Saudi anti-human cancer plants database (SACPD): A collection of plants with anti-human cancer activities

Oncology Reviews ◽

10.4081/oncol.2018.349 ◽

2018 ◽

Cited By ~ 1

Author(s):

Ateeq Ahmed Al-Zahrani

Keyword(s):

Saudi Arabia ◽

Cell Lines ◽

Anticancer Drugs ◽

Plant Species ◽

Cancer Cell ◽

Human Cancer ◽

Cancer Cell Lines ◽

Anticancer Activities ◽

Excellent Starting Point ◽

Starting Point

Several anticancer drugs have been developed from natural products such as plants. Successful experiments in inhibiting the growth of human cancer cell lines using Saudi plants were published over the last three decades. Up to date, there is no Saudi anticancer plants database as a comprehensive source for the interesting data generated from these experiments. Therefore, there was a need for creating a database to collect, organize, search and retrieve such data. As a result, the current paper describes the generation of the Saudi anti-human cancer plants database (SACPD). The database contains most of the reported information about the naturally growing Saudi anticancer plants. SACPD comprises the scientific and local names of 91 plant species that grow naturally in Saudi Arabia. These species belong to 38 different taxonomic families. In Addition, 18 species that represent16 family of medicinal plants and are intensively sold in the local markets in Saudi Arabia were added to the database. The website provides interesting details, including plant part containing the anticancer bioactive compounds, plants locations and cancer/cell type against which they exhibit their anticancer activity. Our survey revealed that breast, liver and leukemia were the most studied cancer cell lines in Saudi Arabia with percentages of 27%, 19% and 15%, respectively. The current SACPD represents a nucleus around which more development efforts can expand to accommodate all future submissions about new Saudi plant species with anticancer activities. SACPD will provide an excellent starting point for researchers and pharmaceutical companies who are interested in developing new anticancer drugs. SACPD is available online at https://teeqrani1.wixsite.com/sapd

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Syntheses and Anticancer Activities of Novel Glucosylated (-)-Epigallocatechin-3-Gallate Derivatives Linked via Triazole Rings

10.21203/rs.3.rs-182372/v1 ◽

2021 ◽

Author(s):

Cheng-Ting Zi ◽

Bo-Ya Shi ◽

Ze-Hao Wang ◽

Ning Zhang ◽

Yin-Rong Xie ◽

...

Keyword(s):

Cell Lines ◽

Cancer Cell ◽

Human Cancer ◽

Cancer Cell Lines ◽

Human Cancer Cell ◽

Anticancer Activities ◽

Glucose Residue ◽

Human Cancer Cell Lines ◽

Mtt Assays ◽

Mcf 7

Abstract Novel glucosylated (-)-epigallocatechin-3-gallate derivatives 10 – 13 having the EGCG analogues conjugated to the D-glucosyl azide were synthesized by carrying out the copper-catalyzed azide-alkyne cycloaddition (CuAAC) reaction, and were evaluated for their cytotoxicities against a panel of five human cancer cell lines (HL-60, SMMC-7721, A-549, MCF-7 and SW480) using MTT assays. Compounds 10 and 11 showed the highest levels of cytotoxicity against the HL-60 cells with IC50 values of 4.57 μM and 3.78 μM, respectively, and showed moderate selectivity towards cancer cell lines. Compound 11 was also shown to induce apoptosis in HL-60 cells. Most notably, inclusion of the perbutyrylated glucose residue in an EGCG derivative was concluded to lead to increased anticancer activity.

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Aaptamines from the Marine SpongeAaptossp. Display Anticancer Activities in Human Cancer Cell Lines and Modulate AP-1-, NF-κB-, and p53-Dependent Transcriptional Activity in Mouse JB6 Cl41 Cells

BioMed Research International ◽

10.1155/2014/469309 ◽

2014 ◽

Vol 2014 ◽

pp. 1-7 ◽

Cited By ~ 19

Author(s):

Sergey A. Dyshlovoy ◽

Sergey N. Fedorov ◽

Larisa K. Shubina ◽

Alexandra S. Kuzmich ◽

Carsten Bokemeyer ◽

...

