Preparation and Characterization of Cyclophosphamide-Loaded Chitosan Microspheres
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Chitosan microspheres were prepared by using a cross linking agent combined with an emulsion technique. Cyclophosphamide was loaded as an anticancer agent. Obtained microspheres were spherical and regular, with a smooth surface morphology, having an average diameter of 15.7±9.0μm. After preparation, the drug-loading rate and entrapment rate of cyclophosphamide was investigated by UV spectrophotometry. Drug release was tested in vitro in a dynamic dialysis system with a dialysis bag. The chitosan microspheres prepared were proved to have good drug release profiles.
2017 ◽
Vol 10
(10)
◽
pp. 136
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2018 ◽
Vol 10
(6)
◽
pp. 234
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Keyword(s):
2009 ◽
Vol 1
(1)
◽
2020 ◽
Vol 12
(2)
◽
pp. 4474-4491
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