scholarly journals Study of NT-pro-BNP and Hs-Troponin I biomarkers for early detection of children’s heart function of protein-energy malnutrition

2019 ◽  
Vol 11 (2) ◽  
Author(s):  
Herlina Dimiati ◽  
Abdus Samik Wahab ◽  
Mohammad Juffrie ◽  
Madarina Julia ◽  
Basri A. Gani
Keyword(s):  
Troponin I ◽  
Heart Function ◽  
Protein Energy Malnutrition ◽  
Area Under The Curve ◽  
Left Ventricular ◽  
The Body ◽  
Chromatography Method ◽  
Blood Electrolytes ◽  
Ventricular Mass ◽  
Protein Energy

The Protein Energy Malnutrition (PEM) is the condition of a lack of carbohydrate and protein stores in the body that trigger chronic failure nutrient intake and body maintenance function caused to impact the heart functions. The NT-pro-BNP and Hs- Troponin I proteins were found as the indicator of cardiac dysfunction. The sixty subjects of PEM, analyzed by standard of Indonesia Healt Ministry as well as nutritional status. The blood electrolytes examined by laboratory assay and the levels of Hs-Troponin 1 and NT-Pro-BNP were analyzed by Immune-Chromatography method. Assessing of the ventricular mass with the seeing the peak of the diastolic flow rate of left ventricular that estimated by the curve of the receiver operating characteristic and the area under the curve (P<0.05). The result has shown that the PEM decreased in the left ventricular mass for impaired heart function and systolic disorder. The Hs- Troponin I (90.9%) has better sensitivity than NT-pro-BNP (85.5%) if the merger of those markers possesses the lowest sensitivity (81.8%). These proteins have good biomarkers in heart function, mainly in cases where PEM is present.

Left ventricular mass and function in children with severe protein energy malnutrition

1992 ◽  
Vol 35 (1) ◽  
pp. 19-25 ◽  
Author(s):  
Shyam Sunder Kothari ◽  
Tejas M. Patel ◽  
Amulyaratha N. Shetalwad ◽  
Thakorebhai K. Patel
Keyword(s):  
Left Ventricular Mass ◽  
Protein Energy Malnutrition ◽  
Left Ventricular ◽  
Ventricular Mass ◽  
Protein Energy ◽  
And Function

scholarly journals Aflatoxins in body fluids and food of Nigeria children with protein-energy malnutrition

2012 ◽  
Vol 12 (53) ◽  
pp. 6553-6566
Author(s):  
GC Onyemelukwe ◽  
◽  
D Ogoina ◽  
GE Ibiam ◽  
GH Ogbadu
Keyword(s):  
Protein Energy Malnutrition ◽  
Cross Sectional Study ◽  
Body Fluids ◽  
The Body ◽  
Healthy Controls ◽  
Cross Sectional ◽  
Detection Rates ◽  
Nigerian Children ◽  
Protein Energy ◽  
Patient Groups

Aflatoxins are natural contaminants of food crops implicated in the pathogenesis of various human diseases. This study aimed to determine the associations between aflatoxins and protein- energy malnutrition ( PEM) by measurements of aflatoxins in serum, urine and food on plate of Nigerian children with PEM. A cross - sectional study was undertaken in 3 agro - ecological regions of Nigeria (Guinea savannah, Sudan savannah and Rain forest), where aflatoxins B1 , B2, G1, G2, M1, and M2 were measured in sera, urine and food on plate of 79 children with PEM (kwashiorkor n=36, marasmic kwashiorkor n=29 and marasmus n=13) and 33 healthy controls, matched for age and sex. Among healthy controls, aflatoxin detection rates were higher in the Guinea Savannah (72.2%) than in the Sudan Savannah (53.8%), albeit statistically insignificant. In relation to nutritional groups, the rates of detection of aflatoxins were higher in marasmic kwashiorkor (93.1%) and kwashiorkor patients (88.9%) , compared to marasmus (76.9%) and controls (63.6%, p=0.013). The rates of detection of B1 aflatoxin followed a similar trend viz. marasmic kwashiorkor (82.4%), kwashiorkor (69.4%), marasmus (53.8%) and controls (42.4%, p=0.007). Of all types of aflatoxins detected in serum, M2 had the highest rates of detection in all patient groups and controls. The median concentrations of aflatoxins detected in sera of each PEM group were significantly higher than those of controls, but comparisons between PEM groups were not statistically significant. The frequency and concentration of aflatoxins detected in urine and food of PEM groups and controls were not statistically different. However, controls had the lowest serum / urine aflatoxin ratio as well as lowest median aflatoxins concentrations in their food as compared to PEM patient s. In conclusion, aflatoxins are commonly detected in the body fluids and food of Nigerian children , but more frequently and at higher concentrations in children with PEM , possibly due to decreased excretion or increased exposure. Future prospective studies are desirable to determine if aflatoxins contribute to the pathogenesis of all types of PEM and not necessarily kwashiorkor alone.

