Simulation about Bionic Push of Amphibious Vehicle

2011 ◽  
Vol 48-49 ◽  
pp. 1057-1060
Author(s):  
Zhi Sheng Jing ◽  
Yun Liu ◽  
Shan Chao Tu ◽  
Feng Li ◽  
Guo Wei Qin
Keyword(s):  
Wing Disc ◽  
Travel Agency ◽  
Reciprocating Motion ◽  
Forward Movement ◽  
Propulsive Efficiency ◽  
Straight Line ◽  
Biological Methods ◽  
Design And Manufacture ◽  
Bionic Propulsion

The traditional method of propulsion of Amphibious vehicles in water has tracked the water, propeller and waterjet propulsion. But the propulsive efficiency is very low, the maximum not more than 30%. Biological methods used to promote, through the million years of evolution, its power utilization of the highest, the best way. Bionic propulsion system designed in this paper consists of two umbrella-shaped wing plate in the large travel agency travel back and forth, driven by a straight line, Carried out along the longitudinal reciprocating motion of vehicles in the water under the influence of backward movement of the wing disk automatically open, resulting in tension on the vehicle forward, Forward movement of the wing disc automatically shut down to reduce the flow resistance. In this way, amphibious vehicles, with the wing disc back and forth movement, has been the role of forward traction, so that forward movement of vehicle. In this paper, the same wing disc, wing disc at different angles, different velocity simulation of the situation. Come forward to promote strength and speed, angle of the curve. To promote the device provides the basis for the physical design and manufacture.

Efficiency Measurement of Bionic Propulsion

2011 ◽  
Vol 217-218 ◽  
pp. 1014-1019
Author(s):  
Yun Liu ◽  
Wei Jiang ◽  
Zhi Sheng Jing ◽  
Xiang Yong Su ◽  
Ming Lu
Keyword(s):  
Water Resistance ◽  
Efficiency Measurement ◽  
Propulsion System ◽  
Reciprocating Motion ◽  
Forward Movement ◽  
Wing Disk ◽  
Travel Agencies ◽  
Low Efficiency ◽  
Maximum Utilization ◽  
Bionic Propulsion

The existences of traditional water propulsion promote low efficiency. Used by biological propulsion, after the last million years of evolution, the maximum utilization of its power, the best way. Bionic propulsion system designed in this paper consists of two large travel umbrella wing plate in reciprocating linear travel agencies, led by the reciprocating motion along the vertical, in the water under the influence of backward movement of the wing disk automatically open, resulting in the pull forward, the forward movement of the wing disk automatically shut down to reduce water resistance. This paper designs a bionic propulsion and efficiency measurement tests carried out.

scholarly journals Classic Prescription, Kai-Xin-San, Ameliorates Alzheimer’s Disease as an Effective Multitarget Treatment: From Neurotransmitter to Protein Signaling Pathway

2019 ◽  
Vol 2019 ◽  
pp. 1-14 ◽  
Author(s):  
Sirui Guo ◽  
Jiahong Wang ◽  
Huarong Xu ◽  
Weiwei Rong ◽  
Cheng Gao ◽  
...  
Keyword(s):  
Alzheimer’S Disease ◽  
Alzheimer's Disease ◽  
Pc12 Cells ◽  
Protein Signaling ◽  
Pi3k Inhibitor Ly294002 ◽  
Single Target ◽  
Biological Methods ◽  
Cognition Impairment ◽  
First Time

Alzheimer’s disease (AD) is a widespread neurodegenerative disease caused by complicated disease-causing factors. Unsatisfactorily, curative effects of approved anti-AD drugs were not good enough due to their actions on single-target, which led to desperate requirements for more effective drug therapies involved in multiple pathomechanisms of AD. The anti-AD effect with multiple action targets of Kai-Xin-San (KXS), a classic prescription initially recorded in Bei Ji Qian Jin Yao Fang and applied in the treatment of dementia for thousands of years, was deciphered with modern biological methods in our study. Aβ25-35 and D-gal-induced AD rats and Aβ25-35-induced PC12 cells were applied to establish AD models. KXS could significantly improve cognition impairment by decreasing neurotransmitter loss and enhancing the expression of PI3K/Akt. For the first time, KXS was confirmed to improve the expression of PI3K/Akt by neurotransmitter 5-HT. Thereinto, PI3K/Akt could further inhibit Tau hyperphosphorylation as well as the apoptosis induced by oxidative stress and neuroinflammation. Moreover, all above-mentioned effects were verified and blocked by PI3K inhibitor, LY294002, in Aβ25-35-induced PC12 cells, suggesting the precise regulative role of KXS in the PI3K/Akt pathway. The utilization and mechanism elaboration of KXS have been proposed and dissected in the combination of animal, molecular, and protein strategies. Our results demonstrated that KXS could ameliorate AD by regulating neurotransmitter and PI3K/Akt signal pathway as an effective multitarget treatment so that the potential value of this classic prescription could be explored from a novel perspective.

scholarly journals Topoisomerase II is regulated by translationally controlled tumor protein for cell survival during organ growth in Drosophila

