Extrusion Uniformity Optimization for Shaping Channel Design in Large-Scale Die-Plate of Underwater Pelletizing

2013 ◽  
Vol 275-277 ◽  
pp. 562-566 ◽  
Author(s):  
Bing Zhang ◽  
Xiao Feng Liu ◽  
Chao Bi
Keyword(s):  
Large Scale ◽  
Three Dimensional ◽  
Polymer Melt ◽  
Optimization Method ◽  
Three Dimensional Flow ◽  
Element Simulation ◽  
Bp Neural Network Model ◽  
Plate Channel ◽  
The Relationship

As an important component of large-scale extruder system for polymer material, Die-plate can be regarded as the final determinant for pelletization uniformity. Polymer melt was shaped in shaping channels and extruded from die-holes from Die-plate and then be diced. The design of shaping channels directly influences the uniformity for polymer-melt extrusion pressure and extrusion velocity of different die holes. In this paper, a three-dimensional flow model for polymer flow in Die-plate channel was presented, and then finite element simulation was used to analyze the distribution of extrusion velocity in each die-hole. Based on simulation result, a BP neural network model was applied to analyze the relationship between geometry factors of Die-plate, such as length of shaping channels, die hole extrusion velocity distribution, and extrusion uniformity. This optimization method can be used in the design of Die-plate to improve effect and quality of actual polymer production and processing.

scholarly journals Are “Internet+” tactics the key to poverty alleviation in China’s rural ethnic minority areas? Empirical evidence from Sichuan Province

2021 ◽  
Vol 7 (1) ◽  
Author(s):  
Xiang Yin ◽  
Zhiyi Meng ◽  
Xin Yi ◽  
Yong Wang ◽  
Xia Hua
Keyword(s):  
Ethnic Minority ◽  
Poverty Alleviation ◽  
Large Scale ◽  
Sichuan Province ◽  
Infrastructure Investment ◽  
Communication Infrastructure ◽  
Gdp Growth Rate ◽  
The Relationship ◽  
Positive Effect

AbstractChina has made great efforts to alleviate poverty in rural ethnic minority areas and targeted achieving the poverty-alleviation task by the end of 2020. Aba, Ganzi, and Liangshan, three of the poorest ethnic prefectures in Sichuan Province, Southwest China, have all implemented “Internet+” tactics since 2013, which have had the positive effect of increasing family revenues by improving communication infrastructure and encouraging the large-scale use of e-commerce. This paper aims to comprehensively investigate whether “Internet+” tactics play a key role in poverty alleviation in Sichuan’s rural ethnic minority areas and to propose further measures to enhance the efficiency of e-commerce practice. To this end, we conduct an analysis using the framework of classic growth theory and use panel data from 2000 to 2018 to examine the relationship between Communication Infrastructure Investment (CII) and a set of poverty-alleviation indicators, including local GDP growth rate (LGGR), local government revenue (LGR), and per-capita income of residents (PCIR). The results indicate that strengthening CII improves the PCIR and local economic growth, playing a key role in poverty alleviation. However, the stimulation of CII on LGGR and LGR wanes as time passes. More financial and technical actions will be needed to improve the efficiency and quality of current strategies for sustainable development in those areas.

Finite Element Simulation of Cartilage Mechanics During Diarthrodial Joint Motion Using Physiological Data

2000 ◽  
Author(s):  
Kerem Ün ◽  
Peter S. Donzelli ◽  
Robert L. Spilker
Keyword(s):  
Finite Element ◽  
Large Scale ◽  
Glenohumeral Joint ◽  
Three Dimensional ◽  
Physiological Data ◽  
Cartilage Mechanics ◽  
Moving Contact ◽  
Diarthrodial Joint ◽  
Element Simulation ◽  
Diarthrodial Joints

Abstract Moving contact is fundamental to understanding the mechanical environment of articular cartilage in diarthrodial joints. This study presents a method for approximating three-dimensional (3D) moving contact of biphasic tissue layers using a time-dependent penetration method. This technique has been implemented in a custom finite element solution framework for large-scale simulation that includes a graphical user interface, automatic meshing, and visualization tools. Thus, physiological geometry and load levels can be simulated by this approximate technique. The method is illustrated for canonical and physiological problems representing the glenohumeral joint (GHJ) of the shoulder.

