽  
K Sujatha ◽  
B Sreedevi ◽  
T Prasad
Keyword(s):  
Albino Rats ◽  
Serum Biochemical ◽  
Wistar Albino Rats ◽  
Experimentally Induced

scholarly journals Assessment of the nutritive value of toasted castor seed cake-based diets as a reflect on blood profile of weanling wistar albino rats

2021 ◽  
Vol 44 (3) ◽  
Author(s):  
A. F Agboola
Keyword(s):  
Blood Cell ◽  
Castor Seed ◽  
Albino Rats ◽  
Blood Profile ◽  
Seed Cake ◽  
Soyabean Meal ◽  
Serum Biochemical ◽  
Wistar Albino Rats ◽  
Biochemical Indices ◽  
Dietary Treatments

Since the cost of feed is increasing due to the keen competition between humans and animals, there is a need to critically seek for a matching alternative. Castor seed cake, a residue after the extraction of oil from nutrients-rich castor seed constitutes a waste which can be converted into livestock feed. Thus, the study was carried out to investigate the effect of graded levels of castor seed cake diets on haematological and serum biochemical indices of weanling albino rats in an experiment that lasted 21 days. Thirty weanling Wistar albino rats were weighed individually and randomly assigned to 5 dietary treatments with 3 replicates of two rats in a completely randomized design. Diet 1 was a nitrogen-free diet (NFD), while diets 2, 3, 4, and 5 had 0% (without castor seed cake inclusion), 2, 4 and 6% castor seed cake replacing soyabean meal respectively. At day 21, blood samples were obtained from two rats per replicate for haematological and serum analysis. There were no significant differences (P>0.05) observed in all the parameters (packed cell volume, haemaglobin, red blood cell, white blood cell, lymphocyte, neutrophil, monocyte, eosinophil and platelet) measured. Similarly, diet had no effect on the serum biochemical indices (creatinine, urea, total protein and globulin) measured. Significant difference (P<0.05) was however observed in albumin (2.62 – 3.18g/dL) of rats on the different experimental diets. The albumin concentrations of weanling albino rats on dietary treatments were similar to those on the control diet but significantly (P<0.05) higher (3.09 – 3.18g/dL) than those on the nitrogen free diet. It can be concluded that castor seed cake can replace soyabean meal up to 6% inclusion level without eliciting detrimental effect on blood profile of weanling wistar albino rats.

scholarly journals Ameliorative effect of Albizzia procera leaves extract against experimentally induced gastric ulcer models in Wistar albino rats

2021 ◽  
Vol 13 (1) ◽  
pp. 308-315
Author(s):  
Vivek Srivastava ◽  
Santosh Kumar Verma ◽  
Neha Mathur ◽  
Kapil Kumar Goel
Keyword(s):  
Gastric Ulcer ◽  
Ethanolic Extract ◽  
Gastric Fluid ◽  
Gastric Ulcers ◽  
Albino Rats ◽  
Traditional Medicines ◽  
Pylorus Ligation ◽  
Ameliorative Effect ◽  
Wistar Albino Rats ◽  
Experimentally Induced

Albizzia procera belongs to family Fabaceae and has several phytoconstituents like flavonoids, terpenes, alkaloids, saponins etc. The plant is commonly used in traditional medicines. The objective of the present study was to assess the ameliorative effect of A. procera leaves extract against an experimentally induced gastric ulcer in albino rats. The antiulcer, antisecretory and cytoprotective properties of an ethanolic extract prepared from the leaves was evaluated. When given in a 200 mg/kg oral (per. os) dose, the extract produced 74% and 85% protection index in ethanol-induced ulcer model and pylorus ligation model, respectively.  Additionally, the extract also prohibited the formation of haemorrhage and edema, significantly lessened catalase activity (p<0.0001) and the lipid peroxidation level (p<0.0001) in the glandular tissue of Wistar albino rats. Furthermore, the extract also significantly diminished the total acidity(p<0.0001) of the gastric fluid by increasing its pH (p<0.0001). The occupancy of different phytoconstituents in the extract, such as flavonoids and tannins were identified that may be responsible for its gastro-protective activity. All these results provide a basis explaining the antiulcer ability of A. procera being useful in the management of gastric ulcers.

scholarly journals Tubular Necrosis, Acid-Base and Electrolyte Abnormalities Associated with Gasoline Vapour-induced Nephrotoxicity

2020 ◽  
Vol 2 (3) ◽  
Keyword(s):  
Renal Function ◽  
Biochemical Markers ◽  
Histopathological Examination ◽  
Albino Rats ◽  
Renal Vasculature ◽  
Tubular Necrosis ◽  
Serum Biochemical ◽  
Group 2 ◽  
Wistar Albino Rats ◽  
Electrolyte Abnormalities

