Smart Medical Kit in Chronic Kidney Disease Management

2022 ◽  
pp. 24-40
Author(s):  
Pitchumani Angayarkanni Sekaran
Keyword(s):  
Chronic Disease ◽  
Kidney Disease ◽  
Remote Monitoring ◽  
Patient Monitoring ◽  
Quality Care ◽  
Heterogeneous Systems ◽  
Health Conditions ◽  
Health Issues ◽  
Camera Systems ◽  
Wide Range

Internet of things (IoT)-enabled devices perform remote monitoring of patients and keep them healthy. They also facilitate physicians to provide high-quality care to their patients with accurate data. Chronic disease involves a wide range of health issues like diabetics, asthma, heart disease, kidney disease, and other disorders. To avoid disease progression, the IoT-based smart medical kit helps in episodic patient monitoring, continuous patient monitoring in acute conditions, and patient alarm monitoring. The chapter focuses on the deployment of interconnected devices (sensors, actuators, monitors, detectors, and camera systems) to collect data from heterogeneous systems. The output is connected to a think speak dashboard for monitoring the variation over the period. The smart kit provides more accurate and reliable recommendations to assist patients in controlling their chronic disease and assists in remote monitoring of a patient's health conditions.

Augmented care: An alternative model of care for people with chronic disease

2017 ◽  
Vol 20 (1-2) ◽  
pp. 5-7 ◽  
Author(s):  
Michael Gill
Keyword(s):  
Health Care ◽  
Chronic Disease ◽  
Chronic Conditions ◽  
Patient Empowerment ◽  
World Health Organisation ◽  
World Health ◽  
Health Issues ◽  
Model Of Care ◽  
Current Health ◽  
Wide Range

This opinion piece challenges the concept of ‘patient’ and discusses an alternative aspect to delivering health care for those with chronic disease. Chronic conditions are defined by the World Health Organisation (WHO), as illnesses requiring ongoing management over a long period of time and may address a wide range of health issues. Success is highly dependent upon optimised patient empowerment. I argue that it is not health care that really matters but opportunities to build upon optimising wellness. This leads to the idea where I suggest that current health system rigidities inadvertently promote illness.

scholarly journals Prevalence of concordant and discordant comorbidity in chronic kidney disease: a large cross-sectional study

2020 ◽  
pp. bjgp20X714125
Author(s):  
Clare Elizabeth MacRae ◽  
Stewart Mercer ◽  
Bruce Guthrie ◽  
David Henderson
Keyword(s):  
Mental Health ◽  
Primary Care ◽  
Chronic Kidney Disease ◽  
Kidney Disease ◽  
Secondary Analysis ◽  
Routine Care ◽  
Health Conditions ◽  
Physical And Mental Health ◽  
Cross Sectional ◽  
Wide Range

Abstract Background: Chronic kidney disease (CKD) is commonly comorbid with hypertension, diabetes and cardiovascular disease (CVD). However, the extent of comorbidity in CKD across a wider range of conditions is not well documented. Aim: To ascertain the prevalence of comorbidity (across 39 physical and mental health comorbidities) in adults aged 25 years and over with CKD in a large nationally representative primary care population. Design and Setting: Cross-sectional analysis of a primary care dataset representing 1,274,374 adults in Scotland. Method: Secondary analysis of general practice electronic medical record data. Comparison was made with the entire population without CKD, standardised for age, sex, and socioeconomic status (SES). Results: A total of 98.2% of adults with CKD had at least one comorbidity (vs. 51.8% in controls). After adjustment for age, sex, and deprivation, people with CKD were more likely to have 1-3 conditions (OR 11.2, 95% CI 10.3-12.2), 4-6 conditions (OR 24.9, 95% CI 22.9-27.0), and ≥7 conditions (OR 38.9, 95% CI 35.6-42.6. Furthermore, all concordant (7 out of 7) and the majority of discordant physical health conditions (17 out of 24) and mental health conditions (6 out of 8) had significantly positive associations with CKD after adjustment. Conclusion: CKD is associated with extreme comorbidity, across a wide range of mental and physical conditions. Routine care for people with CKD should include recognition and management of comorbidities and clinical guidelines should support clinicians to do this.

