Environmental and Occupational Factors on Implantation Failure

2021 ◽  
pp. 27-41
Author(s):  
Khursheed Ahmad Wani ◽  
Javid Ahmad Lone ◽  
Waseem Yaseen ◽  
Junaid Ahmad Malik
Keyword(s):  
Occupational Exposure ◽  
Indirect Effect ◽  
Lower Incidence ◽  
Reproductive Activity ◽  
Coping Mechanisms ◽  
Hazardous Substances ◽  
Implantation Failure ◽  
Reproductive Outcomes ◽  
Wide Range ◽  
Occupational Settings

It has been shown that reproductive activity is responsive to changes in the physical, psychosocial, and chemical environments. Occupational exposure has been identified to a wide range of putative hazards and adverse reproductive outcomes, or fertility. Such risks include the physical environment such as VDT and noise, as well as psychosocial stress and chemical agents. Some of these may have a direct or indirect effect on IVF outcomes. Psychosocial factors such as inadequate coping mechanisms, anxiety and/or depression are related to a lower incidence of IVF pregnancy. In this chapter the authors focus on the difficulties involved in linking exposure to putative hazardous substances to adverse reproductive outcomes in environmental and occupational settings, particularly the effectiveness of IVF procedures.

The Politics of Precaution

2012 ◽  
Author(s):  
David Vogel
Keyword(s):  
United States ◽  
Animal Feed ◽  
The United States ◽  
Hazardous Substances ◽  
Risk Regulation ◽  
Scientific Certainty ◽  
European Public ◽  
Wide Range ◽  
Regulatory Controls ◽  
Milk Hormones

This book examines the politics of consumer and environmental risk regulation in the United States and Europe over the last five decades, explaining why America and Europe have often regulated a wide range of similar risks differently. It finds that between 1960 and 1990, American health, safety, and environmental regulations were more stringent, risk averse, comprehensive, and innovative than those adopted in Europe. But since around 1990 global regulatory leadership has shifted to Europe. What explains this striking reversal? This book takes an in-depth, comparative look at European and American policies toward a range of consumer and environmental risks, including vehicle air pollution, ozone depletion, climate change, beef and milk hormones, genetically modified agriculture, antibiotics in animal feed, pesticides, cosmetic safety, and hazardous substances in electronic products. The book traces how concerns over such risks—and pressure on political leaders to do something about them—have risen among the European public but declined among Americans. The book explores how policymakers in Europe have grown supportive of more stringent regulations while those in the United States have become sharply polarized along partisan lines. And as European policymakers have grown more willing to regulate risks on precautionary grounds, increasingly skeptical American policymakers have called for higher levels of scientific certainty before imposing additional regulatory controls on business.

Lung Function and Quality of Life in Workers with Chemical and Dust Exposure

2018 ◽  
Vol 69 (2) ◽  
pp. 346-349 ◽  
Author(s):  
Marina Ruxandra Otelea ◽  
Oana Cristina Arghir ◽  
Corina Zugravu ◽  
Eugenia Naghi ◽  
Sabina Antoniu ◽  
...  
Keyword(s):  
Quality Of Life ◽  
Occupational Exposure ◽  
Lung Function ◽  
Lung Diseases ◽  
Dust Exposure ◽  
Chronic Lung Diseases ◽  
Respiratory Exposure ◽  
Increased Risk ◽  
Occupational Settings

Regarding the widely distribution of respiratory exposure hazards in occupational settings, workers have an increased risk for chronic lung diseases. For assessing the quality of life and lung function in workers exposed to chemicals and dust, St George�s Respiratory Questionnaire (SGRQ) and spirometry were performed among 40 patients, admitted in Occupational Clinic Department of Colentina Hospital, Bucharest, Romania, during February, 2017. SGRQ showed different predictors for patients according to their occupational exposure and total symptoms score correlated better with decreased spirometric parameters in defining lung function deterioration. Quality of life is earlier affected than lung function deterioration and emphasises the need of more sensitive methods for an earlier identification and better evaluation of respiratory hazards in different workplaces.

scholarly journals The Role of the Reactive Species Involved in the Photocatalytic Degradation of HDPE Microplastics Using C,N-TiO2 Powders

