Physical activity and all-cause mortality across levels of overall and abdominal adiposity in European men and women: the European Prospective Investigation into Cancer and Nutrition Study (EPIC)

AbstractObjective:To describe physical activity of participants in the European Prospective Investigation into Cancer and Nutrition (EPIC).Design:A cross-sectional analysis of baseline data of a European prospective cohort study.Subjects:This analysis was restricted to participants in the age group 50–64 years, which was represented in all EPIC centres. It involved 236 386 participants from 25 centres in nine countries. In each EPIC centre, physical activity was assessed by standardised and validated questions. Frequency distribution of type of professional activity and participation in non-professional activities, and age-adjusted means, medians and percentiles of time dedicated to non-professional activities are presented for men and women from each centre.Results:Professional activity was most frequently classified as sedentary or standing in all centres. There was a wide variation regarding participation in different types of non-professional activities and time dedicated to these activities across EPIC centres. Over 80% of all EPIC participants engaged in walking, while less than 50% of the subjects participated in sport. Total time dedicated to recreational activities was highest among the Dutch participants and lowest among men from Malmö (Sweden) and women from Naples (Italy). In all centres, total time dedicated to recreational activity in the summer was higher than in the winter. Women from southern Europe spent the most time on housekeeping.Conclusions:There is a considerable variation of physical activity across EPIC centres. This variation was especially evident for recreational activities in both men and women.

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The effects of physical activity and body mass index on cardiovascular, cancer and all-cause mortality among 47 212 middle-aged Finnish men and women

International Journal of Obesity ◽

10.1038/sj.ijo.0802870 ◽

2005 ◽

Vol 29 (8) ◽

pp. 894-902 ◽

Cited By ~ 176

Author(s):

G Hu ◽

J Tuomilehto ◽

K Silventoinen ◽

N C Barengo ◽

M Peltonen ◽

...

Keyword(s):

Physical Activity ◽

Body Mass Index ◽

Body Mass ◽

Middle Aged ◽

Men And Women ◽

All Cause Mortality

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Abstract 047: Trajectories of Maintaining Recommended Amounts of Physical Activity in Young Adulthood and Associations with Abdominal Adiposity in Middle Age: The Cardia Study

Circulation ◽

10.1161/circ.127.suppl_12.a047 ◽

2013 ◽

Vol 127 (suppl_12) ◽

Author(s):

Christina M Shay ◽

Laura Colangelo ◽

Mercedes R Carnethon ◽

Kiang Liu ◽

Norrina B Allen ◽

...

Keyword(s):

Physical Activity ◽

Adipose Tissue ◽

Young Adulthood ◽

Middle Age ◽

White Men ◽

Abdominal Adiposity ◽

Men And Women ◽

Highly Active ◽

Active Adults ◽

Modest Activity

Background: Greater abdominal adiposity is associated with insulin resistance and obesity-related vascular disease. Physical activity (PA) is inversely associated with abdominal adiposity yet associations between trends in adherence to PA recommendations through young adulthood and abdominal adiposity in middle age is unclear. Objective: To identify common trajectories of maintaining recommended levels of PA through young adulthood and to examine associations between trajectories and abdominal adiposity at middle age. Methods: The Coronary Artery Risk Development in Young Adults (CARDIA) study is a population-based, prospective, observational study of black and white men and women. PA was assessed at 8 exams across 25 years of follow-up. PA trajectories were identified by group-based modeling (PROC TRAJ) based on likelihood of maintaining recommended PA levels across exams. Visceral, subcutaneous, and abdominal intermuscular adipose tissue volumes (cm3) were assessed by computed tomography at the year 25 exam (43-55 yrs, n=3180). Results: Four major PA trajectories were identified: highly active (27.3%), declining activity (18.2%), modestly active (20.7%) and always sedentary (33.8%). Abdominal adipose tissue volumes by PA trajectory, race, and sex are displayed in Figure 1. Among white men and women, abdominal adiposity was lowest in always active adults and highest in those always sedentary; higher abdominal adiposity was observed with declining activity compared to modest activity. In black women, highest levels of abdominal adiposity were observed with declining activity. Black men exhibited no differences in abdominal adiposity across PA trajectory groups. Conclusions: Maintaining recommended physical activity levels through young adulthood is associated with lower abdominal adiposity at middle age. Highly active adults who exhibit declining physical activity towards middle age exhibit higher abdominal adiposity compared to adults with consistent modest activity throughout adulthood.