Introduction: This study aimed to assess the effect of exposure to gasoline vapor (GV) on the histomorphology and biochemical markers of renal function in rats. Methods: Twenty-four mature Wistar Albino rats weighing 180–200 g were randomly divided into two groups (n = 12 per group). Animals in group 1 (G1) served as unexposed controls, while animals in group 2 (G2) were exposed to GV for 35 days. At the end of the exposure, the animals were sacrificed, and blood samples were collected for biochemical analysis while the kidneys were removed and processed for histopathological evaluation. Results: Serum biochemical markers of renal function in the exposed group differed significantly (p< 0.05) from the unexposed group in urea (45.16 ± 1.00mg/dl versus(vs) 13.20 ± 0.69 mg/dl), creatinine (1.16 ± 0.27mg/dl vs 0.38 ± 0.10mg/dl), uric acid (3.66 ± 0.82mmol/L vs 1.96 ± 0.08mmol/L), potassium (6.90 ± 0.27mmol/L vs 3.57 ± 0.26mmol/L), sodium (182.60 ± 3.21mmol/L vs 141.33 ± 10.46mmol/L), chloride (119.00 ± 1.58mmol/L vs 103.33 ± 2.07mmol/L), pH (6.82 ± 0.22 vs 7.38 ± 0.25), bicarbonate (16.60 ± 5.03mmol/L vs 26.50 ± 3.45mmol/L), and glucose (125.60 ± 16.23mg/ dl vs 83.33 ± 4.46mg/dl). Histopathological examination of kidney sections revealed areas of degenerative and necrotic changes in the glomerulus, tubules, and renal vasculature, particularly in the cortical portion of the kidney. Conclusion: Chronic exposure to gasoline compounds may be associated with significant structural and biochemical derangements in kidney function.

Effect of Carum carvi on Experimentally Induced Gastric Mucosal Damage in Wistar Albino Rats

2006 ◽  
Vol 2 (3) ◽  
pp. 309-315 ◽  
Author(s):  
A.A. Alhaider ◽  
I.A. Al-Mofleh . ◽  
J.S. Mossa . ◽  
M.O. Al-Sohaibani . ◽  
S. Rafatullah . ◽  
...  
Keyword(s):  
Mucosal Damage ◽  
Gastric Mucosal Damage ◽  
Albino Rats ◽  
Carum Carvi ◽  
Wistar Albino Rats ◽  
Experimentally Induced

scholarly journals Feed Efficiency and Serobiochemical Profile of Wistar Rats Fed With Spirulina As Functional Food

2016 ◽  
Vol 4 (2) ◽  
pp. 135-140 ◽  
Author(s):  
K Manjula ◽  
M Raj ◽  
Ramya Krishna
Keyword(s):  
Sea Water ◽  
Arthrospira Platensis ◽  
Feed Consumption ◽  
Albino Rats ◽  
Test Results ◽  
Model Study ◽  
Study Test ◽  
Serum Biochemical ◽  
Serum Biochemical Profile ◽  
Wistar Albino Rats

Spirulina is an algae that grow in fresh and sea water and itself known to the human community with its unique Neutraceuticals properties, generally produced from the species named Arthrospira platensis, and Arthrospira maxima. Arthrospira species were cultivated throughout the world to fulfil the need of human dietary supplementation. An experimental study was planned to know the effect of spirulina supplementation on serum biochemical profile of Wistar albino rats as model study. Test results clearly denoted that diet planned with spirulina fed rats showed better serobiochemical profile when compared with stock diet and rice based diet. The protein and albumin values were significantly higher in spirulina fed rats. Feed consumption rate is very low in spirulina diet but gained more weight when compared to stock and rice diets, this might be due to high biological value protein in spirulina.

scholarly journals Anticonvulsant activity of nicardipine in experimentally induced seizures in wistar albino rats.

2020 ◽  
Vol 9 (3) ◽  
pp. 413
Author(s):  
Kayalvizhi M. K. ◽  
Sathiya Vinotha A. T.
Keyword(s):  
Experimental Animal ◽  
Anticonvulsant Activity ◽  
Albino Rats ◽  
Anticonvulsant Effect ◽  
Maximal Electroshock ◽  
Standard Drug ◽  
Wistar Albino Rats ◽  
Electroshock Seizures ◽  
Experimentally Induced

Background: The objective of the study was to evaluate the anticonvulsant activity of nicardipine in wistar albino rats.Methods: Anticonvulsant activity of nicardipine in a dose 10 mg/kg, and its effect with the standard drug lamotrigine (5 mg/kg) was studied in a maximal electroshock seizures (MES) experimental animal model.Results: Nicardipine in dose of 10 mg/kg showed significant anticonvulsant effect (p<0.001) and combination with standard drug lamotrigine (p<0.001) also showed more significant anticonvulsant effect in MES model.Conclusions: Nicardipine is having anticonvulsant activity and it also potentiates the anticonvulsant effect of lamotrigine in MES model.

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