Fabrication of UV-Curing Polyurethane Methacrylate (PUMA) Microchannel and Fluidics Interconnect for Microfluidics Applications

2016 ◽  
Vol 819 ◽  
pp. 351-355
Author(s):  
Ummikalsom Abidin ◽  
Majlis Burhanuddin Yeop ◽  
Jumril Yunas
Keyword(s):  
Rapid Prototyping ◽  
Uv Light ◽  
Light Exposure ◽  
Uv Curing ◽  
Clinical Diagnostics ◽  
Pdms Substrate ◽  
Pdms Mold ◽  
Nitrogen Gas ◽  
Reversible Bonding ◽  
Microfluidics Platform

Microfluidics platform offers a great advantage in bio-sensing and clinical diagnostics miniaturization. The requirement of inexpensive and rapid-prototyping materials are essential in microfluidics device commercialization. This paper presents rapid prototyping of UV-curing Polyurethane Methacrylate (PUMA) microchannel from the Polydimethlsiloxane (PDMS) mold. Two techniques in PUMA microchannel UV-curing rapid prototyping have successfully demonstrated in this work. The first technique utilized thin film transparency sheet as PUMA resin top surface cover in facilitating PUMA UV-curing. The second method exploited confined nitrogen gas environment in Pyrex dish chamber in expediting PUMA curing under UV light exposure. In this work, two different approaches of fluidic interconnect tubings for PUMA microchannel inlet and outlet are also presented. Reversible bonding techniques using corona discharge treatment are utilized for bonding of PUMA microchannel and fluidic interconnect with PUMA, silicon, glass and PDMS substrate. Accomplishment of preliminary fluid flow testing using PUMA microchannel proved its capability for microfluidics applications.

scholarly journals UV Treatment of the Stabilizing Shell for Improving the Photostability of Silver Nanoparticles

2016 ◽  
Vol 2016 ◽  
pp. 1-7 ◽  
Author(s):  
Silvia Rinaldi ◽  
Luigi Tarpani ◽  
Loredana Latterini
Keyword(s):  
Silver Nanoparticles ◽  
Optical Properties ◽  
Laser Scanning ◽  
Prolonged Exposure ◽  
Uv Light ◽  
Light Exposure ◽  
Uv Curing ◽  
Laser Scanning Microscopy ◽  
Localized Surface Plasmon ◽  
Confocal Laser

Silver nanoparticles or nanoclusters are quite sensitive to light exposure. In particular, irradiation in the localized surface plasmon resonance (LSPR) region brings about a drastic modification of their optical properties due to growth and reshaping of the nanoparticles. In order to obtain luminescent colloids, small silver colloidal nanoparticles were prepared in chloroform using vinylpyrrolidone oligomers as capping agent and their luminescence properties were used to control their stability upon prolonged exposure to visible light. The polymeric shell around the metal clusters was hardened through photo-cross-linking by UV light. This process did not alter the morphology and the optical properties of the nanoparticles but greatly improved the particle photostability as confirmed also by confocal laser scanning microscopy measurements. The data clearly show that UV curing of the stabilizing layer could be a simple postsynthetic procedure to obtain materials with stable properties.

scholarly journals Stability and ocular biodistribution of topically administered PLGA nanoparticles

2021 ◽  
Vol 11 (1) ◽  
Author(s):  
Sean Swetledge ◽  
Renee Carter ◽  
Rhett Stout ◽  
Carlos E. Astete ◽  
Jangwook P. Jung ◽  
...  
Keyword(s):  
Uv Light ◽  
Light Exposure ◽  
Polymeric Nanoparticles ◽  
Plga Nanoparticles ◽  
Eye Disease ◽  
Control Group ◽  
Eye Tissues ◽  
Nanoparticle Morphology ◽  
The Stability