scholarly journals Non-Albumin Proteinuria (NAP) as a Complementary Marker for Diabetic Kidney Disease (DKD)

Life ◽  
2021 ◽  
Vol 11 (3) ◽  
pp. 224
Author(s):  
Jaehyun Bae ◽  
Young Jun Won ◽  
Byung-Wan Lee
Keyword(s):  
Kidney Disease ◽  
Filtration Rate ◽  
Diabetic Kidney Disease ◽  
Estimated Glomerular Filtration Rate ◽  
Early Stage ◽  
Screening Tools ◽  
Tubular Injury ◽  
Current Standard ◽  
Diabetic Kidney ◽  
Wide Range

Diabetic kidney disease (DKD) is one of the most common forms of chronic kidney disease. Its pathogenic mechanism is complex, and it can affect entire structures of the kidney. However, conventional approaches to early stage DKD have focused on changes to the glomerulus. Current standard screening tools for DKD, albuminuria, and estimated glomerular filtration rate are insufficient to reflect early tubular injury. Therefore, many tubular biomarkers have been suggested. Non-albumin proteinuria (NAP) contains a wide range of tubular biomarkers and is convenient to measure. We reviewed the clinical meanings of NAP and its significance as a marker for early stage DKD.

scholarly journals Exploring Suppliers’ Approaches toward Workplace Safety Compliance in the Global Garment Sector: From Bangladesh Perspective

2021 ◽  
Vol 10 (3) ◽  
pp. 90
Author(s):  
Md Sultan Mahmood ◽  
Nilima Haque Ruma ◽  
Toufiq Ahmed ◽  
Yukari Nagai
Keyword(s):  
Case Study Research ◽  
Code Of Conduct ◽  
Workplace Safety ◽  
Research Strategy ◽  
Social Needs ◽  
Health Issues ◽  
Labor Laws ◽  
Wide Range ◽  
Safety Compliance ◽  
Health Rights

The readymade garment (RMG) sector is one of the main drivers of the Bangladesh economy with over 4 million employed. In the 2013 Rana Plaza accident aftermath, the implementation of workplace safety compliance (WSC) became imperative. The paper investigated the WSC initiatives implemented by the RMG sector to overcome safety challenges and their effectiveness for a safe and healthy workplace. We employed a multi-case study research strategy over three Bangladeshi garment manufacturers to resolve these queries. The result revealed that the manufacturers joined in the safety governance programs to protect workers’ health safety rights immediately after the accidents. They participated in inspections and remediations programs over structural, electrical, and fire protection as a priority. Moreover, several other human rights conventions, national labor laws and, buyer code of conduct were also adopted as regulatory and voluntary initiatives to settle workers’ health rights and social needs. The WSC enforcement empowered workers to bargain their rights toward a safe workplace and made them responsible for responding during an emergency. Finally, the paper argues that the WSC in the RMG sector nowadays covers a wide range of initiatives in three broad areas: physical environment safety, workers’ health issues, and workers’ rights.

scholarly journals Testing the Mig-HealthCare Algorithm in Greece

2020 ◽  
Vol 30 (Supplement_5) ◽  
Author(s):  
E Riza ◽  
P Karnaki ◽  
D Zota ◽  
A Linos
Keyword(s):  
Health Care ◽  
Early Stage ◽  
Health Care Systems ◽  
Health Conditions ◽  
Health Issues ◽  
Host Countries ◽  
Local Hospital ◽  
Raising Awareness ◽  
Significant Burden ◽  
Care Systems

