scholarly journals C-reactive protein estimation: A quantitative analysis for three nonsteroidal anti-inflammatory drugs: A randomized control trial

2015 ◽  
Vol 26 (1) ◽  
pp. 43 ◽  
Author(s):  
Lakshmi Shetty ◽  
Gaurav Salgia ◽  
DeepakG Kulkarni
Keyword(s):  
Quantitative Analysis ◽  
Randomized Control Trial ◽  
C Reactive Protein ◽  
Reactive Protein ◽  
Protein Estimation ◽  
Inflammatory Drugs ◽  
Randomized Control ◽  
Anti Inflammatory

Influence of Non-steroidal Anti-Inflammatory Drugs and Paracetamol on the Level of C-Reactive Protein of Rat Blood Serum in Experimental Equivalents of Hypothyroidism and Osteoarthritis

2020 ◽  
Vol 5 (6) ◽  
pp. 79-83
Author(s):  
D. S. Nosivets ◽  
Keyword(s):  
Blood Serum ◽  
Bone Tissue ◽  
Diclofenac Sodium ◽  
Arithmetic Mean ◽  
Vacuum System ◽  
C Reactive Protein ◽  
Reactive Protein ◽  
Inflammatory Drugs ◽  
Anti Inflammatory ◽  
Experimental Osteoarthritis

The article investigated changes in the level of C-reactive protein under the influence of non-steroidal anti-inflammatory drugs and paracetamol under experimental equivalents of hypothyroidism and osteoarthritis. There is a clear need to identify biomarkers that could predict a patient's response to osteoarthritis treatment, primarily in comorbid conditions. It is known that hypofunction of the thyroid gland leads to metabolic disorders that negatively affect the condition of bone and cartilage, causing the development of osteoarthritis. One manifestation of osteoarthritis is considered to be a pathological change in the subchondral bone, which responds to the disease by the formation of sclerosis, marginal bone growths and the formation of deformation of the joint surfaces due to the destruction of bone tissue. Although non-steroidal anti-inflammatory drugs are effective in reducing pain and disability in patients with osteoarthritis, it is still unclear to what extent these drugs can affect joint metabolism and, therefore, joint structure, especially against the background of functional thyroid insufficiency. The purpose of the study was to research the pharmacological activity of non-steroidal anti-inflammatory drugs and paracetamol on the level of C-reactive protein in the serum of rats with experimental equivalents of hypothyroidism and osteoarthritis. Material and methods. The experiments were carried out on 70 white outbred rats of both sexes, which recreated osteoarthritis and hypothyroidism. Experimental osteoarthritis was performed by single intra-articular administration of 0.1 ml of monoacetic acid solution in the knee joint, which was prepared at a rate of 3 mg of the reagent on 50 μl of sterile physiological saline. Experimental hypothyroidism was reconstructed by enteral administration of a 0.02% solution of carbimazole, which was prepared at a rate of 5 mg per 250 ml of physiological solution and given with a drinking ration of animals for 6 weeks. The adequacy of the model was confirmed by the level of serum TSH, T3 and T4 in rats. Results and discussion. After the formation of experimental models on the 42nd day of the experiment, the animals were divided into 14 groups and drug administration began daily for 5 days. The quantitative level of C-reactive protein of blood serum was determined by competitive in vitro ELISA twice on 42 and 47 days of the experiment. Blood samples were obtained from the rat tail vein by puncture using a vacuum system at 42 and 47 days of the experiment. Statistical data processing was performed using the Statistica 6.1 software package (StatSoftInc., Serial number AGAR909E415822FA) and included calculations of arithmetic mean values (M) and their errors (± m). The probability of the difference between the arithmetic mean (p) values of the indices was made using non-parametric U-criterion Mann-Whitney. The determination of the probability of intragroup and intergroup differences was performed using the parametric t-criterion of the Student and the method of single-factor dispersion analysis (ANOVA). Differences were considered statistically significant at p≤0.05. Conclusion. The author found that determining the level of C-reactive protein allowed evaluating the anti-inflammatory activity non-steroidal anti-inflammatory drugs on the background of experimental equivalents of osteoarthritis and hypothyroidism. The data obtained from rat’s serum C-reactive protein reflects the extent of the effects of non-steroidal anti-inflammatory drugs and paracetamol due to the interaction of drugs in experimental osteoarthritis and hypothyroidism. According to the degree of influence on degenerative-dystrophic processes in bone tissue the investigated drugs can be arranged as follows: diclofenac sodium > ibuprofen > nimesulide = meloxicam > celecoxib > paracetamol