AbstractPolymeric nanoparticles have been investigated as potential delivery systems for therapeutic compounds to address many ailments including eye disease. The stability and spatiotemporal distribution of polymeric nanoparticles in the eye are important regarding the practical applicability and efficacy of the delivery system in treating eye disease. We selected poly(lactic-co-glycolic acid) (PLGA) nanoparticles loaded with lutein, a carotenoid antioxidant associated with eye health, as our model ophthalmic nanodelivery system and evaluated its stability when suspended in various conditions involving temperature and light exposure. We also assessed the ocular biodistribution of the fluorescently labeled nanoparticle vehicle when administered topically. Lutein-loaded nanoparticles were stable in suspension when stored at 4 °C with only 26% lutein release and no significant lutein decay or changes in nanoparticle morphology. When stored at 25 °C and 37 °C, these NPs showed signs of bulk degradation, had significant lutein decay compared to 4 °C, and released over 40% lutein after 5 weeks in suspension. Lutein-loaded nanoparticles were also more resistant to photodegradation compared to free lutein when exposed to ultraviolet (UV) light, decaying approximately 5 times slower. When applied topically in vivo, Cy5-labled nanoparticles showed high uptake in exterior eye tissues including the cornea, episcleral tissue, and sclera. The choroid was the only inner eye tissue that was significantly higher than the control group. Decreased fluorescence in all exterior eye tissues and the choroid at 1 h compared to 30 min indicated rapid elimination of nanoparticles from the eye.

795 A multicenter phase II trial (SWOG S1609, cohort 51) of ipilimumab and nivolumab in metastatic or unresectable angiosarcoma: a substudy of dual anti-CTLA-4 and anti-PD-1 blockade in rare tumors (DART)

2020 ◽  
Vol 8 (Suppl 3) ◽  
pp. A843-A843
Author(s):  
Michael Wagner ◽  
Megan Othus ◽  
Sandip Patel ◽  
Christopher Ryan ◽  
Ashish Sangal ◽  
...  
Keyword(s):  
Phase Ii ◽  
Immune Checkpoint ◽  
Uv Light ◽  
Light Exposure ◽  
Case Reports ◽  
Objective Response ◽  
Open Label ◽  
Primary Tumors ◽  
Multicenter Phase ◽  
Grade 3

BackgroundAngiosarcoma is a rare cancer of endothelial cells that can be aggressive and carries a high mortality. A subset of angiosarcomas are characterized by high tumor mutational burden (TMB) and UV light exposure DNA mutational signature. Isolated case reports have suggested clinical efficacy of immune checkpoint blockade in angiosarcoma; no prospective studies of immune checkpoint inhibition in angiosarcoma have been reported. We report efficacy analysis results for patients with advanced or unresectable angiosarcoma treated with ipilimumab and nivolumab as a cohort of an ongoing phase II study for rare cancers (NCT02834013).MethodsThis is a prospective, open-label, multicenter phase II clinical trial of ipilimumab (1mg/kg IV q6weeks) plus nivolumab (240mg IV q2weeks) for patients with metastatic or unresectable angiosarcoma. Primary endpoint is objective response rate as assessed by RECIST v1.1, including measurable cutaneous disease that can be followed by photography. Secondary endpoints include PFS, OS, stable disease at six months, and toxicity. A two-stage design is used with six patients in the first stage and an additional ten patients in the second stage.ResultsAt data cutoff, 16 patients with angiosarcoma were enrolled. Median age was 68 years (25-81 years). Median number of prior lines of therapy was 2 (0-5). 9 patients had cutaneous primary tumors of any cutaneous site, 7 had non-cutaneous primary tumors. ORR for all patients was 25% (4/16, table 1, figure 1). Subgroup analysis revealed that 60% (3/5) of patients with primary cutaneous tumors of the scalp or face had a confirmed objective response. 6-month PFS was 38%. 75% of patients experienced an adverse event (AE), and 25% experienced a grade 3-4 AE. 68.8% experienced an immune related AE (irAE), and 2 (12.5%) developed grade 3 or 4 irAEs. Grade 3-4 irAEs were ALT and AST increase and diarrhea. There were no grade 5 toxicities.ConclusionsThe combination of ipilimumab and nivolumab was well tolerated and had an ORR of 25% in angiosarcoma regardless of primary site, with 3 of 5 patients with cutaneous tumors of the scalp or face responding. Ipilimumab and nivolumab warrant further investigation in angiosarcoma.AcknowledgementsFunding: National Institutes of Health/National Cancer Institute grant awards CA180888, CA180819, CA180868; and in part by Bristol-Myers Squibb CompanyTrial RegistrationNCT02834013Ethics ApprovalThis study was approved by the NCI CIRB.

