Synthesis of Zingerone Using NiCl2•6H2O-NaBH4 as a Selective Hydrogenation Reaction Agent
Synthesis of zingerone (4-(4-hydroxy-3-methoxyphenyl)-2-butanone) has been done. The first step was to synthesize the compound (4-(4-hydroxy-3-methoxyphenyl)-3-buten-2-on) through a cross aldol condensation reaction between vanilin:acetone mol ratio of 1:5:5, for 5 hours in high yields (97%). The second step was the selective hydrogenation of (4-(4-hydroxy-3-methoxyphenyl)-3-buten-2-on) with NiCl2•6H2O-NaBH4 catalyst in mild condition. Based on the FT-IR, 13C-NMR and 1H-NMR and GC-MS analyses, the synthesis of zingerone has been successfully synthesized by selective hydrogenation reaction with 80% yield.