scholarly journals Efektivitas Pemberian Biocurpain untuk Memperbaiki Status Fungsional pada Pasien Osteoarthritis

2020 ◽  
Vol 7 (1) ◽  
pp. 51
Author(s):  
Rizaldy Taslim Pinzon ◽  
Eric Eric
Keyword(s):  
Randomized Control Trial ◽  
Rescue Medication ◽  
Curcuma Longa ◽  
Boswellia Serrata ◽  
Inflammatory Drugs ◽  
Randomized Control ◽  
Anti Inflammatory ◽  
Lost To Follow Up

Pendahuluan: Osteoarthritis (OA) merupakan penyakit radang sendi progresif yang menurunkan kualitas hidup. Penyakit ini tidak dapat disembuhkan dan terbatas hanya mengurangi nyeri yang dialami oleh pasien. Obat yang sering digunakan adalah non-steroidal anti-inflammatory drugs (NSAIDs), namun penggunaan obat tersebut tidak terlepas dari efek samping jika digunakan dalam jangka panjang. Maka diperlukan obat yang efektif dan aman untuk memperbaiki status fungsional pada pasien osteoarthritis. Tujuan: membandingkan efektifitas dari pemberian Biocurpain yang memiliki Nomor Izin Edar (NIE) TR172599281 dengan NSAIDs untuk memperbaiki status fungsional pada terapi pasien OA. Metode: Penelitian ini menggunakan metode Randomized Control Trial (RCT) yang melibatkan pasien OA. Perlakuan yang diberikan berupa Biocurpain (Curcuma longa 300 mg dan Boswellia serrata 150 mg) dan NSAIDs (ibuprofen 400 mg). Subjek diacak menjadi 2 kelompok (kelompok 1 memperoleh Biocurpain dan kelompok 2 memperoleh NSAIDs). Pengukuran status fungsional menggunakan Western Ontario and McMaster Universities Osteoarthritis Index (WOMAC). Hasil: Terdapat 67 subjek yang mengikuti penelitian ini, 5 subjek lost to follow up dan 3 subjek tidak dapat melanjutkan penelitian karena efek samping yang dirasakan. Sebanyak 59 subjek mengikuti penelitian hingga selesai (kelompok 1 berisi 29 subjek dan kelompok 2 berisi 30 subjek). Tidak ada perbedaan yang signifikan antar kelompok dalam memperbaiki status fungsional (p: 0,771), penggunaan rescue medication (p: 0,370), kejadian efek samping pada visit II (0,215) dan visit III (0,537) pada subjek OA. Kelompok 2 menunjukkan lebih banyak subjek yang mengalami efek samping. Kesimpulan: Biocurpain memiliki efektivitas yang setara dengan NSAIDs dalam memperbaiki status fungsional pada pasien OA.

scholarly journals Association of C-reactive protein and non-steroidal anti-inflammatory drugs with cardiovascular events in patients with psoriatic arthritis: a time-dependent Cox regression analysis

2021 ◽  
Vol 13 ◽  
pp. 1759720X2110277
Author(s):  
Steven H. Lam ◽  
Ho So ◽  
Isaac T. Cheng ◽  
Edmund K. Li ◽  
Priscilla Wong ◽  
...  
Keyword(s):  
Risk Factors ◽  
Psoriatic Arthritis ◽  
Cox Regression ◽  
Time Varying ◽  
C Reactive Protein ◽  
Cox Regression Analysis ◽  
Reactive Protein ◽  
Inflammatory Drugs ◽  
Anti Inflammatory ◽  
Inflammatory Burden

