Automation of an Atomized Meter Dose Inhaler for Lung Disease Patients

2013 ◽  
Vol 394 ◽  
pp. 612-616 ◽  
Author(s):  
Song Hao Wang ◽  
Angel Bernal Menéndez Cifuentes

A reliable universal triggering system for atomized meter doseinhalers was built. Although the exact dosage into the airway system at different triggering delays was not possible to be determined by means of directly measuring its weight, the use of lasers reflection and high speed movie is an effective comparison method to determine the appropriate triggering moment. A set of transparent tubes was built to imitate the dimensions of a human trachea and bronchiole and two lasers were placed coaxially with such tubes. Light from the lasers was only reflected when the atomized medicine was passing through the tubes;so the longer the time the laser light could be seen, the more effective amount of dosage was being delivered to the lungs. From the experiment, it seems that the best delay time for triggering an inhaler is in the range between 0.7-1.s under the flow rate specified. Any time before that will result in medicine loss, and any time after that the patient might not be able to keep inhaling.

CICTP 2020 ◽  
2020 ◽  
Author(s):  
Jing Shi ◽  
Qiyuan Peng ◽  
Ling Liu

2021 ◽  
Vol 11 (9) ◽  
pp. 4232
Author(s):  
Krishan Harkhoe ◽  
Guy Verschaffelt ◽  
Guy Van der Sande

Delay-based reservoir computing (RC), a neuromorphic computing technique, has gathered lots of interest, as it promises compact and high-speed RC implementations. To further boost the computing speeds, we introduce and study an RC setup based on spin-VCSELs, thereby exploiting the high polarization modulation speed inherent to these lasers. Based on numerical simulations, we benchmarked this setup against state-of-the-art delay-based RC systems and its parameter space was analyzed for optimal performance. The high modulation speed enabled us to have more virtual nodes in a shorter time interval. However, we found that at these short time scales, the delay time and feedback rate heavily influence the nonlinear dynamics. Therefore, and contrary to other laser-based RC systems, the delay time has to be optimized in order to obtain good RC performances. We achieved state-of-the-art performances on a benchmark timeseries prediction task. This spin-VCSEL-based RC system shows a ten-fold improvement in processing speed, which can further be enhanced in a straightforward way by increasing the birefringence of the VCSEL chip.


2021 ◽  
Vol 13 (5) ◽  
pp. 168781402110208
Author(s):  
Yuan Zhang ◽  
Lifeng Wang ◽  
Yaodong Zhang ◽  
Yongde Zhang

The thermal deformation of high-speed motorized spindle will affect its reliability, so fully considering its thermal characteristics is the premise of optimal design. In order to study the thermal characteristics of high-speed motorized spindles, a coupled model of thermal-flow-structure was established. Through experiment and simulation, the thermal characteristics of spiral cooling motorized spindle are studied, and the U-shaped cooled motorized spindle is designed and optimized. The simulation results show that when the diameter of the cooling channel is 7 mm, the temperature of the spiral cooling system is lower than that of the U-shaped cooling system, but the radial thermal deformation is greater than that of the U-shaped cooling system. As the increase of the channel diameter of U-shaped cooling system, the temperature and radial thermal deformation decrease. When the diameter is 10 mm, the temperature and radial thermal deformation are lower than the spiral cooling system. And as the flow rate increases, the temperature and radial thermal deformation gradually decrease, which provides a basis for a reasonable choice of water flow rate. The maximum error between experiment and simulation is 2°C, and the error is small, which verifies the accuracy and lays the foundation for future research.


Author(s):  
Afshin Goharzadeh ◽  
Keegan Fernandes

This paper presents an experimental investigation on a modified airlift pump. Experiments were undertaken as a function of air-water flow rate for two submergence ratios (ε=0.58 and 0.74), and two different riser geometries (i) straight pipe with a constant inner diameter of 19 mm and (ii) enlarged pipe with a sudden expanded diameter of 19 to 32 mm. These transparent vertical pipes, of 1 m length, were submerged in a transparent rectangular tank (0.45×0.45×1.1 m3). The compressed air was injected into the vertical pipe to lift the water from the reservoir. The flow map regime is established for both configurations and compared with previous studies. The two phase air-water flow structure at the expansion region is experimentally characterized. Pipeline geometry is found to have a significant influence on the output water flow rate. Using high speed photography and electrical conductivity probes, new flow regimes, such as “slug to churn” and “annular to churn” flow, are observed and their influence on the output water flow rate and efficiency are discussed. These experimental results provide fundamental insights into the physics of modified airlift pump.


2001 ◽  
Vol 204 (24) ◽  
pp. 4345-4351
Author(s):  
Bruce A. Young ◽  
Krista Zahn

SUMMARY The functional morphology of venom injection in Crotalus atrox was explored using high-speed digital videography combined with direct recording of venom flow using perivascular flow probes. Although venom flow was variable, in most strikes the onset of venom flow was coincidental with fang penetration, and retrograde flow (venom suction) was observed prior to fang withdrawal. The duration of venom flow was consistently less than the duration of fang penetration. The occurrence of retrograde flow, ‘dry bites’ (which accounted for 35 % of the strikes) and unilateral strikes all support a hypothesis for venom pooling in the distal portion of the venom-delivery system. No significant difference in temporal or volumetric aspects of venom flow were found between defensive strikes directed at small and large rodents. With the species and size of target held constant, the duration of venom flow, maximum venom flow rate and total venom volume were all significantly lower in predatory than in defensive strikes.