INFRA-OBTURATOR TENSION SLING FOR URINARY INCONTINENCE TREATMENT

2019 ◽  
Vol 19 (03) ◽  
pp. 1950001
Author(s):  
YEONGJIN KIM ◽  
YOUNGJIN NA ◽  
SOOBYEONG KIM ◽  
JEONGYOON YI ◽  
BUMMO AHN
Keyword(s):  
Daily Life ◽  
Contact Point ◽  
Three Dimensional ◽  
Geometrical Model ◽  
Abdominal Pressure ◽  
Computed Tomography Images ◽  
Pubourethral Ligament ◽  
Element Simulation ◽  
Rotatory Motion

Stress incontinence occurs due to the inability to control an urge to urinate, which affects the quality of daily life. Although there is an existing therapeutics with polymer mesh tape, it is hard to fix around the urethra to restore the function of the pubourethral ligament. Therefore, in this research, an infra-obturator tension (IOT) sling was introduced to minimize the mobility of the bladder and urethra against intra-abdominal pressure. To verify the IOT performance, two different hypotheses were formulated: The hardness and volume of the IOT support the urethra and help prevent it from deforming by intra-abdominal pressure. The rotatory motion of the IOT can bend the urethra at the contact point and help restore the function of pubourethral ligament to increase vaginal tension. For the first hypothesis, a finite element simulation was conducted using three-dimensional geometrical model obtained by the computed tomography images of patients. For the second hypothesis, surgeons performed an IOT insertion operation and analyzed the sling rotation from the patients’ CT images (mean: 21∘). From the results, the mobility of the urethra was decreased because of IOT insertion. The mobility was also decreased because of the subsequent fibrotic changes from the encapsulation of the IOT.

scholarly journals Proactive Health Support: Exploring Face-to-Face Start-Up Sessions Between Participants and Registered Nurses at the Onset of Telephone-Based Self-Management Support

2020 ◽  
Vol 7 ◽  
pp. 233339362093002
Author(s):  
Susanne Winther ◽  
Mia Fredens ◽  
Marie Brund Hansen ◽  
Kirstine Skov Benthien ◽  
Camilla Palmhøj Nielsen ◽  
...  
Keyword(s):  
Registered Nurses ◽  
Large Scale ◽  
Self Management ◽  
Management Support ◽  
Continuous Contact ◽  
Face To Face ◽  
Start Up ◽  
Health Support ◽  
The Relationship

Proactive Health Support (PaHS) is a large-scale intervention in Denmark carried out by registered nurses (RNs) who provide self-management support to people at risk of hospital admission to enhance their health, coping, and quality of life. PaHS is initiated with a face-to-face session followed by telephone conversations. We aimed to explore the start-up sessions, including if and how the relationship between participants and RNs developed at the onset of PaHS. We used an ethnographic design including observations and informal interviews. Data were analyzed using a phenomenological–hermeneutical approach. The study showed that contexts such as hospitals and RNs legitimized the intervention. Face-to-face communication contributed to credibility, just as the same RN throughout the intervention ensured continuity. We conclude that start-up sessions before telephone-based self-management support enable a trust-based relationship between participants and RNs. Continuous contact with the same RNs throughout the session promoted participation in the intervention.

Large-scale three-dimensional anisotropic topology optimization of variable-axial lightweight composite structures

2021 ◽  
pp. 1-15
Author(s):  
Yuqing Zhou ◽  
Tsuyoshi Nomura ◽  
Enpei Zhao ◽  
Kazuhiro Saitou
Keyword(s):  
Topology Optimization ◽  
Composite Structures ◽  
Large Scale ◽  
Volume Fraction ◽  
Three Dimensional ◽  
Optimization Method ◽  
Optimized Design ◽  
Adaptive Meshing ◽  
Design Synthesis ◽  
Fiber Placement

