Compressive Property and Electrochemistry Behavior of Porous Ti-Nb-Ta-Zr for Biomedical Applications

2019 ◽  
Vol 803 ◽  
pp. 178-181
Author(s):  
Bo Qiong Li ◽  
Chun Lin Li ◽  
Xing Lu
Keyword(s):  
Porous Structure ◽  
Trabecular Bone ◽  
Bone Substitute ◽  
Biomedical Applications ◽  
Corrosion Potential ◽  
Strain Ratio ◽  
Compressive Property ◽  
Porous Ti ◽  
Electrochemistry Behavior ◽  
Zr Alloys

Porous Ti-Nb-Ta-Zr alloys for biomedical applications were successfully fabricated by PM. The microstructure, cycle compressive and electrochemistry behavior were studied. It results that the porous structure of Ti-Nb-Ta-Zr with 0.8 GPa Young’s modulus, 2.7% pseudoelastic strain ratio and-0.44 V corrosion potential in SBF, can be applied to the trabecular bone prosthesis or bone substitute for spinal vertebral body.

scholarly journals Surface Properties and Biocompatibility of Anodized Titanium with a Potential Pretreatment for Biomedical Applications

Metals ◽  
2021 ◽  
Vol 11 (7) ◽  
pp. 1090
Author(s):  
Bai-Hung Huang ◽  
Yi-Jung Lu ◽  
Wen-Chien Lan ◽  
Muhammad Ruslin ◽  
Hung-Yang Lin ◽  
...  
Keyword(s):  
Porous Structure ◽  
Biomedical Applications ◽  
Grazing Incidence ◽  
Acid Pretreatment ◽  
Osteoblast Cells ◽  
In Vitro Biocompatibility ◽  
Porous Ti ◽  
Diphenyltetrazolium Bromide ◽  
Anodized Titanium

The effects of anodized titanium (Ti) with a potential hydrogen fluoride (HF) acid pretreatment through cathodization on the formation of nano-porous Ti dioxide (TiO2) layer were characterized using field-emission scanning electron microscopy, grazing incidence X-ray diffractometer, and contact angle goniometer. The biocompatibility was determined by 3-[4,5-dimethylthiazol-2-yl]-2,5-diphenyltetrazolium bromide (MTT) test. Analytical results found that a well-aligned nano-porous structure was formed on the anodized Ti surface with HF pretreatment concentration above 0.5%. Microstructure of the nano-porous Ti dioxide surface generated by anodization with HF pretreatment was composed of anatase and rutile phases, while the anodized Ti sample with HF pretreatment concentration of 0.5% presented excellent hydrophilicity surface. An in-vitro biocompatibility also indicated that osteoblast cells grown on the surface of the anodized Ti sample with HF pretreatment increased with the increase of culture time. The filopodia of osteoblast cells not only adhered flat, but also tightly grabbed the nano-porous structure for promoting cell adhesion and proliferation. Therefore, the anodized Ti with HF pretreatment can form a functionalized surface with great biocompatibility for biomedical applications, particularly for dental implants.

scholarly journals Development of elastically graded titanium alloys for biomedical applications

2020 ◽  
Vol 321 ◽  
pp. 05016
Author(s):  
Stéphanie DELANNOY ◽  
Sarah BAÏZ ◽  
Pascal LAHEURTE ◽  
Laurence JORDAN ◽  
Frédéric PRIMA
Keyword(s):  
Titanium Alloys ◽  
Biomedical Applications ◽  
Surface Deformation ◽  
Stress Shielding ◽  
Bone Implant ◽  
Strategy Process ◽  
Elastic Mismatch ◽  
Graded Properties ◽  
Selection Of ◽  
Zr Alloys

Recent works have shown that the elastic mismatch observed at the bone / implant interface could be responsible for stress shielding issues causing bone resorption phenomena and potentially implant failures. In the present study, new advanced thermomechanical approaches leading to titanium alloys with graded elastic properties are proposed. The underlying philosophy and the whole methodology is detailed here, from the selection of candidates with large elastic variability to the creation of gradients, involving the identification of microstructure-properties relationships and the use of appropriate thermo-mechanical treatments. Applied on Ti-Nb-Zr alloys, these original routes enabled to get the following graded properties: elastic modulus from 85 to 65GPa over 400μm for TNZ alloy by surface deformation, and from 130 to 75GPa over 100μm for Ti-13-13 by preferential dissolution. These promising results thus validated the previously designed material-strategy-process combinations.