Abstract The Mig-HealthCare Algorithm is a tool, comprising a set of questions developed with the aim to (a) guide the user on how to access all the categories and tools that are available through the Roadmap & Toolbox (b) help the user identify the health issues of importance when providing care to a specific migrant/refugee. At the end of a series of questions, a brief report summarizing the main outcomes is generated. The algorithm was tested in Greece in two mainland reception centres and a local hospital in an area serving migrants/refugees. Results discuss the usefulness of the algorithm for improving the delivery of appropriate health services to migrants/refugees and its importance in raising awareness about the health conditions which are crucial for migrants/refugees and are expected to pose a significant burden on the health care systems of host countries unless dealt with adequately at an early stage.

scholarly journals Diffuse Water Pollution from Agriculture: A Review of Nature-Based Solutions for Nitrogen Removal and Recovery

Water ◽  
2021 ◽  
Vol 13 (14) ◽  
pp. 1893
Author(s):  
Giuseppe Mancuso ◽  
Grazia Federica Bencresciuto ◽  
Stevo Lavrnić ◽  
Attilio Toscano
Keyword(s):  
Water Pollution ◽  
Nitrogen Removal ◽  
Plant Uptake ◽  
Environmental Issues ◽  
Polluted Water ◽  
Health Issues ◽  
Agricultural Wastewater ◽  
Research Activities ◽  
Wide Range ◽  
Different Types

The implementation of nature-based solutions (NBSs) can be a suitable and sustainable approach to coping with environmental issues related to diffuse water pollution from agriculture. NBSs exploit natural mitigation processes that can promote the removal of different contaminants from agricultural wastewater, and they can also enable the recovery of otherwise lost resources (i.e., nutrients). Among these, nitrogen impacts different ecosystems, resulting in serious environmental and human health issues. Recent research activities have investigated the capability of NBS to remove nitrogen from polluted water. However, the regulating mechanisms for nitrogen removal can be complex, since a wide range of decontamination pathways, such as plant uptake, microbial degradation, substrate adsorption and filtration, precipitation, sedimentation, and volatilization, can be involved. Investigating these processes is beneficial for the enhancement of the performance of NBSs. The present study provides a comprehensive review of factors that can influence nitrogen removal in different types of NBSs, and the possible strategies for nitrogen recovery that have been reported in the literature.

P0031AURINE METABOLOMICS: AN EMERGING TOOL FOR DISSECTING BIOLOGICAL ABERRATIONS UNDERLYING RENAL DYSFUNCTION IN BARDET-BIEDL SYNDROME

2020 ◽  
Vol 35 (Supplement_3) ◽  
Author(s):  
Miriam Zacchia ◽  
Emanuela Marchese ◽  
Marianna Caterino ◽  
Margherita Ruoppolo ◽  
Giovambattista Capasso
Keyword(s):  
Lactic Acid ◽  
Kidney Disease ◽  
Renal Disease ◽  
Renal Dysfunction ◽  
Metabolic Pathways ◽  
Healthy Subjects ◽  
Hexadecenoic Acid ◽  
Kidney Dysfunction ◽  
Bardet Biedl Syndrome ◽  
Wide Range