Polymers ◽  
2021 ◽  
Vol 13 (7) ◽  
pp. 999 ◽  
Author(s):  
Aranza Denisse Vital-Grappin ◽  
Maria Camila Ariza-Tarazona ◽  
Valeria Montserrat Luna-Hernández ◽  
Juan Francisco Villarreal-Chiu ◽  
Juan Manuel Hernández-López ◽  
...  
Keyword(s):  
Wastewater Treatment Plants ◽  
Reaction System ◽  
Terrestrial Ecosystems ◽  
Degradation Process ◽  
Reactive Species ◽  
Hazardous Substances ◽  
Wide Range ◽  
Degradation Behaviors ◽  
Environmentally Friendly Process

Microplastics (MPs) are distributed in a wide range of aquatic and terrestrial ecosystems throughout the planet. They are known to adsorb hazardous substances and can transfer them across the trophic web. To eliminate MPs pollution in an environmentally friendly process, we propose using a photocatalytic process that can easily be implemented in wastewater treatment plants (WWTPs). As photocatalysis involves the formation of reactive species such as holes (h+), electrons (e−), hydroxyl (OH●), and superoxide ion (O2●−) radicals, it is imperative to determine the role of those species in the degradation process to design an effective photocatalytic system. However, for MPs, this information is limited in the literature. Therefore, we present such reactive species’ role in the degradation of high-density polyethylene (HDPE) MPs using C,N-TiO2. Tert-butanol, isopropyl alcohol (IPA), Tiron, and Cu(NO3)2 were confirmed as adequate OH●, h+, O2●− and e− scavengers. These results revealed for the first time that the formation of free OH● through the pathways involving the photogenerated e− plays an essential role in the MPs’ degradation. Furthermore, the degradation behaviors observed when h+ and O2●− were removed from the reaction system suggest that these species can also perform the initiating step of degradation.

Gefahrstoffe am Arbeitsplatz – Arbeitsplatzgrenzwert, Immissionsgrenzwert oder Innenraumrichtwert?/Hazardous substances at workplace – Occupational exposure limit, immission limit value or indoor air guide value?

Gefahrstoffe ◽  
2019 ◽  
Vol 79 (07-08) ◽  
pp. 255-259
Author(s):  
R. Hebisch ◽  
T. Kuhlbusch ◽  
K. Bux ◽  
D. Breuer ◽  
T. Lahrz
Keyword(s):  
Occupational Exposure ◽  
Indoor Air ◽  
Hazardous Substances ◽  
Occupational Exposure Limit ◽  
Guide Value ◽  
Limit Value ◽  
Exposure Limit

Die Beurteilung der Konzentrationen von Gefahrstoffen in der Luft kann anhand verschiedener Beurteilungsmaßstäbe erfolgen. Einerseits ist dafür ausschlaggebend, ob Tätigkeiten mit Gefahrstoffen oder ohne Gefahrstoffe ausgeführt werden. Andererseits ist auch immer zu berücksichtigen, ob die Tätigkeiten im Freien, in teilweise geschlossenen oder geschlossenen Arbeitsbereichen erfolgen. Es werden einzelne Szenarien näher betrachtet und die Expositionsbeurteilung wird anhand von Arbeitsplatzgrenzwerten, Immissionsgrenzwerten und Innenraumrichtwerten dargestellt. Dabei wird insbesondere auf solche Situationen eingegangen, die sich nicht eindeutig voneinander abgrenzen lassen.

scholarly journals 178Depression but not physical activity mediates the fatigue-mental quality of life relationship in multiple sclerosis

2021 ◽  
Vol 50 (Supplement_1) ◽  
Author(s):  
Alexander Fidao ◽  
Alysha De Livera ◽  
Tracey Weiland ◽  
George Jelinek ◽  
Sandra Neate ◽  
...  
Keyword(s):  
Quality Of Life ◽  
Physical Activity ◽  
Multiple Sclerosis ◽  
Indirect Effect ◽  
Mediation Effect ◽  
Study Cohort ◽  
Wide Range ◽  
Clinically Significant