UV-light-assisted green preparation of Bi/BiOBr/RGO composites with oxygen vacancies toward enhanced photocatalytic removal of organic dye

2020 ◽  
Vol 44 (19) ◽  
pp. 7749-7757 ◽  
Author(s):  
Wen Jia ◽  
Dong Peng ◽  
Zijuan Feng ◽  
Xue Wu ◽  
Yi Liu ◽  
...  
Keyword(s):  
Oxygen Vacancies ◽  
Uv Light ◽  
Light Exposure ◽  
Organic Dye ◽  
Photocatalytic Removal ◽  
Bi Nanoparticles

Concomitant formation of metallic Bi nanoparticles and oxygen vacancies was successfully achieved within Bi/BiOBr/RGO composites by green UV-light exposure.

scholarly journals Hydrophylicity Enhancement of Modified Cellulose Acetate Membrane to Improve the Membrane Performance in Produced Water Treatment

2018 ◽  
Vol 156 ◽  
pp. 08003 ◽  
Author(s):  
Tutuk Djoko Kusworo ◽  
Danny Soetrisnanto ◽  
Cynthia Santoso ◽  
Tyas Dwi Payanti ◽  
Dani Puji Utomo
Keyword(s):  
Water Treatment ◽  
Produced Water ◽  
Uv Light ◽  
Light Exposure ◽  
Membrane Surface ◽  
Asymmetric Structure ◽  
Dense Layer ◽  
Cellulose Acetate Membrane ◽  
Permeate Flux ◽  
Produced Water Treatment

Produced water is a wastewater generated from petroleum industry with high concentration of pollutants such as Total Dissolved Solid, Organic content, and Oil and grease. Membrane technology has been currently applied for produced water treatment due to its efficiency, compact, mild and clean process. The main problem of produced water using membrane is fouling on the membrane surface which causes on low permeate productivity. This paper is majority focused on the improvement of anti-fouling performance through several modifications to increase CA membrane hydrophilicity. The membrane was prepared by formulating the dope solution consists of 18 wt-% CA polymer, acetone, and PEG additive (3 wt-%, 5 wt-%, and 7 wt-%). The membranes are casted using NIPS method and being irradiated under UV light exposure. The SEM images show that parepared membrane has asymmetric structure consist of dense layer, intermediete layer, and finger-like support layer. The filtration test shows that PEG addition increase the membrane hydrophilicity and the permeate flux increases. UV light exposure on the membrane improves the membrane stability and hydrophilicity. The imrpovement of membrane anti-fouling performance is essential to achieve the higher productivity without lowering its pollutants rejection.

scholarly journals A Left-Sided Prevalence of Lentigo Maligna: A UK Based Observational Study and Review of the Evidence

2015 ◽  
Vol 2015 ◽  
pp. 1-6 ◽  
Author(s):  
Mark Gorman ◽  
Andrew Hart ◽  
Bipin Mathew
Keyword(s):  
Risk Factor ◽  
Uv Light ◽  
Light Exposure ◽  
Significant Risk ◽  
Significant Risk Factor ◽  
Evidence Base ◽  
The Body ◽  
Cumulative Exposure ◽  
Lentigo Maligna ◽  
Recent Trends