Abstract Background and Aims Bardet Biedl Syndrome (BBS) is a rare genetic disorder characterized by a wide range of organ dysfunction, including kidney disease. The severity of renal dysfunction is highly variable in this setting, ranging from tubular defects to the end stage renal disease, with poor genotype-phenotype correlation. Proteomics and metabolomics are powerful tools able to contribute to the better understanding of molecular basis of disease conditions. Our previous studies demonstrated that the urinary proteomic pattern of BBS patients differed from that of healthy subjects, with a set of deregulated proteins including cell adhesion and extracellular matrix organization proteins (1). The present study aims to characterize urine metabolomic profile of BBS patients, in order to identify both 1) potential disease biomarkers and 2) aberrant metabolic pathways underlying renal disease Method To this end, in the pilot study urine samples have been collected from 14 adult BBS patients and have been compared with healthy volunteers, using an untargeted strategy. In the confirmation study, 24 BBS patients with wide range of kidney dysfunction have been enrolled, and additional control groups, besides healthy subjects, were included: 1) age-gender-matched chronic kidney disease patients by other causes and 2) obese individuals. Results Several metabolites were de-regulated in BBS patients compared with normal subjects (lactic acid, glycolic acid,3-Hydroxypropionic acid, pyruvic acid, 3-hydroxyisobutyric acid, 2-ethyl-3-hydroxy-propionic acid, succinic acid, fumaric acid, erythropentonic acid, 2-hydroxyglutaric acid, 4-hydroxyphenyllactic acid, 3,4-pyridinedicarboxylic acid, retinoic acid, 4-hydroxyphenylacetic acid, palmitic acid, 9-Hexadecenoic acid, oleic acid and 9-Octadecenoic acid). The clusterization performed by MetaboAnalyst tool, revealed a possible deregulation of different metabolic pathways, including glycolysis, TCA cycle, pyruvate metabolism, lipids biosynthesis and glutamate metabolism (p-value <0.01) (figure 1); some of these pathways were described as de-regulated in other ciliopathies (2). In the confirmation study (on-going studies) some metabolites, including lactic acid and intermediates of Krebs cycle, correlated with kidney dysfunction only in the BBS group. Conclusion These findings suggest that urine metabolomic fingerprint of BBS patients is different from that of healthy subjects and indicate a possible deregulation of several metabolic pathways; some urinary molecules correlated with kidney dysfunction only in BBS patients, suggesting the specificity of these results.

scholarly journals New PAX2 Mutation Associated with Polycystic Kidney Disease: A Case Report

2021 ◽  
Vol 15 ◽  
pp. 117955652199235
Author(s):  
Jessica Maria Forero-Delgadillo ◽  
Vanessa Ochoa ◽  
Natalia Duque ◽  
Jaime Manuel Restrepo ◽  
Hernando Londoño ◽  
...  
Keyword(s):  
Kidney Disease ◽  
Novel Mutation ◽  
Clinical Manifestations ◽  
Renal Cysts ◽  
Renal Dysplasia ◽  
Cystic Kidney Disease ◽  
Cystic Kidney ◽  
Incomplete Penetrance ◽  
Wide Range ◽  
Stage Renal Disease

Background: Congenital anomalies of the kidney and urinary tract (CAKUT) are the leading cause of end stage renal disease in children. Diagnosis by genetic testing has proven challenging due to its genetic and phenotypic heterogeneity, as well as incomplete penetrance. We report a case on a 16-months old female with a history of renal cysts and a PAX2 mutation. Case presentation: The patient presented with a prenatal diagnosis of Potter sequence and a postnatal diagnosis of renal cysts. An ultrasound at 20 weeks gestation revealed right renal agenesis and possible left renal dysplasia. Post natal genetic analyses identified a novel mutation in PAX2. Conclusion: Cystic kidney disease is often underdiagnosed due to its variable expressivity and wide range of clinical manifestations; PAX2 genetic screening should be considered for all patients with CAKUT.

scholarly journals Role of Serum Transferrin Receptor in Diagnosing and Differentiating Iron Deficiency Anemia from Anemia of Chronic Disease in Patients with Chronic Kidney Disease

2017 ◽  
Vol 7 (2) ◽  
pp. 132-137
Author(s):  
Abdul Latif ◽  
Muhammad Rafiqul Alam ◽  
Asia Khanam ◽  
Farhana Hoque ◽  
Muhammad Abdur Rahim ◽  
...  
Keyword(s):  
Chronic Kidney Disease ◽  
Chronic Disease ◽  
Kidney Disease ◽  
Iron Deficiency ◽  
Iron Deficiency Anemia ◽  
Transferrin Receptor ◽  
Deficiency Anemia ◽  
Control Group ◽  
Anemia Of Chronic Disease ◽  
Female Ratio