2021 ◽  
Vol 12 (9) ◽  
Author(s):  
Dae-Wook Yang ◽  
Jung-Wan Mok ◽  
Stephanie B. Telerman ◽  
Robert Amson ◽  
Adam Telerman ◽  
...  
Keyword(s):  
Cell Survival ◽  
Topoisomerase Ii ◽  
Wing Disc ◽  
Organ Development ◽  
Translationally Controlled Tumor Protein ◽  
Protein Levels ◽  
Eye Disc ◽  
Mutual Regulation

AbstractRegulation of cell survival is critical for organ development. Translationally controlled tumor protein (TCTP) is a conserved protein family implicated in the control of cell survival during normal development and tumorigenesis. Previously, we have identified a human Topoisomerase II (TOP2) as a TCTP partner, but its role in vivo has been unknown. To determine the significance of this interaction, we examined their roles in developing Drosophila organs. Top2 RNAi in the wing disc leads to tissue reduction and caspase activation, indicating the essential role of Top2 for cell survival. Top2 RNAi in the eye disc also causes loss of eye and head tissues. Tctp RNAi enhances the phenotypes of Top2 RNAi. The depletion of Tctp reduces Top2 levels in the wing disc and vice versa. Wing size is reduced by Top2 overexpression, implying that proper regulation of Top2 level is important for normal organ development. The wing phenotype of Tctp RNAi is partially suppressed by Top2 overexpression. This study suggests that mutual regulation of Tctp and Top2 protein levels is critical for cell survival during organ development.

scholarly journals Sperm Cryopreservation in American Flamingo (Phoenicopterus Ruber): Influence of Cryoprotectants and Seminal Plasma Removal

Animals ◽  
2021 ◽  
Vol 11 (1) ◽  
pp. 203
Author(s):  
María Gemma Millán de la Blanca ◽  
Eva Martínez-Nevado ◽  
Cristina Castaño ◽  
Juncal García ◽  
Berenice Bernal ◽  
...  
Keyword(s):  
Seminal Plasma ◽  
Genetic Material ◽  
First Year ◽  
Sperm Cryopreservation ◽  
Straight Line ◽  
The Family ◽  
Second Year ◽  
American Flamingo ◽  
Phoenicopterus Ruber

The American flamingo is a useful model for the development of successful semen cryopreservation procedures to be applied to threatened related species from the family Phoenicopteridae, and to permit genetic material banking. Current study sought to develop effective sperm cryopreservation protocols through examining the influences of two permeating cryoprotectants and the seminal plasma removal. During two consecutive years (April), semen samples were collected and frozen from American flamingos. In the first year, the effect of two permeating cryoprotectants, DMA (dimethylacetamide) (6%) or Me2SO (dimethylsulphoxide) (8%), on frozen–thawed sperm variables were compared in 21 males. No differences were seen between DMA and Me2SO for sperm motility, sperm viability, and DNA fragmentation after thawing. In the second year, the role of seminal plasma on sperm cryoresistance was investigated in 31 flamingos. Sperm samples were cryopreserved with and without seminal plasma, using Me2SO (8%) as a cryoprotectant. The results showed that samples with seminal plasma had higher values than samples without seminal plasma for the following sperm variables: Straight line velocity (22.40 µm/s vs. 16.64 µm/s), wobble (75.83% vs. 69.40%), (p < 0.05), linearity (62.73% vs. 52.01%) and straightness (82.38% vs. 73.79%) (p < 0.01); but acrosome integrity was lower (55.56% vs. 66.88%) (p < 0.05). The cryoresistance ratio (CR) was greater in samples frozen with seminal plasma than without seminal plasma for CR-progressive motility (138.72 vs. 54.59), CR-curvilinear velocity (105.98 vs. 89.32), CR-straight line velocity (152.77 vs. 112.58), CR-average path velocity (122.48 vs. 98.12), CR-wobble (111.75 vs. 102.04) (p < 0.05), CR-linearity (139.41 vs. 113.18), and CR-straightness (124.02 vs. 109.97) (p < 0.01). This research demonstrated that there were not differences between Me2SO and DMA to successful freezing sperm of flamingos; seminal plasma removal did not provide a benefit for sperm cryopreservation.

Fray Juan De Zumárraga–His Social Contributions

1949 ◽  
Vol 5 (3) ◽  
pp. 264-274
Author(s):  
James A. Magner
Keyword(s):  
Human Factors ◽  
Human Sacrifice ◽  
Forward Movement ◽  
Charles V ◽  
Social Contributions ◽  
Aztec Empire ◽  
Conquest Of Mexico

To Understand the conquest of Mexico, one must recognize the various human factors and the variety of motives that entered into the titanic struggle for mastery of the land. In the letters of Cortés to the Emperor Charles V, the whole gamut of ambitions—personal, national, grossly material and highly spiritual—are revealed. There can be no doubt that Cortés and the Spaniards with him were moved in the first place by a spirit of personal adventure and a desire to better their fortunes. As the panorama of the Aztec Empire opened itself before his eyes, the dream of expanding the Spanish domains came to Cortés as a justifying cause for his forward movement, so that escape or retreat appeared as treachery to his King. At the same time, as a product of the Spanish crusading era, he beheld himself in the rôle of a spiritual hero bringing the doctrine of Christian Redemption to heathen tribes sunk in idolatry and human sacrifice.