Abstract 2516: Primary Aldosteronism And Inappropriateness Of Left Ventricular Mass

Circulation ◽  
2007 ◽  
Vol 116 (suppl_16) ◽  
Author(s):  
Maria Lorenza Muiesan ◽  
Massimo Salvetti ◽  
Anna Paini ◽  
Claudia Agabiti Rosei ◽  
Cristina Monteduro ◽  
...  
Keyword(s):  
Left Ventricular Mass ◽  
Primary Aldosteronism ◽  
Adrenal Adenoma ◽  
Blood Pressure Measurement ◽  
Reference Population ◽  
Left Ventricular ◽  
The Body ◽  
Stroke Work ◽  
Ventricular Mass ◽  
The Individual

Background: The calculation of values of left ventricular mass (LVM) exceeding individual needs to compensate haemodynamic load (inappropriate LVM) can identify patients with high CV risk (de Simone J. Hypertens 2001, Muiesan Hypertens 2007). However, a substantial percentage of LVM variance remains unexplained, even when the influence of cardiac workload, of the body size and gender are taken into account. It is possibile that other factors, non hemodynamic (genetic) or neurohumoral (renin-angiotensin-aldosterone system) may explain the individual LVM. Aim of this study to evaluate the prevalence of inappropriate LVM (iLVM) in patients with primary aldosteronism (PA). Methods 94 PA (51 with adrenal hyperplasia and 43 with adrenal adenoma), (age 49 ± 11 years, 41 F) and in 94 essential hypertensives (EHT) matched for age and sex, underwent echocardiography. The appropriateness of LVM to cardiac workload was calculated by the ratio of observed LVM to the value predicted for an individual gender, height, and stroke work at rest, from a reference population (de Simone et al, 1998). All subjects underwent laboratory examinations, including PRA and plasma aldosterone, and clinic and 24 hours blood pressure measurement. Results No significant differences were observed for clinic and 24 hours BP, clinic and 24 hours heart rate, glucose and lipids between PA and EHT. The prevalence of traditionally defined LV hypertrophy (LVMI ≥ 47 g/m 2.7 in F and 50g/m 2.7 in M) was greater in PA patients than in EHT (48 vs 19 % chi 2 = 0.02). In patients without LVH, the prevalence of iLVM (> 128% of predicted) was also greater in patients with PA than in EHT controls, (14 % vs 2.5 %, chi 2 p = 0.012). Among PA those with iLVM had a higher BMI, increased uric acid, lower midwall fractional shortening, and prolonged isovolumic relaxation time (p < 0.05 at least). In all patients a small, albeit statistically significant, correlation was observed between the Aldosterone/PRA levels and the ratio of observed/predicted LVM (r = 0.18, p < 0.02). Conclusions: In patients with PA the prevalence of iLVM is increased, even in the absence of traditionally defined LVH. The increase in aldosterone levels could contribute to the increase of LV mass exceeding the amount needed to compensate hemodynamic load.

scholarly journals KADAR TRIGLISERIDA DAN STATUS GIZI PADA KLIEN TUBERKULOSIS

2017 ◽  
Vol 5 (2) ◽  
pp. 101
Author(s):  
Noor Diani ◽  
Devi Rahmayanti
Keyword(s):  
Nutritional Status ◽  
Protein Energy Malnutrition ◽  
The Body ◽  
Nutrition Status ◽  
P Value ◽  
Cross Sectional ◽  
Protein Energy ◽  
Tnf Α ◽  
Relationship Of ◽  
The Relationship