Aims: Psoriatic arthritis (PsA) is associated with accelerated atherosclerosis due to underlying inflammation. Whether inflammatory burden and drugs used to suppress inflammation over time are associated with cardiovascular (CV) events remained unclear. This study aims to examine the time-varying effect of C-reactive protein (CRP) levels and the use of drugs, including non-steroidal anti-inflammatory drugs (NSAIDs) and disease modifying anti-rheumatic drugs, on the risk of CV events independent of traditional CV risk factors in PsA patients. Methods: A retrospective cohort analysis was performed in patients with PsA who were recruited from 2008 to 2015 and followed until the end of 2019. The outcome was occurrence of a first CV event. Framingham risk score (FRS) was used to quantify the traditional CV risk. Cox proportional hazard models with time-varying CRP levels and drugs used were analysed to identify the risk factors for CV events in PsA patients. Results: Two hundred patients with PsA [median age: 47.5 (40.0–56.0); male: 119 (59.5%)] were recruited. After a mean follow-up of 8.8 ± 3.8 years, 30 (15%) patients developed a first CV event. The multivariable Cox regression model showed that time-varying CRP level [hazard ratio (HR) 1.02, 95% confidence interval (CI) 1.00–1.04] and NSAIDs exposure (HR 0.38, 95% CI 0.15–0.96) were significantly associated with CV events after adjusting for baseline FRS (HR 5.06, 95% CI 1.84–13.92). Conclusion: Increased inflammatory burden as reflected by elevated CRP level was associated with increased risk of CV events, while the risk was significantly reduced with NSAIDs use in PsA patients.

scholarly journals Dietary Fiber's Effect on High Sensitivity C-reactive Protein Serum in Sedentary Workers

2021 ◽  
Vol 5 (1) ◽  
pp. 40
Author(s):  
Livia Kurniati Saputra ◽  
Dian Novita Chandra ◽  
Ninik Mudjihartini
Keyword(s):  
Body Weight ◽  
High Sensitivity ◽  
The Body ◽  
Low Grade ◽  
C Reactive Protein ◽  
Reactive Protein ◽  
Dietary Fiber Intake ◽  
Anti Inflammatory ◽  
Low Grade Inflammation ◽  
Inflammatory Effect

Low grade inflammation has been recognized of being involved in the pathogenesis of chronic disease pandemic. Individual lifestyle plays a major role in the development of low grade inflammation. Sedentary workers are at risk of low grade inflammation due to the nature of their work. Dietary habit also contributes to inflammatory status in the body. Dietary fiber intake indirectly affects the immune system. It has been hypothesized that fiber has anti-inflammatory effects, both body weight-related and body weight-unrelated This review will focus more on body weight-unrelated anti-inflammatory effect of fiber, especially through fiber’s fermentation metabolites, the short chain fatty acid (SCFA). Its anti-inflammatory effect can be seen by monitoring a biomarker of inflammation in the body, the high sensitivity C-reactive protein (hsCRP). This review’s objective is to cover the mechanisms and role of dietary fiber intake on serum hsCRP level as a marker of low grade inflammation on sedentary workers. 

scholarly journals Study to Investigate the anti-inflammatory effect of Codelac® Broncho with Thymus Serpyllum (elixir) in comparison with reference drug Fenspiride (syrup) using accute Carrageenan-induced Paw Inflammation Model

2019 ◽  
Vol 5 (1) ◽  
pp. 45-52
Author(s):  
Pavel D. Kolesnichenko ◽  
Anna A. Peresypkina ◽  
Artem A. Poromov ◽  
Elena N. Kareva ◽  
Alexey N. Demidenko
Keyword(s):  
Inflammatory Activity ◽  
C Reactive Protein ◽  
Reference Drug ◽  
Reactive Protein ◽  
Model Control ◽  
Anti Inflammatory ◽  
Thymus Serpyllum ◽  
Carrageenan Inflammation ◽  
Subplantar Injection ◽  
Inflammatory Effect