Skin cancer has been shown to present asymmetrically, prevalent on the left side of the body, more so in subtypes of cutaneous melanoma such as lentigo maligna. Biases have been linked to cumulative UV light exposure and automobile driving patterns. Though left-right ratios have previously correlated with the side men or women tend to position themselves or countries drive on, more recent trends indicate a consistent left-sided bias. To clarify reasons for changing trends, a review of the evidence base and LM’s laterality in a UK cohort (99 cases 2000–2011) was conducted for the first time. The strong correlation of left-sided excess, found in both genders (ratios 1.381–1.5,P<0.05  X20.841), is congruent with more recent findings. Though evidence indicates that driving position is no longer a risk factor for LM, due most likely to improved car window UV protection, it remains the most commonly attributed cause. Understanding phenomena such as UV lights “scatter effect” or that cumulative exposure may not be a significant risk factor helps rationalize older conclusions that would otherwise appear contradictory. The reasons for left-sided excess remain unclear but may be due to factors requiring further research such as the body’s anatomical/embryological asymmetry.

UV-Curable organic-inorganic hybrid films based on tetraethylorthosilicate oligomer and special acrylated polyester

e-Polymers ◽  
2012 ◽  
Vol 12 (1) ◽  
Author(s):  
Jianyun He ◽  
Jinping Xiong ◽  
Bingqian Xia
Keyword(s):  
Uv Light ◽  
Uv Curing ◽  
Organic Matrix ◽  
Dynamic Mechanical Properties ◽  
Hybrid Films ◽  
Uv Curable ◽  
Inorganic Hybrid ◽  
Dynamic Mechanical ◽  
H Nmr ◽  
Uv Curing Process

AbstractOrganic-inorganic hybrid films were prepared using tetraethylorthosilicate (TEOS) oligomer and special acrylated polyester (SAP) via a UV-curing process. TEOS oligomers were prepared in the presence of water and ethanol using hydrochloric acid as the catalyst and characterized using 1H NMR, 29Si NMR and MALDI-TOF mass spectra. Special acrylated polyester was synthesized by 1,4-cyclohexane dimethanol, neopentyl glycol, 1,4-butanediol, maleic anhydride, adipic acid, and acrylic acid. Hybrid films were cured by UV light and the thermal properties, dynamic mechanical properties, and tensile properties of the hybrid films were evaluated as the function of TEOS oligomer content. The morphology of the hybrid films was examined using atomic force microscopy (AFM). The microscopy and dynamic mechanical data indicated that the hybrid films were heterogeneous materials with various inorganic particle sizes dispersed within the organic matrix. The results indicated that after incorporating the TEOS oligomer, the strength and thermal stability of the hybrid films were enhanced.

scholarly journals Suspected Pulmonary Metastasis of Actinic Cutaneous Squamous Cell Carcinoma

2017 ◽  
Vol 2017 ◽  
pp. 1-4 ◽  
Author(s):  
Monet E. Meter ◽  
David J. Nye ◽  
Christian R. Galvez
Keyword(s):  
Squamous Cell Carcinoma ◽  
Cell Carcinoma ◽  
Squamous Cell ◽  
Actinic Keratosis ◽  
Uv Light ◽  
Light Exposure ◽  
Thoracoscopic Surgery ◽  
Wedge Resection ◽  
Lung Lesion ◽  
The Right

Introduction. It is rare for actinic or squamous cell carcinoma (SCC) in situ to metastasize. Case Presentation. A 67-year-old male had a significant medical history including severe psoriatic arthritis treated with UVB, methotrexate, and rapamycin. He had twenty-five different skin excisions of actinic keratosis four of which were invasive SCC. Our patient developed shortness of breath necessitating a visit to the emergency department. A CT scan of his chest revealed a mass in the right lower lung. A subsequent biopsy of the mass revealed well-differentiated SCC. He underwent thoracoscopic surgery with wedge resection of the lung lesion. Discussion. Actinic keratosis (AK) is considered precancerous and associated with UV exposure. It exists as a continuum of progression with low potential for malignancy. The majority of invasive SCCs are associated with malignant progression of AK, but only 5–10% of AKs will progress to malignant potential. Conclusion. In this case, a new finding of lung SCC in the setting of multiple invasive actinic cutaneous SCC associated with a history of extensive UV light exposure and immunosuppression supports a metastatic explanation for lung cancer.

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