Abstrak Tuberkulosis (TBC) mengakibatkan penurunan asupan dan malabsorbsi nutrien serta metabolisme tubuh berubah sehingga terjadi massa otot dan lemak menurun akibat mekanisme malnutrisi dari energi protein. Malnutrisi pada TBC berpengaruh terhadap prognosis dan tingkat kematian. Peningkatan produksi IFNl- γ dan IL-6, TNF α menghambat dari aktivitas Lipo Protein Lipase (LPL) dijaringan lemak. Enzim LPL berperan dalam proses bersihan trigliserida. Peningkatan ini meningkatkan trigliserida sehingga proses sintesis lemak menurun dan proses lipolisis lemak meningkat di jaringan. Tujuan penelitian ini menganalisis hubungan trigliserida dan status gizi pada klien TBC. Metode penelitian ini korelasi analitik dengan pendekatan cross-sectional, sampel 25 orang, dengan uji korelasi Pearson-Product Moment. Hasil penelitian status gizi dibawah normal 56%, normal 40% dan kelebihan berat badan 4%. Kadar Trigliserida normal 84%, trigliserida tinggi 16%. Kesimpulan ada hubungan antara kadar trigliserida dan status gizi yakni r hitung sebesar 0,5: r tabel = 0,396 sehingga r hitung > r tabel dengan korelasi positif.Kata Kunci : Trigliserida, Status Gizi, Tuberkulosis.AbstractTuberculosis(TB) resulting the decreasing of nutrient intake and malabsorbsi as well as changing the metabolism of the body. The wasthing are decreased protein energy. Malnutrition on TB affects the prognosis of the treatment and death rates. The increase TNF α will inhibit the enzyme activity of Lipoprotein Lipase (LPL) in the fat tissue. LPL enzyme plays a role in cleavage process of triglycerides. This research was to analyze the relationship of triglycerides and nutrition status on the client with tuberculosis. The design was cross-sectional approach. The respondents were gathered from 25 newly TB patients. The analyzed using Pearson Product-Moment correlation. The results showed 56% respondents undernutrition, and normal 40% and over nutrition 4%. Most triglyceride level of the respondent were normal (84). The concluded was a relationship between triglycerides and the nutritional status with a positive correlation ( P value 0,396).Keywords : Triglycerides, Nutritional Status, Tuberculosis

scholarly journals Proximate and Phytochemical Compositions of Dried Seeds of Fluted Pumpkin (Telfairia occidentalis)

2021 ◽  
pp. 14-19
Author(s):  
L. C. Chuku ◽  
N. C. Chinaka
Keyword(s):  
Protein Energy Malnutrition ◽  
Proximate Analysis ◽  
The Body ◽  
Diabetic Patients ◽  
Phytochemical Analysis ◽  
Mineral Absorption ◽  
Experimental Procedure ◽  
Telfairia Occidentalis ◽  
Protein Energy ◽  
High Lipid

Proximate and phytochemical analyses were carried out on dried fruited pumpkin (Telfaira occidentalis) seeds. Standard experimental procedure and statistical analysis using SPSS version 20.1 were carried out after triplicate evaluation of the sample. Results of the proximate analysis indicated that the dried seeds contains moderate percent of carbohydrate (11.43±0.92%) and fibre (15.71±0.74%), high percentage protein (34.56±1.36%) and lipid (32.50±1.08%), ash (4.40±0.02%) and moisture (1.40±0.01%) contents were low statistically. The qualitative and quantitative phytochemical analysis showed that dried seeds of Telfairia occidentalis possessed very low (statistically insignificant, p>0.05) level of cyanogenic glycoside (0.001±0.01 µg/g) which makes it non toxic and consumable. Tannin (0.488 ± 0.012 µg/g) and oxalate (0.194±0.01 µg/g) where low in percentage, while phylate (3.75±0.018 µg/g) and saponin (4.00±0.02 µg/g) levels were statistically high (p<0.05). The analysis revealed the sample as rich in protein and lipid, with moderate amounts of carbohydrate and fibre. It also indicates absence of cynogenic glycoside and low oxalate level which interfere with mineral absorption in the body. Hence, the seed is a very good protein source especially for patients with protein energy malnutrition (PEM), growing children and diabetic patients due to its rich energy source for body utilization and for extraction of cooking oil due to its high lipid content.

Abstract 696: Cardiosphere-derived Cells Engraft Long-term in Infarcted Mice and Preserve Left Ventricular Function

Circulation ◽  
2007 ◽  
Vol 116 (suppl_16) ◽  
Author(s):  
Rachel R Smith ◽  
Michelle K Leppo ◽  
Isotta Chimenti ◽  
John Terrovitis ◽  
Andreas S Barth ◽  
...  
Keyword(s):  
Left Ventricular Function ◽  
Ventricular Function ◽  
Cardiac Troponin ◽  
Troponin I ◽  
Heart Function ◽  
Single Cells ◽  
Left Ventricular ◽  
Cardiac Troponin I ◽  
Border Zone