Author(s):  
M. Vardelle ◽  
P. Fauchais ◽  
A. Vardelle ◽  
A.C. Léger

Abstract A study of the flattening and cooling of particles plasma-sprayed on a substrate is presented. The characteristic parameters of the splats are linked to the parameters of the impacting particles by using an experimental device consisting of a phase Doppler particle analyzer and a high-speed pyrometer. However, during the long experiments required to get reliable correlations, it was observed that variations in plasma spray operating conditions may alter the particles behavior in the plasma jet. Therefore, a simple and easy-to-use system was developed to control in real time the spray jet. In this paper, the effect of carrier gas flow rate, arc current and powder mass flow rate is investigated. The results on zirconia and alumina powders show the capability of the technique to sense the particle spray position and width.


2001 ◽  
Author(s):  
Tarek Mekhail ◽  
Zhang Li ◽  
Du Zhaohui ◽  
Willem Jansen ◽  
Chen Hanping

Abstract The PIV (Particle Image Velocimetry) technology is a brand-new technique of measuring velocity. It started in the 1980’s with the development of high-speed photography and the image processing technique of computers. This article deals with PIV applied to the study of unsteady impeller-vaneless diffuser interaction in centrifugal fen. Experiments were carried out at The Turbomachinery Laboratory of Shanghai Jiaotong University. The test rig consists of a centrifugal, shrouded impeller, diffuser and volute casing all made of plexiglass. A series of performance measurements were carried out at different speeds and different vaneless diffuser widths. PIV measurements were applied to measure the unsteady flow at the exit part of the impeller and the inlet part of the diffuser for the case of the same width vaneless diffuser. The absolute flow field is measured at medium flow rate and at maximum flow rate. It is informative to capture the whole flow field at the same instant of time, and it might be more revealing to observe the unstable flow in real time.


2015 ◽  
Vol 10 (1) ◽  
pp. 42-49
Author(s):  
Aleksandr Pavlenko ◽  
Oleg Volodin ◽  
Vladimir Serdyukov

Results of experimental studies on hydrodynamics of the film flow of liquid nitrogen over the surface of the single elements of structured packing are presented. The effect of inclination angle of the large ribs and perforation on the zones of liquid film spreading over the corrugated surface with microtexture at different Reynolds numbers of the film is shown based on a comparison of experimental data. It is shown that the angle of large rib inclination has a significant influence on redistribution of the local flow rate of liquid flowing on the surface with complex geometry. Analysis of results of the high-speed video revealed that in a vicinity of the vertical lateral edges of corrugated plates, the intense rivulet flows are formed, including those with separation from the film flow surface. This negative factor can lead to significant liquid accumulation and flow near the vertical edges of the structured packing and on the inner wall of the heat exchanging apparatuses and, finally, to a significant increase in the degree of maldistribution of local liquid flow rate over the crosssection, for instance, of the distillation columns.


Author(s):  
Gu Shan-Jian ◽  
Yang Mao-Lin ◽  
Li Xiang-Yi

A method to measure the fuel distribution and the percentage of fuel flow rate captured by a V-gutter flameholder in a high speed airstream has been developed. The effects of configuration and size of the probe and temprature of the sample mixture in the probe on measurement have been investigated. The detailed determination of isokinetic sampling condition is described. The effects of V-gutter geometry on flowfield have been considered. The total experimental error is of the order ±5%.


2014 ◽  
Vol 137 (4) ◽  
Author(s):  
David Tan ◽  
Yuanchao Li ◽  
Ian Wilkes ◽  
Rinaldo L. Miorini ◽  
Joseph Katz

A new optically index matched facility has been constructed to investigate tip flows in compressor-like settings. The blades of the one and a half stage compressor have the same geometry, but lower aspect ratio as the inlet guide vanes (IGVs) and the first stage of the low-speed axial compressor (LSAC) facility at NASA Glenn. With transparent blades and casings, the new setup enables unobstructed velocity measurements at any point within the tip region and is designed to facilitate direct measurements of effects of casing treatments on the flow structure. We start with a smooth endwall casing. High speed movies of cavitation and time-resolved PIV measurements have been used to characterize the location, trajectory, and behavior of the tip leakage vortex (TLV) for two flow rates, the lower one representing prestall conditions. Results of both methods show consistent trends. As the flow rate is reduced, TLV rollup occurs further upstream, and its initial orientation becomes more circumferential. At prestall conditions, the TLV is initially aligned slightly upstream of the rotor passage, and subsequently forced downstream. Within the passage, the TLV breaks up into a large number of vortex fragments, which occupy a broad area. Consequently, the cavitation in the TLV core disappears. With decreasing flow rate, this phenomenon becomes more abrupt, occurs further upstream, and the fragments occupy a larger area.


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