Development of Aqueous Formulation Containing the Extracted Mangiferin

Mangiferin, a polyphenol of C-glycosylxanthone, exhibits various bioactivities with poor aqueous solubility. It is known as a potent antioxidant, which leads to remarkable UV protection and anti-aging properties. Mangiferin can be found in many plant species, among which the mango leaf is one of the primary sources. From our study, the extraction yield of mangifein obtained from the leaves of Mangifera indica L. variety Nam Doc Mai was 3.17% with 95.02% ± 0.064 purity (HPTLC analysis). The solubility of mangiferin in the studied pure solvents arranging in descending order were ethoxydiglycol, dimethyl isosorbide, polyethylene glycol 400, polyethylene glycol 600, propylene glycol, dipropylene glycol, glycerin, isopentyldiol, methanol, ethanol and water, whereas the addition of the solvent in water could increase the aqueous solubility of mangiferin. In several cases, the solubility was apparently higher than that dissolved in its pure solvent state. The log-linear solubility model for the cosolvent system was used to calculate the volume fractions of the selected solvents needed to solubilize mangiferin content at the twenty times of the IC50 against DPPH radicals. In conclusion, the developed aqueous formulation contained 0.5% w/v of mangiferin and 20% w/v of polyethylene glycol 600 or dipropylene glycol as a solubilizer in water.

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Flame retardancy of Scots pine (Pinus sylvestris) by using polyethylene glycol 400 and phosphoric acid

International Journal of Psychosocial Rehabilitation ◽

10.37200/ijpr/v24i4/pr201029 ◽

2020 ◽

Vol 24 (04) ◽

pp. 507-515

Author(s):

Fatima Zohra Brahmia ◽

Tibor Alpár ◽

Péter Horváth György

Keyword(s):

Polyethylene Glycol ◽

Phosphoric Acid ◽

Pinus Sylvestris ◽

Scots Pine ◽

Flame Retardancy ◽

Polyethylene Glycol 400

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Development, Evaluation and Optimization of Osmotic Controlled Tablets of Aceclofenac for Rheumatoid Arthritis Management

Drug Delivery Letters ◽

10.2174/2210303109666181203150830 ◽

2019 ◽

Vol 9 (1) ◽

pp. 29-36

Author(s):

Bijaya Ghosh ◽

Niraj Mishra ◽

Preeta Bose ◽

Moumita D. Kirtania

Keyword(s):

Rheumatoid Arthritis ◽

Polyethylene Glycol ◽

Sodium Chloride ◽

Cellulose Acetate ◽

Hydroxypropyl Methylcellulose ◽

Release Profile ◽

Polyethylene Glycol 400 ◽

Permeable Membrane ◽

Cumulative Release ◽

The Core

Objective: Rheumatoid arthritis is a dreaded disease, characterized by pain, inflammation and stiffness of joints, leading to severe immobility problems. The disease shows circadian variation and usually gets aggravated in early morning hours. Aceclofenac, a BCS Class II compound is routinely used in the treatment of pain and inflammation associated with rheumatoid arthritis. The objective of this study was to develop an osmotic delivery system of Aceclofenac that after administration at bedtime would deliver the drug in the morning hours. </P><P> Methods: A series of osmotically controlled systems of aceclofenac was developed by using lactose, sodium chloride and hydroxypropyl methylcellulose K100M as osmogens. Cellulose acetate (2% w/v in acetone) with varying concentrations of polyethylene glycol-400 was used as the coating polymer to create semi permeable membrane and dissolution was carried out in 290 mOsm phosphate buffer. Formulation optimization was done from four considerations: cumulative release at the end of 6 hours (lag time), cumulative release at the end of 7 hours (burst time), steady state release rate and completeness of drug release. </P><P> Results: A formulation having swelling polymer hydroxypropyl methylcellulose in the core and lactose and sodium chloride as osmogens, polyethylene glycol-400 (16.39 %) as pore former, with a coating weight of 5% was a close fit to the target release profile and was chosen as the optimum formulation. Conclusion: Aceclofenac tablets containing lactose, HPMC and sodium chloride in the core, given a coating of cellulose acetate and PEG-400 (5% wt gain), generated a release profile for optimum management of rheumatoid arthritic pain.

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