Antimicrobial Susceptibility Pattern of Microorganisms Involved in the Pathogenesis of Surgical Site Infection (SSI); A 1 Year of Surveillance

2008 ◽  
Vol 11 (15) ◽  
pp. 1940-1944 ◽  
Author(s):  
F. Khorvash ◽  
K. Mostafaviz ◽  
S. Mobasheriz ◽  
M. Behjati ◽  
A. E. Naeini ◽  
...  
Keyword(s):  
Surgical Site Infection ◽  
Antimicrobial Susceptibility ◽  
Site Infection ◽  
Susceptibility Pattern ◽  
Antimicrobial Susceptibility Pattern

scholarly journals Profile of Aerobic Bacteria in Surgical Site Infection Following Caesarean Section and Antibiotic Susceptibility Pattern in Silchar Medical College, India

2021 ◽  
Vol 10 (35) ◽  
pp. 3030-3034
Author(s):  
Nazrana Choudhury ◽  
Abul Barkat Fuzayel Ahmed ◽  
Debadatta Dhar Chanda ◽  
Achinta Kumar Borthakur
Keyword(s):  
Risk Factors ◽  
Staphylococcus Aureus ◽  
Caesarean Section ◽  
Surgical Site Infection ◽  
Site Infection ◽  
Bacterial Isolates ◽  
Susceptibility Pattern ◽  
Gram Negative ◽  
Medical College ◽  
Antimicrobial Susceptibility Pattern

BACKGROUND Caesarean section is one of the most common surgeries performed in women of reproductive age group. Postoperative surgical site infection (SSI) is the third most frequently reported nosocomial infection. Recovery after caesarean section can be more demanding for a woman who develops a post-operative surgical site infection that can even lead to death. Surveillance of surgical site infection is an important infection control activity. A better understanding of the spectrum of pathogens causing SSI as well as their susceptibility pattern is important for prompt management of patients. The main objectives of this study were to identify the bacterial agents causing postoperative wound infection in caesarean section, as well as determine the in-vitro antimicrobial susceptibility pattern of different bacterial isolates and also to examine the risk factors of postoperative caesarean infection. METHODS This is an observational (cross sectional study) where 100 cases of postoperative caesarean section wound infection admitted in the Department of Obstetrics & Gynaecology ̦ Silchar Medical College were studied. Pus samples were collected and cultured, and the pathogenic isolates were tested against different antimicrobial agents by standard disc diffusion method (Kirby-Bauer method) as per the recommendation of Clinical and Laboratory Standard Institute (CLSI) guidelines. RESULTS The study revealed Staphylococcus aureus 38.1 % of which 21.9 % were methicillin resistant (MRSA), as the most common organism responsible for SSI followed by Escherichia coli 23.8 % and Klebsiella pneumoniae 16.7 %. Staphylococcus aureus was 100 % sensitive to vancomycin and linezolid 78.1 % and 71.9 % sensitive to erythromycin and ciprofloxacin respectively. The most sensitive antimicrobials for Gram negative isolates were polymyxin B 96.2 %, imipenem 94.2 % and ciprofloxacin 76.9 %. Emergency C-section (83 %), premature rupture of membranes (PROM) 30 %, prolong labour 26 %, history of previous caesarean section 22 %, anaemia 15 % cases and BMI ≥ 25 (16 %) were found to be risk factors. CONCLUSIONS The findings of preponderance of Staphylococcus aureus and Gram negative bacilli in this study with good antibiotic sensitivity against the fluoroquinolone and aminoglycosides is of local clinical relevance. KEY WORDS Caesarean Section, Surgical Site Infection, Antimicrobial Susceptibility Pattern, Bacterial Isolates, MRSA Strains

scholarly journals Bacterial profile and antimicrobial susceptibility patterns of isolates among patients diagnosed with surgical site infection at a tertiary teaching hospital in Ethiopia: a prospective cohort study

2021 ◽  
Vol 20 (1) ◽  
Author(s):  
Gemedo Misha ◽  
Legese Chelkeba ◽  
Tsegaye Melaku
Keyword(s):  
Escherichia Coli ◽  
Cohort Study ◽  
Surgical Site Infection ◽  
Prospective Cohort Study ◽  
Antimicrobial Susceptibility ◽  
Prospective Cohort ◽  
Site Infection ◽  
Gram Negative ◽  
Tertiary Teaching ◽  
Susceptibility Patterns

Abstract Background Globally, surgical site infections are the most reported healthcare-associated infection and common surgical complication. In developing countries such as Ethiopia, there is a paucity of published reports on the microbiologic profile and resistance patterns of an isolates. Objective This study aimed at assessing the bacterial profile and antimicrobial susceptibility patterns of isolates among patients diagnosed with surgical site infection at Jimma Medical Center in Ethiopia. Methods A prospective cohort study was employed among adult patients who underwent either elective or emergency surgical procedures. All the eligible patients were followed for 30 days for the occurrence of surgical site infection (SSI). From those who developed SSI, infected wound specimens were collected and studied bacteriologically. Results Of 251 study participants, 126 (50.2%) of them were females. The mean ± SD age of the patients was 38 ± 16.30 years. The overall postoperative surgical site infection rate was 21.1% and of these 71.7% (38/53) were culture positive. On gram stain analysis, 78% of them were Gram-negative, 11.5% were Gram-positive and 10.5% were a mixture of two microbial growths. Escherichia coli accounted for (21.43%), followed by Pseudomonas aeruginosa (19.05%), Proteus species (spp.) 14.29%), Staphylococcus aureus (11.90%), Klebsiella species (11.90%), Citrobacter spp. (9.5%), streptococcal spp. (7.14%), Coagulase-negative S. aureus (CoNS) (2.38%) Conclusion Gram-negative bacteria were the most dominant isolates from surgical sites in the study area. Among the Gram-negative bacilli, Escherichia coli were the most common bacteria causing surgical site infection. As there is high antibiotic resistance observed in the current study, it is necessary for routine microbial analysis of samples and their antibiogram.

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