Effect of steroidal saponins-loaded nano-bioglass/phosphatidylserine/collagen bone substitute on bone healing

2017 ◽  
Vol 62 (5) ◽  
Author(s):  
Chunrong Yang ◽  
Huazhong Wu ◽  
Jianhua Wang
Keyword(s):  
Drug Release ◽  
Sustained Release ◽  
Porous Structure ◽  
Bone Healing ◽  
Bone Substitute ◽  
Therapeutic Potential ◽  
Steroidal Saponins ◽  
Skeletal Defects ◽  
Collagen Microsphere

AbstractThe objective of this study was to investigate the therapeutic potential of nano-bioglass/phosphatidylserine/collagen (nBG/PS/COL) scaffolds loaded with steroidal saponins as an inducer factor for skeletal defects. The drugs-encapsulated bone substitute was prepared by loading steroidal saponins-collagen microsphere suspension in nano-bioglass and phosphatidylserine (PS) composite. The scaffolds possess an interconnected porous structure with a porosity of about 82.3%. The pore size ranges from several micrometers up to about 400 μm. The drug release assays showed the long-term sustained release of steroidal saponins from the scaffolds with effective and safe bioactivity. Moreover,

Comparison of PLGA Reinforcement Method for Carbonate Apatite Foam

2012 ◽  
Vol 529-530 ◽  
pp. 417-420 ◽  
Author(s):  
Girlie M. Munar ◽  
Melvin L. Munar ◽  
Kanji Tsuru ◽  
Ishikawa Kunio
Keyword(s):  
Compressive Strength ◽  
Porous Structure ◽  
Cancellous Bone ◽  
Bone Substitute ◽  
Vacuum Infiltration ◽  
Carbonate Apatite ◽  
Potential Candidate ◽  
Bone Substitute Material ◽  
Substitute Material ◽  
Scanning Electron

Carbonate apatite (CO3Ap) foam with interconnecting porous structure is a potential candidate as bone substitute material owing to its similarity to the cancellous bone with respect to composition, morphology and osteoclastic degradation. However, it is brittle and difficult to handle. This is thought to be caused by no organic material in the CO3Ap foam. The aim of this study is to reinforce the CO3Ap foam with poly (DL-lactide-co-glycolide) (PLGA). Immersion and vacuum infiltration methods were compared as reinforcing methods. Compressive strength of unreinforced CO3Ap foam, (12.0 ± 4.9 kPa) increased after PLGA reinforcement by immersion (187.6 ± 57.6 kPa) or by vacuum infiltration (407 ± 111.4 kPa). Scanning electron microscopy (SEM) showed the preservation of full interconnecting porous structure of CO3Ap foam after PLGA reinforcement using immersion or vacuum infiltration. Interface between the PLGA and CO3Ap foam, however revealed that no gap was found between the PLGA and CO3Ap foam interface when vacuum was used to reinforce the PLGA whereas a gap was found when simple immersion was used. Strong interface between PLGA and CO3Ap foam is therefore thought to be the key for higher compressive strength. In conclusion, vacuum infiltration is a more efficient method to reinforce the CO3Ap foam with PLGA for improving the mechanical strength without sacrificing the cancellous bone-type morphology.

scholarly journals Development of a novel bioresorbable bone substitute with a unidirectional porous structure

2016 ◽  
Vol 4 ◽  
Author(s):  
Matsuo Takashi ◽  
Hotta Yuji ◽  
Kuwayama Tomoya ◽  
Sakane Masataka ◽  
Yamazaki Masashi ◽  
...  
Keyword(s):  
Porous Structure ◽  
Bone Substitute
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