Abstract Variable-axial fiber-reinforced composites allow for local customization of fiber orientation and thicknesses. Despite their significant potential for performance improvement over the conventional multiaxial composites and metals, they pose challenges in design optimization due to the vastly increased design freedom in material orientations. This paper presents an anisotropic topology optimization method for designing large-scale, 3D variable-axial lightweight composite structures subject to multiple load cases. The computational challenges associated with large-scale 3D anisotropic topology optimization with extremely low volume fraction are addressed by a tensor-based representation of 3D orientation that would avoid the 2π periodicity of angular representations such as Euler angles, and an adaptive meshing scheme, which, in conjunction with PDE regularization of the density variables, refines the mesh where structural members appear and coarsens where there is void. The proposed method is applied to designing a heavy-duty drone frame subject to complex multi-loading conditions. Finally, the manufacturability gaps between the optimized design and the fabrication-ready design for Tailored Fiber Placement (TFP) is discussed, which motivates future work toward a fully-automated design synthesis.

scholarly journals Understanding the relationship between postpartum depression one month and six months after delivery and mother-infant bonding failure one-year after birth: results from the Japan Environment and Children's study (JECS)

2019 ◽  
Vol 50 (1) ◽  
pp. 161-169 ◽  
Author(s):  
Haruka Kasamatsu ◽  
Akiko Tsuchida ◽  
Kenta Matsumura ◽  
Moeko Shimao ◽  
Kei Hamazaki ◽  
...  
Keyword(s):  
Postpartum Depression ◽  
Large Scale ◽  
Depression Scale ◽  
Japanese Version ◽  
Mental Health Issue ◽  
Bonding Failure ◽  
One Year ◽  
Adjusted Model ◽  
The Relationship

AbstractBackgroundPostpartum depression is a major mental health issue. It not only adversely affects the mother's quality of life, but also mother-infant bonding. However, the relationship between postpartum depression (at multiple points after childbirth) and mother-infant bonding failure one year after birth is not well understood. This study investigates the relationship between postpartum depression at 1-month and 6-month after birth and mother-infant bonding failure at 1 year after birth with a large cohort.MethodsData from 83 109 mothers from the Japan Environment and Children's Study were analyzed. Mother-infant bonding 1-year after delivery was assessed using the Mother-to-Infant Bonding Scale Japanese version (MIBS-J). Postpartum depression was measured using the Edinburgh Postnatal Depression Scale (EPDS) at 1-month and 6-month after delivery. Twenty covariates during pregnancy and one month after delivery were controlled for deriving the odds ratios (ORs) describing postpartum depression to mother-infant bonding.ResultsEPDS Total Score crude ORs and adjusted ORs against the MIBS-J Total Score at 1-month and 6-month after delivery were calculated. Crude ORs were 1.111 (95% CI 1.110–1.112) and 1.122 (95% CI 1.121–1.124) respectively. In the fully adjusted model, ORs were 1.088 (95% CI 1.086–1.089) and 1.085 (95% CI 1.083–1.087), respectively.ConclusionsThis study demonstrated prospectively, in a large-scale cohort, that depression at multiple postpartum points, including associations with each EPDS and MIBS-J factors, may be a robust predictor of mother-infant bonding failure 1-year after birth.

scholarly journals The three-dimensional lattice as an architectural space

2018 ◽  
Vol 212 ◽  
pp. 04005
Author(s):  
Andrey Bolshakov
Keyword(s):  
Three Dimensional ◽  
Human Movement ◽  
Theoretical Understanding ◽  
Architectural Space ◽  
Spatial Lattice ◽  
Spatial Grids ◽  
Relationship Of ◽  
The Relationship ◽  
Main Material

Space is the main material with which the architect works. The space organized by the means of architecture is an art environment for the life of society. With many aspects of the organization of space, which are studied in the literature, the problem of their assembly and integration remains unsolved. The paper proposes a method of assembling spatial representations in architecture-the correlation of the spatial lattice and the factors of its form-formation, considered in the system, i.e. together. The approach is that in a broad overview of the world architecture, both in its theory and in practice, from historical to modern, examples of modification of spatial grids under the influence of one or a group of dominant factors are revealed. As a result, provisions on the relationship of the geometry of spatial grids with the following factors have been revealed: publicity and privacy; architectonics, the influence of the lattice on the differentiation of the streams of human movement; the architecture’s ability to carry a message; navigation properties, evaluation of connectivity and centrality of places in the spatial lattice; evaluation of the quality of the composition through the identification of ways of order and randomness in the elements of the spatial lattice. The results of the work can be used both for theoretical understanding of the architectural space in the study and design of architecture, and in architectural education.

scholarly journals The Prognostic Value of Autophagy-Related Markers Bclin-1 and LC-3 in Colorectal Cancers: A Systematic Review and Meta-analysis

