scholarly journals BONE MARROW ABONRMALITIES IN HIV INFECTION

2013 ◽  
Vol 5 (1) ◽  
pp. e2013033 ◽  
Author(s):  
Sharad Antiram Dhurve
Keyword(s):  
Bone Marrow ◽  
Hiv Infection ◽  
Immune Status ◽  
Complete Blood Count ◽  
Bone Marrow Examination ◽  
Hiv Positive ◽  
Abnormal Cells ◽  
Bone Marrow Study ◽  
Hematological Abnormalities ◽  
Hiv Aids

ABSTRACT Introduction; Hematological abnormalities are a common complication of HIV infection.  Bone marrow abnormalities occur in all stages of HIV infection.  Present work was carried out to study the bone marrow abnormalities in patients with HIV/AIDS.  Methods: 160 patients of HIV +ve were included in the study. A complete blood count, relevant biochemical investigations, CD4   counts were done, besides a thorough history and clinical examination. HIV positive patients were classified as those having AIDS and those without AIDS according to NACO criteria.   Bone marrow examination was performed for indication of anemia, leucopenia, pancytopenia and thrombocytopenia. Results: As per CDC criteria 59.81% patients had AIDS in 107 patients. The most common hematological abnormality was anemia, seen in 93.12% patients.  Bone marrow was normocellular in 79.06% of non-AIDS and 79.68% of AIDS, hypocellular in 13.95%.Thrombocytopenia was seen in 4 cases of ART (4.93%) and 3 cases (4.68%) of AIDS group. Abnormal cells like plasma cell, histocyte and toxic granule found in bone marrow. Conclusions: Myelodysplasia was more common in AIDS than in non AIDS patients. Granulocytic series is most commonly associated with evidence of dysplasia. Anemia in HIV patients can be a good clinical indicator to predict and access the underlying immune status. Thus bone marrow study is imperative to methodically observe and follow clinical and laboratory aberration in such patients in order to improve our diagnostic and therapeutic skills pertinent to HIV/AIDS.

Pancytopenia and Progressive Splenomegaly in Patient with Disseminated Histoplasmosis

2021 ◽  
Vol 27 (2) ◽  
pp. 228
Author(s):  
Paulus Budiono Notopuro ◽  
Arifoel Hajat ◽  
Made Putra Sedana
Keyword(s):  
Bone Marrow ◽  
Hiv Infection ◽  
Fungal Infection ◽  
Blood Count ◽  
Histoplasma Capsulatum ◽  
Complete Blood Count ◽  
Bone Marrow Examination ◽  
Spleen Size ◽  
Disseminated Histoplasmosis ◽  
Severe Manifestation

Disseminated histoplasmosis is a severe manifestation of fungal infection caused by Histoplasma capsulatum. It usuallyoccurs in a patient with an immunodeficiency state. With the increase of HIV infection and the use of immunosuppressantdrugs lately, its prevalence also increases. A case of 43 years old female with prolonged fever, pancytopenia, and massiveprogressive splenomegaly. The diagnosis of disseminated histoplasmosis and the secondary hemophagocytic syndromewas made based on bone marrow examination that showed increased hemophagocytic processes and multipleintracytoplasmic H.capsulatum. She had been treated with Itraconazole 200 mg for three months. In the first month'sevaluation, her complete blood count improved without any transfusions, and the size of her spleen size decreased. She hadbeen fully recovered after the completion of 3-month treatment.

scholarly journals Clinic-etiological profile of pancytopenia in children: a tertiary care center based study of Kumaun region, India

2018 ◽  
Vol 5 (6) ◽  
pp. 2173
Author(s):  
Ramesh Chand ◽  
Nutan Singh
Keyword(s):  
Bone Marrow ◽  
Complete Blood Count ◽  
Megaloblastic Anemia ◽  
Care Center ◽  
Tertiary Care ◽  
Geographical Area ◽  
Bone Marrow Examination ◽  
Male Predominance ◽  
Kala Azar ◽  
Abnormal Cells

Background: Pancytopenia is not a disease entity but a triad of findings in which all blood cell lineages i.e leukocytes, erythrocytes and platelets are reduced in blood .It is consequence of various medical conditions. Present study was conducted to assess the etiology, clinical profile and bone marrow morphology of pancytopenia.Methods: A cross sectional prospective study was carried out among 42 children of age between 1 to 15 year with pancytopenia. Blood samples of the patients were analyzed for complete blood count and peripheral smear along with presence and absence of immature cells and abnormal cells. In bone marrow examination, morphology of all cell’s lineage, cellularity, parasite and abnormal cells were scrutinized. Trephine biopsy was done if indicated. Special investigations were done to confirm the diagnosis.Results: Among the 42 cases studied, age of the patients ranged from 1 to 15 years with a slight male predominance. Most of the patients presented with generalized weakness and weight loss and fever. The commonest physical finding was pallor, followed by splenomegaly and hepatomegaly.  The commonest cause for pancytopenia was megaloblastic anemia Among the non-haematological causes kala azar 5 (11.9%) is the leading cause in this study.Conclusions: The present study concludes that detailed primary haematological investigations along with bone marrow examination in pancytopenic patients are helpful for diagnosis and management. This study also suggests that megaloblastic anaemia, dimorphic anaemia and kala-azar should also be included in differential diagnosis of pancytopenia in this geographical area.