Abstract Background Fatigue is among the most prevalent symptoms of multiple sclerosis (MS), and significantly detrimental to mental quality of life. We examined the role of depression and physical activity as mediators in the fatigue-QoL relationship in MS. Methods Using an international study cohort measuring a wide range of lifestyle and clinical factors, determinants of fatigue (Fatigue Severity Scale) and mental quality of life (MSQoL-54; QoL) were assessed in 2,104 participants using log-binomial and linear regression, respectively. Structural equation modelling (SEM) was used to assess the mediating role of depression and physical activity between fatigue and mental QoL. Results The median mental QoL score in the sample was 73.8/100. The mean fatigue score was 40.5/63, with 65.6% having clinically significant fatigue. In SEM analyses evaluating depression as a mediator of the fatigue-QoL relationship, mental QoL was 14.17-points lower in those with clinically significant fatigue, of which the indirect effect via depression accounted for over 30.8% (p < 0.001). This mediation effect was most pronounced for the Role Limitations from Emotional Issues (44.9%, p < 0.001) and Emotional Wellbeing (41.6%, p < 0.001) subdomains. Evaluating physical activity as a mediator of the fatigue-QoL relationship, mental QoL was 11.03-points lower in those with clinically significant fatigue, of which the indirect effect via physical activity accounted for only 1.0% (p = 0.001). Conclusions This study provides evidence that depression accounts for a majority of the fatigue-mental QoL relationship, while physical activity only plays a small role. While replication and longitudinal studies are required for validation, our findings may inform the development of treatments for reducing the impacts of fatigue and improving QoL in people with MS. Key messages Fatigue’s negative impact on emotional quality of life in multiple sclerosis is not a function of reduced ambulation but instead its impact on depression. Reducing depression may thus markedly improve quality of life in this population.

4. Enforcing EU law rights in national courts

2017 ◽  
Author(s):  
Elspeth Berry ◽  
Matthew J. Homewood ◽  
Barbara Bogusz
Keyword(s):  
Direct Effect ◽  
Indirect Effect ◽  
Eu Law ◽  
National Courts ◽  
Wide Range ◽  
Complete Series ◽  
Explanatory Text ◽  
State Liability ◽  
The Relationship ◽  
Primary Materials

Titles in the Complete series combine extracts from a wide range of primary materials with clear explanatory text to provide readers with a complete introductory resource. This chapter discusses the development of the concepts of the direct effect and indirect effect of EU law—in other words, the rights of an individual or business to rely on a provision of EU law in their national courts; the rules that apply to the grant of remedies in national courts for breach of directly or indirectly effective EU law; and the relationship between direct and indirect effect, and the principle of State liability.

scholarly journals Alterations in immune and renal biomarkers among workers occupationally exposed to low levels of trichloroethylene below current regulatory standards

2019 ◽  
Vol 76 (6) ◽  
pp. 376-381 ◽  
Author(s):  
Kyoung-Mu Lee ◽  
Luoping Zhang ◽  
Roel Vermeulen ◽  
Wei Hu ◽  
Bryan A Bassig ◽  
...  
Keyword(s):  
Occupational Exposure ◽  
Immune Function ◽  
Occupational Exposures ◽  
Effector Memory ◽  
Kidney Toxicity ◽  
Renal Biomarkers ◽  
Regulatory Standards ◽  
Wide Range ◽  
Occupationally Exposed ◽  
Low Levels

ObjectivesThe occupational exposure limit for trichloroethylene (TCE) in different countries varies from 1 to 100 ppm as an 8-hour time-weighted average (TWA). Many countries currently use 10 ppm as the regulatory standard for occupational exposures, but the biological effects in humans at this level of exposure remain unclear. The objective of our study was to evaluate alterations in immune and renal biomarkers among workers occupationally exposed to low levels of TCE below current regulatory standards.MethodsWe conducted a cross-sectional molecular epidemiology study of 80 healthy workers exposed to a wide range of TCE (ie, 0.4–229 ppm) and 96 comparable unexposed controls in China, and previously reported that TCE exposure was associated with multiple candidate biological markers related to immune function and kidney toxicity. Here, we conducted further analyses of all of the 31 biomarkers that we have measured to determine the magnitude and statistical significance of changes in the subgroup of workers (n=35) exposed to <10 ppm TCE compared with controls.ResultsSix immune biomarkers (ie, CD4+ effector memory T cells, sCD27, sCD30, interleukin-10, IgG and IgM) were significantly decreased (% difference ranged from −16.0% to −72.1%) and one kidney toxicity marker (kidney injury molecule-1, KIM-1) was significantly increased (% difference: +52.5%) among workers exposed to <10 ppm compared with the control group. These associations remained noteworthy after taking into account multiple comparisons using the false discovery rate (ie, <0.20).ConclusionOur results suggest that occupational exposure to TCE below 10 ppm as an 8-hour TWA may alter levels of key markers of immune function and kidney toxicity.

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