Keyword(s):

Cell Lines ◽

Cancer Cell ◽

Cellular Response ◽

Transcriptional Activity ◽

Human Cancer ◽

Cell Cancer ◽

Cancer Cell Lines ◽

Human Cancer Cell ◽

Anticancer Activities ◽

Human Cancer Cell Lines

Aaptamine (8,9-dimethoxy-1H-benzo[de][1,6]naphthyridine) is a marine natural compound possessing antioxidative, antimicrobial, antifungal, and antiretroviral activity. Earlier, we have found that aaptamine and its derivatives demonstrate equal anticancer effects against the human germ cell cancer cell lines NT2 and NT2-R and cause some changes in the proteome of these cells. In order to explore further the mechanism of action of aaptamine and its derivatives, we studied the effects of aaptamine (1), demethyl(oxy)aaptamine (2), and isoaaptamine (3) on human cancer cell lines and on AP-1-, NF-κB-, and p53-dependent transcriptional activity in murine JB6 Cl41 cells. We showed that compounds1–3demonstrate anticancer activity in THP-1, HeLa, SNU-C4, SK-MEL-28, and MDA-MB-231 human cancer cell lines. Additionally, all compounds were found to prevent EGF-induced neoplastic transformation of murine JB6 Cl41 cells. Nuclear factors AP-1, NF-κB, and p53 are involved in the cellular response to high and nontoxic concentrations of aaptamine alkaloids1–3. Furthermore, inhibition of EGF-induced JB6 cell transformation, which is exerted by the compounds1–3at low nontoxic concentrations of 0.7–2.1 μM, cannot be explained by activation of AP-1 and NF-κB.

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The cytotoxic and apoptotic effects of Ferulago W. Koch extracts on various cancer cell lines

Turkish Journal of Biochemistry ◽

10.1515/tjb-2020-0225 ◽

2020 ◽

Vol 0 (0) ◽

Author(s):

Filiz Bakar-Ates ◽

Berna Hoti ◽

Ilhan Gurbuz ◽

Tugba Gunbatan ◽

Hayri Duman ◽

...

Keyword(s):

Cell Cycle ◽

Cell Lines ◽

Cancer Cell ◽

Apoptotic Cell ◽

Human Cancer ◽

Annexin V ◽

Cancer Cell Lines ◽

Antimicrobial Activities ◽

Anticancer Activities ◽

Ethanolic Extracts

AbstractBackgroundThe studies investigating the anticancer activities of natural products have accelerated to produce new solutions in the face of increasing cancer cases. Various Ferulago species are reported to exhibit antioxidant, antiulcer and antimicrobial activities.ObjectiveThis study aimed to evaluate the cytotoxic and apoptotic activities of ethanolic extracts of roots of five Ferulago species on various human cancer cell lines.Material and methodsHPLC analyses were performed by HP Agilent 1,100. The cytotoxicity were determined by MTT assay. The cell cycle arrest and Annexin V binding analyses were performed by Muse Cell Analyzer (Millipore).ResultsAll examined species except F. setifolia inhibited cell viability in PC3 and SW480 cells at 0.01 mg/mL and higher concentrations (p<0.05). Ferulago species inhibited cell cycle at different stages for treated cell lines. The ethanolic extracts of Ferulago species also increased Annexin V binding significantly, resulted in apoptosis (p<0.05%). In this context, F. syriaca showed the highest apoptotic activity in MCF-7 cells by increasing the apoptotic cell population to 23.54 ± 2.10% (p<0.0001).ConclusionThe findings of present study have shown that Ferulago species included in the study have potent anticancer effects and this work have the potential to result in further studies.

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Recent development of tetrahydro-quinoline/isoquinoline based compounds as anticancer agents

Current Topics in Medicinal Chemistry ◽

10.2174/1568026621666210526164208 ◽

2021 ◽

Vol 21 ◽

Author(s):

Pratik Yadav ◽

Ashish Kumar ◽

Ismail Althagafi ◽

Vishal Nemaysh ◽

Reeta Rai ◽

...