scholarly journals Manifestations of Bone Marrow Abnormalities of HIV/AIDS Patients

2021 ◽  
Vol 7 (3) ◽  
pp. 119-127
Author(s):  
Dr. Soumya Kanti Pramanik ◽  
◽  
Dr. Mamata Guha Mallick Sinha ◽  
Keyword(s):  
Bone Marrow ◽  
Opportunistic Infections ◽  
Complete Blood Count ◽  
Bone Marrow Aspiration ◽  
Cross Sectional Study ◽  
Hiv Positive ◽  
Aids Patients ◽  
Cross Sectional ◽  
Number Of Patients ◽  
Hiv Aids

Background: Human immunodeficiency virus can involve almost any organ system. Anemia is themost common hematological manifestation in HIV/AIDS patients. Bone marrow changes includevarying degrees of dysplasia in one or more cell lines, plasmacytosis, opportunistic infections andhematological malignancies. There are only a few studies where hematological manifestations ofHIV/AIDS patients had been described. Materials and Methods: 100 HIV positive patients, agedbetween 12-65 years were enrolled in this hospital-based cross-sectional study. The study wasconducted from March 2016 to March 2018. A complete blood count, CD4 counts were done, besidesa thorough history and clinical examination. HIV positive patients were classified as those havingAIDS and Non-AIDS, according to NACO criteria. Written informed consent was taken from patientsand bone marrow aspiration was done. Results: Total number of patients included in the study was100. We were able to do a CD4 count of 91 patients. As per criteria, out of 91 patients, 37 cases hadAIDS. The most common hematological abnormality was anemia, seen in 95.45%of patients. Bonemarrow was normocellular in 86.48% of AIDS and 85.18% of non-AIDS, hypocellular in 8.10% ofAIDS and 9.25%o f non- AIDS, hypercellular in 5.40% of AIDS and 5.55% of non-AIDS patients.Dysplasia was statistically and significantly associated with anemia. The commonest dysplasticfeatures are seen in the granulocytic and erythroid series. L.D. bodies were seen in 2 cases andHistoplasma was found in one case. Conclusion: Normocytic normochromic anemia was the mostcommon peripheral smear finding. Hypocellular bone marrow was more common than hypercellularmarrow in an advanced stage of the disease. Dysplastic changes were more common in AIDS thanNon-AIDS. Granulocytic dysplasia was the most common type of dysplasia. There was evidence ofopportunistic infections and gelatinous transformation were detected in our study.

HIV/AIDS and Children

2021 ◽  
pp. 376-380
Author(s):  
Chandrashekhara Chandrashekhara ◽  
Sandeepkumar O
Keyword(s):  
Sexual Abuse ◽  
Hiv Infection ◽  
Vertical Transmission ◽  
Hiv Positive ◽  
Mother To Child Transmission ◽  
Child Transmission ◽  
Mother To Child ◽  
Hiv Aids

Children are innocent victims of HIV infection through vertical transmission. Children who are HIV positive, either through mother-to-child transmission or following sexual abuse, are often not told what could happen to them, and they will certainly be frightened when they experience symptoms.

Evaluation of platelet parameters in cerebral stroke in patients with HIV infection

2021 ◽  
pp. 48-51
Author(s):  
D. O. Tarasov ◽  
I. A. Lebedev ◽  
S. N. Suplotov ◽  
O. A. Nesterova ◽  
G. O. Tersenov ◽  
...  
Keyword(s):  
Cerebral Infarction ◽  
Hiv Infection ◽  
Complete Blood Count ◽  
Blood Platelets ◽  
High Volume ◽  
Hiv Positive ◽  
Control Group ◽  
Cerebral Stroke ◽  
Giant Platelets ◽  
Distribution Width