Introduction: Evaluation of anti-inflammatory action of Codelac® Broncho with Thymus Serpyllum (elixir) in comparison with Fenspiride was carried out on the model of acute carrageenan inflammation of the paws in rats. Materials and methods: Edema was caused by subplantar injection of 0.1 ml of 1% λ- carrageenan gel into the hind paw. The severity of edema was assessed by using 37140 plethysmometer (UGO BASILE, Italy). The measurements were performed before edema induction and 1, 2, 4, 12, 24, 48, 72, 96 and 120 hours afterwards. Anti-inflammatory activity of the drugs was also evaluated based on the analysis of rats’ blood, C-reactive protein concentration and histological examination results. Results and discussion: A decrease in the paw volume increment was revealed in the group with the studied drug in comparison with the group with the carrageenan edema model (control) 4, 12, 24 hours after injection of carrageenan (p<0.05). As a result of plethysmometry, a more pronounced anti-inflammatory effect of the studied drug than that of Fenspiride was revealed. There was a significant decrease in the levels of leukocytes (p<0.05), lymphocytes (p<0.05), monocytes (p<0.05) and neutrophils (p<0.05) in the group with the studied drug compared to those the the control 48 hours after the initiation of edema, while in the group with Fenspiride, there was only a decrease in the levels of leukocytes (p<0.05) and lymphocytes (p<0.05). There were no differences in the concentration of C-reactive protein between the groups. Conclusion: The obtained data indicate a more pronounced anti-inflammatory activity of Codelac® Broncho with Thymus Serpyllum in comparison with Fenspiride, on the model of acute carrageenan inflammation of the paw in rats.

scholarly journals Gum Arabic (Acacia Senegal) Augmented Total Antioxidant Capacity and Reduced C-Reactive Protein among Haemodialysis Patients in Phase II Trial

2020 ◽  
Vol 2020 ◽  
pp. 1-7 ◽  
Author(s):  
Nour Elkhair Ali ◽  
Lamis AbdelGadir Kaddam ◽  
Suad Yousif Alkarib ◽  
Babikir Gabir Kaballo ◽  
Sami Ahmed Khalid ◽  
...  
Keyword(s):  
Oxidative Stress ◽  
Antioxidant Capacity ◽  
Total Antioxidant Capacity ◽  
Gum Arabic ◽  
Oxidative Stress Marker ◽  
C Reactive Protein ◽  
Reactive Protein ◽  
Total Antioxidant ◽  
Anti Inflammatory ◽  
End Stage

Background. Oxidative processes might increase in patients with end-stage renal disease (ESRD) according to the current literature. Oxidative stress (OS) is a risk factor of atherosclerosis and cardiovascular complications, which are major causes of mortality among ESRD patients. Haemodialysis (HD) is life-saving procedure, nevertheless it is an active chronic inflammatory status that could augment cardiovascular disease and increase mortality. Gum Arabic (GA) has been claimed to act as an antioxidant and anti-inflammatory agent in experimental studies and clinical trials. Therefore, we assumed GA supplementation among haemodialysis patients would reduce oxidative stress and consequently reduce the state of chronic inflammatory activation associated with haemodialysis. Methods. Forty end-stage renal failure (ESRF) patients aged 18–80 years who were on regular haemodialysis in Arif Renal Center, Omdurman, Sudan, were recruited. All recruited patients met the inclusion criteria and signed informed consent prior to enrolment. The patients received 30 g/day of GA for 12 weeks. C-reactive protein (CRP) and complete blood count (CBC) were measured as baseline and monthly. Total antioxidant capacity (TAC) and oxidative stress marker malondialdehyde (MDA) levels were measured before and after GA intake. Ethical approval from the National Medicines and Poisons Board was obtained. Results. Gum Arabic significantly augmented total antioxidant capacity level (P<0.001) (95% CI, 0.408–0.625) and also attenuated oxidative marker MDA and C-reactive protein (P<0.001). Conclusions. GA has revealed potent antioxidative and anti-inflammatory properties in haemodialysis patients. Oral digestion of GA (30 g/day) decreased oxidative stress and inflammatory markers among haemodialysis patients. Trial registration. ClinicalTrials.gov Identifier: NCT03214692, registered 11 July 2017 (prospective registration).

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