Keyword(s):

Cell Lines ◽

Cancer Cell ◽

Anticancer Agents ◽

Human Cancer ◽

Biological Activities ◽

Cancer Cell Lines ◽

New Drugs ◽

Anticancer Activities ◽

Human Cancer Cell Lines ◽

Anticancer Properties

: Tetrahydroquinoline and isoquinoline scaffolds are important class heterocyclic compounds, which is implied for the development of new drugs and diagnostic for therapeutic function. Naturally occurring as well as synthetic tetrahydroquinolines/isoquinolines possess many different biological activities and have been testified as remarkable cytotoxic and potency in human cancer cell lines. Tetrahydroquinoline/isoquinolines based compounds displayed a key role in the development of anticancer drugs or lead molecules and acting through various mechanisms such as cell proliferation, apoptosis, DNA fragmentation, inhibition of tubulin polymerization, induced cell cycle arrest, interruption of cell migration, and modulation. The number of tetrahydroquinoline/isoquinoline derivatives has been reported as potent anticancer agents. Due to promising anticancer activities and wide-ranging properties of these molecules, we have compiled the literature for the synthesis and anticancer properties of various tetrahydroquinolines and isoquinolines. We have reported the synthesis of potent tetrahydroquinoline/isoquinoline molecules of the last 10 years with their anticancer properties in various cancer cell lines and stated their half-maximal inhibitory concentration (IC50). In addition, we also considered the discussion of molecular docking and structural activity relationship wherever provided to understand the possible mode of activity a target involved and structural feature responsible for the better activity, so the reader can directly find the detail for designing new anticancer agents.

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JFCR39, a panel of 39 human cancer cell lines, and its application in the discovery and development of anticancer drugs

Bioorganic & Medicinal Chemistry ◽

10.1016/j.bmc.2012.01.017 ◽

2012 ◽

Vol 20 (6) ◽

pp. 1947-1951 ◽

Cited By ~ 40

Author(s):

Dexin Kong ◽

Takao Yamori

Keyword(s):

Cell Lines ◽

Anticancer Drugs ◽

Cancer Cell ◽

Human Cancer ◽

Cancer Cell Lines ◽

Human Cancer Cell ◽

Human Cancer Cell Lines

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Non-oncology drugs are a source of previously unappreciated anti-cancer activity

10.1101/730119 ◽

2019 ◽

Cited By ~ 6

Author(s):

Steven M. Corsello ◽

Rohith T. Nagari ◽

Ryan D. Spangler ◽

Jordan Rossen ◽

Mustafa Kocak ◽

...

Keyword(s):

Cell Lines ◽

Cancer Cell ◽

Human Cancer ◽

Drug Repurposing ◽

Cancer Cell Lines ◽

Multi Drug Resistance ◽

Human Cancer Cell Lines ◽

Molecular Features ◽

Starting Point ◽

Anti Cancer

ABSTRACTAnti-cancer uses of non-oncology drugs have been found on occasion, but such discoveries have been serendipitous and rare. We sought to create a public resource containing the growth inhibitory activity of 4,518 drugs tested across 578 human cancer cell lines. To accomplish this, we used PRISM, which involves drug treatment of molecularly barcoded cell lines in pools. Relative barcode abundance following treatment thus reflects cell line viability. We found that an unexpectedly large number of non-oncology drugs selectively inhibited subsets of cancer cell lines. Moreover, the killing activity of the majority of these drugs was predictable based on the molecular features of the cell lines. Follow-up of several of these compounds revealed novel mechanisms. For example, compounds that kill by inducing PDE3A-SLFN12 complex formation; vanadium-containing compounds whose killing is dependent on the sulfate transporter SLC26A2; the alcohol dependence drug disulfiram, which kills cells with low expression of metallothioneins; and the anti-inflammatory drug tepoxalin, whose killing is dependent on high expression of the multi-drug resistance gene ABCB1. These results illustrate the potential of the PRISM drug repurposing resource as a starting point for new oncology therapeutic development. The resource is available at https://depmap.org.

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