The article reflects the results of studying platelet parameters in HIV-positive patients with different types of stroke.Aim. To identify changes in laboratory parameters of a complete blood count which characterize the morphofunctional features of platelets in stroke among HIV-positive patients.Materials and methods. 110 HIV-positive patients who received treatment for stroke in hospitals of the Tyumen region were examined. The study of blood parameters was carried out at the analyzer Sysmex XE2100 (Japan). Blood sampling was carried out on the day of patients admission.The number of platelets and platelet indices were analyzed: MPV – mean platelet volume, PDW – platelet distribution width, PCT – plateletcrit and P-LCR – platelet large cell ratio. The control group consisted of 117 patients. The signifcance of the differences was determined at the twotailed signifcance level of p < 0.05.Results. There was a signifcant decrease in the number of platelets (p < 0.05), in average, on 34.3% among patients with hemorrhages and HIV infection. Among patients with ischemic stroke this decrease was less pronounced (p = 0.05). A signifcant decrease in plateletcrit was established among patients with intracranial hemorrhages, while it did not change signifcantly among patients with cerebral infarction. During evaluation of other platelet parameters, no signifcant differences were found between patients in experimental and control groups. The coeffcient of giant platelets prevailed by one and a half times in patients with hemorrhages associated with HIV infection, which turned out to be beyond the statistical signifcance.Conclusion. The presence of HIV infection leads to a more pronounced, reliable decrease in the number of platelets and plateletcrit among patients that have acute phase of the development of hemorrhagic stroke than in patients with cerebral infarction. The development of intracranial hemorrhage among HIV-positive patients is characterized by an increase of blood platelets with a high volume, the level of which increased by one and a half times being beyond the statistical signifcance and having as a leading mechanism the intensifcation of platelet formation in the bone marrow.

Utility of bone marrow examination for workup of fever of unknown origin in patients with HIV/AIDS

2015 ◽  
Vol 68 (3) ◽  
pp. 241-245 ◽  
Author(s):  
Andrés E Quesada ◽  
Ashok Tholpady ◽  
Audrey Wanger ◽  
Andy N D Nguyen ◽  
Lei Chen
Keyword(s):  
Bone Marrow ◽  
Fever Of Unknown Origin ◽  
Unknown Origin ◽  
Bone Marrow Examination ◽  
Hiv Aids

scholarly journals Neurocysticercosis and HIV Infection: what can we learn from the published literature?

2019 ◽  
Vol 77 (5) ◽  
pp. 357-365 ◽  
Author(s):  
Omar Herrera Vazquez ◽  
Matthew L. Romo ◽  
Agnès Fleury
Keyword(s):  
Hiv Infection ◽  
Immune Status ◽  
Taenia Solium ◽  
Response To Treatment ◽  
Hiv Positive ◽  
Historical Series ◽  
Immunodeficiency Virus ◽  
The Central Nervous System ◽  
Published Research ◽  
Hiv Negative

ABSTRACT Infections caused by the human immunodeficiency virus (HIV) and by the larvae of Taenia solium (i.e., cysticercosis) are still widespread in many developing countries. Both pathologies modify host immune status and it is possible that HIV infection may modulate the frequency and pathogeny of cysticercosis of the central nervous system (i.e., neurocysticercosis [NCC]). Objective: To describe published cases of NCC among HIV-positive patients and to evaluate whether the characteristics of NCC, including frequency, symptoms, radiological appearance, and response to treatment differed between HIV-positive and HIV-negative patients. Methods: Forty cases of NCC/HIV co-infected patients were identified in the literature. Clinical and radiological characteristics, as well as response to treatment, were compared with non-matching historical series of NCC patients without HIV infection. Results: Most of these patients had seizures and multiple vesicular parasites located in parenchyma. Clinical and radiological characteristics were similar between HIV-positive and HIV-negative patients with NCC, as well as between immunocompromised and non-immunocompromised HIV-positive patients. Conclusion: Our review did not reveal clear interactions between HIV and NCC. This may be partially due to the small number of cases and reliance on published research. A systematic, multi-institutional effort aiming to report all the cases of this dual pathology is needed to confirm this finding and to clarify the possible relationship between both pathogens.

scholarly journals Mapping evidence on adolescents’ HIV-positive status disclosure in sub-Saharan Africa: a protocol for a scoping review

2020 ◽  
Vol 9 (1) ◽  
Author(s):  
Patience Adzordor ◽  
Clement Avoka ◽  
Vitalis Bawontuo ◽  
Silas Agbesi ◽  
Desmond Kuupiel
Keyword(s):  
Hiv Infection ◽  
Scoping Review ◽  
Keyword Search ◽  
Sub Saharan Africa ◽  
Hiv Positive ◽  
People Living With Hiv ◽  
Sub Saharan ◽  
Living With Hiv ◽  
Status Disclosure ◽  
Hiv Aids

