scholarly journals Polyvinyl alcohol/cellulose hydrogel as possible corneal stroma substitute in drug permeation tests

2021 ◽  
Vol 4 (s1) ◽  
Author(s):  
Erica Zucchetti ◽  
Leonardo Ling ◽  
Daniela Monti ◽  
Patrizia Chetoni ◽  
Silvia Tampucci ◽  
...  

The permeation studies of active compounds and formulations are necessary to verify the capability of molecules to pass through the physiological barrier of our body. In order to develop a 3D model of the cornea, preparation and characterization of different hydrogels as corneal stroma substitutes were tested.

Molecules ◽  
2021 ◽  
Vol 26 (10) ◽  
pp. 2856
Author(s):  
Gary B. Smejkal ◽  
Edmund Y. Ting ◽  
Karthik Nambi Arul Nambi ◽  
Richard T. Schumacher ◽  
Alexander V. Lazarev

Stable, oil-in-water nanoemulsions containing astaxanthin (AsX) were produced by intense fluid shear forces resulting from pumping a coarse reagent emulsion through a self-throttling annular gap valve at 300 MPa. Compared to crude emulsions prepared by conventional homogenization, a size reduction of over two orders of magnitude was observed for AsX-encapsulated oil droplets following just one pass through the annular valve. In krill oil formulations, the mean hydrodynamic diameter of lipid particles was reduced to 60 nm after only two passes through the valve and reached a minimal size of 24 nm after eight passes. Repeated processing of samples through the valve progressively decreased lipid particle size, with an inflection in the rate of particle size reduction generally observed after 2–4 passes. Krill- and argan oil-based nanoemulsions were produced using an Ultra Shear Technology™ (UST™) approach and characterized in terms of their small particle size, low polydispersity, and stability.


2021 ◽  
pp. 110776
Author(s):  
Rahil Ghadiriasli ◽  
Mohamed A.A. Mahmoud ◽  
Maria Wagenstaller ◽  
Jan-Willem van de Kuilen ◽  
Andrea Buettner
Keyword(s):  

2018 ◽  
Vol 13 (5) ◽  
pp. 450-458 ◽  
Author(s):  
Tanikan Sangnim ◽  
Sontaya Limmatvapirat ◽  
Jurairat Nunthanid ◽  
Pornsak Sriamornsak ◽  
Wancheng Sittikijyothin ◽  
...  

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