Background: Anemia is common in patients with chronic kidney disease (CKD) and this is generally anemia of chronic disease, but iron deficiency anemia (IDA) is also common. Soluble transferrin receptor (sTfR) is a useful marker for IDA. Present study was undertaken to assess the utility of sTfR as a marker of IDA in selected group of Bangladeshi patients with CKD.Methods: This cross-sectional study was conducted in the Department of Nephrology, BSMMU, Dhaka, Bangladesh from January 2013 to December 2014. Patients with anemia admitted in nephrology department whether on hemodialysis or not and medicine department of BSMMU were taken for study. The study population was further divided into two groups; Group A, patients who are having IDA and Group B, patients with ACD and a control group was also selected. Data were collected by face to face interview and laboratory investigations with a self-administered questionnaire.Results: The mean age of the patients in two study groups were 38.40±13.23 and 34.85±10.52 years respectively and male-female ratio were 0.5:1 and 1:0.5. Mean sTfR level was higher (4.81± 1.64 ?g/ml) in patients with IDA than (2.89±1.40 ?g/ml) in patients with ACD (p <0.0001). In our study mean ferritin level was 599.59± 449.15?g/L in ACD patients whereas 101.23±119.42 in IDA patients (p<0.0001). Total iron binding capacity (TIBC) was more in ACD patients with sTfRe”3?g/ml as compared to ACD patients with sTfR<3?g/ml. Transferrin saturation (TSAT) level was significantly decreased in ACD patients with sTfR ?3?g/ml as compared to ACD patients with sTfR<3?g/ml.Conclusion: sTfR has a comparable ability to S. ferritin in diagnosing IDA and ACD. However, sTfR and serum ferritin alone cannot definitely exclude co-existing iron deficiency in ACD. As sTfR is not affected by infection and/or inflammation, thus providing a non-invasive alternative to bone marrow study.Birdem Med J 2017; 7(2): 132-137

scholarly journals Heme Oxygenase 1: A Defensive Mediator in Kidney Diseases

2021 ◽  
Vol 22 (4) ◽  
pp. 2009
Author(s):  
Anne Grunenwald ◽  
Lubka T. Roumenina ◽  
Marie Frimat
Keyword(s):  
Kidney Disease ◽  
Heme Oxygenase ◽  
Current Knowledge ◽  
Kidney Diseases ◽  
Heme Oxygenase 1 ◽  
Wide Range ◽  
Significant Burden ◽  
Stage Renal Disease ◽  
End Stage ◽  
Positive Effect

The incidence of kidney disease is rising, constituting a significant burden on the healthcare system and making identification of new therapeutic targets increasingly urgent. The heme oxygenase (HO) system performs an important function in the regulation of oxidative stress and inflammation and, via these mechanisms, is thought to play a role in the prevention of non-specific injuries following acute renal failure or resulting from chronic kidney disease. The expression of HO-1 is strongly inducible by a wide range of stimuli in the kidney, consequent to the kidney’s filtration role which means HO-1 is exposed to a wide range of endogenous and exogenous molecules, and it has been shown to be protective in a variety of nephropathological animal models. Interestingly, the positive effect of HO-1 occurs in both hemolysis- and rhabdomyolysis-dominated diseases, where the kidney is extensively exposed to heme (a major HO-1 inducer), as well as in non-heme-dependent diseases such as hypertension, diabetic nephropathy or progression to end-stage renal disease. This highlights the complexity of HO-1’s functions, which is also illustrated by the fact that, despite the abundance of preclinical data, no drug targeting HO-1 has so far been translated into clinical use. The objective of this review is to assess current knowledge relating HO-1’s role in the kidney and its potential interest as a nephroprotection agent. The potential therapeutic openings will be presented, in particular through the identification of clinical trials targeting this enzyme or its products.

Sign in / Sign up

Export Citation Format

Share Document