Compartments, wingless and engrailed: patterning the ventral epidermis of Drosophila embryos

Development ◽  
1996 ◽  
Vol 122 (12) ◽  
pp. 4095-4103 ◽  
Author(s):  
P.A. Lawrence ◽  
B. Sanson ◽  
J.P. Vincent
Keyword(s):  
Pattern Formation ◽  
Wing Disc ◽  
High Concentration ◽  
Good Region ◽  
Steep Slopes ◽  
Cuticular Structures ◽  
Different Levels ◽  
Promote Cell Death ◽  
Drosophila Embryos

Recent experiments on the wing disc of Drosophila have shown that cells at the interface between the anterior and posterior compartments drive pattern formation by becoming the source of a morphogen. Here we ask whether this model applies to the ventral embryonic epidermis. First, we show that interfaces between posterior (engrailed ON) and anterior (engrailed OFF) cells are required for pattern formation. Second, we provide evidence that Wingless could play the role of the morphogen, at least within part of the segmental pattern. We looked at the cuticular structures that develop after different levels of uniform Wingless activity are added back to unsegmented embryos (wingless- engrailed-). Because it is rich in landmarks, the T1 segment is a good region to analyse. There, we find that the cuticle formed depends on the amount of added Wingless activity. For example, a high concentration of Wingless gives the cuticle elements normally found near the top of the presumed gradient. Unsegmented embryos are much shorter than wild type. If Wingless activity is added in stripes, the embryos are longer than if it is added uniformly. We suggest that the Wingless gradient landscape affects the size of the embryo, so that steep slopes would allow cells to survive and divide, while an even distribution of morphogen would promote cell death. Supporting the hypothesis that Wingless acts as a morphogen, we find that these stripes affect, at a distance, the type of cuticle formed and the planar polarity of the cells.

Role of the EGF receptor pathway in growth and patterning of the Drosophila wing through the regulation of vestigial

Development ◽  
1999 ◽  
Vol 126 (5) ◽  
pp. 975-985 ◽  
Author(s):  
R. Nagaraj ◽  
A.T. Pickup ◽  
R. Howes ◽  
K. Moses ◽  
M. Freeman ◽  
...  
Keyword(s):  
Egf Receptor ◽  
Regulatory Gene ◽  
Ectopic Expression ◽  
Wing Disc ◽  
Loss Of Function ◽  
Drosophila Wing ◽  
Expression Studies ◽  
Coordinated Expression ◽  
Wing Pouch

Growth and patterning of the Drosophila wing disc depends on the coordinated expression of the key regulatory gene vestigial both in the Dorsal-Ventral (D/V) boundary cells and in the wing pouch. We propose that a short-range signal originating from the core of the D/V boundary cells is responsible for activating EGFR in a zone of organizing cells on the edges of the D/V boundary. Using loss-of-function mutations and ectopic expression studies, we show that EGFR signaling is essential for vestigial transcription in these cells and for making them competent to undergo subsequent vestigial-mediated proliferation within the wing pouch.

Adaptive Use of ICT in Response to Disintermediation

2008 ◽  
pp. 1889-1895
Author(s):  
Pramod Sharma ◽  
Dean Carson ◽  
Andrew Taylor
Keyword(s):  
Distribution Systems ◽  
Dominant Role ◽  
Travel Agency ◽  
Financial Viability ◽  
Online Technologies ◽  
Travel Agents ◽  
Adaptive Use ◽  
Distribution Chain

Traditionally, the Australian travel agency sector has operated as the premium intermediary in a relatively simple distribution chain that can be depicted as follows: In such a system, it is estimated that travel agents have traditionally handled over 85% of consumer transactions (Wilde & Rosen, 2000). The advance of online technologies and ICT-based distribution systems has changed the dominant role of travel agents in the distribution and supply of travel products. This has impacted on their relevance, returns, and individual financial viability.

The role of in vitro diagnostic companies in reducing laboratory error

2007 ◽  
Vol 45 (6) ◽  
Author(s):  
Ana K. Stankovic ◽  
Peter Romeo
Keyword(s):  
Product Life Cycle ◽  
Blood Collection ◽  
Laboratory Errors ◽  
Laboratory Error ◽  
Collection Tube ◽  
In Vitro Diagnostic ◽  
Design And Manufacture ◽  
Model Device

AbstractLaboratory errors have a significant impact on patient safety. The manufacturers of in vitro diagnostic (IVD) products play an important role in the reduction of laboratory errors by ensuring the highest possible safety and efficacy of their products. In order to achieve this, the IVD industry has implemented rigorous product development and manufacturing processes. Many IVD companies apply Six Sigma principles in order to minimize variability within the whole product life cycle, starting with customer requirements, through product design and manufacture, as well as management of the potential issues that occur after the products have been released for use. A closer look into this process is presented here, using an evacuated blood collection tube as a model device.Clin Chem Lab Med 2007;45:781–8.

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