2020 ◽  
Vol 2020 ◽  
pp. 1-11
Author(s):  
Jin-xiao Li ◽  
Qian Yan ◽  
Na Liu ◽  
Wen-jiang Zheng ◽  
Man Hu ◽  
...  
Keyword(s):  
Large Scale ◽  
Meta Analysis ◽  
Prognostic Significance ◽  
Beclin 1 ◽  
Cochrane Library ◽  
Comprehensive Treatment ◽  
Newcastle Ottawa Scale ◽  
Related Proteins ◽  
The Relationship

Objective. At present, the relationship between autophagosomes and the prognosis of various cancers has become a subject of active investigation. A series of studies have demonstrated the correlation between autophagy microtubule-associated protein light chain 3 (LC-3), Beclin-1, and colorectal cancer (CRC). Since autophagy has dual regulatory roles in tumors, the results of this correlation are also uncertain. Hence, we summarized the relationship between Beclin-1, LC-3, and CRC using systematic reviews and meta-analysis to clarify their prognostic significance in it. Methods. PubMed, EMBASE, Cochrane Library, and Web of Science databases were searched online up to April 1, 2019. The quality of the involving studies was assessed against the Newcastle-Ottawa Scale (NOS). Pooled hazard ratio (HR) and 95% confidence interval (CI) in a fixed or random effects model were used to assess the strength of correlation between Beclin-1, LC-3, and CRC. Results. A total of 9 articles were collected, involving 2,297 patients. Most literatures scored more than 6 points, suggesting that the quality of our including research was acceptable. Our finding suggested that the expression of Beclin-1 was not associated with overall survival (HR = 0.68, 95% CI (0.31–1.52), P=0.351). Nonetheless, LC-3 expression exerted significant impact on OS (HR = 0.51, 95% CI (0.35–0.74), P<0.05). Subgroup analysis exhibited that Beclin-1 expression was associated with OS at TNM stage III (HR = 0.04, 95% CI = 0.02–0.08, P<0.05), surgical treatment (HR = 1.53, 95% CI (1.15–2.02), P=0.003), and comprehensive treatment (HR = 0.27 95% CI (0.08–0.92), P=0.036), respectively. Similarly, the results showed the increased LC-3 expression in CRC was related to OS in multivariate analyses (HR = 0.44, 95% CI (0.34–0.57), P<0.05), stages (HR = 0.51, 95% CI (0.35–0.74), P<0.05), and comprehensive treatment (HR = 0.44, 95% CI (0.34–0.57), P<0.05). Conclusions. Autophagy-related proteins of LC-3 might be an important marker of CRC progression. However, since the number of the original studies was limited, more well-designed, large-scale, high-quality studies are warranted to provide more convincing and reliable information.

DO INNOVATIVE ORGANISATIONS COMPETE ON SINGLE OR MULTIPLE OPERATIONAL CAPABILITIES?

2014 ◽  
Vol 18 (03) ◽  
pp. 1440001
Author(s):  
ALKA ASHWINI NAND ◽  
PRAKASH J. SINGH ◽  
ANANYA BHATTACHARYA
Keyword(s):  
Cost Efficiency ◽  
Large Scale ◽  
Trade Off ◽  
Manufacturing Plants ◽  
Operational Level ◽  
Operational Capabilities ◽  
Quality Of Products ◽  
Operations Capabilities ◽  
The Relationship

Organisations lack clear guidance on how they can become more innovative at the operational level. The operations strategy literature shows that organisations compete on four generic capabilities: cost efficiency, quality of products or services, speed of delivery, and flexibility of operations. Should organisations choose between these capabilities, i.e., engage in trading-off these capabilities and focussing on one capability ("trade-off" model), or combine them, thereby competing on multiple capabilities simultaneously ("cumulative capabilities" model), remains an unresolved issue. Our paper addresses this by empirically testing the relationship between the four operations capabilities and innovation performance through a large-scale global study of manufacturing plants. Our results show support for the cumulative capabilities model and not the trade-off model. Furthermore, both delivery and flexibility capabilities are comparatively stronger predictors of innovativeness than cost efficiency and quality capabilities. This study provides interesting insights for practitioners and managers in generating clearer guidelines as to what organisations need to do with their key operational capabilities, in order to become more innovative.

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