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Associations of Objectively Measured Physical Activity and Sedentary Time with the Risk of Stroke, Myocardial Infarction or All-Cause Mortality in 70-Year-Old Men and Women: A Prospective Cohort Study

Sports Medicine ◽

10.1007/s40279-020-01356-y ◽

2020 ◽

Author(s):

Marcel Ballin ◽

Peter Nordström ◽

Johan Niklasson ◽

Anna Nordström

Keyword(s):

Physical Activity ◽

Myocardial Infarction ◽

Lower Risk ◽

Sedentary Time ◽

Moderate Intensity ◽

Men And Women ◽

All Cause Mortality ◽

Objectively Measured ◽

Incident Cases ◽

Objectively Measured Physical Activity

Abstract Objective To study the associations of objectively measured physical activity (PA) and sedentary time (ST) with the combined outcome of incident stroke, myocardial infarction (MI) or all-cause mortality in older adults. Methods N = 3343 men and women aged 70 who participated in a health survey between 2012 and 2017 were included. Actigraph GT3X+ accelerometers were used to measure light-intensity PA (LPA), moderate-intensity PA (MPA) and ST for 1 week. Incident cases of cardiovascular disease (CVD) in terms of stroke or MI, and all-cause mortality were identified using national registers. Hazard ratios (HR) and 95% confidence intervals (CI) were estimated using multivariable-adjusted Cox regressions. Results During a mean follow-up of 2.7 years (0.1–5.6), there were 124 events of CVD or all-cause mortality. After adjusting for potential confounders and mediators, every 30-min/day increment in LPA was associated with 11% lower risk of CVD or all-cause mortality (HR 0.89, 95% CI 0.82–0.97), and every 30-min/day increment in MPA was associated with 36% lower risk (HR 0.64, 95% CI 0.48–0.84). Every 1-h/day increment in ST increased the risk of the outcomes by 33% (HR 1.33, 95% CI 1.14–1.56), although there was no significant association among participants who performed ≥ 30 min/day MPA (HR 1.11, 95% CI 0.82–1.50, P = 0.034 for interaction). None of the associations were modified by sex (P > 0.4 for all). Conclusion Objectively measured LPA and MPA are each associated with lower risk of stroke, MI or all-cause mortality in 70-year-old individuals, while ST is associated with increased risk. The greatest risk reduction is observed for MPA, which also appears to attenuate some of the increased risks associated with ST.

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Changes in waist circumference and risk of all-cause and CVD mortality: results from the European Prospective Investigation into Cancer in Norfolk (EPIC-Norfolk) cohort study

BMC Cardiovascular Disorders ◽

10.1186/s12872-019-1223-z ◽

2019 ◽

Vol 19 (1) ◽

Cited By ~ 6

Author(s):

Angela A. Mulligan ◽

Marleen A. H. Lentjes ◽

Robert N. Luben ◽

Nicholas J. Wareham ◽

Kay-Tee Khaw

Keyword(s):

Weight Loss ◽

Waist Circumference ◽

Mortality Risk ◽

Total Mortality ◽

Later Life ◽

Central Adiposity ◽

Men And Women ◽

All Cause Mortality ◽

Cvd Mortality ◽

Prospective Investigation

Abstract Background Measures of abdominal adiposity are strongly associated with all-cause mortality and cardiovascular disease (CVD). However, data are limited and conflicting regarding the consequences of changes in body fat distribution. The main aims of this paper are to investigate the association between changes in waist circumference (WC) and all-cause and CVD mortality and to examine these changes in relation to concurrent changes in weight. Methods The European Prospective Investigation into Cancer and Nutrition (EPIC-Norfolk) study recruited 25,639 participants between 1993 and 1997, aged 39–79, a number of whom also attended a second examination (1998–2000), and were followed up to 2016 for mortality. Participants were eligible for inclusion if they had WC, weight and height measurements at both time-points; those with a self-reported history of CVD or cancer, body mass index < 18.5 kg/m2 or missing data on covariates were excluded, leaving 12,337 participants for analyses. The median (IQR) follow-up time was 16.4 (15.7, 17.2) years. Hazard Ratios (HRs) for all-cause (2866 deaths) and CVD mortality (822 deaths), by categories of WC change, were determined using Cox proportional hazards analyses. Results After multivariable adjustment, the HRs (95% CIs) for all-cause mortality for men and women with a WC gain (WCG) > 5 cm were 1.51 (1.29–1.75) and 1.25 (1.06–1.46) respectively. For CVD mortality in men and women with a WCG > 5 cm, the HRs were 1.84 (1.39–2.43) and 1.15 (0.85–1.55) respectively. In analyses of concurrent changes in WC and weight, the greatest risk (HRs) (95% CIs) in men occurred with weight loss and WCG: 1.80 (1.13–2.86) for all-cause and 2.22 (1.03–4.82) for CVD mortality. In women, the greatest risk for both all-cause (HR 1.50 (1.16–1.95)) and CVD mortality (HR 1.81 (1.15–2.85)) was observed in those with weight loss and maintenance of WC (WCM). Conclusions Objectively measured WCG > 5 cm, was associated with subsequent higher total mortality risk and higher CVD mortality risk in men. Interventions focusing on preventing increase in central adiposity rather than lowering weight per se in later life may potentially have greater health benefits.

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