Cardiosphere-derived cells (CDCs) were grown from rat hearts and percutaneous endomyocardial adult human biopsy specimens. Rat CDCs plated as single cells formed clones with a doubling time of 42.2 ± 0.7 hours (n = 9). Clones from rat CDCs divided steadily for 27 days before proliferation spontaneously slowed and morphological changes occurred in most cells. After 56 days, rat clonal populations contained a small fraction of c-Kit + cells as determined by flow cytometry, and large subsets of cells expressing cardiac troponin I, α-smooth muscle actin, and von Willebrand factor as determined by immunofluorescence, indicative of their multipotentiality in vitro . To assess therapeutic potential, acute myocardial infarcts (MIs) were created in immunodeficient mice and actively proliferating polyclonal human CDCs were injected into the border zone. Echocardiographic left ventricular function, histological examination, and immunofluorescence served as endpoints. CDC-injected animals showed no significant deterioration in ejection fraction (EF) from 2 days (EF = 45.2 ± 4.8%) to 6 weeks post-MI (EF = 40.2 ± 4.5%, n = 7, p = NS), in contrast to fibroblast-injected control animals (EF = 42.8 ± 4.3% at 2 days vs 27.3 ± 4.0% at 6 weeks, p < 0.01). At the 6 week endpoint, the CDC group had thicker infarct walls as measured histologically compared to the fibroblast group (0.26 ± 0.03mm vs 0.12 ± 0.01mm, n = 5, p < 0.01). CDC engraftment was determined by immunofluorescence using a human-specific antibody. CDCs stably engrafted for up to 6 weeks and could be found distributed primarily throughout the infarct (57 ± 3% of engrafted CDCs, n = 5 animals), as well as the border zone (30 ± 5%) and viable tissue (13 ± 3%). After 6 weeks, CDCs within the infarct had formed small myocytes with little cytoplasmic cardiac troponin I, while CDCs within the viable myocardium had formed large myocytes with well-defined sarcomeric organization. We conclude that CDCs are clonogenic and spontaneously multipotent in vitro and capable of preserving heart function in a mouse infarct model. Functional preservation is presumably due in part to maintenance of infarct wall thickness, likely secondary to stable CDC engraftment within the infarct, as well as the formation of morphologically mature myocytes throughout the non-infarcted tissue.

Harmful effects of malnutrition and possible sustainable solution

2022 ◽  
Vol 8 (4) ◽  
pp. 260-264
Author(s):  
S Ravichandran ◽  
Mahrukh Mehraj ◽  
Fathima Feroz ◽  
R M Madhumitha Sri
Keyword(s):  
Immune System ◽  
Lean Body Mass ◽  
Body Mass ◽  
Protein Energy Malnutrition ◽  
Food Prices ◽  
The Body ◽  
Essential Nutrients ◽  
Protein Energy ◽  
Harmful Effects ◽  
Muscle Functions

Malnutrition is a condition that results from eating a diet that does not supply a healthy amount of one or more nutrients. It is a condition characterized by lack of one or more essential nutrients from the diet or a surplus of some nutrients which affect the body negatively. Malnutrition consists of two types: undernutrition and overnutrition. Undernutrition involves the deficiency of macronutrients like protein or calories and micronutrients like iron, iodine and many more. Protein energy malnutrition is caused by the inadequate intake of protein and calories. It is further classified in three types, kwashiorkor, marasmus and marasmic kwashiorkor. Malnutrition mainly affects an individual’s immune system, lean body mass, cardio-respiratory functions, muscle functions. Malnutrition can be caused due to many factors including unavailability of food, poverty, higher food prices and many more. Strategies like biofortification and supplementation are used for the treatment of malnutrition.

NUTRITIONAL STATUS AND RELATED FACTORS AMONG SECONDARY SCHOOL STUDENT IN HUE CITY

2018 ◽  
Vol 8 (5) ◽  
pp. 42-51
Author(s):  
Tu Nguyen Minh ◽  
Nhung Pham Thi Kim ◽  
Hoa Tran Thi ◽  
Nga Nguyen Thanh ◽  
Thang Tran Binh
Keyword(s):  
Secondary School ◽  
Nutritional Status ◽  
Dietary Habits ◽  
Protein Energy Malnutrition ◽  
Public Health Problem ◽  
Secondary School Student ◽  
The Body ◽  
Related Factors ◽  
Factors Associated ◽  
Protein Energy

Introduction: The change in perception of of appearance in the adolescent, which led to shift in the nutritional status of the body. Therefore, a comprehensive assessment of nutritional status at this age needs attention and poses as a public health problem. Objectives: The aims of present study was to describle the prevalance of nutrituon status and obtain associated factors among secondary school student in Hue city. Material and method: A cross-sectional study was conducted on 613 students aged 11-14 years (6 th-9th grade) at two secondary high schools in Hue city. Students were enrolled in anthropometric measures and interviewed with the questionnaire. Results: The prevalence of protein-energy malnutrition accounted for 11.9%, of which severity was 3.9% and mild condition was 8.0%. The prevalence of overweight, obesity was 15.8% (overweight 12.9% and obesity 2.9%, respectively). Regarding factors associated with protein-energy malnutrition was found including educational of mother, dietary habits. Factors associated with overweightobesity including: mother education, snacking habits, eating too much rice. Female tend to be lower risk than male 80%. Conclusion: The prevalence of protein-energy malnutrition accounted for a high proportion of this study, and dietary habits were closely related to an increase in the prevalence of overweight-obesity. Key words: Protein-energy malnutrition, overweight-obesity, nutrition, secondary school, student

scholarly journals Experimental protein-energy deficiency in rats. Ratio of serine+glycine to threonine as an index of deficiency