Abstract Background Sub-Saharan Africa (SSA) homes most of the people living with HIV/AIDS in the world. Adolescents/young people are a vulnerable population and at high risk of HIV infection. Identifying and bridging the research gaps on the disclosure of HIV-positive status among adolescents, particularly to their sexual partners, is essential to inform appropriate policy planning and implementation towards preventing HIV transmission. This study will aim to explore literature and describe the evidence on HIV-positive status disclosure among adolescents in SSA. Methods The framework provided by Arksey and O’Malley’s framework and improved by Levac and colleagues will be used to conduct a scoping review. A keyword search for relevant literature presenting evidence on HIV-positive status disclosure among adolescents in SSA will be conducted in CINAHL, PubMed, Science Direct, Google Scholar, and SCOPUS. Date limitations will be removed, but Boolean terms “AND” and “OR” as well as Medical Subject Headings terms will be included where possible and syntax modified to suit the database during the search. Additional relevant articles will be sought from the reference lists of all included studies using a snowballing method. Two reviewers will independently screen the articles at the abstract and full-text screening phases in order to reduce bias and improve the reliability of this study’s findings. A tabular form will be developed using Microsoft Word and piloted for data extraction. Thematic content analysis will be conducted, and a narrative summary of all relevant outcomes reported. Quality appraisal of the included studies for this proposed study will be performed utilizing the recent mixed methods appraisal tool. Discussion The evidence produced by this review may help inform policy and strategies to reduce the incidence of HIV infection among adolescents and improve social support for adolescents living with HIV/AIDS in SSA. It may also reveal literature gaps to guide future researches to further inform HIV policies for adolescents in SSA. Platforms such as peer review journals, policy briefs, and conferences will be used to disseminate this study’s findings.

scholarly journals Stability of an HIV/AIDS Treatment Model with Different Stages

2015 ◽  
Vol 2015 ◽  
pp. 1-9 ◽  
Author(s):  
Hai-Feng Huo ◽  
Rui Chen
Keyword(s):  
Hiv Infection ◽  
Hiv Positive ◽  
Global Dynamics ◽  
Asymptotically Stable ◽  
Treatment Model ◽  
Globally Asymptotically Stable ◽  
Asymptomatic Stage ◽  
Mathematical Analyses ◽  
Two Stages ◽  
Hiv Aids

An HIV/AIDS treatment model with different stages is proposed in this paper. The stage of the HIV infection is divided into two stages, that is, HIV-positive in the asymptomatic stage of HIV infection and HIV-positive individuals in the pre-AIDS stage. The fact that some individuals with HIV-positive individuals after the treatment can be transformed into the compartment of HIV-positive individuals in the asymptomatic stage of HIV infection, the compartment of HIV-positive individuals in the pre-AIDS stage, or the compartment of individuals with full-blown AIDS is also considered. Mathematical analyses establish the idea that the global dynamics of the HIV/AIDS model are determined by the basic reproduction numberR0. The disease-free equilibrium is globally asymptotically stable ifR0<1. The endemic equilibrium is globally asymptotically stable ifR0>1for a special case. Numerical simulations are also conducted to support the analytic results.

scholarly journals Clinico-haematological profile of adult pancytopenia patients at a tertiary care institute in South India

2021 ◽  
Vol 9 (2) ◽  
pp. 521
Author(s):  
Nadia Shafi Chikan ◽  
Qazi Mohammad Iqbal ◽  
Altaf Hussain Mir
Keyword(s):  
Bone Marrow ◽  
Megaloblastic Anemia ◽  
Tertiary Care ◽  
Bone Marrow Examination ◽  
Hematological Disorders ◽  
Medical College ◽  
Haematological Profile ◽  
Bone Marrow Study ◽  
Hypercellular Marrow ◽  
Rule Out

Background: Pancytopenia is not a disease by itself; rather it describes simultaneous presence of anemia, leukopenia and thrombocytopenia resulting from a number of disease processes. Varieties of hematological and non-hematological disorders may affect bone marrow either primarily or secondarily, resulting in the manifestation of pancytopenia. The incidence of various hematological disorders causing pancytopenia varies due to geographical distribution and genetic predisposition. This study highlights the spectrum of causes, clinical presentation and bone marrow morphology of pancytopenia.Methods: This prospective observational study was conducted for a period of two years at Al-Ameen Medical College, Bijapur, Bangalore. During this period, fifty patients with a hematological diagnosis of pancytopenia were studied during period in the department of pathology.Results: Among the 50 cases studied, 35 were males and 15 were females. Most of the patients presented with generalized weakness and fever. The commonest physical finding was pallor, followed by splenomegaly and hepatomegaly. Dimorphic anemia was predominant blood picture. Bone marrow study showed 72% hypercellular marrow, 12% normocellular and 16% hypocellular marrow. The commonest cause for pancytopenia was megaloblastic anemia followed by iron deficiency anaemia and malaria.Conclusions: The present study concludes that detailed hematological investigations along with bone marrow examination in pancytopenic patients is helpful to diagnose or rule out the causes of pancytopenia. 

Sign in / Sign up

Export Citation Format

Share Document