1973 ◽  
Vol 29 (1) ◽  
pp. 113-120 ◽  
Author(s):  
Sohair I. Salem ◽  
S. M. Hegazi ◽  
S. R. Morcos
Keyword(s):  
Amino Acids ◽  
Essential Amino Acid ◽  
Protein Energy Malnutrition ◽  
The Body ◽  
Protein Deficiency ◽  
Energy Deficiency ◽  
Low Protein ◽  
Protein Energy ◽  
Serum Amino Acids ◽  
Full Picture

1. Rats were given a low-protein (10 g/kg) diet for 16 weeks and the changes occurring in their serum amino acids were studied; during this time a full picture of protein-energy malnutrition was manifested. Groups of rats were killed at intervals of 4 weeks.2. Food intake decreased gradually from the 4th to the 8th week, then increased slightly from the 9th to the 11th week, and then decreased again.3. The body-weight of the rats fell progressively from the 1st week on the low-protein diet, remained stationary from the 10th to the 13th week, and then decreased again during the last 4 weeks.4. The ratio of non-essential to essential amino acid was not correlated with the severity of protein deficiency.5. The ratios between some individual amino acids were compared with these ratios in control rats during the 4-week periods of protein deficiency. The ratio of serine+glycine to threonine was always significantly higher in the protein-deficient than in the control rats.

MethotrexaTE THerapy in ST-Segment Elevation MYocardial InfarctionS

2017 ◽  
Vol 22 (6) ◽  
pp. 538-545 ◽  
Author(s):  
Daniel Medeiros Moreira ◽  
Maria Emilia Lueneberg ◽  
Roberto Leo da Silva ◽  
Tammuz Fattah ◽  
Carlos Antonio Mascia Gottschall
Keyword(s):  
Myocardial Infarction ◽  
Infarct Size ◽  
Troponin I ◽  
Area Under The Curve ◽  
Left Ventricular ◽  
Left Ventricular Ejection ◽  
Ventricular Ejection Fraction ◽  
St Segment Elevation ◽  
Timi Frame Count ◽  
St Segment

Purpose: Methotrexate is an anti-inflammatory drug that has been shown to have anti-ischemic effects. Our aim was to evaluate if methotrexate could reduce infarct size in patients with ST-segment elevation myocardial infarction (STEMI). Methods: We randomly assigned patients with STEMI to receive either methotrexate or placebo. Primary outcome was infarct size determined by calculating the area under the curve (AUC) for creatine kinase (CK) release. Secondary outcomes were AUC of CK MB (CK-MB) and AUC of troponin I; peak CK, peak CK-MB, and troponin I; B-type natriuretic peptide (BNP) level, high-sensitivity C-reactive protein (hsCRP) result, and erythrocyte sedimentation rate (ESR); left ventricular ejection fraction (LVEF); thrombolysis in myocardial infarction (TIMI) frame count; Killip score; mortality and reinfarction incidence; and incidence of adverse reactions. Results: We included 84 patients. Median AUC of CK was 78 861.0 in the methotrexate group and 68 088.0 in the placebo group ( P = .10). Patients given methotrexate and placebo exhibited, respectively, median AUC for CK-MB of 9803.4 and 8037.0 ( P = .42); median AUC for troponin of 3691.1 and 2132.6 ( P = .09); peak CK of 2806.0 and 2147.0 ( P = .05); peak CK-MB of 516.0 and 462.3 ( P = .25); and peak troponin of 121.0 and 85.1 ( P = .06). At 3 months, LVEF was lower in patients who received methotrexate (49.0% ± 14.1%) than in patients given placebo (56.4% ± 10.0%; P = .01). There were no differences in hsCRP, ESR, BNP, Killip scores, TIMI frame count, reinfarction, and mortality rates. There was a higher median serum glutamic–pyruvic transaminase levels in the methotrexate group. Conclusion: Methotrexate did not reduce infarction size and worsened LVEF at 3 months ( Clinicaltrials.gov identifier NCT01741558).

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